Journal of Pediatric Hematology/Oncology最新文献_第7页

Significant Gastrointestinal Bleeding Due to Jejunal Metastasis as the Harbinger of Choriocarcinoma Syndrome in an Adolescent Boy. 一例青春期男孩空肠转移引起的显著胃肠道出血是绒毛膜癌综合征的先兆。

IF 0.9 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2026-09-14 DOI: 10.1097/MPH.0000000000003275

Sarthak Chakrabarti, Sourish K Roy, Sanjiban Patra, Surabhi Jajodia, Rajat Khandelwal, Indrajeet K Tiwary, Mahesh K Goenka

引用次数: 0

Comments on "Initial Cerebrospinal Fluid Blast Clearance Rate in Pediatric B-Lymphoblastic Leukemia Is Associated With Overall Survival". 关于“儿童b淋巴细胞白血病初始脑脊液清除率与总生存率相关”的评论。

IF 0.9 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2026-09-09 DOI: 10.1097/MPH.0000000000003269

Munazza Khan, Wamiq Saeed

引用次数: 0

Audiological Outcomes Following Platinum-Based Chemotherapy in Pediatric Oncology Patients. 儿童肿瘤患者铂类化疗后的听力学结果。

IF 0.9 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2026-09-07 DOI: 10.1097/MPH.0000000000003270

Mehmet Fatih Orhan, Öznur Tiryaki, Aslı Akdeniz Kudubeş, Hamide Zengin, Köksal Delibaş

{"title":"Audiological Outcomes Following Platinum-Based Chemotherapy in Pediatric Oncology Patients.","authors":"Mehmet Fatih Orhan, Öznur Tiryaki, Aslı Akdeniz Kudubeş, Hamide Zengin, Köksal Delibaş","doi":"10.1097/MPH.0000000000003270","DOIUrl":"https://doi.org/10.1097/MPH.0000000000003270","url":null,"abstract":"Purpose: This study aimed to retrospectively evaluate the audiological monitoring of ototoxicity developing in pediatric oncology patients receiving platinum-based chemotherapy.Methods: This retrospective study included 14 patients aged 1 month to 18 years who received platinum-based chemotherapy at the pediatric hematology/oncology clinic between 2015 and 2023 and had pre- and post-treatment audiometric evaluations. Audiometric evaluations were performed in the 250 to 6000 Hz frequency range, and hearing loss was classified according to American Speech-Language-Hearing Association criteria.Results: A general increase in hearing thresholds was observed post-treatment, with the magnitude varying by frequency. While significant changes were detected in low and midfrequencies, the most pronounced increase was observed in high frequencies (4000 to 6000 Hz), and the effect size was large at these frequencies. In the assessment of high-frequency hearing loss, 85.7% of patients had hearing loss. When comparing low and high frequencies, the increase in hearing thresholds was significantly greater at high frequencies. In comparisons between the right and left ears, a tendency toward greater hearing loss was observed in the left ear; however, this difference was not statistically significant.Conclusion: Platinum-based chemotherapy may be associated with clinically relevant hearing threshold shifts in pediatric oncology patients, particularly at high frequencies. Regular audiological monitoring is important for the early identification and management of hearing loss.","PeriodicalId":16693,"journal":{"name":"Journal of Pediatric Hematology/Oncology","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148900841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Central Nervous System Immune Reconstitution Inflammatory Syndrome During Neutrophil Recovery in Pediatric Acute Myeloid Leukemia: A Clinical and Laboratory Observation. 小儿急性髓性白血病中性粒细胞恢复过程中的中枢神经系统免疫重建炎症综合征：临床和实验室观察。

IF 0.9 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2026-08-03 DOI: 10.1097/MPH.0000000000003260

Adnan Deniz, Sevgi Tale, Gökçe Cırdı, Ayfer Sakarya Güneş, Leman Tekin Orgun, Emine Zengin, Bülent Kara

引用次数: 0

MTHFD1 Deficiency in Two Unrelated Children: Highlights on Phenotypic Spectrum and Response to Folic Acid Therapy. 两个不相关儿童的MTHFD1缺乏：表型谱和对叶酸治疗的反应的重点。

IF 0.9 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2026-08-01 Epub Date: 2026-06-16 DOI: 10.1097/MPH.0000000000003238

Fajer Altammar, Haidy Elsayed, Mohamed Elshinawy, Waleed Al-Herz

{"title":"MTHFD1 Deficiency in Two Unrelated Children: Highlights on Phenotypic Spectrum and Response to Folic Acid Therapy.","authors":"Fajer Altammar, Haidy Elsayed, Mohamed Elshinawy, Waleed Al-Herz","doi":"10.1097/MPH.0000000000003238","DOIUrl":"10.1097/MPH.0000000000003238","url":null,"abstract":"Background and aims: Methylene-tetrahydrofolate dehydrogenase 1 (MTHFD1) deficiency is a rare inborn error of immunity (IEI) involving defects in folate metabolism. It can present with combined immunodeficiency and variable phenotypic features, including recurrent bacterial infections, megaloblastic anemia, and failure to thrive.Methods: We describe 2 unrelated Kuwaiti children with MTHFD1 deficiency caused by a homozygous pathogenic variant [c.517C>T (Arg173Cys)].Results: Both cases presented with unexplained megaloblastic anemia, recurrent sinopulmonary infections, failure to thrive, and developmental delay. The first patient, a 10-year-old girl, was diagnosed with combined immunodeficiency and autoimmune thyroiditis. Treatment with folic acid resulted in significant clinical improvement. The second patient, a 3-year-old girl, presented with sepsis secondary to progressive lobar pneumonia and bone marrow failure. Despite intensive treatment, including broad-spectrum antibiotics, antifungals, IVIG, and dexamethasone for suspected hemophagocytic lymphohistiocytosis, she developed severe complications and passed away on day 18 of PICU admission.Conclusion: As there is no specific clinical or laboratory phenotype for most IEIs, we emphasize the importance of molecular diagnosis through urgent genetic testing in patients with suspected MTHFD1 deficiency. Precision therapy with prompt folate or folinic acid supplementation can significantly improve outcomes, as evidenced by the survival of one patient with minimal intervention.","PeriodicalId":16693,"journal":{"name":"Journal of Pediatric Hematology/Oncology","volume":" ","pages":"e241-e244"},"PeriodicalIF":0.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148258563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Frequent Use of Hematologic Testing in Children Admitted for Nonaccidental Trauma. 非意外创伤入院儿童血液学检查的频繁使用。

IF 0.9 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2026-08-01 Epub Date: 2026-06-29 DOI: 10.1097/MPH.0000000000003236

Meghan McCormick, Ramasubramanian Kalpatthi

{"title":"Frequent Use of Hematologic Testing in Children Admitted for Nonaccidental Trauma.","authors":"Meghan McCormick, Ramasubramanian Kalpatthi","doi":"10.1097/MPH.0000000000003236","DOIUrl":"10.1097/MPH.0000000000003236","url":null,"abstract":"Nonaccidental trauma (NAT) can present with bleeding symptoms. Judicious use of hematologic testing is recommended to evaluate for medical causes of bleeding, while acknowledging inherited bleeding disorders and NAT may be present concurrently. A retrospective chart review using the Pediatric Health Information System database identified pediatric patients <18 years of age with an ICD diagnostic code for NAT associated with admission. Using laboratory charge data, we identified the hematologic testing sent and the number of encounters with expanded hematologic testing (EHT), defined as testing beyond CBC, PT, PTT, Factor IX, and von Willebrand testing (and fibrinogen/d-dimer in cases of intracranial hemorrhage). In 9561 admissions meeting inclusion criteria, laboratory testing was sent in 91.9% of encounters and EHT in 35.9% of encounters. The most common EHT test being fibrinogen. EHT was associated with a significant increase in laboratory-associated charges. Only 69 children (0.7%) were later identified to have an underlying bleeding disorder, most commonly von Willebrand Disease. Factors associated with EHT included hematology consultation, young age, higher income, and private health insurance. Despite few patients diagnosed with underlying bleeding disorders, EHT was frequently obtained. Sociodemographic features may influence testing decisions. Adherence to guidelines for evaluation may help reduce disparities.","PeriodicalId":16693,"journal":{"name":"Journal of Pediatric Hematology/Oncology","volume":" ","pages":"e250-e254"},"PeriodicalIF":0.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148352198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Presentation and Treatment Outcomes of Pediatric Acute Promyelocytic Leukemia: A Study From a Developing Country. 一个发展中国家儿童急性早幼粒细胞白血病的临床表现和治疗结果。

IF 0.9 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2026-08-01 Epub Date: 2026-06-15 DOI: 10.1097/MPH.0000000000003231

Naila Rafiq, Ghulam Q Pathan, Sadia Muhammad, Neelum Mansoor

{"title":"Clinical Presentation and Treatment Outcomes of Pediatric Acute Promyelocytic Leukemia: A Study From a Developing Country.","authors":"Naila Rafiq, Ghulam Q Pathan, Sadia Muhammad, Neelum Mansoor","doi":"10.1097/MPH.0000000000003231","DOIUrl":"10.1097/MPH.0000000000003231","url":null,"abstract":"Acute promyelocytic leukemia (APL) is a highly curable form of acute myeloid leukemia (AML) when treated early with all-trans retinoic acid (ATRA) and arsenic trioxide (ATO). Resource constraints in low- and middle-income countries (LMICs) may affect results. This study examined the clinical characteristics and outcomes of pediatric patients with APL receiving an ATRA-ATO-based regimen. The retrospective review included 1- to 16-year-olds diagnosed between January 2019 and December 2022. Morphology and PML-RARA detection by fluorescence in situ hybridization (FISH) confirmed the diagnosis. Patients were stratified by initial white cell count (WCC) (low-risk <10×10 9 /L; high-risk ≥10×10 9 /L). Data were retrieved from electronic medical records. Event-free survival (EFS) rates were obtained using the Kaplan-Meier analysis. Fifty patients (mean age: 10.7 y; 56% male) were evaluated. Low-risk was 32%, and high-risk was 68%. Thrombocytopenia and hypofibrinogenemia were common. All patients had PML-RARA FISH-positives, and 100% of evaluated patients attained morphologic and molecular remissions. Eleven (22%) patients died, mostly from hemorrhage. Abandonment and relapses were observed in 10% and 8% of patients, respectively. Two-year EFS was 60% (low-risk 81%; high-risk 50%). The ATRA-ATO regimen showed substantial remission rates, but early deaths remain a concern. Increased survival rates in resource-constrained environments require improved early detection, referral, and supportive care.","PeriodicalId":16693,"journal":{"name":"Journal of Pediatric Hematology/Oncology","volume":" ","pages":"277-282"},"PeriodicalIF":0.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148252036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Local Control and Survival Outcomes in Pediatric Nonrhabdomyosarcoma Soft Tissue Sarcoma: The Mayo Clinic Experience. 儿童非横纹肌肉瘤软组织肉瘤的局部控制和生存结果：梅奥诊所的经验。

IF 0.9 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2026-08-01 Epub Date: 2026-04-27 DOI: 10.1097/MPH.0000000000003202

Elizabeth L McKone, Kristofer W Roberts, William S Harmsen, William G Breen, Anita Mahajan, Wendy A Allen-Rhoades, Peter S Rose, Nadia N Laack, Safia K Ahmed

{"title":"Local Control and Survival Outcomes in Pediatric Nonrhabdomyosarcoma Soft Tissue Sarcoma: The Mayo Clinic Experience.","authors":"Elizabeth L McKone, Kristofer W Roberts, William S Harmsen, William G Breen, Anita Mahajan, Wendy A Allen-Rhoades, Peter S Rose, Nadia N Laack, Safia K Ahmed","doi":"10.1097/MPH.0000000000003202","DOIUrl":"10.1097/MPH.0000000000003202","url":null,"abstract":"Objective: This single institutional analysis explored outcomes and factors associated with local control and survival in pediatric patients with nonrhabdomyosarcoma soft tissue sarcoma (NRSTS).Methods: Patients 18 years of age or younger diagnosed between October 1990 and November 2021 who received external beam radiotherapy (EBRT) were retrospectively identified. Overall survival (OS) and disease-free survival (DFS) were analyzed using Kaplan-Meier methods and univariate Cox models.Results: Among 51 included patients, there were 33 extremity tumors (65%), with 80% T1/T2 and 90% M0. Surgery in 49/51 (96%) resulted in 32 (65%) R0 resections. All received EBRT, with brachytherapy or intraoperative radiotherapy boosts in 21/51 (41%). Thirty-four (66.7%) received chemotherapy. With 5.7 years median follow-up, 5-year OS and DFS were 70.7% and 67.9%, respectively. Positive margins were significantly associated with worse OS. Two-year local failure incidence was 18.1% for EBRT versus 5.3% for EBRT+boost (HR 3.67, P =0.24). Among 6 local failures, 5 received EBRT alone, including 3 with positive margins. Two treated with EBRT+boost had positive margins, neither with local recurrence.Conclusion: Multimodality treatment of pediatric NRSTS results in 5-year OS and DFS around 70%. Although complete resection remains essential, and the modern incidence of R1 resection has declined, IORT/brachytherapy boost may continue to have a role in selected patients with a high local recurrence risk.","PeriodicalId":16693,"journal":{"name":"Journal of Pediatric Hematology/Oncology","volume":" ","pages":"261-269"},"PeriodicalIF":0.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148330540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Unexpected Malignancy Behind Pediatric Microangiopathic Hemolytic Anemia: Gastric Signet Ring Cell Carcinoma. 儿童微血管病溶血性贫血背后的一种意想不到的恶性肿瘤：胃印戒细胞癌。

IF 0.9 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2026-08-01 Epub Date: 2026-06-22 DOI: 10.1097/MPH.0000000000003240

Gokalp Rustem Aksoy, Hatice Zeynep Terzi, Yunus Murat Akcabelen, Aytul Temuroglu, Arzu Oto

引用次数: 0

Letter to the Editor: Primary Extraosseous Ewing Sarcoma of the Right L5 Nerve Root Mimicking a Schwannoma. 致编辑的信：右侧L5神经根的原发性骨外尤文氏肉瘤模仿神经鞘瘤。

IF 0.9 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2026-08-01 Epub Date: 2026-06-09 DOI: 10.1097/MPH.0000000000003229

Kyohei Furusawa, Jumpei Ito, Yayoi Ichikawa, Fumito Yamazaki, Risako Narukama, Narihito Nagoshi, Robert Nakayama, Manabu Arai, Kyohei Isshiki, Hiroyuki Shimada

引用次数: 0