Journal of Pediatric Hematology/Oncology最新文献_第2页

Asynchronous Development of B-cell and T-cell Post-transplant Lymphoproliferative Disorder in a Pediatric Heart Transplant Patient. 儿童心脏移植患者b细胞和t细胞移植后淋巴增生性疾病的非同步发展。

IF 0.8 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2025-09-05 DOI: 10.1097/MPH.0000000000003113

Amanda Young, Dan Larson, Paul Galardy, Asma Ferdjallah

引用次数: 0

Isolated Anterior Segment Relapse in a Child With B-Cell Precursor Acute Lymphoblastic Leukemia: A Rare Case Report. 儿童b细胞前体急性淋巴母细胞白血病孤立性前段复发：一例罕见病例报告。

IF 0.8 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2025-09-03 DOI: 10.1097/MPH.0000000000003117

Dolika D Vasović, Dejan M Rašić, Jelica Pantelić, Bojana Dačić-Krnjaja, Tanja Kalezić, Jelena Vasilijević, Igor Kovačević, Ivan Marjanović

{"title":"Isolated Anterior Segment Relapse in a Child With B-Cell Precursor Acute Lymphoblastic Leukemia: A Rare Case Report.","authors":"Dolika D Vasović, Dejan M Rašić, Jelica Pantelić, Bojana Dačić-Krnjaja, Tanja Kalezić, Jelena Vasilijević, Igor Kovačević, Ivan Marjanović","doi":"10.1097/MPH.0000000000003117","DOIUrl":"10.1097/MPH.0000000000003117","url":null,"abstract":"Ocular relapse in pediatric acute lymphoblastic leukemia (ALL) is rare and typically associated with central nervous system or bone marrow involvement. Anterior segment infiltration as the sole manifestation of relapse is exceptionally uncommon and may mimic noninfectious uveitis, leading to diagnostic delay. We report the case of a 4-year-old boy with a history of B-cell precursor ALL, diagnosed at age 2 and treated according to the ALL IC BFM 2009 protocol. The patient remained in remission until presenting with persistent redness and irritation of the left eye, unresponsive to topical corticosteroids and cycloplegics. Slit-lamp examination revealed sectoral iris thickening, which was further assessed using ultrasound biomicroscopy and confirmed localized stromal infiltration without ciliary body involvement. The posterior segment was unremarkable. Initial systemic reevaluation showed no evidence of hematologic or CNS relapse, and at that time, ocular findings were provisionally considered an isolated recurrence. However, ∼3 months after the onset of ocular symptoms, the patient exhibited hematologic abnormalities, and relapse was confirmed with 31% circulating blasts, thrombocytopenia, and 92% blasts in bone marrow aspirate. He was subsequently reclassified as high-risk and systemic therapy was resumed. This case illustrates a rare presentation of anterior segment involvement as the initial manifestation of relapse in pediatric ALL. Clinicians should maintain a high index of suspicion when evaluating persistent or atypical anterior uveitis in leukemia survivors, as early recognition of ocular involvement may be critical for timely diagnosis and treatment of systemic recurrence.","PeriodicalId":16693,"journal":{"name":"Journal of Pediatric Hematology/Oncology","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnosis and Management of a Child With Primary Pancreatic Neuroblastoma: Case Report of a Common Malignancy at a Rare Site. 儿童原发性胰腺神经母细胞瘤的诊断和治疗：罕见部位常见恶性肿瘤病例报告。

IF 0.8 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2025-09-03 DOI: 10.1097/MPH.0000000000003118

Dipesh Dave, Maharshi Trivedi, Chinmay Doctor, Harsha Panchal, Biren Parikh, Ritesh Suthar

引用次数: 0

Trametinib-Induced Hyponatremia in a Patient With Craniopharyngioma and Diabetes Insipidus. 曲美替尼诱发的低钠血症在颅咽管瘤和尿崩症患者中的应用。

IF 0.8 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2025-09-03 DOI: 10.1097/MPH.0000000000003116

Buddhi Gunasekara, Harriet Gunn, Arif H B Jalal, Darren Hargrave, Hoong Wei Gan

{"title":"Trametinib-Induced Hyponatremia in a Patient With Craniopharyngioma and Diabetes Insipidus.","authors":"Buddhi Gunasekara, Harriet Gunn, Arif H B Jalal, Darren Hargrave, Hoong Wei Gan","doi":"10.1097/MPH.0000000000003116","DOIUrl":"https://doi.org/10.1097/MPH.0000000000003116","url":null,"abstract":"Adamantinomatous craniopharyngiomas (ACPs) are rare, sellar-suprasellar benign tumors that cause considerable morbidity and mortality due to local invasion and treatment-related damage to surrounding structures, including central diabetes insipidus (CDI). Trametinib is a highly selective inhibitor of MEK1 and MEK2, which has been evaluated in both adult and pediatric cancers/ tumors with activation of the oncogenic mitogen-activated protein kinase (MAPK) pathway. Despite being thought to have fewer side effects than conventional cytotoxic chemotherapy, off-target toxicities such as hyponatremia have been described. The use of MEK inhibitors in ACPs are limited to case reports and a phase II trial is currently underway. We report a pediatric patient with multiply progressive ACP and known brittle CDI who developed severe hyponatremia associated with a significant decrease in desmopressin dosing after starting trametinib and a rapid rebound of desmopressin requirement with its cessation. We recommend close monitoring of serum sodium levels and a review of desmopressin doses in patients with CDI when started on treatment with MEK inhibitors.","PeriodicalId":16693,"journal":{"name":"Journal of Pediatric Hematology/Oncology","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Whole-Body MRI in Pediatric Langerhans Cell Histiocytosis-A Comparison With FDG-PET/CT. 小儿朗格汉斯细胞组织细胞增多症的全身MRI与FDG-PET/CT的比较。

IF 0.8 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2025-09-03 DOI: 10.1097/MPH.0000000000003114

Neha Baijal, Manisha Jana, Devasenathipathy Kandasamy, Priyanka Naranje, Rachna Seth, Nishikant Damle, Maroof A Khan

{"title":"Whole-Body MRI in Pediatric Langerhans Cell Histiocytosis-A Comparison With FDG-PET/CT.","authors":"Neha Baijal, Manisha Jana, Devasenathipathy Kandasamy, Priyanka Naranje, Rachna Seth, Nishikant Damle, Maroof A Khan","doi":"10.1097/MPH.0000000000003114","DOIUrl":"https://doi.org/10.1097/MPH.0000000000003114","url":null,"abstract":"Purpose: In children with Langerhans Cell Histiocytosis (LCH), FDG-PET/CT is used for staging and response assessment. Whole-body MRI (WB-MRI) can serve as an ionizing radiation-free alternative for repeated whole-body imaging. The aim of this study was to compare WB-MRI with FDG-PET/CT for staging and response assessment in pediatric LCH.Methods: This was a prospective cohort study conducted at an apex tertiary care center from August 2021 to March 2023 after approval from the Institutional Ethics Committee. WB-MRI was done in biopsy-proven cases of LCH, 18 years old or less, undergoing FDG-PET/CT for staging or response assessment. With FDG-PET/CT as the reference standard, diagnostic accuracy and agreement for stage and response assessment were calculated. Assessment of impact on clinical management and image quality was done.Results: Eleven patients of LCH (F:M=5:6, mean age: 6.95 y) were included. Diagnostic accuracy and agreement were 90.6% and 80% (kappa: 0.69) at baseline; 96% and 83.3% (kappa: 0.74) at follow-up, respectively. Clinical management was altered in 2 of 11 patients based on WB-MRI. Image quality was rated as 3.91 +/-1.30 and 4.82 +/- 0.40; artifacts 3.82 +/- 1.33 and 4.55 +/- 0.52 in 11 scans for DWI and STIR, respectively (1 worst, 5 best).Conclusion: Diagnostic accuracy and absolute agreement of WB-MRI were high at baseline and follow-up in LCH. WB-MRI can provide a radiation-free alternative to FDG-PET/CT in children with LCH.","PeriodicalId":16693,"journal":{"name":"Journal of Pediatric Hematology/Oncology","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hematologic Variations in Children With Down Syndrome. 唐氏综合症儿童的血液学变异。

IF 0.8 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2025-09-01 DOI: 10.1097/MPH.0000000000003092

Golda Grinberg, Gwen Sokoloff, Beverly Hay, Stefanie Lowas

引用次数: 0

Imatinib For Treatment of Multifocal Maxillofacial Giant Cell Lesions: A Case Series. 伊马替尼治疗颌面部多灶性巨细胞病变：一个病例系列。

IF 0.8 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2025-08-28 DOI: 10.1097/MPH.0000000000003087

Aparna B Bhat, Jesse T Han, Mark A Egbert, Sue Ehling, Kristin Gard, Tyler G Ketterl

引用次数: 0

Evaluation of Thromboembolic Events in Patients Hospitalized in the Palliative Care Unit: A Single Center Experience. 姑息治疗病房住院患者血栓栓塞事件的评估：单中心经验。

IF 0.8 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2025-08-27 DOI: 10.1097/MPH.0000000000003091

Zeliha Güzelküçük, Hatice Dilara Aydoğdu, Ganime Ayar, Namik Yaşar Özbek

{"title":"Evaluation of Thromboembolic Events in Patients Hospitalized in the Palliative Care Unit: A Single Center Experience.","authors":"Zeliha Güzelküçük, Hatice Dilara Aydoğdu, Ganime Ayar, Namik Yaşar Özbek","doi":"10.1097/MPH.0000000000003091","DOIUrl":"https://doi.org/10.1097/MPH.0000000000003091","url":null,"abstract":"Objectives: Although thromboembolic events are less common in children compared with adults, complications related to thromboembolism are becoming more frequent due to improved care for children with chronic illnesses. The aim of the study was to evaluate thromboembolic events in pediatric patients hospitalized in palliative care unit (PCU).Materials and methods: The files of the patients who were hospitalized in PCU of our hospital between January 2020 and January 2023 were retrospectively analyzed. A total of 1002 hospitalizations of 449 patients were examined.Results: The median age was 6.1 years, F/M: 214/235. We found that 83 (18.4%) patients had thrombosis. In most patients with thrombosis, the primary diseases were malignancy and trauma. During hospitalization, the median time for detecting thrombosis was 26 days (range: 1 to 180 d). We treated 67 out of 83 thrombosis patients with low-molecular-weight heparin (LMWH) for an average of 26 days, ranging from 1 to 188 days. Unfractionated heparin was used in 2 patients, while thrombolytic therapy was used in 2 patients with massive pulmonary embolism and middle cerebral artery thrombosis. None of the thromboembolic events resulted in fatality.Conclusions: This study revealed that the frequency of thrombosis in pediatric patients hospitalized in PCU was ∼1/5, which is significantly higher than the rates observed in childhood. Catheter-related thrombosis was more frequently observed among patients with thrombosis in the PCU, with malignancy and trauma representing the most common indications for hospitalization. Our findings suggest that certain patient groups should be evaluated for prophylactic anticoagulation.","PeriodicalId":16693,"journal":{"name":"Journal of Pediatric Hematology/Oncology","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144958083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Incidence and Burden of Peripheral Neuropathy in Pediatric Oncology Patients Receiving Levofloxacin and Vincristine Compared With Vincristine Alone. 小儿肿瘤患者左氧氟沙星联合长春新碱与单用长春新碱比较周围神经病变的发生率和负担

IF 0.8 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2025-08-25 DOI: 10.1097/MPH.0000000000003103

Prerna Kumar, Molly Meister, Ramkumar Narendran, Kejin Lee

{"title":"The Incidence and Burden of Peripheral Neuropathy in Pediatric Oncology Patients Receiving Levofloxacin and Vincristine Compared With Vincristine Alone.","authors":"Prerna Kumar, Molly Meister, Ramkumar Narendran, Kejin Lee","doi":"10.1097/MPH.0000000000003103","DOIUrl":"https://doi.org/10.1097/MPH.0000000000003103","url":null,"abstract":"Levofloxacin is the first line antibiotic used to prevent infection in pediatric oncology patients with prolonged and profound neutropenia. These patients often receive vincristine, a critical component of therapy for leukemia and for many solid tumors. Both levofloxacin and vincristine are known to cause peripheral neuropathy (PN); however, the cumulative effect of both drugs on PN remains unknown. The objective of this study was to evaluate the incidence and extent of PN in pediatric oncology patients receiving vincristine and levofloxacin (VL) compared with vincristine alone (VA). In this retrospective cohort study, manual chart review was performed to extract demographic and clinical data for newly diagnosed patients treated at our institution between 2015 and 2020. Patients who received vincristine alone (VA) were compared with patients who received vincristine and levofloxacin (VL). There was no significant difference in the incidence of peripheral neuropathy between the 2 groups; however, the cohort exposed to vincristine and levofloxacin (VL) experienced significantly more peripheral neuropathy symptoms, had more affected categories of peripheral neuropathy, and received additional treatment for their neuropathy symptoms. Exposure to levofloxacin in addition to vincristine therapy was associated with an increased burden of peripheral neuropathy in this pediatric oncology cohort.","PeriodicalId":16693,"journal":{"name":"Journal of Pediatric Hematology/Oncology","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144958122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epigenetic Aging in Childhood Cancer Survivors. 儿童癌症幸存者的表观遗传衰老。

IF 0.8 4区医学

Journal of Pediatric Hematology/Oncology Pub Date : 2025-08-25 DOI: 10.1097/MPH.0000000000003104

Prerna Kumar, Beth Speckhart, Yanzhi Wang, Kristen Dotson, Susan Gaitros, Brinda Mehta

{"title":"Epigenetic Aging in Childhood Cancer Survivors.","authors":"Prerna Kumar, Beth Speckhart, Yanzhi Wang, Kristen Dotson, Susan Gaitros, Brinda Mehta","doi":"10.1097/MPH.0000000000003104","DOIUrl":"https://doi.org/10.1097/MPH.0000000000003104","url":null,"abstract":"Background: Pediatric cancer survivors remain at risk for numerous late effects of therapy and have shown signs of advanced aging. The specific mechanisms at play are unclear but epigenetic modulation may play a role.Methods: This cross-sectional study included 20 pediatric cancer survivors who received intensive chemotherapy with or without radiation and were a minimum of 5 years from treatment and 20 healthy biological siblings. DNA methylation patterns were analyzed from peripheral blood samples to determine epigenetic age (the difference between biological age and chronological age). Paired t test analysis or the Wilcoxon signed-rank test was used to compare results between survivors and siblings.Results: The childhood cancer survivor cohort consisted of 12 males and 8 females; the comparative sibling cohort consisted of 8 males and 12 females. Mean chronological age was 15.2±6.28 years for survivors and 16.4±8.31 years for siblings (mean±SD). Survivors demonstrated increased epigenetic age compared with siblings (1.38±3.71 vs. -0.03±3.12 y (mean±SD), mean difference 1.41, [0.30 to 2.52], P=0.016, n=20 pairs). Patients who additionally received photon radiation demonstrated a more notable increase in epigenetic age compared with siblings (3.33±4.13 vs. 0.78±3.04 y (mean±SD), mean difference 2.55, [0.75 to 4.35], P=0.012, n=8 pairs).Conclusions: Childhood cancer survivors demonstrate increased epigenetic age compared with their healthy siblings. Exposure to radiation was associated with further increased epigenetic age. Epigenetic modulation through DNA methylation may be a potential mechanism contributing to the aging process in childhood cancer survivors.","PeriodicalId":16693,"journal":{"name":"Journal of Pediatric Hematology/Oncology","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144958141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0