Journal of Pharmaceutical Investigation最新文献

{"title":"Nanomedicine-based commercial formulations: current developments and future prospects.","authors":"Raj Kumar Thapa,&nbsp;Jong Oh Kim","doi":"10.1007/s40005-022-00607-6","DOIUrl":"https://doi.org/10.1007/s40005-022-00607-6","url":null,"abstract":"<p><strong>Background: </strong>In recent decades, there has been a considerable increase in the number of nanomedicine-based formulations, and their advantages, including controlled/targeted drug delivery with increased efficacy and reduced toxicity, make them ideal candidates for therapeutic delivery in the treatment of complex and difficult-to-treat diseases, such as cancer.</p><p><strong>Areas covered: </strong>This review focuses on nanomedicine-based formulation development, approved and marketed nanomedicines, and the challenges faced in nanomedicine development as well as their future prospects.</p><p><strong>Expert opinion: </strong>To date, the Food and Drug Administration and the European Medicines Agency have approved several nanomedicines, which are now commercially available. However, several critical challenges, including reproducibility, proper characterization, and biological evaluation, e.g., via assays, are still associated with their use. Therefore, rigorous studies alongside stringent guidelines for effective and safe nanomedicine development and use are still warranted. In this study, we provide an overview of currently available nanomedicine-based formulations. Thus, the findings here reported may serve as a basis for further studies regarding the use of these formulations for therapeutic purposes in near future.</p>","PeriodicalId":16702,"journal":{"name":"Journal of Pharmaceutical Investigation","volume":"53 1","pages":"19-33"},"PeriodicalIF":5.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9761651/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10472499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug delivery to the brain via the nasal route of administration: exploration of key targets and major consideration factors.","authors":"Seung-Hyun Jeong,&nbsp;Ji-Hun Jang,&nbsp;Yong-Bok Lee","doi":"10.1007/s40005-022-00589-5","DOIUrl":"https://doi.org/10.1007/s40005-022-00589-5","url":null,"abstract":"<p><strong>Background: </strong>Cranial nerve-related diseases such as brain tumors, Alzheimer's disease, and epilepsy are serious diseases that continue to threaten human. Brain-related diseases are increasing worldwide, including in the United States and Korea, and these increases are closely related to the exposure to harmful substances and excessive stress caused by rapid industrialization and environmental pollution. Drug delivery to the brain is very important for the effective prevention and treatment of brain-related diseases. However, due to the presence of the blood-brain barrier and the extensive first-pass metabolism effect, the general routes of administration such as oral and intravenous routes have limitations in drug delivery to the brain. Therefore, as an alternative, the nasal-brain drug delivery route is attracting attention as a route for effective drug delivery to the brain.</p><p><strong>Areas covered: </strong>This review includes physiological factors, advantages, limitations, current application status, especially in clinical applications, and the necessary factors for consideration in formulation development related to nasal-brain drug delivery.</p><p><strong>Expert opinion: </strong>The nasal-brain drug delivery route has the advantage of enhancing drug delivery to the brain locally, mainly through the olfactory route rather than the systemic circulation. The nasal-brain lymphatic system has recently attracted attention, and it has been implied that the delivery of anticancer drugs to the brain nervous system is possible effectively. However, there are limitations such as low drug permeability, as well as nasal mucosa and the mucociliary system, as obstacles in nasal-brain drug delivery. Therefore, to overcome the limitations of nasal-brain drug delivery, the use of nanocarriers and mucoadhesive agents is being attempted. However, very few drugs have been officially approved for clinical application via the nasal-brain drug delivery route. This is probably because the understanding of and related studies on nasal-brain drug delivery are limited. In this review, we tried to explore the major considerations and target factors in drug delivery through the nasal-brain route based on physiological knowledge and formulation research information. This will help to provide a mechanistic understanding of drug delivery through the nasal-brain route and bring us one step closer to developing effective formulations and drugs in consideration of the key factors for nasal-brain drug delivery.</p>","PeriodicalId":16702,"journal":{"name":"Journal of Pharmaceutical Investigation","volume":"53 1","pages":"119-152"},"PeriodicalIF":5.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9308891/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10481642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacokinetic modulation of substrate drugs via the inhibition of drug-metabolizing enzymes and transporters using pharmaceutical excipients","authors":"Min‐Koo Choi, Jihoon W. Lee, I. Song","doi":"10.1007/s40005-022-00606-7","DOIUrl":"https://doi.org/10.1007/s40005-022-00606-7","url":null,"abstract":"","PeriodicalId":16702,"journal":{"name":"Journal of Pharmaceutical Investigation","volume":"53 1","pages":"1-18"},"PeriodicalIF":5.5,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45056805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality by design approach with multivariate analysis and artificial neural network models to understand and control excipient variability","authors":"J. Y. Kim, D. Choi","doi":"10.1007/s40005-022-00608-5","DOIUrl":"https://doi.org/10.1007/s40005-022-00608-5","url":null,"abstract":"","PeriodicalId":16702,"journal":{"name":"Journal of Pharmaceutical Investigation","volume":"53 1","pages":"389-406"},"PeriodicalIF":5.5,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44572131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peptide permeation enhancers for improving oral bioavailability of macromolecules","authors":"Dohyun Kim, Lan Jin, Eun Ji Park, D. Na","doi":"10.1007/s40005-022-00609-4","DOIUrl":"https://doi.org/10.1007/s40005-022-00609-4","url":null,"abstract":"","PeriodicalId":16702,"journal":{"name":"Journal of Pharmaceutical Investigation","volume":"53 1","pages":"59-72"},"PeriodicalIF":5.5,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43537851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digestive enzyme supplementation in prescription drugs, over-the-counter drugs, and enzyme foods","authors":"Hyun Jung Park, H. Lee","doi":"10.1007/s40005-022-00605-8","DOIUrl":"https://doi.org/10.1007/s40005-022-00605-8","url":null,"abstract":"","PeriodicalId":16702,"journal":{"name":"Journal of Pharmaceutical Investigation","volume":"53 1","pages":"343 - 355"},"PeriodicalIF":5.5,"publicationDate":"2022-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48860133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complexation of levocetirizine with ion-exchange resins and its effect on the stability of powder mixtures containing levocetirizine and montelukast","authors":"HyeogJin Park, Su Hyun Seok, E. Park","doi":"10.1007/s40005-022-00604-9","DOIUrl":"https://doi.org/10.1007/s40005-022-00604-9","url":null,"abstract":"","PeriodicalId":16702,"journal":{"name":"Journal of Pharmaceutical Investigation","volume":"53 1","pages":"377-388"},"PeriodicalIF":5.5,"publicationDate":"2022-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49101348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation development and pharmacokinetic evaluation of enteric-coated dexrabeprazole tablets","authors":"Tae-Jin Lee, Dohyun Kim, J. Kim, Simpson Ro, D. Na","doi":"10.1007/s40005-022-00602-x","DOIUrl":"https://doi.org/10.1007/s40005-022-00602-x","url":null,"abstract":"","PeriodicalId":16702,"journal":{"name":"Journal of Pharmaceutical Investigation","volume":"53 1","pages":"323-331"},"PeriodicalIF":5.5,"publicationDate":"2022-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47389105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A quality by design approach in oral extended release drug delivery systems: where we are and where we are going?","authors":"A. Sousa, J. Serra, C. Estevens, R. Costa, A. Ribeiro","doi":"10.1007/s40005-022-00603-w","DOIUrl":"https://doi.org/10.1007/s40005-022-00603-w","url":null,"abstract":"","PeriodicalId":16702,"journal":{"name":"Journal of Pharmaceutical Investigation","volume":"53 1","pages":"269-306"},"PeriodicalIF":5.5,"publicationDate":"2022-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46964548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanomedicine approaches for medulloblastoma therapy","authors":"Chaemin Lim, Jain Koo, K. Oh","doi":"10.1007/s40005-022-00597-5","DOIUrl":"https://doi.org/10.1007/s40005-022-00597-5","url":null,"abstract":"","PeriodicalId":16702,"journal":{"name":"Journal of Pharmaceutical Investigation","volume":"53 1","pages":"213 - 233"},"PeriodicalIF":5.5,"publicationDate":"2022-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45878558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}