唐氏综合症儿童的血液学变异。

IF 0.8 4区医学 Q4 HEMATOLOGY

Journal of Pediatric Hematology/Oncology Pub Date : 2025-09-01 DOI:10.1097/MPH.0000000000003092

Golda Grinberg, Gwen Sokoloff, Beverly Hay, Stefanie Lowas

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引用次数: 0

摘要

儿童唐氏综合症（DS）的血液学异常以前有过描述，但结论不一致。进行了一项回顾性单机构队列研究，以评估DS患儿的全血细胞计数（CBC）范围。CBC结果的平均值按年龄和性别呈现，作为评估DS儿童的临床资源。与参考值相比，DS患儿的平均红细胞体积（MCV）更高，绝对淋巴细胞计数更低，血红蛋白（Hgb）值有升高的趋势。在整个队列中出现的这些发现表明，这些是DS的良性血液学变异。

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Hematologic Variations in Children With Down Syndrome.

Hematologic abnormalities in children with Down Syndrome (DS) have previously been described, but with inconsistent conclusions. A retrospective single-institution cohort study was conducted to evaluate complete blood count (CBC) ranges in children with DS. Mean values for CBC results are presented by age and sex, as a clinical resource for the evaluation of DS children. In comparison to reference values, children with DS had higher mean corpuscular volume (MCV), lower absolute lymphocyte count, and a trend toward higher hemoglobin (Hgb) values. The presence of these findings across the cohort suggests that these are benign hematologic variations in DS.

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来源期刊

Journal of Pediatric Hematology/Oncology 医学-小儿科

CiteScore

1.90

自引率

8.30%

发文量

415

审稿时长

2.5 months

期刊介绍： Journal of Pediatric Hematology/Oncology (JPHO) reports on major advances in the diagnosis and treatment of cancer and blood diseases in children. The journal publishes original research, commentaries, historical insights, and clinical and laboratory observations.