Journal of Pharmaceutical Investigation最新文献_第10页

Three-Dimensional Printing for Oral Pharmaceutical Dosage Forms 口服药物剂型的三维打印

IF 5.5 4区医学

Journal of Pharmaceutical Investigation Pub Date : 2022-03-07 DOI: 10.1007/s40005-022-00561-3

Ji Hoon Kim, Kyeong-Lim Kim, Hyo-Eon Jin

引用次数: 7

Regulatory and safe-use considerations related to stability after opening of nonsterile dosage forms 与非无菌剂型打开后稳定性相关的监管和安全使用注意事项

IF 5.5 4区医学

Journal of Pharmaceutical Investigation Pub Date : 2022-03-07 DOI: 10.1007/s40005-022-00564-0

Haesoo Lee, Minki Jin, W. Jeon, Haeun Kim, M. Jung, Hyelim Yoo, Jong-Hee Won, C. Cho

引用次数: 2

A review of glucoregulatory hormones potentially applicable to the treatment of Alzheimer’s disease: mechanism and brain delivery 可能适用于治疗阿尔茨海默病的血糖调节激素的综述:机制和脑输送

IF 5.5 4区医学

Journal of Pharmaceutical Investigation Pub Date : 2022-03-01 DOI: 10.1007/s40005-022-00566-y

Reeju Amatya, K. Min, M. Shin

引用次数: 2

Population pharmacokinetic modeling and simulation of choline in healthy Korean subjects after oral administration of choline alfoscerate 口服胆碱脂酸后朝鲜族健康受试者胆碱的群体药代动力学建模与模拟

IF 5.5 4区医学

Journal of Pharmaceutical Investigation Pub Date : 2022-02-14 DOI: 10.1007/s40005-022-00562-2

Ae-Gyeoing Im, Go-Wun Choi, D. Kang, Seok-jin Cho, Jaehee Kim, Kyu Yeon Kim, Hea‐Young Cho

引用次数: 1

Ultra deformable vesicles for boosting transdermal delivery of 2-arylpropionic acid class drug for management of musculoskeletal pain 用于促进2-芳基丙酸类药物经皮递送的超变形囊泡，用于治疗肌肉骨骼疼痛

IF 5.5 4区医学

Journal of Pharmaceutical Investigation Pub Date : 2022-02-06 DOI: 10.1007/s40005-021-00555-7

Shreya Kaul, N. Jain, Upendra Nagaich

引用次数: 12

Formulation of sustained-release orodispersible film containing drug–resin complexes of donepezil hydrochloride 盐酸多奈哌齐药物-树脂复合物口腔分散缓释膜的研制

IF 5.5 4区医学

Journal of Pharmaceutical Investigation Pub Date : 2022-02-05 DOI: 10.1007/s40005-022-00560-4

HyeogJin Park, Su Hyun Seok, Kyu‐Mok Hwang, Juyoung Kim, Chun-Woong Park, E. Park

引用次数: 4

Ophthalmic dosage forms for drug delivery to posterior segment 后部给药的眼科剂型

IF 5.5 4区医学

Journal of Pharmaceutical Investigation Pub Date : 2022-01-27 DOI: 10.1007/s40005-021-00554-8

Jaemin Lee, Yun-Seok Rhee

引用次数: 6

Active targeting via ligand-anchored pH-responsive strontium nanoparticles for efficient nucleic acid delivery into breast cancer cells 通过配体锚定ph响应锶纳米颗粒的主动靶向，有效地将核酸递送到乳腺癌细胞中

IF 5.5 4区医学

Journal of Pharmaceutical Investigation Pub Date : 2022-01-25 DOI: 10.1007/s40005-022-00559-x

Athirah Bakhtiar, Qing Xin Liew, K. Ng, E. Chowdhury

引用次数: 14

Microneedle systems for delivering nucleic acid drugs. 用于输送核酸药物的微针系统。

IF 5.5 4区医学

Journal of Pharmaceutical Investigation Pub Date : 2022-01-01 Epub Date: 2022-01-04 DOI: 10.1007/s40005-021-00558-4

Inhwan Noh, Kyuri Lee, Yun-Seok Rhee

{"title":"Microneedle systems for delivering nucleic acid drugs.","authors":"Inhwan Noh, Kyuri Lee, Yun-Seok Rhee","doi":"10.1007/s40005-021-00558-4","DOIUrl":"https://doi.org/10.1007/s40005-021-00558-4","url":null,"abstract":"Background: Nucleic acid-based gene therapy is a promising technology that has been used in various applications such as novel vaccination platforms for infectious/cancer diseases and cellular reprogramming because of its fast, specific, and effective properties. Despite its potential, the parenteral nucleic acid drug formulation exhibits instability and low efficacy due to various barriers, such as stability concerns related to its liquid state formulation, skin barriers, and endogenous nuclease degradation. As promising alternatives, many attempts have been made to perform nucleic acid delivery using a microneedle system. With its minimal invasiveness, microneedle can deliver nucleic acid drugs with enhanced efficacy and improved stability.Area covered: This review describes nucleic acid medicines' current state and features and their delivery systems utilizing non-viral vectors and physical delivery systems. In addition, different types of microneedle delivery systems and their properties are briefly reviewed. Furthermore, recent advances of microneedle-based nucleic acid drugs, including featured vaccination applications, are described.Expert opinion: Nucleic acid drugs have shown significant potential beyond the limitation of conventional small molecules, and the current COVID-19 pandemic highlights the importance of nucleic acid therapies as a novel vaccination platform. Microneedle-mediated nucleic acid drug delivery is a potential platform for less invasive nucleic acid drug delivery. Microneedle system can show enhanced efficacy, stability, and improved patient convenience through self-administration with less pain.","PeriodicalId":16702,"journal":{"name":"Journal of Pharmaceutical Investigation","volume":"52 3","pages":"273-292"},"PeriodicalIF":5.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8726529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39662371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Lipid-based nanoparticles for photosensitive drug delivery systems. 用于光敏药物输送系统的脂基纳米颗粒。

IF 5.5 4区医学

Journal of Pharmaceutical Investigation Pub Date : 2022-01-01 DOI: 10.1007/s40005-021-00553-9

Gayong Shim, Sieon Jeong, Jung Leem Oh, Yeongseon Kang

{"title":"Lipid-based nanoparticles for photosensitive drug delivery systems.","authors":"Gayong Shim, Sieon Jeong, Jung Leem Oh, Yeongseon Kang","doi":"10.1007/s40005-021-00553-9","DOIUrl":"https://doi.org/10.1007/s40005-021-00553-9","url":null,"abstract":"Background: Numerous drug delivery strategies have been studied, but many hurdles exist in drug delivery rates to the target site. Recently, researchers have attempted to remotely control the in vivo behavior of drugs with light to overcome the shortcomings of conventional drug delivery systems. Photodynamic and photothermal systems are representative strategies wherein a photosensitive material is activated in response to a specific wavelength of light.Area covered: Photosensitive materials generally exhibit poor solubility and low biocompatibility. Additionally, their low photostability negatively affects delivery performance. A formulation of lipid-based nanoparticles containing photosensitive substances can help achieve photosensitive drug delivery with improved biocompatibility. The lipid bilayer structure, which can be assembled and disassembled by modulating the surrounding conditions (temperature, pH, etc.), can also be crucial for controlled release of drugs.Expert opinion: To the best of our knowledge, translation research on photoresponsive nanoparticles is scarce. However, as various drugs based on lipid nanoparticles have been clinically approved, the development potential of the lipid-based photoresponsive nanoparticles seems high. Thus, the identification of valid indications and development of optimum medical devices will increase the interest in photoresponsive material-based nanoparticles.","PeriodicalId":16702,"journal":{"name":"Journal of Pharmaceutical Investigation","volume":"52 2","pages":"151-160"},"PeriodicalIF":5.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8731178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10687928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17