Journal of Pediatric Hematology/Oncology最新文献

Follow-Up Outcomes of Patients Presenting With Ovarian Masses in Childhood: A 15-Year Single-Center Experience. 儿童期卵巢肿块患者的随访结果：15年单中心经验。

IF 0.9 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2025-05-26 DOI: 10.1097/MPH.0000000000003043

Aytül Temuroğlu, Betül B Sevinir

{"title":"Follow-Up Outcomes of Patients Presenting With Ovarian Masses in Childhood: A 15-Year Single-Center Experience.","authors":"Aytül Temuroğlu, Betül B Sevinir","doi":"10.1097/MPH.0000000000003043","DOIUrl":"https://doi.org/10.1097/MPH.0000000000003043","url":null,"abstract":"Objective: Ovarian tumors in childhood are rare. This study aimed to examine the clinical characteristics of pediatric patients presenting with ovarian masses.Materials and methods: A retrospective review of patient data was conducted for patients who presented to our clinic with an ovarian mass between 2009 and 2024.Results: The study included 85 patients treated for ovarian masses in our clinic. The mean age of the patients was 12.2±4.6 (range: 0 to 18) years. The mean size of malignant tumors was 12.1±7.2 cm, and that of benign tumors was 10.74±7 cm (P=0.43). On the basis of operation type, the mean tumor size in patients who underwent oophorectomy was 12.66±7.2 cm, compared with 8.59±6.15 cm in those with a cystectomy (P=0.017). Histopathologic examination reported 54.1% (n=46) of tumors as benign, 32.9% (n=31) as malignant, 5.9% (n=5) as borderline, and 3.5% (n=3) as non-neoplastic lesions. Germ cell tumors were the most common, constituting 67.1% (n=57) of cases, followed by epithelial tumors at 22.4% (n=19). Synchronous bilateral ovarian tumors were identified in 4 cases. Chemotherapy was administered to 32.9% (n=28) of the patients. The mean follow-up period was 45 (1 to 204) months. A recurrence was observed in 1 patient, followed up with a diagnosis of immature teratoma. Two patients (2.4%) died, 1 due to acute renal failure and the other due to sepsis.Conclusions: Ovarian tumors in childhood are rare and have high treatment success rates. Further research is needed to improve ovary-preserving surgical approaches and mitigate the side effects of chemotherapy.","PeriodicalId":16693,"journal":{"name":"Journal of Pediatric Hematology/Oncology","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Discovering a Rare Connection: Hereditary Thrombotic Thrombocytopenic Purpura and Large Placental Lakes. 发现罕见的联系：遗传性血栓性血小板减少性紫癜和大胎盘湖。

IF 0.9 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2025-05-26 DOI: 10.1097/MPH.0000000000003053

Refika S Dokuzboy, Dilek Çetin, Ali U Tuğcu, Şerife S Oğuz

引用次数: 0

Variability in the Recommendations for Management of Vaso-Occlusive Crisis and Acute Chest Syndrome in Sickle Cell Disease: Review of Institutional Algorithms of Pediatric Hospitals Across the United States. 镰状细胞病血管闭塞危象和急性胸综合征管理建议的差异：美国儿科医院机构算法综述

IF 0.9 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2025-05-14 DOI: 10.1097/MPH.0000000000003052

Amr Elgehiny, Mariam Z Quraishi, Aravind Yadav, Lakshmi V Srivaths, Olayinka Okeleji, Deborah L Brown, Neethu M Menon

{"title":"Variability in the Recommendations for Management of Vaso-Occlusive Crisis and Acute Chest Syndrome in Sickle Cell Disease: Review of Institutional Algorithms of Pediatric Hospitals Across the United States.","authors":"Amr Elgehiny, Mariam Z Quraishi, Aravind Yadav, Lakshmi V Srivaths, Olayinka Okeleji, Deborah L Brown, Neethu M Menon","doi":"10.1097/MPH.0000000000003052","DOIUrl":"https://doi.org/10.1097/MPH.0000000000003052","url":null,"abstract":"This study aims to review institutional algorithms for vaso-occlusive crisis (VOC) and acute chest syndrome (ACS) in pediatric sickle cell disease (SCD), comparing them to each other and to national recommendations. Algorithms collected from children's hospitals across the country were compared with recommendations made by the National Heart, Lung, and Blood Institute 2014 and the American Society of Hematology 2020 regarding management of VOC/ACS in SCD. Review of 37 VOC and 17 ACS algorithms from 40 children's hospitals showed that most followed national guidelines for diagnostic evaluation of VOC/ACS. Parenteral opioids and NSAIDs were recommended by all VOC algorithms, with variations in dosing and administration. Intranasal fentanyl was recommended by 31 algorithms. Incentive spirometry was included in 16 of 17 ACS algorithms, but only in 11 of 37 VOC algorithms. Antibiotics were recommended by all ACS algorithms, but 4 used regimens were different from national recommendations. Most ACS algorithms had recommendations regarding transfusion, but with considerable variability. Intravenous fluid management strategies were highly variable, and hypotonic fluids were recommended in 6 VOC and 4 ACS algorithms. Overall, internal algorithms for pediatric SCD showed variability compared with each other and with national guidelines, likely due to the lack of robust evidence supporting specific recommendations.","PeriodicalId":16693,"journal":{"name":"Journal of Pediatric Hematology/Oncology","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pediatric Cancer Survivorship Program in Low-income and Middle-income Countries; A Dire Need of Comprehensive Approach to a Healthy Life After Cancer: Perspective and Literature Review. 低收入和中等收入国家的儿童癌症生存方案；癌症后健康生活的综合方法的迫切需要：观点和文献综述。

IF 0.9 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2025-05-14 DOI: 10.1097/MPH.0000000000003044

Gashaw Arega, Syed Ibrahim Bukhari, Sadaf Altaf, Asim Fakhruddin Belagaumi

引用次数: 0

Genomic Sequencing in Pediatric Oncology: Perspectives of Parents and Adolescents on Ethical Issues. 儿童肿瘤学的基因组测序：父母和青少年在伦理问题上的观点。

IF 0.9 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2025-05-13 DOI: 10.1097/MPH.0000000000003048

Esther E Knapp, Jennifer Hall, Alyssa A Middleton, Carla A Rich, Kyle B Brothers

{"title":"Genomic Sequencing in Pediatric Oncology: Perspectives of Parents and Adolescents on Ethical Issues.","authors":"Esther E Knapp, Jennifer Hall, Alyssa A Middleton, Carla A Rich, Kyle B Brothers","doi":"10.1097/MPH.0000000000003048","DOIUrl":"https://doi.org/10.1097/MPH.0000000000003048","url":null,"abstract":"This study aimed to elicit the perspectives of adolescents with cancer, and parents of children with cancer regarding tumor and germline genomic sequencing in pediatric oncology. Semistructured interviews were conducted with adolescents and parents/guardians of children with cancer. The interview guide included potential benefits of genomic sequencing, heritable cancer predisposition conditions, impacts on family relationships, and secondary findings. Participants reported several ways they believed sequencing results could be valuable, including more targeted therapy and knowledge regarding heritable variants. However, opinions varied on what information would be useful, with many participants reporting an interest only in those results that would directly impact therapy. Several parents were inclined to feel guilty about their children having cancer, whether genetically linked or not. Adolescent patients tended to be protective towards their parents and generally felt they would not blame their parents, even for an inherited condition. Many participants felt they lacked the knowledge to make a completely informed decision on results derived from complex scientific technology. These findings will help inform the process of obtaining informed consent for genomic sequencing in children with cancer.","PeriodicalId":16693,"journal":{"name":"Journal of Pediatric Hematology/Oncology","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Consolidation Strategies for Pediatric Patients With Acute Myeloid Leukemia: Results of the Randomized GATLA 8-LMA-P'07 Trial. 儿科急性髓性白血病患者巩固策略的比较：随机GATLA 8-LMA-P'07试验的结果

IF 0.9 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2025-05-12 DOI: 10.1097/MPH.0000000000003028

Alejandra Deana, Sergio M Gomez, Alcira Beatriz Fynn, Daniel Freigeiro, Maria Cecilia Riccheri, Lorena Elizabeth Moran, Monica Leonor Makiya, Lilian Sung

{"title":"Comparison of Consolidation Strategies for Pediatric Patients With Acute Myeloid Leukemia: Results of the Randomized GATLA 8-LMA-P'07 Trial.","authors":"Alejandra Deana, Sergio M Gomez, Alcira Beatriz Fynn, Daniel Freigeiro, Maria Cecilia Riccheri, Lorena Elizabeth Moran, Monica Leonor Makiya, Lilian Sung","doi":"10.1097/MPH.0000000000003028","DOIUrl":"https://doi.org/10.1097/MPH.0000000000003028","url":null,"abstract":"Objective: The primary objective was to determine whether consolidation (CONS) with 2 short chemotherapy cycles using cytarabine plus idarubicin and high dose cytarabine plus mitoxantrone (2-cycle) reduced the cumulative incidence of relapse compared with the standard regimen of a 6-week CONS phase among newly diagnosed pediatric patients with acute myeloid leukemia (AML).Patients and methods: GATLA 8-LMA-P'07 was a phase 3 trial conducted in 26 centers in Argentina. We included newly diagnosed pediatric patients with AML 0 to 18 years of age. Patients with M3 AML were excluded. After 2 cycles of induction, patients in remission were randomized to either CONS or 2-cycle CONS chemotherapy. High-risk patients received matched family stem cell transplantation or maintenance therapy for 12 months.Results: One hundred seven patients younger than 18 years with de novo AML were randomized to CONS (n = 52) or 2-cycle (n = 57). Cumulative incidence (SE) of relapse was not significantly different between CONS (31% [0.1]) and 2-cycle (39% [0.1]) CONS (P = 0.25). There was no significant difference in 5-year event-free survival (53.6% [0.8] vs 44.3 [0.7], P = 0.31) or 5-year overall survival (55.0% [0.8] vs 53.7% [0.7], P = 0.91) for CONS and 2-cycle CONS respectively.Conclusions: CONS with 2 cycles of chemotherapy was not significantly better than the standard CONS in reducing the cumulative risk of relapse among newly diagnosed children with AML from Argentina. Future research should evaluate new approaches to improve outcomes for pediatric patients with AML.","PeriodicalId":16693,"journal":{"name":"Journal of Pediatric Hematology/Oncology","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Successful Unmanipulated Haploidentical Hematopoietic Stem Cell Transplant With Post-Transplant Cyclophosphamide in a Child With Down Syndrome and Myelodysplastic Syndrome. 移植后环磷酰胺治疗唐氏综合征和骨髓增生异常综合征患儿的单倍体造血干细胞移植成功

IF 0.9 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2025-05-12 DOI: 10.1097/MPH.0000000000003051

Chane Choed-Amphai, Yigal Dror, Michaela Cada, Tal Schechter, Joerg Krueger, Muhammad Ali, Yogi Chopra

引用次数: 0

Hybrid Treatment Approach for a Rare Middle Cranial Fossa Intracranial Tumor in a Pediatric Patient: A Case Report. 小儿罕见中颅窝颅内肿瘤的综合治疗方法1例报告。

IF 0.9 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2025-05-09 DOI: 10.1097/MPH.0000000000003049

Ryan Wang, Shervin Pejhan, Qi Zhang, Robert Siddaway, Cynthia Hawkins, S Danielle MacNeil, Glenn Bauman, Sandrine de Ribaupierre, Chantel Cacciotti

引用次数: 0

The Tale of Pediatric Hematopoietic Stem Cell Transplantation in Iran: An Uphill Battle. 伊朗儿童造血干细胞移植的故事：一场艰苦的战斗。

IF 0.9 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2025-05-08 DOI: 10.1097/MPH.0000000000003050

Maryam Behfar, Pouya Mahdavi Sharif, Amir Ali Hamidieh

{"title":"The Tale of Pediatric Hematopoietic Stem Cell Transplantation in Iran: An Uphill Battle.","authors":"Maryam Behfar, Pouya Mahdavi Sharif, Amir Ali Hamidieh","doi":"10.1097/MPH.0000000000003050","DOIUrl":"https://doi.org/10.1097/MPH.0000000000003050","url":null,"abstract":"Hematopoietic stem cell transplantation (HSCT) has revolutionized the treatment of hematologic malignancies, immunodeficiencies, and storage disorders. While this transformative therapy is widely adopted globally, its introduction in Iran faced significant challenges due to geopolitical and economic hardships. In 2007, the first pediatric HSCT department in Iran was established at Tehran University of Medical Sciences. Over the past 18 years, this department has made substantial contributions to the field, including pioneering various HSCT modalities and establishing the first HLA registry in the region, facilitating access to matched unrelated donors. Despite significant challenges, including economic constraints and limited access to advanced therapies, the department and its affiliated research center have persevered in their mission to provide care to pediatric patients and advance in cutting-edge research, including immune cell therapies and gene therapies. With constantly aggravating economic hurdles and geopolitical issues, these milestones could not be achieved without the financial support of health care philanthropies and the sacrifices of dedicated physicians, researchers, and nurses. However, no health system, no matter how resilient, is immune to debacle under perpetuated hurdles, underscoring the need for global collaborations. This letter highlights the journey of pediatric HSCT in Iran and the importance of public advocacy in overcoming obstacles.","PeriodicalId":16693,"journal":{"name":"Journal of Pediatric Hematology/Oncology","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Agrobacterium radiobacter-induced Port Catheter Bacteremia in a Pediatric Acute Lymphoblastic Leukemia Patient: A Rare Clinical Case. 农杆菌引起的儿科急性淋巴细胞白血病患者端口导管菌血症：一例罕见的临床病例。

IF 0.9 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2025-05-05 DOI: 10.1097/MPH.0000000000003045

Fatma Burçin Kurtipek, Dilek Kaçar, Bedia Dinç, Aslinur Özkaya Parlakay, Neşe Yarali

引用次数: 0