Journal of Pharmaceutical Research最新文献

{"title":"Ayurvedic Management of Hypothyroidism - A Case Report","authors":"Meghna ., Lalit Nagar, Ringzin Lamo, Kamal Nayan Dwivedi","doi":"10.18579/jopcr/v22.2.23.19","DOIUrl":"https://doi.org/10.18579/jopcr/v22.2.23.19","url":null,"abstract":"Hypothyroidism is the significant endocrine problem found in general public. It is characterized by insufficient production of thyroid hormones, leading to abnormal levels. This condition prompts the decrease in Basal metabolic rate of the body. Ayurveda places a significant part to preclude the basic reason and to treat it. In Ayurveda, it tends to be associated with Kapha-vata dosha dushti, Rasavaha Strotasadushti, Medadushti and Agnimandya. In present study, a 22 years old female patient suffering from Sthaulya (~Weight gain), Duarbalya (~Weakness), Twak rukshata (~Dry skin), Kesh patana (hair loss), puffiness around eyes, mood swings, impaired memory, emotional depression, drowsiness, headache, Amalapitta (~Hyperacidity) and lethargy from last three years. She had been taking allopathic medicine without experiencing any satisfactory relief in her symptoms. In the present study, group of Herbo-mineral preparation was prescribed to the patient for a period of 4 months. After four months patient experienced relief, and her allopathic medicine was completely stopped. Keywords: Hypothyroidism, Agnimandya, Sthaulya","PeriodicalId":16706,"journal":{"name":"Journal of Pharmaceutical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135094736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Study and Assessment of Efficacy of Polyherbal Combination (KNDBHU) in COVID 19 Patients","authors":"Kamal Nayan Dwivedi, Poonam Sharma, Daneshwari Kanashetti, Meghna ., Lalit Nagar","doi":"10.18579/jopcr/v22.2.ms230502","DOIUrl":"https://doi.org/10.18579/jopcr/v22.2.ms230502","url":null,"abstract":"Even three years after the COVID-19 pandemic initially appeared in December of the year 2019, it is still raging over the globe. There have been numerous attempts to use well-known medications in new ways to treat COVID-19 infection. Many nations, including India, implemented a series of lock downs in an effort to limit the pandemic. Sanitation practices, social seclusion, routine mask wearing, testing, and quarantining of suspected carriers were among the recommended methods for limiting the illness. Numerous treatment strategies have also been used to prevent and treat the illness, but no formal studies using well-known Ayurvedic formulations or any polyherbal combinations have been conducted. A clinical study was planned to test the noble polyherbal combination containing Withania somnifera, Tinospora cordifolia, Moringa oleifera, Adhatoda vasica, Piper longum, Glycyrrhiza glabra, Ocimum sanctum and Curcuma longa. The study checked the rate of symptom remission in individuals receiving the polyherbal combination in addition to standard of care (SoC) to that in patients with mild and moderate symptoms of COVID-19 infections receiving SoC alone. A prospective randomized interventional clinical study was planned comparing outcomes in 2 cohorts with mild to moderate COVID-19 as under. Cohort-1 was trialled with conventional treatment as per government advisory. Cohort-2 was trialled with polyherbal combination and with conventional treatment as per government advisory. With the current add-on Polyherbal regimen, an early clinical improvement in breathlessness was seen along with early ageusia and cough reduction when compared with conventional treatment. The polyherbal combination (KNDBHU) enhanced recovery in COVID-19 Patients. Given the lack of hospital beds in India, the median length of hospital stays was shortened; this development is significant. Keywords: Covid­19, Add on polyherbal combinationregimen for Corona virus, Early Clinical Improvement, Shortened hospital stays","PeriodicalId":16706,"journal":{"name":"Journal of Pharmaceutical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135096752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simultaneous Determination of 11 Commonly used Cephalosporin Antibiotics Residue by High Performance Liquid Chromatography - Diode Array Detectors in Pharmaceutical Waste Water - A Tool for Controlling One of the Source of Antibiotic Resistance","authors":"Mohabbat Ullah, Md. Sohel Rana, Md. Monjil Hossain","doi":"10.18579/jopcr/v22.2.23.10","DOIUrl":"https://doi.org/10.18579/jopcr/v22.2.23.10","url":null,"abstract":"11 commonly used Cephalosporin drugs from 1st, 2nd & 3rd Generation in wastewater from Cephalosporin Antibiotics Manufacturing plant is developed, validated and proposed for routine analysis of wastewater collected from waste water pre-treatment plant (wwptp). The determined residues included the routinely manufactured cephalosporin drugs for the treatment as β-Lactams Antibiotic drugs like Cefepime, Cefadroxil, Ceftazidime, Cephradine, Cefaclor, Cefotaxime, Ceftibuten, Ceftriaxone, Cefixime, Cefuroxime Axetil and Cefpodoxime proxetil. A gradient program was developed with Xterra RP-18 (250 cm x 4.6 mm, 5 µm) column as stationary phase. All cephalosporin molecules were selective and separated with a 0.2 M Tetra-butyl Ammonium Hydroxide (TBAH) buffer and Acetonitrile in the ratio of 85:15 V/V (Solution-A) and 25:75 V/V (Solution-B), pH 6.8 was adjusted with O-phosphoric acid into the buffer solution as the mobile phase at flow of 1.2 mL min- 1 with a UV detection at 254 nm using DAD. All peaks eluted within 60 minutes gradient run. The system suitability parameters such as theoretical plate count, tailing and resolution between the closest peaks were within the limit. The method was validated following all criteria regarding ICH (Q2) guidelines. Calibrations were linear over the concentration range of 0.5–150 µg mL-1 as indicated by correlation coefficient (r) of 0.999. The developed method can be the tool for determining the Cephalosporins residue as routine quantitative analysis of waste water discharged from the Antibiotic manufacturing plant. Keywords: Cephalosporins, Waste water, Method validation, Antibiotic Resistance, Antibiotic manufacturing plant","PeriodicalId":16706,"journal":{"name":"Journal of Pharmaceutical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135141192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Virgin Coconut Oil Solubilised Curcumin Protects Nephropathy in Diabetic Rats","authors":"Pradnya Jadhav, Gaurav Kasar, Pooja Rasal, Manoj Mahajan, Aman Upaganlawa, Chandrashekhar Upasani","doi":"10.18579/jopcr/v22.2.23.22","DOIUrl":"https://doi.org/10.18579/jopcr/v22.2.23.22","url":null,"abstract":"Nephropathy is considered as one of the major secondary complications in diabetic patients. The goal of the current study was to perform preclinical screening of virgin coconut oil (VCO) solubilised curcumin in diabetes-induced nephropathy. Male albino rats of the Wistar strain were injected with a single dose of streptozotocin (STZ) (60 mg/kg/i.p). Diabetic nephropathy (DN) was developed after 4 weeks of STZ injection and the treatment was continued for further 4 weeks (i.e 8 weeks). DN rats were treated with VCO (8ml), VCO solubilised curcumin at a low dose (0.66mg/4ml/kg) and high dose (1.32mh/8ml/kg). DN was assessed by evaluating biochemical parameters such as blood glucose, total protein, albumin, urea, creatinine, and total bilirubin from serum and urine sample, whereas the activity of endogenous antioxidant and membrane- bound phosphatases were studied from kidney homogenate. VCO-solubilised curcumin significantly reduced blood and urine glucose level, increased body weight and reduced kidney weight and kidney hypertrophy. It also normalized urine volume, albumin, creatinine, total protein, total bilirubin and urea levels. Treatment also significantly improved antioxidants and membrane-bound phosphatase activities. In conclusion, compared to the individual treatment group, VCO solubilized curcumin significantly modifies the altered parameters toward normal. The potent antioxidant activity of these substances may be to blame for this defense. Keywords: Virgin coconut oil, curcumin, diabetes, nephropathy, antioxidants","PeriodicalId":16706,"journal":{"name":"Journal of Pharmaceutical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135141201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-vivo Hepatoprotective Evaluation of Sicyos edulis on Wistar Albino Rats","authors":"Karisma Borah, Devid Chutia, Manodeep Chakraborty, Ananya Bhattacharjee, Nihar Ranjan Bhuyan","doi":"10.18579/jopcr/v22.2.23.34","DOIUrl":"https://doi.org/10.18579/jopcr/v22.2.23.34","url":null,"abstract":"The liver is known for synthesising enzymes, metabolism, and excretion of drugs and food. However, during biological processes, the abnormality occurs in the liver, which becomes a significant global health burden in humans, characterised by loss of synthetic function, breakdown of blood, irregular vitamin K, and localised, permanent changes to parenchymal cells. The study was designed to research the Phytochemical and biological screening of Sicyos edulis leaf for hepatoprotective activity on laboratory animals using paracetamol and methotrexate model for acute incidence. The study evaluated liver toxicity in healthy Wistar albino rats using two in vivo models. Each study group consists of six animals. In the first model, paracetamol p.o. for seven days. Similarly, in the second model, methotrexate was administered (single dose treatment) to animals with 20mg/kg, b.w., p.o. Both models were challenged with methanolic extract of Sicyos edulis leaf (MESEL) of doses 100mg/kg (low) and 200 mg/kg (high) p.o. for seven days, respectively. On day 8th, the blood samples were collected from the tail vein and analysed for various biochemical parameters. MESEL successfully restored the elevated serum biomarker levels in our study. The decrease in aspartate aminotransferase was observed by removing toxic metabolites, the reduction in alanine aminotransferase was due to an increase in ATP synthesis in mitochondria, thereby modulating the balance of liver energy metabolism, and the decrease in alkaline phosphates is due to tissue regeneration, an increase in total protein denotes the restoration of protein imbalance from acute liver injury. At different concentrations, all these effects strengthen the liver, regulate body metabolism, and ultimately inhibit further liver cell damage in favour of their regeneration. Our study also evidences the protective action of MESEL in rats against the Paracetamol and methotrexate model. The study reveals hepatocyte regeneration followed by hepatic restoration in pre-clinical settings. Keywords: Acute liver disease, Sicyos edulis, Silymarin, Methotrexate, Liver enzymes","PeriodicalId":16706,"journal":{"name":"Journal of Pharmaceutical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135141939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ligand Based Multi-Targeted Molecular Docking Analysis o f Terpenoid Phytoconstituents as Potential Chemotherapeutic Agents Against Breast Cancer: An In Silico Approach","authors":"Senthil Kumar Raju, Shridharshini Kumar, Praveen Sekar, Naveena Sundhararajan, Yogadharshini Nagalingam","doi":"10.18579/jopcr/v22.2.23.5","DOIUrl":"https://doi.org/10.18579/jopcr/v22.2.23.5","url":null,"abstract":"Breast cancer is one of the most common cancers in women all around the world and is a dominant cause of deaths occurring all around the globe. The available potent drugs for breast cancer show adverse effects and resistance and are found to be ineffective in patients. The high cost of currently available cancer therapy and certain limitations of current treatment make it necessary to search for novel, cost-effective and efficient methods of cancer treatment. Phytochemicals are directly involved in treatment or precursors to synthesize useful drugs. Therefore, in the current investigation, 500 terpenoid phytoconstituents and five proteins associated with breast cancer including EGFR, ERα, HER2, NF-κB and Topo IIa were selected from various databases. Selected compounds were screened for their molecular properties based on Lipinski's rule of five resulting in 235 compounds exclusion. Drug-likeness and PAINS alert properties were predicted using pkCSM and SwissADME web servers which led to the omission of 43 compounds. The remaining 222 compounds were screened to predict their ADMET properties and based on these results, 117 compounds were selected to predict the anti-breast cancer potential. Finally, 73 compounds, which showed anti-breast cancer activity prediction, were virtually screened and the top four best-scoring compounds were selected as lead-like molecules and docked with the five respective breast cancer targets. The results showed that the top four lead-like molecules exhibited greater binding affinity and lesser toxicity than the standard drugs namely 4–Hydroxytamoxifen, Daunorubicin, Erlotinib and Lapatinib. Keywords: ADMET, Breast cancer, Chemotherapeutic agents, In silico analysis, Molecular docking, Terpenoids","PeriodicalId":16706,"journal":{"name":"Journal of Pharmaceutical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135141341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Study on Prognostic Factors in Management of Breast Carcinoma in A Tertiary Care Hospital","authors":"Sivaramakrishna Valluru, C Srikanth Reddy, Shanmukha Srinivasulu Udayagiri, Sada Surya Vidavaluru","doi":"10.18579/jopcr/v22.2.23.42","DOIUrl":"https://doi.org/10.18579/jopcr/v22.2.23.42","url":null,"abstract":"Breast cancer is the most common malignant tumor and leading cause of death in women worldwide. It accounts for 15% of all cancer deaths According to World Health Organisation (WHO), approximately 70% of breast malignancies occur in women with unknown risk factorsThe prognostic factor can be defined as a measurable variable which correlates with natural history of the disease. The most significant factor which influences prognosis in breast cancer is axillary lymph node involvement, which is usually assessed at time of surgery using sentinel lymph node biopsy or axillary lymph node dissection. The number of lymph nodal involvement is also significant. Involvement of 1-3 lymph nodes carry better prognosis than 4-9 and more than 9 lymph nodes involvement. Size of the tumour has long been recognized as a prognostic factor and as predictor of axillary node status, with larger tumours being associated with a bad prognosis and an increased incidence of nodal metastasis. This study is conducted in Department of General Surgery, SVRRGGH, Sri Venkateswara Medical College, Tirupati for a period of more than one and half year after getting approval from Institutional Ethical Committee on March 2021. A prospective study of 50 patients who fulfilled Inclusion Criteria is taken into consideration to know how prognostic factors like tumor size & grade, axillary lymphnode involvement are influencing the prognosis and management of breast carcinoma. Patients who took part in the study were from 28-68 years of age. Majority of people were in the age group of 46-55 years (38%). Increasing age, involvement of axillary lymph nodes, tumors with larger size and higher grade, and lymphovascular invasions are all associated with worse prognosis Keywords: Estrogen Receptor, Progesterone Receptor, Locally Advanced Breast Carcinoma","PeriodicalId":16706,"journal":{"name":"Journal of Pharmaceutical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135141187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Crafting a Convincing Research Proposal: A Guide to Writing Successful Funding Applications","authors":"B. M. Ishaq, C. H. Kumar","doi":"10.18579/jopcr/v22.1.22.ms230301","DOIUrl":"https://doi.org/10.18579/jopcr/v22.1.22.ms230301","url":null,"abstract":"Writing a research proposal for funding is a crucial skill for researchers seeking to secure financial support for their projects. A well-drafted proposal can convince funding agencies about scientific, commercial and social impact of the research project and also researcher's competence and skill. However, crafting a persuasive proposal is always challenging, and many researchers struggle with where to start and how to structure the proposal. This manuscript aims to provide a comprehensive guide for writing a research project proposal for funding. It discusses the key elements involved in the research process and outlines the essential components of a persuasive research proposal. It provides a helpful guidance on how to hone in on a research question, pinpoint a knowledge gap, and define specific goals for the study. It also explores different research methodologies and provides guidance on how to select the most appropriate approach for a given research project. It further provides tips on how to structure the proposal effectively, including the use of clear and concise language, and the inclusion of relevant and compelling supporting evidence. In conclusion, it will serve as a thorough and practical resource for anyone looking to secure financial backing for their next research endeavor. Our endeavor is to provide invaluable tool for scientists who are applying for grants or seeking funding for their research endeavors. Keywords: Research proposal, Well-crafted proposal, Manuscript, Writing, Comprehensive guide","PeriodicalId":16706,"journal":{"name":"Journal of Pharmaceutical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42782153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physicochemical and Rheological Characterization of Native and Thermally Silicified Blends of Sweet Potato and Sorghum Starch Granules","authors":"O. Adetunji, Elizabeth Alabi, M. Adeyemo","doi":"10.18579/jopcr/v22.1.ms230208","DOIUrl":"https://doi.org/10.18579/jopcr/v22.1.ms230208","url":null,"abstract":"The aim of the study was to characterize native and thermally silicified blends of sweet potato and sorghum starch granules using their physicochemical and rheological properties. Sweet potato ( Ipomea batatas L., Family: Convolvulaceae ) and sorghum ( Sorghum bicolor , Family: Poaceae ) starches (PS and SS respectively) were extracted and silicified by dissolving 25%w/w silicon dioxide in ultra-pure water containing 75%w/w starch with continuous stirring at 42 (cid:6) 0.5 o C for 4 mins and subsequently oven-dried (45 (cid:6) 0.5 o C) to form sPS and sSS respectively. Physical blends of sPS and sSS granules in ratios 1:1, 1:2 and 2:1 were made and compared with granule blends of PS and SS at similar ratios. Angle of repose, density measurements, Carr’s index, Hausner’s ratio, morphology, pH, swelling capacity and FTIR spectroscopy were","PeriodicalId":16706,"journal":{"name":"Journal of Pharmaceutical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46427266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neem (Azadirachta indica): A Panacea of all Diseases","authors":"P. Sidat, Sakshi Modh, Niyati Chavda, V. Chauhan, Geera Kankura, Aneri Dindoliwala","doi":"10.18579/jopcr/v22.1.22.31","DOIUrl":"https://doi.org/10.18579/jopcr/v22.1.22.31","url":null,"abstract":"Neem (Azadirachta indica) belongs to the Meliaceae family. Neem is well-known around the world for its medicinal and nutritional properties. Various parts of the plant like fruits, leaves, flowers, twigs, gum, seed, oil, bark, and root are known to have medicinal properties and are scientifically established for the various properties. Since ancient times, plant’s parts have been utilized for their medicinal value. The plant contains a high amount of catalase (CAT), peroxidase (POD), polyphenol oxidase (PPO) and ascorbate peroxidase (APX) enzyme, and many other phytoconstituents such as isoprenoid-containing protomeliacins, limonoids, azadirone and Csecomeliacins such as azadirachtin, nimbin, and salanin. The non-isoprenoids include sulphurous compounds, polyphenolics like flavonoids and their glycosides, dihydrochalcone, coumarin and tannins, proteins (amino acids) and carbohydrates (polysaccharides), as well as aliphatic compounds. Due to such type of versatile phytoconstituents, the plants show lots of pharmacological applications. In this review article, we summarized the information regarding the various pharmacological activities of neem plants. All information presented in this review article regarding the beneficial application of Neem (Azadirachta indica) has been acquired by imminent various electronic databases including Scopus, Google scholar, Science Direct, Web of Science, and PubMed. The Neem plant, including leaves, bark, latex, seed, and their active constituents, plays a significant part in the management of progressive illness. The neem plant contains active ingredients were accountable for the basketful therapeutic function such as anticancer, anti-inflammatory, antidiabetic, antispasmodic, antifungal, antioxidant, antimicrobial, antimalarial, antifertility, and also helps in proper digestion, hair growth, skin related problems and relief in menstrual pain and many more. The main findings showed that neem has strong medicinal properties and is also useful in cosmetic applications. There is no evidence of adverse effects of neem in literature. Only the people who are allergic to it can have side effects otherwise it is stomach friendly in all conditions due to which it can be applicable for treatment of various health related disorders. Keywords: Neem (Azadirachta indica), Phytochemical constituents, Therapeutic application","PeriodicalId":16706,"journal":{"name":"Journal of Pharmaceutical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46459614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}