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Journal of Pharmaceutical Investigation最新文献

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Zwitterionic alginate derivative as a new delivery platform for enhanced blood circulation. 海藻酸两性离子衍生物作为促进血液循环的新给药平台。
IF 5.1 4区 医学
Journal of Pharmaceutical Investigation Pub Date : 2025-01-01 Epub Date: 2024-08-30 DOI: 10.1007/s40005-024-00703-9
Hyeri Lee, Yan Li, Kai Bao, Seon Sook Lee, Homan Kang, Hak Soo Choi, Yongdoo Choi
{"title":"Zwitterionic alginate derivative as a new delivery platform for enhanced blood circulation.","authors":"Hyeri Lee, Yan Li, Kai Bao, Seon Sook Lee, Homan Kang, Hak Soo Choi, Yongdoo Choi","doi":"10.1007/s40005-024-00703-9","DOIUrl":"10.1007/s40005-024-00703-9","url":null,"abstract":"<p><strong>Purpose: </strong>Poly(ethylene glycol) (PEG), a synthetic polymer known for its hydrophilicity and biocompatibility, has long been used in drug delivery systems to prevent non-specific protein adsorption and to extend the blood circulation time of drug carriers and protein drugs. However, PEG has several drawbacks including poor stability, accumulated toxicity, and immunogenicity induced by repeated injections. Recently, zwitterionic polymers, known for their super-hydrophilic and antifouling properties, have been considered excellent alternatives to PEG. In this study, we synthesized a new zwitterionic polymer from biocompatible sodium alginate and lysine.</p><p><strong>Methods: </strong>Sodium alginate (Alg) was conjugated with lysine (Lys) using the EDC/sulfo-NHS chemistry to form a zwitterionic alginate derivative (Alg-Lys). The biocompatibility was evaluated using in vitro cellular assays and in vivo animal studies. After further conjugation of zwitterionic near-infrared (NIR) fluorescent dye ZW800, an in vivo NIR fluorescence imaging study was conducted to evaluate the ability of Alg-Lys to enhance blood circulation time.</p><p><strong>Results: </strong>Characterization of Alg-Lys showed that the carboxylic acid groups in Alg were completely replaced by Lys molecules. No cytotoxic effects were observed in the in vitro cytotoxicity tests of Alg-Lys-treated cancer cells and normal cells. Serum biochemical analysis confirmed the biocompatibility of Alg-Lys. ZW800-conjugated Alg-Lys exhibited strong fluorescence signals throughout the body 24 h after intravenous injection, whereas ZW800-conjugated Alg was rapidly removed from the body.</p><p><strong>Conclusion: </strong>The zwitterionic alginate derivative showed potential utility as a new delivery platform for imaging agents and drugs.</p>","PeriodicalId":16702,"journal":{"name":"Journal of Pharmaceutical Investigation","volume":"55 1","pages":"143-154"},"PeriodicalIF":5.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12360706/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144883069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of abiraterone acetate tablets with enhanced oral bioavailability 开发口服生物利用度更高的醋酸阿比特龙片剂
IF 5.5 4区 医学
Journal of Pharmaceutical Investigation Pub Date : 2024-01-09 DOI: 10.1007/s40005-023-00654-7
Jin Wook Tak, T. Kwon, Yong-Il Kim, Jung Hyun Cho, Jeonghwan Kim, Jong Oh Kim
{"title":"Development of abiraterone acetate tablets with enhanced oral bioavailability","authors":"Jin Wook Tak, T. Kwon, Yong-Il Kim, Jung Hyun Cho, Jeonghwan Kim, Jong Oh Kim","doi":"10.1007/s40005-023-00654-7","DOIUrl":"https://doi.org/10.1007/s40005-023-00654-7","url":null,"abstract":"","PeriodicalId":16702,"journal":{"name":"Journal of Pharmaceutical Investigation","volume":"39 14","pages":""},"PeriodicalIF":5.5,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139442781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multicompartmental pharmacokinetic evaluation of enavogliflozin eye drop formulation: Understanding its distribution to posterior segments 对依那韦利嗪滴眼液配方进行多室药代动力学评估：了解其在眼球后段的分布
IF 5.5 4区 医学
Journal of Pharmaceutical Investigation Pub Date : 2024-01-08 DOI: 10.1007/s40005-023-00653-8
Seok-jin Cho, Dong Wook Kang, Ju Hee Kim, Go-Wun Choi, Minhyung Kang, Hea‐Young Cho
{"title":"Multicompartmental pharmacokinetic evaluation of enavogliflozin eye drop formulation: Understanding its distribution to posterior segments","authors":"Seok-jin Cho, Dong Wook Kang, Ju Hee Kim, Go-Wun Choi, Minhyung Kang, Hea‐Young Cho","doi":"10.1007/s40005-023-00653-8","DOIUrl":"https://doi.org/10.1007/s40005-023-00653-8","url":null,"abstract":"","PeriodicalId":16702,"journal":{"name":"Journal of Pharmaceutical Investigation","volume":"8 6","pages":""},"PeriodicalIF":5.5,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139445294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A two-step design of experiments approach to investigate the simultaneous effects of ion-pairing and chemical enhancers to improve the permeability of lornoxicam in a topical hydrogel patch 采用两步实验设计法研究离子配对和化学增强剂对改善洛诺昔康在局部水凝胶贴片中的渗透性的同时效应
IF 5.5 4区 医学
Journal of Pharmaceutical Investigation Pub Date : 2024-01-08 DOI: 10.1007/s40005-023-00660-9
Huu-Manh Nguyen, The-Khang Duong, Van-Khuyen Nguyen, Thi-Khanh-Ly Nguyen, Thi-Hoang-Yen Dong, Canh-Hung Nguyen, Nguyen-Thach Tung
{"title":"A two-step design of experiments approach to investigate the simultaneous effects of ion-pairing and chemical enhancers to improve the permeability of lornoxicam in a topical hydrogel patch","authors":"Huu-Manh Nguyen, The-Khang Duong, Van-Khuyen Nguyen, Thi-Khanh-Ly Nguyen, Thi-Hoang-Yen Dong, Canh-Hung Nguyen, Nguyen-Thach Tung","doi":"10.1007/s40005-023-00660-9","DOIUrl":"https://doi.org/10.1007/s40005-023-00660-9","url":null,"abstract":"","PeriodicalId":16702,"journal":{"name":"Journal of Pharmaceutical Investigation","volume":"52 19","pages":""},"PeriodicalIF":5.5,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139448286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transferrin modified PEG–PLGA nanoparticles: highly effective notoginsenoside R1 formulations for the treatment of ulcerative colitis 转铁蛋白修饰的 PEG-PLGA 纳米颗粒：用于治疗溃疡性结肠炎的高效 notoginsenoside R1 制剂
IF 5.5 4区 医学
Journal of Pharmaceutical Investigation Pub Date : 2024-01-04 DOI: 10.1007/s40005-023-00657-4
Limei Zhou, Yunxia Shang, Yaru Wang, Xiaohui Wei
{"title":"Transferrin modified PEG–PLGA nanoparticles: highly effective notoginsenoside R1 formulations for the treatment of ulcerative colitis","authors":"Limei Zhou, Yunxia Shang, Yaru Wang, Xiaohui Wei","doi":"10.1007/s40005-023-00657-4","DOIUrl":"https://doi.org/10.1007/s40005-023-00657-4","url":null,"abstract":"","PeriodicalId":16702,"journal":{"name":"Journal of Pharmaceutical Investigation","volume":"33 4","pages":""},"PeriodicalIF":5.5,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139385973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Applying polyvinyl alcohol to the preparation of various nanoparticles 应用聚乙烯醇制备各种纳米粒子
IF 5.5 4区 医学
Journal of Pharmaceutical Investigation Pub Date : 2024-01-03 DOI: 10.1007/s40005-023-00649-4
Bomin Song, Cheong-Weon Cho
{"title":"Applying polyvinyl alcohol to the preparation of various nanoparticles","authors":"Bomin Song, Cheong-Weon Cho","doi":"10.1007/s40005-023-00649-4","DOIUrl":"https://doi.org/10.1007/s40005-023-00649-4","url":null,"abstract":"","PeriodicalId":16702,"journal":{"name":"Journal of Pharmaceutical Investigation","volume":"16 12","pages":""},"PeriodicalIF":5.5,"publicationDate":"2024-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139450921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of a spray-dried amorphous solid dispersion formulation of ID11916, a new molecular entity with dual inhibition mechanisms targeting the androgen receptor and phosphodiesterase type-5 对具有针对雄激素受体和5型磷酸二酯酶的双重抑制机制的新分子实体ID11916的喷雾干燥无定形固体分散制剂进行评估
IF 5.5 4区 医学
Journal of Pharmaceutical Investigation Pub Date : 2023-12-28 DOI: 10.1007/s40005-023-00652-9
Tae-Kwang Kim, Fabrizio Fina, Francesco Rossignolo, Sang-Hyun Kim, Haneul Lee, Kyuho Jeong, Xiaoyan Xu, Chiara Pignaffo, Cheng Yang, Jina Koo, Myongjae Lee, Min-Jun Baek, Dahan Kim, Dae-Duk Kim
{"title":"Evaluation of a spray-dried amorphous solid dispersion formulation of ID11916, a new molecular entity with dual inhibition mechanisms targeting the androgen receptor and phosphodiesterase type-5","authors":"Tae-Kwang Kim, Fabrizio Fina, Francesco Rossignolo, Sang-Hyun Kim, Haneul Lee, Kyuho Jeong, Xiaoyan Xu, Chiara Pignaffo, Cheng Yang, Jina Koo, Myongjae Lee, Min-Jun Baek, Dahan Kim, Dae-Duk Kim","doi":"10.1007/s40005-023-00652-9","DOIUrl":"https://doi.org/10.1007/s40005-023-00652-9","url":null,"abstract":"","PeriodicalId":16702,"journal":{"name":"Journal of Pharmaceutical Investigation","volume":"334 12","pages":""},"PeriodicalIF":5.5,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139152547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Strategic design and clinical evaluation of a fixed-dose combination tablet comprising valsartan, amlodipine, rosuvastatin and ezetimibe for patients with hypertension and dyslipidemia 针对高血压和血脂异常患者的缬沙坦、氨氯地平、罗伐他汀和依折麦布固定剂量复方片剂的战略设计和临床评估
IF 5.5 4区 医学
Journal of Pharmaceutical Investigation Pub Date : 2023-12-20 DOI: 10.1007/s40005-023-00651-w
Tae-Kwang Kim, Jeong-Eun Lee, Kyuho Jeong, Min-Jun Baek, Dahan Kim, Jun-Young Jeon, Sangyoung Lee, Dae-Duk Kim
{"title":"Strategic design and clinical evaluation of a fixed-dose combination tablet comprising valsartan, amlodipine, rosuvastatin and ezetimibe for patients with hypertension and dyslipidemia","authors":"Tae-Kwang Kim, Jeong-Eun Lee, Kyuho Jeong, Min-Jun Baek, Dahan Kim, Jun-Young Jeon, Sangyoung Lee, Dae-Duk Kim","doi":"10.1007/s40005-023-00651-w","DOIUrl":"https://doi.org/10.1007/s40005-023-00651-w","url":null,"abstract":"","PeriodicalId":16702,"journal":{"name":"Journal of Pharmaceutical Investigation","volume":"122 49","pages":""},"PeriodicalIF":5.5,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138953784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In vitro–in vivo correlation of microsphere formulations: recent advances and challenges 微球制剂的体内外相关性：最新进展与挑战
IF 5.5 4区 医学
Journal of Pharmaceutical Investigation Pub Date : 2023-12-19 DOI: 10.1007/s40005-023-00655-6
Sung Soo Kim, Simpson Ro, Dong Hee Na
{"title":"In vitro–in vivo correlation of microsphere formulations: recent advances and challenges","authors":"Sung Soo Kim, Simpson Ro, Dong Hee Na","doi":"10.1007/s40005-023-00655-6","DOIUrl":"https://doi.org/10.1007/s40005-023-00655-6","url":null,"abstract":"","PeriodicalId":16702,"journal":{"name":"Journal of Pharmaceutical Investigation","volume":" 94","pages":""},"PeriodicalIF":5.5,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138961338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of red ginseng extract on the pharmacokinetics and disposition of warfarin via intestinal Cyp2c11 modulation in rats 红参提取物通过调节大鼠肠道 Cyp2c11 对华法林药代动力学和处置的影响
IF 5.5 4区 医学
Journal of Pharmaceutical Investigation Pub Date : 2023-12-13 DOI: 10.1007/s40005-023-00650-x
S. Jeon, Jin-Hyang Park, M. Kwon, Min‐Koo Choi, I. Song
{"title":"Effects of red ginseng extract on the pharmacokinetics and disposition of warfarin via intestinal Cyp2c11 modulation in rats","authors":"S. Jeon, Jin-Hyang Park, M. Kwon, Min‐Koo Choi, I. Song","doi":"10.1007/s40005-023-00650-x","DOIUrl":"https://doi.org/10.1007/s40005-023-00650-x","url":null,"abstract":"","PeriodicalId":16702,"journal":{"name":"Journal of Pharmaceutical Investigation","volume":"13 10","pages":""},"PeriodicalIF":5.5,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139004740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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