Journal of Pediatric Hematology/Oncology最新文献_第7页

Characterization of Thrombocytopenia in Pediatric Patients in Noncritical Hospital Setting: An Institutional Review From Pakistan. 非危重医院儿科患者血小板减少的特征：来自巴基斯坦的机构回顾。

IF 0.9 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2025-01-01 Epub Date: 2024-11-11 DOI: 10.1097/MPH.0000000000002972

Haleema Urooj, Sadaf Altaf, Eisha Saadat, Mohammad Shahzaib Qadir, Bushra Moiz

{"title":"Characterization of Thrombocytopenia in Pediatric Patients in Noncritical Hospital Setting: An Institutional Review From Pakistan.","authors":"Haleema Urooj, Sadaf Altaf, Eisha Saadat, Mohammad Shahzaib Qadir, Bushra Moiz","doi":"10.1097/MPH.0000000000002972","DOIUrl":"10.1097/MPH.0000000000002972","url":null,"abstract":"Pediatric thrombocytopenia is frequently observed in critical care and oncology settings with an increased risk of bleeding and platelet transfusions. However, little is known about low platelets in childhood during seasonal influence. This study aimed to evaluate the frequency and severity of pediatric thrombocytopenia in the postflood period. The patients 1 to 18 years of age with thrombocytopenia (platelet count <150×109/L) were studied from August to December 2022 after institutional ethical approval (ERC-Path-2022-8044-23395). Data was collected from electronic health records and laboratory information systems. Of 2318 admitted patients, 192 (8.3%) including 128 males and 64 females had thrombocytopenia. The median (IQR) age was 12 (8 to 15) years. Mild, moderate, and severe thrombocytopenia were seen in 109 (56.8%), 76 (39.5%), and 7 (3.6%) patients, respectively. Concomitant leucopenia was observed in 77 of 192 patients (40.1%). Infection was the predominant cause of low platelets (N=175 or 91.1%). Only 15 patients (7.8%) had grade 1/2 bleeding. Overall, 176 patients (92%) were discharged in stable conditions and no mortality was observed. The frequency of pediatric thrombocytopenia in the noncritical and nononcological care settings was <10% and mostly observed in association with underlying infections. The frequency of bleeding manifestation and platelet transfusions was minimal in this group.","PeriodicalId":16693,"journal":{"name":"Journal of Pediatric Hematology/Oncology","volume":"47 1","pages":"1-6"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142907065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vanishing Bile Duct Syndrome in Pediatric Hodgkin Lymphoma: First Statistical Analysis of All Published Cases in Children and a Case Report. 小儿霍奇金淋巴瘤胆管消失综合征：首次对所有已发表的儿童病例进行统计分析并进行病例报告。

IF 0.9 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2025-01-01 Epub Date: 2024-11-06 DOI: 10.1097/MPH.0000000000002969

Rahat Ul Ain, Aiman Gull, Bushra Mohsin, Zonaira Rathore, Mahwish Faizan

{"title":"Vanishing Bile Duct Syndrome in Pediatric Hodgkin Lymphoma: First Statistical Analysis of All Published Cases in Children and a Case Report.","authors":"Rahat Ul Ain, Aiman Gull, Bushra Mohsin, Zonaira Rathore, Mahwish Faizan","doi":"10.1097/MPH.0000000000002969","DOIUrl":"10.1097/MPH.0000000000002969","url":null,"abstract":"Hodgkin lymphoma with vanishing bile duct syndrome is a rare paraneoplastic syndrome and has never been studied in the pediatric population. The objectives of this study were to determine the clinical characteristics of this rare condition in children through a literature review, and a descriptive analysis of all published cases with the index case report. All reported cases fulfilling the inclusion criteria were found through a literature search, and analyzed in descriptive statistics. A total of 10 cases were included in the study with a median age of 9.5 years and a male-to-female ratio of 9:1. The median duration of symptoms was 5.5 weeks with 3 cases having jaundice before the symptoms of lymphoma. The median bilirubin level was 8.4 mg/dL. Seven cases received modified chemotherapy, and 5 used ursodeoxycholic acid. The survival rate was 50%. Normalization of liver functions after the lymphoma treatment was observed in 4 cases and was the only statistically significant factor ( P =0.01) associated with the outcome. This is a rare entity in the pediatric population with a guarded prognosis comparable to the adult counterparts but a marked male predominance.","PeriodicalId":16693,"journal":{"name":"Journal of Pediatric Hematology/Oncology","volume":" ","pages":"e48-e51"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142622714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pyrites: A Scalp Mass. 黄铁矿头皮肿块

IF 0.9 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2025-01-01 Epub Date: 2024-12-16 DOI: 10.1097/MPH.0000000000002982

Bun Sereyleak, Sam Lyvannak, Thy Bunpaov, Has Sotherak, Bruce Camitta, Frank Keller

引用次数: 0

Neuroblastoma Occurring in Nijmegen Breakage Syndrome. 神经母细胞瘤发生于奈亨断裂综合征。

IF 0.9 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2025-01-01 Epub Date: 2024-11-15 DOI: 10.1097/MPH.0000000000002965

Marina Djurisic, Adrijan Sarajlija, Danijela Radivojevic, Sanja Cirkovic, Dragoljub Djokic, Slavisa Djuricic, Gordana Samardzija, Srdjan Pasic

引用次数: 0

Machine Learning-based Prediction of Blood Stream Infection in Pediatric Febrile Neutropenia. 基于机器学习的儿童发热性中性粒细胞减少症血流感染预测。

IF 0.9 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2025-01-01 Epub Date: 2024-12-02 DOI: 10.1097/MPH.0000000000002974

Jun Sung Park, Jongkeon Song, Reenar Yoo, Dahyun Kim, Min Kyo Chun, Jeeho Han, Jeong-Yong Lee, Seung Jun Choi, Jong Seung Lee, Jeong-Min Ryu, Sung Han Kang, Kyung-Nam Koh, Ho Joon Im, Hyery Kim

{"title":"Machine Learning-based Prediction of Blood Stream Infection in Pediatric Febrile Neutropenia.","authors":"Jun Sung Park, Jongkeon Song, Reenar Yoo, Dahyun Kim, Min Kyo Chun, Jeeho Han, Jeong-Yong Lee, Seung Jun Choi, Jong Seung Lee, Jeong-Min Ryu, Sung Han Kang, Kyung-Nam Koh, Ho Joon Im, Hyery Kim","doi":"10.1097/MPH.0000000000002974","DOIUrl":"10.1097/MPH.0000000000002974","url":null,"abstract":"Objectives: This study aimed to develop machine learning (ML) prediction models for identifying bloodstream infection (BSI) and septic shock (SS) in pediatric patients with cancer who presenting febrile neutropenia (FN) at emergency department (ED) visit.Materials and methods: A retrospective study was conducted on patients, younger than 18 years of age, who visited a tertiary university-affiliated hospital ED due to FN between January 2004 and August 2022. ML models, based on XGBoost, were developed for BSI and SS prediction.Results: After applying the exclusion criteria, we identified 4423 FN events during the study period. We identified 195 (4.4%) BSI and 107 (2.4%) SS events. The BSI and SS models demonstrated promising performance, with area under the receiver operating characteristic curve values of 0.87 and 0.88, respectively, which were superior to those of the logistic regression models. Clinical features, including body temperature, some laboratory results, vital signs, and diagnosis of acute myeloblastic leukemia were identified as significant predictors.Conclusions: The ML-based prediction models, which use data obtainable at ED visits may be valuable tools for ED physicians to predict BSI or SS.","PeriodicalId":16693,"journal":{"name":"Journal of Pediatric Hematology/Oncology","volume":" ","pages":"12-18"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11676618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142786164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hepatoblastoma in a 13-Month-old Male With Oculofaciocardiodental Syndrome. 一名 13 个月大的患有眼耳鼻畸形综合征的男婴体内的肝母细胞瘤

IF 0.9 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2025-01-01 Epub Date: 2024-11-07 DOI: 10.1097/MPH.0000000000002973

Kriti Kumar, Chitra Prasad, Diana Masse, Jennifer Seelisch

引用次数: 0

Atypical Teratoid Rhabdoid Tumor of the Brain in a Young Adult With Down Syndrome: Case Report and Literature Review. 一名患有唐氏综合征的年轻成人脑部非典型畸胎横纹肌瘤：病例报告和文献综述。

IF 0.9 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2025-01-01 Epub Date: 2024-11-26 DOI: 10.1097/MPH.0000000000002977

Dallin Judd, Kaith K Almefty, Tamara Z Vern-Gross, Lindsey M Hoffman, Zied Kh Abdullaev, Martha M Quezado, Kenneth D Aldape, Nishant Tiwari, Jennifer A Vaughn, Ross Mangum

{"title":"Atypical Teratoid Rhabdoid Tumor of the Brain in a Young Adult With Down Syndrome: Case Report and Literature Review.","authors":"Dallin Judd, Kaith K Almefty, Tamara Z Vern-Gross, Lindsey M Hoffman, Zied Kh Abdullaev, Martha M Quezado, Kenneth D Aldape, Nishant Tiwari, Jennifer A Vaughn, Ross Mangum","doi":"10.1097/MPH.0000000000002977","DOIUrl":"10.1097/MPH.0000000000002977","url":null,"abstract":"Atypical teratoid/rhabdoid tumor (ATRT) is an aggressive, malignant embryonal tumor with dismal long-term survival despite aggressive multimodal therapy. While this tumor typically presents in infancy or early childhood, there are published case reports of adult-onset ATRT. Making prognostic conclusions or therapeutic decisions for this older patient population remains challenging due to the paucity of these reports. A 25-year-old female with Down syndrome presented with dysphagia and facial droop and was found to have an avidly enhancing, cerebellopontine angle mass. Histology demonstrated sheets of rhabdoid cells with loss of INI1 expression, pathognomonic for ATRT. Further sequencing detected a frameshift SMARCB1 mutation and methylation profiling matched with high confidence to the MYC subclass of ATRT. The patient was treated with subtotal surgical resection and focal proton beam irradiation, followed by chemotherapy on a modified regimen due to concern for heightened risk of treatment-related toxicity. On most recent follow-up 22 months from diagnosis, the patient remains without evidence of disease. This report represents the first known case of ATRT in a young adult patient with Down syndrome, offering unique mechanistic insight into the tumorigenesis of ATRT. Further studies are needed to define an appropriate risk-adapted and standardized therapeutic approach for this patient population.","PeriodicalId":16693,"journal":{"name":"Journal of Pediatric Hematology/Oncology","volume":" ","pages":"e52-e57"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bloodstream Infections in Childhood Acute Myeloid Leukemia and Machine Learning Models: A Single-institutional Analysis. 儿童急性髓性白血病血流感染与机器学习模型：单机构分析

IF 0.9 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2025-01-01 Epub Date: 2024-10-22 DOI: 10.1097/MPH.0000000000002957

Taylor L Chappell, Ellen G Pflaster, Resty Namata, Jometa Bell, Lane H Miller, William F Pomputius, Justin J Boutilier, Yoav H Messinger

{"title":"Bloodstream Infections in Childhood Acute Myeloid Leukemia and Machine Learning Models: A Single-institutional Analysis.","authors":"Taylor L Chappell, Ellen G Pflaster, Resty Namata, Jometa Bell, Lane H Miller, William F Pomputius, Justin J Boutilier, Yoav H Messinger","doi":"10.1097/MPH.0000000000002957","DOIUrl":"10.1097/MPH.0000000000002957","url":null,"abstract":"Childhood acute myeloid leukemia (AML) requires intensive chemotherapy, which may result in life-threatening bloodstream infections (BSIs). This study evaluated whether machine learning (ML) could predict BSI using electronic medical records. All children treated for AML at Children's Minnesota between 2005 and 2019 were included. Patients with Down syndrome AML or acute promyelocytic leukemia were excluded. Standard statistics analyzed predictors of BSI, and ML models were trained to predict BSI. Of 95 AML patients, 54.7% had BSI. Of 480 admissions, 19% included BSI. No deaths were related to BSI, and survival of non-Whites was significantly inferior to White patients. Logistic regression revealed that higher cytarabine doses increased the risk of BSI, with an odds ratio (OR) of 1.110 ( P < 0.05). Prophylactic levofloxacin-vancomycin reduced the risk of BSI, with OR of 0.495 ( P < 0.05). The best-performing ML model was regularized logistic regression with an area under the curve (AUC) of 0.748, improved specificity by 37.5% compared with neutropenia, and 2.6% compared with fever. In conclusion, BSI risk was increased by cytarabine and reduced by levofloxacin-vancomycin prophylaxis. ML predicted BSI with improvement over fever or neutropenia. In clinical practice, ML may offer flexibility by controlling sensitivity and specificity by adjusting BSI diagnosis thresholds.","PeriodicalId":16693,"journal":{"name":"Journal of Pediatric Hematology/Oncology","volume":" ","pages":"e26-e33"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142622664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Case Report of Dinutuximab-induced Atypical Hemolytic Uremic Syndrome. 地纽昔单抗诱发非典型溶血性尿毒症病例报告

IF 0.9 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2025-01-01 Epub Date: 2024-11-07 DOI: 10.1097/MPH.0000000000002966

Letha Huang, Danielle Miller, Fouad Hajjar

引用次数: 0

Pediatric Plasmablastic Lymphoma in the Setting of CD70 Deficiency. 缺乏 CD70 的小儿浆细胞性淋巴瘤

IF 0.9 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2024-11-01 Epub Date: 2024-09-05 DOI: 10.1097/MPH.0000000000002948

Kubra Baskin, Ozge Vural, Sule Haskologlu, Baran Erman, Pinar Uyar Gocun, Arzu Okur, Figen Dogu, Faruk Guclu Pinarli, Aydan Ikinciogullari

引用次数: 0