Journal of Pediatric Hematology/Oncology最新文献_第2页

Sclerosing Epithelioid Fibrosarcoma Harboring the EWSR1 - CREB3L1 Gene Fusion: The Importance of Molecular Classification in Pediatric Sarcomas. 携带 EWSR1-CREB3L1 基因融合的硬化性上皮样纤维肉瘤：小儿肉瘤分子分类的重要性》。

IF 0.9 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2024-11-01 Epub Date: 2024-09-13 DOI: 10.1097/MPH.0000000000002952

Rachel Offenbacher, Sara Kaswan, Lara Fabish, Carly Barron, Jana Fox, Steven Chin, Matija Snuderl, Alice Lee, David M Loeb, Alissa Baker

{"title":"Sclerosing Epithelioid Fibrosarcoma Harboring the EWSR1 - CREB3L1 Gene Fusion: The Importance of Molecular Classification in Pediatric Sarcomas.","authors":"Rachel Offenbacher, Sara Kaswan, Lara Fabish, Carly Barron, Jana Fox, Steven Chin, Matija Snuderl, Alice Lee, David M Loeb, Alissa Baker","doi":"10.1097/MPH.0000000000002952","DOIUrl":"10.1097/MPH.0000000000002952","url":null,"abstract":"Background: Sclerosing epithelioid fibrosarcoma (SEF) is a very rare soft tissue sarcoma that most commonly presents in middle-aged and elderly adults but has been rarely seen in children. SEF is a very aggressive tumor with over 50% of patients experiencing local recurrence and 40% to 80% of patients experiencing distant metastatic spread. This disease has been shown to be resistant to chemotherapy and is classically treated with surgical excision.Case: We describe the case of a 10-year-old girl with Graves' disease who presented with protruding eyes (to a greater extent on the left side) and was found to have a large mass in her left inferior rectus muscle that was diagnosed as SEF. After treatment with incomplete resection, due to the benign-appearing nature of the tumor on imaging, and proton radiation therapy, she remains disease-free at 18 months post-therapy.Discussion: SEF is typically identified via genetic testing and recognition of the EWSR1 - CREB3L1 gene fusion as well as MUC4 expression via immunohistochemistry. DNA methylation profiling, which has traditionally been used in brain tumors, can also efficiently identify this tumor, and we recommend expanding the use of this technology for difficult to classify pediatric sarcomas.","PeriodicalId":16693,"journal":{"name":"Journal of Pediatric Hematology/Oncology","volume":" ","pages":"433-437"},"PeriodicalIF":0.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hiding in Plain Sight: Radiologic and Pathologic Findings Can Identify Beckwith-Wiedemann Syndrome in Patients With Wilms Tumor. 隐藏在众目睽睽之下：放射学和病理学发现可识别 Wilms 肿瘤患者的 Beckwith-Wiedemann 综合征。

IF 0.9 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2024-11-01 Epub Date: 2024-10-14 DOI: 10.1097/MPH.0000000000002951

Laura M Molina, Akhila Rao, Julia Meade, Judy H Squires, Svetlana A Yatsenko, Claudia M Salgado, Miguel Reyes-Múgica

引用次数: 0

Emerging CART Therapies for Pediatric Acute Myeloid Leukemia. 治疗小儿急性髓性白血病的新兴CART疗法

IF 0.9 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2024-11-01 Epub Date: 2024-10-29 DOI: 10.1097/MPH.0000000000002956

Valeria Ceolin, Manuela Spadea, Vincenzo Apolito, Francesco Saglio, Franca Fagioli

引用次数: 0

Cancer Predisposition Syndromes in Children: Who, How, and When Should Genetic Studies Be Considered? 儿童癌症易感综合征：应考虑对哪些人、如何以及何时进行基因研究？

IF 0.9 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2024-11-01 Epub Date: 2024-09-06 DOI: 10.1097/MPH.0000000000002932

Mónica Camacho-Arias, Marta Villa, Sara Álvarez de Andres, Bárbara Rivera, Paula Vázquez, Patricia Letón, Laura Martín-López, Marta Pilar Osuna-Marco, Blanca López-Ibor

引用次数: 0

Pyrites: A Rectal Mass. 黄铁矿直肠肿块

IF 0.9 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2024-11-01 Epub Date: 2024-07-19 DOI: 10.1097/MPH.0000000000002900

Sam Lyvannak, Bun Sereyleak, Mariko Kakazu, Hor Bisiphan, Jason Jarzembowski, Bruce Camitta

引用次数: 0

Eosinophilia in a Neonate With Trisomy 21, Transient Abnormal Myelopoiesis, and Neurofibromatosis Type 1. 患有 21 三体综合征、一过性骨髓造血异常和神经纤维瘤病 1 型的新生儿嗜酸性粒细胞增多症

IF 0.9 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2024-11-01 Epub Date: 2024-09-18 DOI: 10.1097/MPH.0000000000002950

Kayla M Schmittau, Brian M Walker, Nupur Mittal, Lisa Giordano

引用次数: 0

Effect of Donor/Recipient ABO Mismatch on Outcome of Allogenic Hematopoietic Stem Cell Transplantation in Children: Single-Center Study. 捐献者/受者 ABO 血型不匹配对儿童异基因造血干细胞移植结果的影响：单中心研究

IF 0.9 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2024-10-28 DOI: 10.1097/MPH.0000000000002958

Asmaa Abdel-Raof El-Kaffas, Amany Mahmoud El-Barky, Eslam Elsayed Elhawary

{"title":"Effect of Donor/Recipient ABO Mismatch on Outcome of Allogenic Hematopoietic Stem Cell Transplantation in Children: Single-Center Study.","authors":"Asmaa Abdel-Raof El-Kaffas, Amany Mahmoud El-Barky, Eslam Elsayed Elhawary","doi":"10.1097/MPH.0000000000002958","DOIUrl":"https://doi.org/10.1097/MPH.0000000000002958","url":null,"abstract":"ABO blood group mismatch between donor and recipient is thought to be associated with several immunopharmacological complications but is not considered a major contraindication to allogeneic hematopoietic stem cell transplantation (HSCT). However, the impact of such a mismatch on overall survival, transplant-related mortality, graft-versus-host disease, and time to neutrophil and platelet engraftment seems to be conflicting. This retrospective cohort was carried out on children and adolescents who underwent allogenic HSCT between January 2016 and January 2023. ABO compatibility state was assessed and grouped into compatible, minor, major, and bidirectional incompatible groups. The effect of ABO compatibility on various transplantation outcomes was assessed. Forty-three children (25 males and 18 females) with different diagnoses were included. More than half of the patients had no ABO mismatch. Major ABO mismatch was found to be associated with a higher incidence of acute graft-versus-host-disease (aGVHD), whereas near significantly higher mortality was observed in the minor mismatch group. Otherwise, no association was found between ABO mismatch and platelet or neutrophil engraftment. ABO mismatch does not affect the overall survival or the posttransplant engraftment of patients undergoing allogeneic HSCT. aGVHD was observed to be the only factor affected by ABO compatibility.","PeriodicalId":16693,"journal":{"name":"Journal of Pediatric Hematology/Oncology","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142622674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bloodstream Infections in Childhood Acute Myeloid Leukemia and Machine Learning Models: A Single-Institutional Analysis. 儿童急性髓性白血病血流感染与机器学习模型：单机构分析

IF 0.9 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2024-10-22 DOI: 10.1097/MPH.0000000000002957

Taylor L Chappell, Ellen G Pflaster, Resty Namata, Jometa Bell, Lane H Miller, William F Pomputius, Justin J Boutilier, Yoav H Messinger

{"title":"Bloodstream Infections in Childhood Acute Myeloid Leukemia and Machine Learning Models: A Single-Institutional Analysis.","authors":"Taylor L Chappell, Ellen G Pflaster, Resty Namata, Jometa Bell, Lane H Miller, William F Pomputius, Justin J Boutilier, Yoav H Messinger","doi":"10.1097/MPH.0000000000002957","DOIUrl":"https://doi.org/10.1097/MPH.0000000000002957","url":null,"abstract":"Childhood acute myeloid leukemia (AML) requires intensive chemotherapy, which may result in life-threatening bloodstream infections (BSIs). This study evaluated whether machine learning (ML) could predict BSI using electronic medical records. All children treated for AML at Children's Minnesota between 2005 and 2019 were included. Patients with Down syndrome AML or acute promyelocytic leukemia were excluded. Standard statistics analyzed predictors of BSI, and ML models were trained to predict BSI. Of 95 AML patients, 54.7% had BSI. Of 480 admissions, 19% included BSI. No deaths were related to BSI, and survival of non-Whites was significantly inferior to White patients. Logistic regression revealed that higher cytarabine doses increased the risk of BSI, with an odds ratio (OR) of 1.110 (P < 0.05). Prophylactic levofloxacin-vancomycin reduced the risk of BSI, with OR of 0.495 (P < 0.05). The best-performing ML model was regularized logistic regression with an area under the curve (AUC) of 0.748, improved specificity by 37.5% compared with neutropenia, and 2.6% compared with fever. In conclusion, BSI risk was increased by cytarabine and reduced by levofloxacin-vancomycin prophylaxis. ML predicted BSI with improvement over fever or neutropenia. In clinical practice, ML may offer flexibility by controlling sensitivity and specificity by adjusting BSI diagnosis thresholds.","PeriodicalId":16693,"journal":{"name":"Journal of Pediatric Hematology/Oncology","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142622664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Successful Development and Implementation of Communication Skills Simulation Training Within Pediatric Hematology-oncology Fellowship Education. 在儿科血液学-肿瘤学研究员教育中成功开发和实施交流技能模拟培训。

IF 0.9 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2024-10-17 DOI: 10.1097/MPH.0000000000002959

Kerri Becktell, Sarah Rumler, Richard L Tower

{"title":"Successful Development and Implementation of Communication Skills Simulation Training Within Pediatric Hematology-oncology Fellowship Education.","authors":"Kerri Becktell, Sarah Rumler, Richard L Tower","doi":"10.1097/MPH.0000000000002959","DOIUrl":"https://doi.org/10.1097/MPH.0000000000002959","url":null,"abstract":"Difficult discussions with patients and families are a primary component of pediatric oncology care. We report our experience in the development and implementation of a longitudinal simulation-based Communication Skills Curriculum within a pediatric hematology-oncology fellowship training program. A 6-session simulation curriculum was created for fellows to practice difficult oncology related discussions with a standardized patient (SP). This program was implemented in 2017 and continues presently. Throughout fellowship training the scenarios progress in content and scope. Each simulation was observed and recorded, and written and verbal feedback was provided. The Gap-Kalamazoo Communication Skills Assessment Form was used to assess communication skills in each session. A total of 15 fellows (100% of possible participants) have participated in this curriculum to date. Across all domains of communication skills assessed, the ratings given by the physician evaluators and self-evaluations improved over the course of the scenarios completed throughout fellowship training. This type of simulation-based communication skills curriculum within a pediatric hematology-oncology fellowship training program is feasible to implement. This training is useful to fellows beyond training in improving communication skills, which has the potential to directly benefit the future patients they care for.","PeriodicalId":16693,"journal":{"name":"Journal of Pediatric Hematology/Oncology","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142622713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Allogeneic Hematopoietic Cell Transplantation With Reduced Toxicity Conditioning for Pediatric B Lymphoid Malignancy. 针对小儿B淋巴细胞恶性肿瘤的异体造血细胞移植与减毒调理。

IF 0.9 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2024-10-01 Epub Date: 2024-08-12 DOI: 10.1097/MPH.0000000000002936

Yuki Naito, Shinya Osone, Kohei Mitsuno, Takuyo Kanayama, Azusa Mayumi, Toshihiko Imamura, Tomoko Iehara

引用次数: 0