Journal of Pharmaceutical Investigation最新文献_第5页

Solid dispersion of mebendazole via surfactant carrier to improve oral bioavailability and in vitro anticancer efficacy 表面活性剂载体对甲苯咪唑的固体分散，提高口服生物利用度和体外抗癌效果

IF 5.5 4区医学

Journal of Pharmaceutical Investigation Pub Date : 2023-03-20 DOI: 10.1007/s40005-023-00616-z

Thu Nhan Nguyen, Phuong Tran, Y. Choi, J. Park

引用次数: 1

Tumor extracellular vesicles carrying antitumor (KLAKLAK)2 peptide and tumor-specific antigens for improved tumor therapy 携带抗肿瘤（KLAKLAK）2肽和肿瘤特异性抗原的肿瘤细胞外小泡用于改进肿瘤治疗

IF 5.5 4区医学

Journal of Pharmaceutical Investigation Pub Date : 2023-03-20 DOI: 10.1007/s40005-023-00617-y

Eunsol Lee, Eun-Seong Lee

引用次数: 2

Establishment of a fexofenadine population pharmacokinetic (PK)–pharmacodynamic (PD) model and exploration of dosing regimens through simulation 非索非那定群体药代动力学（PK）-药效学（PD）模型的建立和模拟给药方案的探索

IF 5.5 4区医学

Journal of Pharmaceutical Investigation Pub Date : 2023-03-11 DOI: 10.1007/s40005-023-00615-0

J. Jang, Seung-Hyun Jeong, Yong-Bok Lee

引用次数: 3

Size matters: differential property of hyaluronan and its fragments in the skin- relation to pharmacokinetics, immune activity and wound healing 大小问题:透明质酸及其碎片在皮肤中的不同性质——与药代动力学、免疫活性和伤口愈合的关系

IF 5.5 4区医学

Journal of Pharmaceutical Investigation Pub Date : 2023-02-27 DOI: 10.1007/s40005-023-00614-1

Ae-Ri Cho Lee

引用次数: 1

Orodispersible film incorporating nanoparticulate loratadine for an enhanced oral bioavailability 含有纳米粒氯雷他定的可分散膜，用于增强口服生物利用度

IF 5.5 4区医学

Journal of Pharmaceutical Investigation Pub Date : 2023-02-21 DOI: 10.1007/s40005-023-00613-2

Khanh Van Nguyen, Thu Kim Dang, Linh Thi Dieu Vu, Nhan Thi Ha, Hieu Duy Truong, T. H. Tran

引用次数: 5

Wound dressing using graphene quantum dots: a proof of concept 使用石墨烯量子点的伤口敷料：概念验证

IF 5.5 4区医学

Journal of Pharmaceutical Investigation Pub Date : 2023-02-07 DOI: 10.1007/s40005-023-00612-3

Vanessa Gonzalez Ferreira Caminha Martins, L. Alencar, P. F. N. Souza, C. Lorentino, Heloisa F. Frota, A. L. D. dos Santos, S. Gemini-Piperni, V. Morandi, Vinicius Gonçalves Rodrigues, Jonathas Xavier Pereira, E. Ricci-Júnior, Aline Oliveira da Silva de Barros, R. Santos-Oliveira

引用次数: 2

Design of experiment (DoE)-based formulation design of bepotastine sustained-release tablet and in vitro-in vivo pharmacokinetic correlation 以实验设计(DoE)为基础的贝伐他汀缓释片处方设计及体内外药动学相关性

IF 5.5 4区医学

Journal of Pharmaceutical Investigation Pub Date : 2023-02-05 DOI: 10.1007/s40005-023-00611-4

S. Jeon, Jin-Hyun Park, Joo-Eun Kim, Young-Joon Park

引用次数: 2

Current perspectives of artificial oxygen carriers as red blood cell substitutes: a review of old to cutting-edge technologies using in vitro and in vivo assessments. 人工氧载体作为红细胞替代品的当前观点:从体外和体内评估的老技术到前沿技术的回顾。

IF 5.5 4区医学

Journal of Pharmaceutical Investigation Pub Date : 2023-01-01 DOI: 10.1007/s40005-022-00590-y

Nijaya Mohanto, Young-Joon Park, Jun-Pil Jee

{"title":"Current perspectives of artificial oxygen carriers as red blood cell substitutes: a review of old to cutting-edge technologies using in vitro and in vivo assessments.","authors":"Nijaya Mohanto, Young-Joon Park, Jun-Pil Jee","doi":"10.1007/s40005-022-00590-y","DOIUrl":"https://doi.org/10.1007/s40005-022-00590-y","url":null,"abstract":"Background: Several circumstances such as accidents, surgery, traumatic hemorrhagic shock, and other causalities cause major blood loss. Allogenic blood transfusion can be resuscitative for such conditions; however, it has numerous ambivalent effects, including supply shortage, needs for more time, cost for blood grouping, the possibility of spreading an infection, and short shelf-life. Hypoxia or ischemia causes heart failure, neurological problems, and organ damage in many patients. To address this emergent medical need for resuscitation and to treat hypoxic conditions as well as to enhance oxygen transportation, researchers aspire to achieve a robust technology aimed to develop safe and feasible red blood cell substitutes for effective oxygen transport.Area covered: This review article provides an overview of the formulation, storage, shelf-life, clinical application, side effects, and current perspectives of artificial oxygen carriers (AOCs) as red blood cell substitutes. Moreover, the pre-clinical (in vitro and in vivo) assessments for the evaluation of the efficacy and safety of oxygen transport through AOCs are key considerations in this study. With the most significant technologies, hemoglobin- and perfluorocarbon-based oxygen carriers as well as other modern technologies, such as synthetically produced porphyrin-based AOCs and oxygen-carrying micro/nanobubbles, have also been elucidated.Expert opinion: Both hemoglobin- and perfluorocarbon-based oxygen carriers are significant, despite having the latter acting as safeguards; they are cost-effective, facile formulations which penetrate small blood vessels and remove arterial blockages due to their nano-size. They also show better biocompatibility and longer half-life circulation than other similar technologies.","PeriodicalId":16702,"journal":{"name":"Journal of Pharmaceutical Investigation","volume":"53 1","pages":"153-190"},"PeriodicalIF":5.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9344254/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10477329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

COVID-19 drugs: potential interaction with ATP-binding cassette transporters P-glycoprotein and breast cancer resistance protein. COVID-19药物:与atp结合盒转运蛋白p糖蛋白和乳腺癌耐药蛋白的潜在相互作用

IF 5.5 4区医学

Journal of Pharmaceutical Investigation Pub Date : 2023-01-01 DOI: 10.1007/s40005-022-00596-6

Jaeok Lee, Jihye Kim, Jiyeon Kang, Hwa Jeong Lee

{"title":"COVID-19 drugs: potential interaction with ATP-binding cassette transporters P-glycoprotein and breast cancer resistance protein.","authors":"Jaeok Lee, Jihye Kim, Jiyeon Kang, Hwa Jeong Lee","doi":"10.1007/s40005-022-00596-6","DOIUrl":"https://doi.org/10.1007/s40005-022-00596-6","url":null,"abstract":"Background: The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2, has resulted in acute respiratory distress, fatal systemic manifestations (extrapulmonary as well as pulmonary), and premature mortality among many patients. Therapy for COVID-19 has focused on the treatment of symptoms and of acute inflammation (cytokine storm) and the prevention of viral infection. Although the mechanism of COVID-19 is not fully understood, potential clinical targets have been identified for pharmacological, immunological, and vaccinal approaches.Area covered: Pharmacological approaches including drug repositioning have been a priority for initial COVID-19 therapy due to the time-consuming nature of the vaccine development process. COVID-19 drugs have been shown to manage the antiviral infection cycle (cell entry and replication of proteins and genomic RNA) and anti-inflammation. In this review, we evaluated the interaction of current COVID-19 drugs with two ATP-binding cassette transporters [P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP)] and potential drug-drug interactions (DDIs) among COVID-19 drugs, especially those associated with P-gp and BCRP efflux transporters.Expert opinion: Overall, understanding the pharmacodynamic/pharmacokinetic DDIs of COVID-19 drugs can be useful for pharmacological therapy in COVID-19 patients.","PeriodicalId":16702,"journal":{"name":"Journal of Pharmaceutical Investigation","volume":"53 2","pages":"191-212"},"PeriodicalIF":5.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9607806/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9381780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Recent progress in drying technologies for improving the stability and delivery efficiency of biopharmaceuticals. 用于提高生物药品稳定性和输送效率的干燥技术的最新进展。

IF 5.5 4区医学

Journal of Pharmaceutical Investigation Pub Date : 2023-01-01 DOI: 10.1007/s40005-022-00610-x

Fakhrossadat Emami, Mahsa Keihan Shokooh, Seyed Jamaleddin Mostafavi Yazdi

{"title":"Recent progress in drying technologies for improving the stability and delivery efficiency of biopharmaceuticals.","authors":"Fakhrossadat Emami, Mahsa Keihan Shokooh, Seyed Jamaleddin Mostafavi Yazdi","doi":"10.1007/s40005-022-00610-x","DOIUrl":"https://doi.org/10.1007/s40005-022-00610-x","url":null,"abstract":"Background: Most biopharmaceuticals are developed in liquid dosage forms that are less stable than solid forms. To ensure the stability of biopharmaceuticals, it is critical to use an effective drying technique in the presence of an appropriate stabilizing excipient. Various drying techniques are available for this purpose, such as freeze drying or lyophilization, spray drying, spray freeze-drying, supercritical fluid drying, particle replication in nonwetting templates, and fluidized bed drying.Area covered: In this review, we discuss drying technologies and their applications in the production of stable solid-state biopharmaceuticals, providing examples of commercially available products or clinical trial formulations. Alongside this, we also review how different analytical methods may be utilized in the evaluation of aerosol performance and powder characteristics of dried protein powders. Finally, we assess the protein integrity in terms of conformational and physicochemical stability and biological activity.Expert opinion: With the aim of treating either infectious respiratory diseases or systemic disorders, inhaled biopharmaceuticals reduce both therapeutic dose and cost of therapy. Drying methods in the presence of optimized protein/stabilizer combinations, produce solid dosage forms of proteins with greater stability. A suitable drying method was chosen, and the process parameters were optimized based on the route of protein administration. With the ongoing trend of addressing deficiencies in biopharmaceutical production, developing new methods to replace conventional drying methods, and investigating novel excipients for more efficient stabilizing effects, these products have the potential to dominate the pharmaceutical industry in the future.","PeriodicalId":16702,"journal":{"name":"Journal of Pharmaceutical Investigation","volume":"53 1","pages":"35-57"},"PeriodicalIF":5.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9768793/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10472500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6