Journal of periodontal research最新文献

{"title":"The Journey of Oral Hygiene: The Past, the Present, the Future","authors":"Fridus van der Weijden","doi":"10.1111/jre.70136","DOIUrl":"10.1111/jre.70136","url":null,"abstract":"<p>This narrative review traces the evolution of personal oral hygiene from antiquity to the present, examining the shift from rudimentary tools to evidence-based, technologically advanced systems. Historical developments were reviewed alongside current clinical research, including systematic reviews and professional guidelines (e.g., EFP S3-level), to evaluate the efficacy, safety, and behavioral aspects of oral hygiene practices. Oral hygiene has progressed from ancient chewing sticks to modern powered toothbrushes and interdental devices. While manual toothbrushes remain effective, oscillating–rotating and sonic technologies offer more plaque reduction and better gingival outcomes. Interdental cleaning has increasingly favored interdental brushes over dental floss, though rubber picks and oral irrigators provide effective and patient-preferred alternatives. Dentifrices have evolved from simple abrasives to vehicles for fluoride, antimicrobial, and other therapeutic agents. Despite these innovations, oral disease persists, largely due to discrepancies between perceived and actual brushing behaviors, including inadequate duration and technique. Optimal gingival health continues to depend on the quality and consistency of self-performed mechanical plaque removal. Emerging technologies and sustainable, eco-friendly materials may enhance compliance and accessibility, yet they cannot replace professional instruction or habit formation. Future strategies should prioritize personalized, evidence-based oral care that balances clinical efficacy, environmental sustainability, and equitable access.</p>","PeriodicalId":16715,"journal":{"name":"Journal of periodontal research","volume":"61 5","pages":"425-451"},"PeriodicalIF":5.4,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jre.70136","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148391142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peri-Implant Soft-Tissue Phenotype Modification for Refractory Peri-Implant Mucositis: A 12-Month Prospective Clinical Study With Ultrasonographic Analysis","authors":"Shayan Barootchi,&nbsp;Lorenzo Tavelli,&nbsp;Hamoun Sabri,&nbsp;Hom-Lay Wang,&nbsp;Erfan Barootchi,&nbsp;Mario Romandini,&nbsp;Istvan A. Urban,&nbsp;Zoltan Barath","doi":"10.1111/jre.70090","DOIUrl":"10.1111/jre.70090","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This prospective observational study evaluated the clinical, ultrasonographic, and patient-reported (PROMs) outcomes following surgical treatment of refractory/recurrent peri-implant mucositis (PM) using implant decontamination combined with soft tissue phenotype modification via a free gingival graft (FGG).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Subjects presenting with PM unresponsive to two consecutive cycles of non-surgical therapy—and exhibiting both inadequate midbuccal mucosa width (KMW ≤ 1 mm) and absence of adherent/firm mucosa (AM)—were included. Treatment consisted of an apically positioned flap (APF) with thorough decontamination of implant surfaces and restorative components, combined by placement of a facial FGG. Clinical, high-frequency ultrasonographic, and PROMs data were assessed at 2 weeks, and at 3, 6, and 12 months post-operatively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Twenty subjects with 27 implants were treated. At 12 months, 22 implants (81.5%) were classified as clinically healthy. Significant reductions were observed in bleeding on probing (−85.2%), suppuration (−18.5%), and probing pocket depth (PPD: −0.3 mm). In parallel, significant gains were noted in KMW (+4.42 mm), mucosal recession coverage (+45.7%), and mucosal thickness (MT: +0.87 and 1.04 mm at 1.5 and 3 mm apical to the mucosal margin, respectively). Ultrasonography revealed significantly decreased perfusion parameters and a marked increase in tissue “stiffness” in the coronal facial zone, with 100% of treated sites exhibiting a non-displaceable band of AM. PROMs showed marked improvements in overall discomfort, discomfort during probing, and overall satisfaction.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Within the limitations of this study, surgical treatment of refractory PM using APF + FGG was effective in disease resolution, achieving reductions in PPD and clinical inflammation, significant gains in MT and KMW, partial recession coverage, and the re-establishment of a non-mobile band of AM. Ultrasonographic data confirmed reduced inflammatory perfusion and enhanced soft tissue stiffness in the grafted area, particularly in the most coronal region.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16715,"journal":{"name":"Journal of periodontal research","volume":"61 5","pages":"606-623"},"PeriodicalIF":5.4,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jre.70090","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146180226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Multifunctional β-Defensin-3 Mimetic Peptide Modulates Host–Biofilm Interactions and Reduces Bone Loss in Periodontitis","authors":"Beom Soo Jo,&nbsp;Dong Woo Lee,&nbsp;Ji-Young Lee,&nbsp;Sanghui Seok,&nbsp;Yu-Bin Kim,&nbsp;Jue-Yeon Lee,&nbsp;Shin-Young Park,&nbsp;Young Dan Cho,&nbsp;Yang Jo Seol,&nbsp;Yoon Shin Park,&nbsp;Shahram Ghanaati,&nbsp;Homayoun H. Zadeh,&nbsp;Chong Pyung Chung,&nbsp;Yoon Jeong Park","doi":"10.1111/jre.70079","DOIUrl":"10.1111/jre.70079","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Aim&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This study evaluated the potential of a beta-defensin-3 mimetic peptide (BDMP), a synthetic cell-penetrating peptide with antimicrobial and immunomodulatory properties, as an adjunctive therapeutic approach for periodontitis.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;BDMP was formulated in a hydroxyethyl cellulose (HEC) gel and assessed for binding affinity, release kinetics, and ability to penetrate cells and gingival tissues. Anti-inflammatory and osteoclast-related signaling pathways were examined in vitro using RAW264.7 macrophages stimulated with lipopolysaccharide (LPS). Effects on osteogenic recovery were evaluated in periodontal ligament stem cells (PDLSCs) under inflammatory conditions. Antimicrobial activity against multispecies biofilms was analyzed by confocal microscopy. In a ligature-induced experimental periodontitis model in beagle dogs, BDMP gel was compared with a subgingival instrumentation (SI)-only (standard-of-care) control, and minocycline gel was included as an active adjunctive comparator. Clinical parameters, inflammatory markers, microbial load, radiographs, micro-CT images, and histology were evaluated.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;In vitro, BDMP reduced histone deacetylase 5 (HDAC5) phosphorylation and attenuated downstream NF-κB–associated inflammatory signaling without altering upstream kinase activity. BDMP decreased osteoclast differentiation, reduced inflammatory cytokine transcription, and partially restored osteogenic capacity in LPS-stimulated PDLSCs. BDMP also demonstrated broad-spectrum antimicrobial activity and disrupted mature multispecies biofilms. In vivo, BDMP resulted in greater reductions in gingival inflammation, bleeding, IL-1β levels, and oral spirochetes over 12 weeks compared with the SI-only control. Radiographic images provided qualitative support for reduced bone loss, which was corroborated by micro-CT and histology, indicating attenuation of alveolar bone resorption. When compared with the combination of SI and minocycline arm, BDMP showed comparable or greater improvements in several inflammatory and microbiological parameters.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;BDMP exhibited sustained antimicrobial and anti-inflammatory activity and attenuated bone loss in a beagle periodontitis model when used alongside standard SI therapy. These findings support BDMP as a promising adjunctive therapeutic candidate for managing periodontal inflammation and biofilm-associated disease, although further studies are needed to confirm long-ter","PeriodicalId":16715,"journal":{"name":"Journal of periodontal research","volume":"61 5","pages":"586-605"},"PeriodicalIF":5.4,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jre.70079","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146105939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peri-Implantitis and Periodontitis: Biological Convergence, Contextual Divergence","authors":"Pablo Galindo-Moreno,&nbsp;Pablo Galindo-Fernandez,&nbsp;Allinson Olaechea,&nbsp;Francisco O'Valle,&nbsp;Abdusalam E. Alrmali,&nbsp;Hom-Lay Wang,&nbsp;Miguel Padial-Molina","doi":"10.1111/jre.70109","DOIUrl":"10.1111/jre.70109","url":null,"abstract":"<p>Periodontitis and peri-implantitis are chronic inflammatory conditions of microbial origin that affect the supporting tissues of teeth and dental implants, respectively. Although they share comparable clinical features and several histopathological characteristics, they have traditionally been classified as distinct diseases, largely because they arise in different anatomical and clinical contexts. This narrative, question-driven review evaluates clinical, microbiological, histological, and molecular evidence to address whether observed similarities and differences between the two conditions reflect truly distinct diseases, context-dependent variations of a shared inflammatory spectrum, or artifacts of study design and nomenclature. While peri-implantitis is often described as progressing more rapidly or exhibiting more pronounced inflammatory infiltrates, the underlying reasons for these patterns remain under investigation. To date, no microbial species or host-response pathway has been conclusively identified as exclusive to either disease, although most available data derive from heterogeneous, often underpowered studies with limited head-to-head comparisons. Structural and anatomical distinctions, such as the absence of a periodontal ligament around implants and differences in connective tissue organization, may influence disease behavior, yet their precise role in determining divergent outcomes is still debated. Microbial variability also appears to reflect host-specific and site-specific factors more than strict disease categorization, and molecular and transcriptomic studies generally reveal overlapping patterns of immune activation and gene expression, although some analyses suggest potential quantitative or contextual differences, whose interpretation is constrained by small sample sizes and indirect comparisons. Overall, current evidence supports a substantial convergence in pathogenic pathways, superimposed on site-specific and host-specific modulators, rather than clearly segregated disease-specific mechanisms. Given the limited and inconsistent literature, particularly for advanced omics and tissue-based studies, any categorical distinction between periodontitis and peri-implantitis as separate entities remains premature. Future research should prioritize adequately powered, longitudinal, within-subject comparisons and high-resolution approaches, including spatial transcriptomics and integrated immune-molecular profiling, to refine diagnostic concepts and inform individualized therapeutic strategies.</p>","PeriodicalId":16715,"journal":{"name":"Journal of periodontal research","volume":"61 5","pages":"473-517"},"PeriodicalIF":5.4,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jre.70109","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147723157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Keratinized Mucosa Width and Incidence of Peri-Implant Diseases: A Systematic Review With Meta-Analysis","authors":"Isabella Neme Ribeiro dos Reis,&nbsp;Daniel Stefan Thoma,&nbsp;Thaís Emília da Silva,&nbsp;Milena Quesada Passos,&nbsp;Luisa Souza Feitosa,&nbsp;Cláudio Mendes Pannuti,&nbsp;Ronald Ernest Jung,&nbsp;Nadja Naenni","doi":"10.1111/jre.70123","DOIUrl":"10.1111/jre.70123","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To assess whether the presence and width of keratinized mucosa (KM) influence the <i>incidence</i> of peri-implant mucositis and peri-implantitis at the implant level.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Electronic searches were conducted in MEDLINE/PubMed, Scopus, Embase, and Web of Science, complemented by gray literature and manual searches. Prospective and retrospective cohort studies reporting implant-level incidence of peri-implant diseases in sites with adequate versus inadequate KM were included. Random-effects meta-analyses were performed for two KM thresholds (&gt; 0 mm vs. 0 mm; ≥ 2 mm vs. &lt; 2 mm), and subgroup analyses compared prospective versus retrospective cohorts. Risk of bias assessment was performed using the Joanna Briggs Institute (JBI) checklist for cohort studies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Twelve cohort studies (938 patients; 2646 implants) were included. KM was not associated with the incidence of peri-implant mucositis for either threshold (&gt; 0 mm vs. 0 mm: RR = 0.92, 95% CI 0.69–1.21; ≥ 2 mm vs. &lt; 2 mm: RR = 0.70, 95% CI 0.41–1.20). In contrast, peri-implantitis incidence was significantly lower in implants with KM (&gt; 0 mm) compared to those without KM (0 mm) (RR = 0.62, 95% CI 0.42–0.91) and in implants with KM ≥ 2 mm compared to &lt; 2 mm (RR = 0.56, 95% CI 0.37–0.84). No significant subgroup differences were observed between prospective and retrospective studies. According to the JBI checklist, 75% of the included studies were classified as having a low risk of bias.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Evidence from cohort studies suggests no association between KM and peri-implant mucositis incidence, whereas both the presence of KM and a width of ≥ 2 mm are associated with a lower incidence of peri-implantitis. Thus, KM assessment may be considered as a part of peri-implant risk evaluation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16715,"journal":{"name":"Journal of periodontal research","volume":"61 5","pages":"452-472"},"PeriodicalIF":5.4,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jre.70123","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147930745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diet Quality as a Mediator Linking Tooth Loss and Cardiovascular Diseases in Older Adults","authors":"Ashish C. Kalhan,&nbsp;Tosha A. Kalhan,&nbsp;Marco A. Peres,&nbsp;Fábio R. Leite,&nbsp;Gustavo G. Nascimento","doi":"10.1111/jre.70080","DOIUrl":"10.1111/jre.70080","url":null,"abstract":"<p>Drawing on a large, nationally representative population of older American adults (<i>n</i> = 3610), the study shows that individuals with more than eight missing teeth have a 6%–10% higher likelihood of cardiovascular disease compared with those with fewer tooth losses. Poorer diet quality emerged as a key pathway linking tooth loss and cardiovascular outcomes.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":16715,"journal":{"name":"Journal of periodontal research","volume":"61 5","pages":"627-629"},"PeriodicalIF":5.4,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jre.70080","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147306794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Timing of Re-Evaluation After Periodontal Therapy: A Randomized Clinical Trial","authors":"Walter Castelluzzo,&nbsp;Cosimo Rupe,&nbsp;Michele Nieri,&nbsp;Maria di Martino,&nbsp;Marco Zini,&nbsp;Anna Sartori,&nbsp;Alessia Tasco,&nbsp;Folco Spoleti,&nbsp;Luigi Barbato,&nbsp;Francesco Cairo","doi":"10.1111/jre.70086","DOIUrl":"10.1111/jre.70086","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To evaluate clinical and patient reported outcomes after subgingival instrumentation at two different re-evaluation timings in stage III/IV periodontitis and the influence of clinical and radiographic variables on final outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Forty participants were assigned to 3-month (control) or 6-month (test) re-evaluation after steps 1–2 of therapy. The primary outcome was the number of teeth reaching the Endpoints of Treatment (EoT). EoT was defined as a site with PPD &lt; 6 mm or PPD = 4/5 mm without BoP. Secondary outcomes included changes in clinical parameters and in oral health-related quality of life (OHIP-14) scores. ANOVA, ANCOVA, mixed-effects models and multilevel models were applied.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Thirty-six patients completed the study. Patients allocated to the 3-month group had 15.8 ± 4.0 teeth reaching the EoT, accounting for 65.8% ± 14.3 of the teeth, while patients assigned to the 6-month group had 15.5 ± 5.9 (64.9% ± 21.5), without statistically significant differences. Percentages of sites achieving EoT were 68.5% ± 11.6 in the 3-month group and 71.9% ± 14.4 in the 6-month group, without statistically significant differences. Final OHIP-14 scores were 6.5 ± 8.9 in the 3-month group and 7.3 ± 7.5 in the 6-month group, without statistically significant differences. Risk for residual pockets at re-evaluation was influenced by higher baseline PPD (<i>p</i> &lt; 0.0001), plaque (PI) at site level (<i>p</i> = 0.011), molar tooth (<i>p</i> = 0.012), furcation involvement (<i>p</i> &lt; 0.0001), shallow intrabony defect (<i>p</i> = 0.018), deep intrabony defect (<i>p</i> = 0.002).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>No difference in clinical and patient-centered outcomes was observed between groups. NSPT frequently failed to achieve EoT at pockets with intrabony defects, while EoT were frequently achieved at sites with mainly horizontal bony defects.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>ClinicalTrials.gov identifier: NCT06086821 (https://clinicaltrials.gov/study/NCT06086821?cond=re-evaluation%20periodontal&amp;rank=1)</p>\u0000 </section>\u0000 </div>","PeriodicalId":16715,"journal":{"name":"Journal of periodontal research","volume":"61 5","pages":"560-571"},"PeriodicalIF":5.4,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jre.70086","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146150385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Next Generation Smart Implant Surfaces: Engineering Multifunctional Antimicrobial, Immunomodulatory and Regenerative Interfaces.","authors":"Roberto S Pessoa, Lauren E Steele, Mehvish Mumtaz, Denver P Linklater, Neil M O'Brien-Simpson, Vladimir Baulin, Peter Kingshott, Roy Judge, Alastair J Sloan, Elena P Ivanova","doi":"10.1111/jre.70149","DOIUrl":"https://doi.org/10.1111/jre.70149","url":null,"abstract":"<p><p>Dental implants rely on a stable and functional interface between the implant surface, surrounding tissues, and the oral microbial environment. While titanium remains the clinical gold standard due to its mechanical properties and capacity for osseointegration, peri-implant inflammation and biofilm-associated infection continue to compromise long-term outcomes. Consequently, there is growing interest in multifunctional implant surfaces capable of simultaneously regulating microbial colonisation, immune responses and peri-implant tissue integration. Advances in surface engineering and biomaterials science have revealed that implant surface chemistry and micro- and nanoscale topography strongly influence protein adsorption, immune activation, cellular behaviour, and bacterial attachment at the host-implant interface. Inspired by naturally antimicrobial and self-cleaning biological surfaces, biomimetic approaches have led to the development of mechano-bactericidal nanostructured titanium interfaces capable of physically inactivating bacteria while maintaining cytocompatibility and enhancing osteogenesis. This review examines the mechanobiological principles governing host-implant interactions and examines current strategies for engineering multifunctional antimicrobial, immunomodulatory, and regenerative implant surfaces. The translational challenges limiting clinical implementation, including mechanical durability, biological masking of engineered surfaces and long-term functional stability, are also discussed, together with emerging interest in alternative implant materials such as zirconia. Collectively, biomimetic multifunctional implant surfaces represent a promising strategy for improving long-term implant integration and peri-implant tissue health, although further translational and clinical validation remains necessary before widespread clinical adoption.</p>","PeriodicalId":16715,"journal":{"name":"Journal of periodontal research","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148471492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shifting Concepts in Esthetic-Zone Implant Therapy: Reflections From a 15-Year Institutional Registry.","authors":"Miha Pirc, Eugenia Settecase, Margherita Giorgia Liguori, Tobias Janson, Ronald Ernst Jung, Tim Joda","doi":"10.1111/jre.70146","DOIUrl":"https://doi.org/10.1111/jre.70146","url":null,"abstract":"<p><p>This registry-based analysis provides a longitudinal overview of implant therapy within the maxillary esthetic zone over a 15-year period. The data suggest three developments: (1) increasing integration of digital workflows through CAIS; (2) a cautious tendency toward earlier implant placement protocols; (3) a gradual reduction in simultaneous guided bone augmentation.</p>","PeriodicalId":16715,"journal":{"name":"Journal of periodontal research","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148391217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Viruses, Periodontitis, and Systemic Diseases.","authors":"Kim Natalie Solte, Yvonne L Hernandez-Kapila, Henrik Dommisch","doi":"10.1111/jre.70137","DOIUrl":"10.1111/jre.70137","url":null,"abstract":"<p><p>Viruses are increasingly recognized as potential modulators of oral biofilm ecology and periodontal inflammation, expanding the traditional bacterial paradigm of periodontitis. Members of the Herpesviridae family, including Epstein-Barr virus (EBV), human cytomegalovirus (HCMV), and herpes simplex virus (HSV), are frequently detected in periodontal tissues and may influence disease activity through latency, reactivation, immune modulation, epithelial barrier disruption, and interactions with bacteria. These processes may contribute to local dysbiosis and sustained periodontal inflammation. The potential systemic relevance of oral viruses is biologically plausible but remains incompletely established. Viral persistence or reactivation in oral niches may contribute to systemic immune activation through hematogenous spread, saliva-mediated dissemination, aspiration, or amplification of inflammatory mediators as IL-1β, IL-6, and TNF-α. Accordingly, viruses may act as disease modifiers within the broader relationship between periodontitis and systemic conditions including cardiovascular, metabolic, respiratory, neurogenerative, pregnancy-related, and cancer-associated outcomes. However, the strength of evidence differs across these conditions. Current data support a model in which oral viruses, bacteriophages, bacteria, and fungi form an interconnected biofilm ecosystem that may influence periodontitis progression and systemic inflammatory burden. Nevertheless, most available evidence is observational, associative, or derived from mechanistic experimental models, and definitive proof that viruses are independent etiopathogenic drivers of periodontitis is lacking. Future longitudinal and interventional studies are needed to determine whether viral detection reflects bystander association, disease amplification, or a true pathogenic role, and whether antiviral or phage-based strategies offer clinical benefit beyond established periodontal therapy.</p>","PeriodicalId":16715,"journal":{"name":"Journal of periodontal research","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148361022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}