Journal of Pediatric Hematology/Oncology最新文献_第6页

Patterns and Predictors of Hydroxyurea Use Among Californians Living With Sickle Cell Disease. 加州镰状细胞病患者羟基脲使用的模式和预测因素

IF 0.9 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2025-05-01 Epub Date: 2025-04-22 DOI: 10.1097/MPH.0000000000003027

Melinda Rushing, Sophia Horiuchi, Mariam Kayle, Sarah L Reeves, Alexander K Glaros, Susan Paulukonis

{"title":"Patterns and Predictors of Hydroxyurea Use Among Californians Living With Sickle Cell Disease.","authors":"Melinda Rushing, Sophia Horiuchi, Mariam Kayle, Sarah L Reeves, Alexander K Glaros, Susan Paulukonis","doi":"10.1097/MPH.0000000000003027","DOIUrl":"https://doi.org/10.1097/MPH.0000000000003027","url":null,"abstract":"Hydroxyurea is the primary disease-modifying therapy for sickle cell disease (SCD), yet adherence is low. Our objective was to identify patterns and predictors of hydroxyurea adherence among Medicaid enrollees with SCD. Children and adults with SCD who received Medicaid benefits between 2009 and 2018 in California were included. Monthly hydroxyurea possession ratios were calculated using filled hydroxyurea prescriptions. Group-based trajectory modeling was applied to identify hydroxyurea possession trajectories and multinomial logistic regression modeling to evaluate predictors of hydroxyurea possession group membership: prior acute care visits due to VOCs, prescriber specialty, and participant sex and age. 713 participants (48% in the 0 to 17 age group, 50% male) had 3 distinct hydroxyurea possession groups: persistently high (n=263, 37%), moderate to low (n=253, 35%), and low to no possession (n=197, 28%). The 18 to 24 and 25+ age groups had greater odds of being in the moderate to low (OR: 2.62, 1.70) and low to no (OR: 3.60, 2.45) than the persistently high possession group compared with the 0 to 17 age group when adjusted for prior VOCs. Children had greater odds of being in the persistently high hydroxyurea possession group compared with young adults and adults, suggesting there are protective factors at this age that promotes better hydroxyurea adherence.","PeriodicalId":16693,"journal":{"name":"Journal of Pediatric Hematology/Oncology","volume":"47 4","pages":"169-176"},"PeriodicalIF":0.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alternaria Invasive Infection in Children With Hemato-Oncological Disease: A National Multicenter Report. 儿童血液肿瘤疾病的侵袭性感染：一项全国多中心报告。

IF 0.9 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2025-05-01 Epub Date: 2025-03-06 DOI: 10.1097/MPH.0000000000003016

Aviv Sever, Chen Rosenberg Danziger, Nimrod Sachs, Salvador Fisher, Efraim Bilavsky, Gilad Sherman, Yael Shachor-Meyouhas, Galia Grisaru, Haim Ben Zvi

{"title":"Alternaria Invasive Infection in Children With Hemato-Oncological Disease: A National Multicenter Report.","authors":"Aviv Sever, Chen Rosenberg Danziger, Nimrod Sachs, Salvador Fisher, Efraim Bilavsky, Gilad Sherman, Yael Shachor-Meyouhas, Galia Grisaru, Haim Ben Zvi","doi":"10.1097/MPH.0000000000003016","DOIUrl":"10.1097/MPH.0000000000003016","url":null,"abstract":"Invasive fungal diseases significantly impact hemato-oncology pediatric patients, with Aspergillus and Candida being the primary culprits. However, pediatric Alternaria infections remain understudied. This study aims to characterize Alternaria infections in pediatric hemato-oncology cases nationwide. This retrospective multicenter observational study reviewed medical records from Israel's 5 largest tertiary pediatric centers between 2011 and 2023. We identified 22 patients aged 4 to 18 years with invasive Alternaria infection. Predominant diagnoses were acute lymphoid leukemia (55%) and acute myeloid leukemia (23%), with 86% presenting neutropenic fever. Alternaria infections manifested as invasive rhinosinusitis (77%), skin lesions resembling ecthyma (14%), and pulmonary infection (9%). Notably, 76% of sinusitis cases exhibited suggestive symptoms. Voriconazole treatment led to a 90% recovery rate, irrespective of surgery. Two fatalities were unrelated to the infections. This study, the largest on Alternaria infections in children, emphasizes their occurrence in leukemia patients with neutropenic fever, showcasing common clinical presentations and a favorable prognosis despite underlying diseases.","PeriodicalId":16693,"journal":{"name":"Journal of Pediatric Hematology/Oncology","volume":" ","pages":"185-189"},"PeriodicalIF":0.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dupilumab for Atopic Dermatitis-like Chronic Graft-versus-Host Disease in Three Pediatric Hematopoietic Cell Transplant Recipients. Dupilumab治疗三名儿童造血细胞移植受者的特应性皮炎样慢性移植物抗宿主病

IF 0.9 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2025-05-01 Epub Date: 2025-03-11 DOI: 10.1097/MPH.0000000000003018

Savannah L Ishee, Meredith M Jenkins, Margaret M Jones, James A Connelly

{"title":"Dupilumab for Atopic Dermatitis-like Chronic Graft-versus-Host Disease in Three Pediatric Hematopoietic Cell Transplant Recipients.","authors":"Savannah L Ishee, Meredith M Jenkins, Margaret M Jones, James A Connelly","doi":"10.1097/MPH.0000000000003018","DOIUrl":"10.1097/MPH.0000000000003018","url":null,"abstract":"Atopic dermatitis (AD)-like graft-versus-host disease (GVHD) is a chronic form of skin GVHD with features that include erythema, xerosis, scaling, and pruritus. Patients often require treatment with systemic immunosuppression and aggressive topical therapies for relief. Long-term effects of chronic immunosuppression are undesirable and alternative therapies are needed. A retrospective review of 3 patients receiving dupilumab (DUP) for AD-like cGVHD was conducted. Data collected included demographics, transplant history, and GVHD management and outcomes. Information relating to DUP included dose, route, frequency, and safety based on dermatologic reactions, ocular toxicities, and infections. Patients had differing underlying conditions, transplant types, cell sources, and GVHD prophylactic therapies. Three patients received tacrolimus and topical corticosteroids for GVHD treatment, and 1 also received sirolimus and ruxolitinib. After the initial DUP dose, all patients experienced improvement in their GVHD. To date, all patients have complete remission of their skin cGVHD and have weaned off other therapies. No patients experienced dermatologic or ocular toxicities, and no infections were reported. DUP was efficacious and safe for treating AD-like cGVHD in our 3 pediatric patients. Further investigations are warranted to determine the appropriate placement in therapy.","PeriodicalId":16693,"journal":{"name":"Journal of Pediatric Hematology/Oncology","volume":" ","pages":"e128-e130"},"PeriodicalIF":0.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 0.9 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2025-05-01 Epub Date: 2025-04-02 DOI: 10.1097/MPH.0000000000003025

Seval Özen, Volkan Köse, Yunus M Akçabelen, Fatih Üçkardeş, Saliha Kanik Yüksek, Özlem A Bilir, Şerife M Kanbur, Belgin Gülhan, Gülsüm I Bayhan, Ikbal O Bozkaya, Asli N Ö Parlakay, Namik Y Özbek

{"title":"Catheter-related Bloodstream Infection in Pediatric Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation.","authors":"Seval Özen, Volkan Köse, Yunus M Akçabelen, Fatih Üçkardeş, Saliha Kanik Yüksek, Özlem A Bilir, Şerife M Kanbur, Belgin Gülhan, Gülsüm I Bayhan, Ikbal O Bozkaya, Asli N Ö Parlakay, Namik Y Özbek","doi":"10.1097/MPH.0000000000003025","DOIUrl":"10.1097/MPH.0000000000003025","url":null,"abstract":"The aim of this study was to identify catheter-related bloodstream infection (CRBSI) episodes, to determine the causative agents and antibiotic susceptibility profiles, demographic characteristics, and clinical outcomes of patients treated in the pediatric bone marrow transplant (BMT) unit between November 2019 and July 2022. Forty patients were included in the study. The median patient age was 7.5 years (range: 1.5 to 19.9 y) and the most common underlying disease was ALL (77.5%). CRBSI was found to be significantly higher in haploidentic donors ( P <0.001). When CRBSI was confirmed, 65% of the patients were neutropenic with a median duration of 17.5 days (range: 3 to 150). It was found that the mean time to CVC infection was 22 days (range: 5 to 118). As a result of multivariate logistic analysis (OR: 1.038 [95% CI: 1.007-1.070], P =0.018) of the time of infection of the catheter and mortality, it was determined that the mortality rate increased as the duration of the catheter remained. CRBSI was detected in 41.2% of transplanted patients and the overall mortality rate attributed to this complication was 10%. Among the patients, 22 (55%) were colonized before hematopoietic stem cell transplantation (HSCT), and Gram-negative agents (n=15, 68%) mostly accounted for colonization. Gram-negative pathogens (60%) were found to be statistically significantly more common in CRBSI ( P <0.01). The most common causative agent was K. pneumoniae (n=13, 32.5%). Of the Gram-negative isolates (n=24), 17 (70.8%) were multidrug-resistant organisms (MDRO). A fluoroquinolone (80%) was used for antibiotic prophylaxis. Among patients with CRBSI, 65% had a fluoroquinolone-resistant isolate. We found a high rate of quinolone resistance among CRBSI isolates after the use of fluoroquinolone prophylaxis at our unit.","PeriodicalId":16693,"journal":{"name":"Journal of Pediatric Hematology/Oncology","volume":" ","pages":"155-160"},"PeriodicalIF":0.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Full House Agglutination - An Interesting Finding in Mycoplasma pneumoniae Infection. 满屋凝集--肺炎支原体感染中的有趣发现

IF 0.9 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2025-05-01 Epub Date: 2025-03-05 DOI: 10.1097/MPH.0000000000003015

Jayashree D Kulkarni, Arjun Kashyap

引用次数: 0

Neuropsychologic Resource Utilization in Solid Tumor Survivors at a Single Institution: A Retrospective Chart Review. 单一机构实体瘤幸存者的神经心理资源利用：回顾性图表回顾。

IF 0.9 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2025-05-01 Epub Date: 2025-03-21 DOI: 10.1097/MPH.0000000000003020

Kaitlyn Brown, Laura K Sedig, Kaitlin Oswald-McCloskey, Yujie Wang, Elizabeth Stuchell, Rama Jasty-Rao

引用次数: 0

Haploidentical Stem Cell Transplantation With TCR-αβ + /CD19 + Depletion in High-risk Pediatric Leukemias: Experience From a Referral Center in Peru. 高风险小儿白血病的 TCR-αβ+/CD19+ 去势单倍体干细胞移植：秘鲁转诊中心的经验。

IF 0.9 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2025-05-01 Epub Date: 2025-03-31 DOI: 10.1097/MPH.0000000000003021

Jackeline C Rodriguez-Torres, Alejandra Pando-Caciano, Benigno Future, Marco E Guerrero, Tatiana Saldarriaga, María A Pereda, Sergio A Murillo-Vizcarra

{"title":"Haploidentical Stem Cell Transplantation With TCR-αβ + /CD19 + Depletion in High-risk Pediatric Leukemias: Experience From a Referral Center in Peru.","authors":"Jackeline C Rodriguez-Torres, Alejandra Pando-Caciano, Benigno Future, Marco E Guerrero, Tatiana Saldarriaga, María A Pereda, Sergio A Murillo-Vizcarra","doi":"10.1097/MPH.0000000000003021","DOIUrl":"10.1097/MPH.0000000000003021","url":null,"abstract":"Haploidentical hematopoietic stem cell transplantation (haplo-HSCT) using TCR αβ+/CD19+ depletion provides an alternative treatment for patients with high-risk (HR) leukemias without a matched donor, especially in developing nations with limited donor registries. We present the outcomes of 36 patients <16 years with HR leukemia who underwent haplo-HSCT with TCR αβ + /CD19 + depletion between 2018 and 2022 at a referral center in Peru. Survival probabilities and cumulative incidence functions were calculated using the Kaplan-Meier method. Patients were followed for a median of 17.38 months (range: 2.34 to 60.36 mo). The 5-year overall survival (OS), 5-year event-free survival (EFS), and non-relapse mortality rates were 72.1%, 72.2%, and 16.7%, respectively. The incidence of relapse for the entire group was 11.1%. Acute graft versus host disease (GvHD) was observed in 36.1% of the patients, with only 2.8% experiencing grade III-IV acute GvHD. No patients developed chronic GvHD. Among all patients, CMV reactivations were observed in 27.78%, HHV-6 reactivations in 33.33%, and ADV or BK virus reactivations in 16.67%. Our study suggests that haplo-HSCT with TCR αβ+/CD19+ depletion is a safe and effective treatment for HR pediatric leukemias. Adopting this approach in major transplant centers throughout the country could improve outcomes for this group of patients.","PeriodicalId":16693,"journal":{"name":"Journal of Pediatric Hematology/Oncology","volume":" ","pages":"161-168"},"PeriodicalIF":0.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12002040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Splenic Embolization for Primary Immune Thrombocytopenia Complicated With Intracranial Hemorrhage-Case Report of 2 Patients. 脾栓塞治疗原发性免疫性血小板减少症合并颅内出血2例报告。

IF 0.9 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2025-05-01 Epub Date: 2025-04-22 DOI: 10.1097/MPH.0000000000003029

Olivier Cusson, Mira Liebman, Robert J Klaassen, Brianna Mckelvie

引用次数: 0

Palliative and End-of-Life Disparities for Pediatric Hispanic, Spanish-preferring Patients With Cancer. 儿童西班牙语和偏爱西班牙语的癌症患者的姑息治疗和临终差异。

IF 0.9 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2025-05-01 Epub Date: 2025-03-21 DOI: 10.1097/MPH.0000000000003026

Batool El-Atoum, Katie Gradick, Kellee Parker, Dominic Moore, Mark Fluchel, Ana C Sanchez-Birkhead

{"title":"Palliative and End-of-Life Disparities for Pediatric Hispanic, Spanish-preferring Patients With Cancer.","authors":"Batool El-Atoum, Katie Gradick, Kellee Parker, Dominic Moore, Mark Fluchel, Ana C Sanchez-Birkhead","doi":"10.1097/MPH.0000000000003026","DOIUrl":"10.1097/MPH.0000000000003026","url":null,"abstract":"The influence of ethnicity and language preference on palliative and end-of-life (EOL) experiences in children with cancer is poorly understood. Existing data relies on adult studies and suggests that patients from underserved populations often receive inferior palliative and EOL care, characterized by medically intense care at EOL. This qualitative study explores the EOL experiences of English and Spanish-preferring families of children with poor-prognosis cancers, with the hypothesis that language-based disparities exist. English and Spanish-preferring parents of children with poor-prognosis cancers, and bereaved parents whose children died of cancer within the last 5 years were eligible. Language preference and ethnicity data were obtained from the patient chart and confirmed by self-report during interviews. We conducted 11 interviews with 15 caregivers: 6 in Spanish and 5 in English. Interviews were recorded, transcribed, and analyzed using Braun and Clarke inductive coding approach. Our analysis revealed that many Hispanic, particularly Spanish-preferring families, reported disparities compared with non-Hispanic families, including inconsistent interpreter use, confusion about prognosis and treatment, perceived discrimination, inadequate EOL anticipatory guidance, and dissatisfaction with hospice. The study identifies perceived gaps in our current practices that negatively impact pediatric Hispanic, Spanish-preferring patients and their families. Larger scale studies are needed to further explore the influence of language preference on EOL experiences. There is a critical need to better assess the effective delivery of pediatric palliative care among Spanish-preferring families, and interventions to reduce disparities in EOL/palliative care should be founded on the expressed needs of families who prefer to communicate in languages other than English.","PeriodicalId":16693,"journal":{"name":"Journal of Pediatric Hematology/Oncology","volume":" ","pages":"197-203"},"PeriodicalIF":0.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute Myeloblastic Leukemia in a Child With Duchenne Muscular Dystrophy: A Novel Case and Brief Review of the Literature. 杜氏肌营养不良儿童急性髓母细胞白血病一例新病例及文献综述。

IF 0.9 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2025-05-01 Epub Date: 2025-03-17 DOI: 10.1097/MPH.0000000000003019

Daniel S Cirotski, Lindsey Sawyer, Wilson File, Linda Pegram

引用次数: 0