Journal of Pharmaceutical Investigation最新文献_第10页

Regulatory and safe-use considerations related to stability after opening of nonsterile dosage forms 与非无菌剂型打开后稳定性相关的监管和安全使用注意事项

IF 5.5 4区医学

Journal of Pharmaceutical Investigation Pub Date : 2022-03-07 DOI: 10.1007/s40005-022-00564-0

Haesoo Lee, Minki Jin, W. Jeon, Haeun Kim, M. Jung, Hyelim Yoo, Jong-Hee Won, C. Cho

引用次数: 2

A review of glucoregulatory hormones potentially applicable to the treatment of Alzheimer’s disease: mechanism and brain delivery 可能适用于治疗阿尔茨海默病的血糖调节激素的综述:机制和脑输送

IF 5.5 4区医学

Journal of Pharmaceutical Investigation Pub Date : 2022-03-01 DOI: 10.1007/s40005-022-00566-y

Reeju Amatya, K. Min, M. Shin

引用次数: 2

Population pharmacokinetic modeling and simulation of choline in healthy Korean subjects after oral administration of choline alfoscerate 口服胆碱脂酸后朝鲜族健康受试者胆碱的群体药代动力学建模与模拟

IF 5.5 4区医学

Journal of Pharmaceutical Investigation Pub Date : 2022-02-14 DOI: 10.1007/s40005-022-00562-2

Ae-Gyeoing Im, Go-Wun Choi, D. Kang, Seok-jin Cho, Jaehee Kim, Kyu Yeon Kim, Hea‐Young Cho

引用次数: 1

Ultra deformable vesicles for boosting transdermal delivery of 2-arylpropionic acid class drug for management of musculoskeletal pain 用于促进2-芳基丙酸类药物经皮递送的超变形囊泡，用于治疗肌肉骨骼疼痛

IF 5.5 4区医学

Journal of Pharmaceutical Investigation Pub Date : 2022-02-06 DOI: 10.1007/s40005-021-00555-7

Shreya Kaul, N. Jain, Upendra Nagaich

引用次数: 12

Formulation of sustained-release orodispersible film containing drug–resin complexes of donepezil hydrochloride 盐酸多奈哌齐药物-树脂复合物口腔分散缓释膜的研制

IF 5.5 4区医学

Journal of Pharmaceutical Investigation Pub Date : 2022-02-05 DOI: 10.1007/s40005-022-00560-4

HyeogJin Park, Su Hyun Seok, Kyu‐Mok Hwang, Juyoung Kim, Chun-Woong Park, E. Park

引用次数: 4

Ophthalmic dosage forms for drug delivery to posterior segment 后部给药的眼科剂型

IF 5.5 4区医学

Journal of Pharmaceutical Investigation Pub Date : 2022-01-27 DOI: 10.1007/s40005-021-00554-8

Jaemin Lee, Yun-Seok Rhee

引用次数: 6

Active targeting via ligand-anchored pH-responsive strontium nanoparticles for efficient nucleic acid delivery into breast cancer cells 通过配体锚定ph响应锶纳米颗粒的主动靶向，有效地将核酸递送到乳腺癌细胞中

IF 5.5 4区医学

Journal of Pharmaceutical Investigation Pub Date : 2022-01-25 DOI: 10.1007/s40005-022-00559-x

Athirah Bakhtiar, Qing Xin Liew, K. Ng, E. Chowdhury

引用次数: 14

Microneedle systems for delivering nucleic acid drugs. 用于输送核酸药物的微针系统。

IF 5.5 4区医学

Journal of Pharmaceutical Investigation Pub Date : 2022-01-01 Epub Date: 2022-01-04 DOI: 10.1007/s40005-021-00558-4

Inhwan Noh, Kyuri Lee, Yun-Seok Rhee

{"title":"Microneedle systems for delivering nucleic acid drugs.","authors":"Inhwan Noh, Kyuri Lee, Yun-Seok Rhee","doi":"10.1007/s40005-021-00558-4","DOIUrl":"https://doi.org/10.1007/s40005-021-00558-4","url":null,"abstract":"Background: Nucleic acid-based gene therapy is a promising technology that has been used in various applications such as novel vaccination platforms for infectious/cancer diseases and cellular reprogramming because of its fast, specific, and effective properties. Despite its potential, the parenteral nucleic acid drug formulation exhibits instability and low efficacy due to various barriers, such as stability concerns related to its liquid state formulation, skin barriers, and endogenous nuclease degradation. As promising alternatives, many attempts have been made to perform nucleic acid delivery using a microneedle system. With its minimal invasiveness, microneedle can deliver nucleic acid drugs with enhanced efficacy and improved stability.Area covered: This review describes nucleic acid medicines' current state and features and their delivery systems utilizing non-viral vectors and physical delivery systems. In addition, different types of microneedle delivery systems and their properties are briefly reviewed. Furthermore, recent advances of microneedle-based nucleic acid drugs, including featured vaccination applications, are described.Expert opinion: Nucleic acid drugs have shown significant potential beyond the limitation of conventional small molecules, and the current COVID-19 pandemic highlights the importance of nucleic acid therapies as a novel vaccination platform. Microneedle-mediated nucleic acid drug delivery is a potential platform for less invasive nucleic acid drug delivery. Microneedle system can show enhanced efficacy, stability, and improved patient convenience through self-administration with less pain.","PeriodicalId":16702,"journal":{"name":"Journal of Pharmaceutical Investigation","volume":"52 3","pages":"273-292"},"PeriodicalIF":5.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8726529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39662371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Lipid-based nanoparticles for photosensitive drug delivery systems. 用于光敏药物输送系统的脂基纳米颗粒。

IF 5.5 4区医学

Journal of Pharmaceutical Investigation Pub Date : 2022-01-01 DOI: 10.1007/s40005-021-00553-9

Gayong Shim, Sieon Jeong, Jung Leem Oh, Yeongseon Kang

{"title":"Lipid-based nanoparticles for photosensitive drug delivery systems.","authors":"Gayong Shim, Sieon Jeong, Jung Leem Oh, Yeongseon Kang","doi":"10.1007/s40005-021-00553-9","DOIUrl":"https://doi.org/10.1007/s40005-021-00553-9","url":null,"abstract":"Background: Numerous drug delivery strategies have been studied, but many hurdles exist in drug delivery rates to the target site. Recently, researchers have attempted to remotely control the in vivo behavior of drugs with light to overcome the shortcomings of conventional drug delivery systems. Photodynamic and photothermal systems are representative strategies wherein a photosensitive material is activated in response to a specific wavelength of light.Area covered: Photosensitive materials generally exhibit poor solubility and low biocompatibility. Additionally, their low photostability negatively affects delivery performance. A formulation of lipid-based nanoparticles containing photosensitive substances can help achieve photosensitive drug delivery with improved biocompatibility. The lipid bilayer structure, which can be assembled and disassembled by modulating the surrounding conditions (temperature, pH, etc.), can also be crucial for controlled release of drugs.Expert opinion: To the best of our knowledge, translation research on photoresponsive nanoparticles is scarce. However, as various drugs based on lipid nanoparticles have been clinically approved, the development potential of the lipid-based photoresponsive nanoparticles seems high. Thus, the identification of valid indications and development of optimum medical devices will increase the interest in photoresponsive material-based nanoparticles.","PeriodicalId":16702,"journal":{"name":"Journal of Pharmaceutical Investigation","volume":"52 2","pages":"151-160"},"PeriodicalIF":5.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8731178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10687928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Smart pH-responsive nanomedicines for disease therapy. 用于疾病治疗的智能ph反应纳米药物。

IF 5.5 4区医学

Journal of Pharmaceutical Investigation Pub Date : 2022-01-01 DOI: 10.1007/s40005-022-00573-z

Jongyoon Shinn, Nuri Kwon, Seon Ah Lee, Yonghyun Lee

{"title":"Smart pH-responsive nanomedicines for disease therapy.","authors":"Jongyoon Shinn, Nuri Kwon, Seon Ah Lee, Yonghyun Lee","doi":"10.1007/s40005-022-00573-z","DOIUrl":"https://doi.org/10.1007/s40005-022-00573-z","url":null,"abstract":"Background: Currently nanomedicines are the focus of attention from researchers and clinicians because of the successes of lipid-nanoparticles-based COVID-19 vaccines. Nanoparticles improve existing treatments by providing a number of advantages including protection of cargo molecules from external stresses, delivery of drugs to target tissues, and sustained drug release. To prevent premature release-related side effects, stable drug loading in nanoformulations is required, but the increased stability of the formulation could also lead to a poor drug-release profile at the target sites. Thus, researchers have exploited differences in a range of properties (e.g., enzyme levels, pH, levels of reduced glutathione, and reactive oxygen species) between non-target and target sites for site-specific release of drugs. Among these environmental stimuli, pH gradients have been widely used to design novel, responsive nanoparticles.Area covered: In this review, we assess drug delivery based on pH-responsive nanoparticles at the levels of tissues (tumor microenvironment, pH ~ 6.5) and of intracellular compartments (endosome and lysosome, pH 4.5-6.5). Upon exposure to these pH stimuli, pH-responsive nanoparticles respond with physicochemical changes to their material structure and surface characteristics. These changes include swelling, dissociation, or surface charge switching, in a manner that favors drug release at the target site (the tumor microenvironment region and the cytosol followed by endosomal escape) rather than the surrounding tissues.Expert opinion: Lastly, we consider the challenges involved in the development of pH-responsive nanomedicines.","PeriodicalId":16702,"journal":{"name":"Journal of Pharmaceutical Investigation","volume":"52 4","pages":"427-441"},"PeriodicalIF":5.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9083479/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10252369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20