初榨椰子油溶解姜黄素对糖尿病大鼠肾病的保护作用

Pradnya Jadhav, Gaurav Kasar, Pooja Rasal, Manoj Mahajan, Aman Upaganlawa, Chandrashekhar Upasani
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引用次数: 0

摘要

肾病被认为是糖尿病患者的主要继发性并发症之一。当前研究的目的是进行临床前筛选初榨椰子油(VCO)可溶性姜黄素在糖尿病肾病中的作用。Wistar株雄性白化大鼠注射单剂量链脲佐菌素(STZ) (60 mg/kg/i.p)。注射STZ 4周后出现糖尿病肾病(DN),继续治疗4周(即8周)。DN大鼠分别用VCO (8ml)、VCO低剂量(0.66mg/4ml/kg)和高剂量(1.32mh/8ml/kg)溶解姜黄素。通过评估血清和尿液中的血糖、总蛋白、白蛋白、尿素、肌酐和总胆红素等生化参数来评估DN,而从肾脏匀浆中研究内源性抗氧化剂和膜结合磷酸酶的活性。vco溶解的姜黄素显著降低了血液和尿液中的葡萄糖水平,增加了体重,减轻了肾脏重量和肾脏肥大。它还使尿量、白蛋白、肌酐、总蛋白、总胆红素和尿素水平正常化。处理还显著提高了抗氧化剂和膜结合磷酸酶活性。综上所述,与单独治疗组相比,VCO溶解的姜黄素显著地改变了改变的参数,使其趋于正常。这些物质的强大抗氧化活性可能是这种防御的原因。关键词:初榨椰子油,姜黄素,糖尿病,肾病,抗氧化剂
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Virgin Coconut Oil Solubilised Curcumin Protects Nephropathy in Diabetic Rats
Nephropathy is considered as one of the major secondary complications in diabetic patients. The goal of the current study was to perform preclinical screening of virgin coconut oil (VCO) solubilised curcumin in diabetes-induced nephropathy. Male albino rats of the Wistar strain were injected with a single dose of streptozotocin (STZ) (60 mg/kg/i.p). Diabetic nephropathy (DN) was developed after 4 weeks of STZ injection and the treatment was continued for further 4 weeks (i.e 8 weeks). DN rats were treated with VCO (8ml), VCO solubilised curcumin at a low dose (0.66mg/4ml/kg) and high dose (1.32mh/8ml/kg). DN was assessed by evaluating biochemical parameters such as blood glucose, total protein, albumin, urea, creatinine, and total bilirubin from serum and urine sample, whereas the activity of endogenous antioxidant and membrane- bound phosphatases were studied from kidney homogenate. VCO-solubilised curcumin significantly reduced blood and urine glucose level, increased body weight and reduced kidney weight and kidney hypertrophy. It also normalized urine volume, albumin, creatinine, total protein, total bilirubin and urea levels. Treatment also significantly improved antioxidants and membrane-bound phosphatase activities. In conclusion, compared to the individual treatment group, VCO solubilized curcumin significantly modifies the altered parameters toward normal. The potent antioxidant activity of these substances may be to blame for this defense. Keywords: Virgin coconut oil, curcumin, diabetes, nephropathy, antioxidants
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