Journal of Parasitology Research最新文献

{"title":"Plasmodium falciparum Clinical Isolates Reveal Analogous Circulation of 3D7 and FC27 Allelic Variants and Multiplicity of Infection in Urban and Rural Settings: The Case of Adama and Its Surroundings, Oromia, Ethiopia","authors":"Temesgen File, L. Golassa, H. Dinka","doi":"10.1155/2022/5773593","DOIUrl":"https://doi.org/10.1155/2022/5773593","url":null,"abstract":"Background Despite significant progress achieved globally in reducing malaria burden, still it is one of the major public health and economic problems in Ethiopia. Investigation of the local genetic polymorphism of P. falciparum, the most virulent and predominant malaria parasite primarily targeted in malaria control and elimination program, is paramount to assess intensity of parasite transmission. Analysis of the block 3 region of the msp-2 gene of P. falciparum provides strong molecular evidence to evaluate the real picture of malaria epidemiology to fine-tune the ongoing control and elimination programs in the region. Thus, this study was aimed at examining the status of such polymorphic gene and its implications in Adama and its surroundings. Methods 148 isolates from patients with uncomplicated falciparum malaria were collected in the study from September 2019 to August 2020. Tween® 20 and the Chelex method were employed for parasite DNA extraction. msp-2 allelic families were genotyped by using nested polymerase chain reaction targeting its 3D7 and FC27 allelic variants followed by gel electrophoresis for fragment analysis. Results Seventeen different polymorphic forms of msp-2 allelic fragments were detected in the study area. Moreover, 47 (31.8%) and 41(27.7%) were detected for 3D7 and FC27 allelic families, respectively. Furthermore, the multiclonal allele type accounted for 60 (40.5%). The mean MOI was 1.4, and the heterogeneity index (He) is 0.49 indicating nearly intermediate malaria transmission in the study area. Conclusions The study revealed nearly intermediate genetic diversity and mean MOI of P. falciparum in the study area, demanding further scale up of the ongoing control and elimination efforts.","PeriodicalId":16662,"journal":{"name":"Journal of Parasitology Research","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2022-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46245348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Giardiasis and Entamoeba Species in Two of the Six Governorates of Kuwait","authors":"Rania M. AlAyyar, A. Alaqeel, Muna Sh. AlAwadhi","doi":"10.1155/2022/5972769","DOIUrl":"https://doi.org/10.1155/2022/5972769","url":null,"abstract":"Intestinal parasitic infections are a global concern owing to elevated rates of morbidity and mortality in many parts of the world. Increased rates of intestinal parasitic infections are observed in developing and low-income countries. In Kuwait, many expatriates and foreigners hail from endemic countries, thus increasing the rate and risk factor of infection. This retrospective study is aimed at assessing the prevalence of Giardia lamblia and Entamoeba sp. in stool samples handled by two of Kuwait's general hospitals during the period from January 2018 to July 2019: Mubarak Al Kabeer (serving Hawalli governorate population) and Aladan hospitals (serving Mubarak Al Kabeer governorate population) serving 27% of total Kuwait population with Kuwaitis making up only 32%. A total of 9,653 samples were tested for consistency and the availability of any parasitic particles using visual, direct wet mount, and concentration method. Statistical analysis was implemented using SPSS statistical program, at p < 0.05. Of all the 9,653 tested stool samples, 74 were positive for G. lamblia or Entamoeba sp. This represented a mere 1% rate of infection and showed no significant correlation to the prevalence of intestinal parasite infections in Kuwait. On the other hand, comparing the rate of infection in different seasons revealed an increased rate of infection during spring compared to other seasons (p = 0.03). Findings revealed low rates of intestinal parasitic infection within the two governorates of Kuwait representing no statistical significance to the distribution of the investigated parasites in Kuwait. This may be attributed to improved living conditions and healthcare. Elevated infection rates in spring in relation to other seasons raised the importance of increasing public awareness during camping season for maintaining proper personal hygiene and waste management to contain and decrease the rate on infection.","PeriodicalId":16662,"journal":{"name":"Journal of Parasitology Research","volume":"2022 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2022-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41644435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seasonal Prevalence of Helminthic Infections in the Gastrointestinal Tract of Sheep in Mazandaran Province, Northern Iran.","authors":"Alireza Salehi,&nbsp;Mahsa Razavi,&nbsp;Nasrollah Vahedi Nouri","doi":"10.1155/2022/7392801","DOIUrl":"https://doi.org/10.1155/2022/7392801","url":null,"abstract":"<p><p>Helminthic infection is the major cause of the sheep's reduced productivity. In this study, a total number of 240 fecal samples of sheep from stationary flocks of four different zones of Mazandaran province (Amol, Babol, Sari, and Nowshahr cities) were examined each season, out of which 53.33% of animals were affected by the helminthic infections. The most prevalent infecting parasites were the <i>Trichostrongylidae</i> (46.61%), followed by the <i>Fasciola</i> (9.96%). In addition, the <i>Strongyloides</i> had the lowest proportion with only 2.39%. The other detected parasites included <i>Chabertia</i> (5.98%), <i>Cooperia</i> (3.19%), <i>Nematodirus</i> (3.19%), <i>Trichuris</i> (5.58%), <i>Toxocaridae</i> (4.78%), <i>Haemonchus</i> (4.78%), <i>Ostertagia</i> (5.58%), <i>Oesophagostomum</i> (4.78%), and <i>Dicrocoelium</i> (3.19%). The nematodes had the highest percentage with 86.85%, whereas the trematodes followed them with 13.15%. No significant difference was observed between the infection level in females and males, with 56.9% and 43.94% rates of infection, respectively. Significantly lower infection was observed in winter compared with the other seasons. <i>Trichostrongylidae</i> was the dominant genus across all seasons. It was also noted that winter had the lowest percentage of helminthic infection significantly. The eggs per gram of feces was also estimated, and it showed that a significant number of sheep are infected with a moderate number of parasites. In a conclusion, even though livestock farmers have been using antiparasitic drugs in their livestock in recent years, parasitic infection still exists in livestock. Thus, a proper implementation of helminthic infection control programs in this area should be employed as the key element for reducing the high prevalence of livestock helminthic infection.</p>","PeriodicalId":16662,"journal":{"name":"Journal of Parasitology Research","volume":"2022 ","pages":"7392801"},"PeriodicalIF":2.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9797291/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10457792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Diversity of Merozoite Surface Protein-1 and -2 Genes in <i>Plasmodium falciparum</i> Isolates among Asymptomatic Population in Boset and Badewacho Districts, Southern Ethiopia.","authors":"Tsegaye Chekol,&nbsp;Gezahegn Solomon Alemayehu,&nbsp;Weynshet Tafesse,&nbsp;Gudeta Legesse,&nbsp;Biruk Zerfu,&nbsp;Temesgen File,&nbsp;Mistire Wolde,&nbsp;Lemu Golassa","doi":"10.1155/2022/7728975","DOIUrl":"https://doi.org/10.1155/2022/7728975","url":null,"abstract":"<p><strong>Background: </strong>The genetic variation of <i>Plasmodium falciparum</i> has been studied to assess local malaria transmission genetic profile using evidence-based intervention measures. However, there are no known previous reports of <i>P. falciparum</i> polymorphism in Badewacho and Boset districts, Southern Ethiopia. The purpose of this study was to determine the genetic diversity of the merozoite surface protein-1 and -2 (<i>msp</i>-1 and <i>msp</i>-2) allelic families in <i>P. falciparum</i> isolates from an asymptomatic populations.</p><p><strong>Methods: </strong>This study was conducted from finger-prick blood samples spotted on 3 mm Whatman filter paper collected during a community-based cross-sectional study. Nested polymerase chain reaction amplification was used to type the allelic variants of <i>msp</i>-1 and <i>msp</i>-2.</p><p><strong>Results: </strong>From 669 asymptomatic study participants, a total of 50 samples positive for <i>P. falciparum</i> were included for molecular analysis. Of 50 positive samples, 43 <i>P. falciparum</i> isolates were successfully amplified for the <i>msp</i>-1 and <i>msp</i>-2 allelic families. A total of twelve different allele sizes (75-250 bp) were identified within the three allelic families of <i>msp</i>-1, whereas ten different allele sizes (250-500 bp) were detected within the two allelic families of <i>msp</i>-2. MAD20 had a higher allelic proportion, 65% among allelic families of <i>msp</i>-1, whereas the 3D7 allelic family 90.7% was higher in <i>msp</i>-2. A slightly higher frequency of polyclonal infection 53.5% was found in <i>msp</i>-2 allelic family, whereas a low proportion polyclonal infection 46.5% was found in <i>msp</i>-1 allelic family. The overall mean multiplicity of infection (MOI) for <i>msp</i>-1 and <i>msp</i>-2 was identical (MOI = 1.56). Correspondingly, the expected heterozygosity (He) value for <i>msp</i>-1 (He = 0.23) and <i>msp</i>-2 (He = 0.22) was almost similar.</p><p><strong>Conclusions: </strong>The findings of this study revealed low genetic diversity of the <i>msp</i>-1 and <i>msp</i>-2 allelic families in <i>P. falciparum</i> isolates. However, continued monitoring status of the local genetic diversity profile in the <i>P. falciparum</i> population is required to support current malaria control and elimination strategies.</p>","PeriodicalId":16662,"journal":{"name":"Journal of Parasitology Research","volume":"2022 ","pages":"7728975"},"PeriodicalIF":2.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9771644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10786294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anemia, Thrombocytopenia, and Changes in Biochemical Parameters Occurring in Patients with Uncomplicated <i>Plasmodium falciparum</i> Malaria: Data Analysis from Antimalarial Efficacy-Randomized Trials in Dakar and Kaolack Regions, Senegal.","authors":"Khadime Sylla,&nbsp;Roger Tine,&nbsp;Doudou Sow,&nbsp;Souleye Lelo,&nbsp;Annie Abiola,&nbsp;Jean Louis NDiaye,&nbsp;Magatte NDiaye,&nbsp;Kuaku Folly,&nbsp;Léon Amath NDiaye,&nbsp;Oumar Gaye,&nbsp;Babacar Faye","doi":"10.1155/2022/1635791","DOIUrl":"https://doi.org/10.1155/2022/1635791","url":null,"abstract":"<p><strong>Background: </strong>Artemisinin-based Combination Therapies (ACTs) are widely used in the treatment of uncomplicated malaria. <i>Plasmodium falciparum</i> infection is often accompanied by disturbances of hematological and biochemical parameters. The objective of this study was to evaluate the changes in biochemical and hematological parameters during uncomplicated malaria in patients treated with ACTs.</p><p><strong>Methods: </strong>Data from patient with uncomplicated <i>Plasmodium falciparum</i> malaria were pooled from different open-randomized trial evaluating the efficacy of Artesunate-Mefloquine (ASMQ), Artesunate-Amodiaquine (ASAQ), Artemether-Lumefantrine (AL), and Dihydro-artemisinin-Piperaquine (DHAPQ) combinations. Biochemical (transaminases, creatinine, and bilirubin) and hematological (hemoglobin and platelet levels) parameters were performed at baseline (D0) and at day 7 after treatment (D7). Data were analyzed as both continuous and categorical variables with 95% confidence interval. Risks and trends were calculated using multivariate logistic random effect models.</p><p><strong>Results: </strong>A total of 720 patients with completed biological data were included in the analysis (320 in the AL arm, 160 in the ASMQ arm, 120 in the DHAPQ arm, and 88 in the ASAQ arm). The mean age of the patients was 9.43 ± 9.1 years. Male subjects represented 58.47% (sex ratio was 1.4 for males). The mean hemoglobin level at inclusion (D0) was 9.79 g/dl and anemia (Hb < 11 g/dl) was 71.43% (aOR = 1.16 [0.68 - 1.98]<i>p</i> = 0.57). At D7, hemoglobin level was 9.63 g/dl and anemia was significantly more frequent (78.29% [<i>p</i> = 0.002]). The mean platelet count at day 0 was 154075.5 platelets/mm³ of blood and 339328.7 platelets/mm³ at day 7. Thrombocytopenia was about 53.61% and was associated with malaria (aOR = 3.4 [2.18 - 5.3]<i>p</i> < 10^-3). 19.58% of patients had abnormal ALT and 40.28% had abnormal AST at D0. 27.22% of patients had normal bilirubin at D0. Renal function was normal in all patients in the study. Normalization of transaminases was noted between D0 and D7. The percentage of subjects with normal bilirubin increased between D0 and D7. Renal function did not vary significantly between D0 and D7.</p><p><strong>Conclusion: </strong>Results from this analysis showed that subjects with high parasitaemia had a greater risk of anemia and thrombocytopenia. Artemisinin combinations were well-tolerated as no major biological disturbances were noted. The effects of ACTs on hematologic and biochemical parameters were not different.</p>","PeriodicalId":16662,"journal":{"name":"Journal of Parasitology Research","volume":"2022 ","pages":"1635791"},"PeriodicalIF":2.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9800081/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10457794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Associated Risk Factors of Soil-Transmitted Helminth Infections among Schoolchildren around Lake Tana, Northwest Ethiopia.","authors":"Melsew Getaneh,&nbsp;Tamirat Hailegebriel,&nbsp;Abaineh Munshea,&nbsp;Endalkachew Nibret","doi":"10.1155/2022/4603638","DOIUrl":"https://doi.org/10.1155/2022/4603638","url":null,"abstract":"<p><strong>Background: </strong>Soil-transmitted helminths (STHs) are among the most common neglected tropical diseases widely distributed in tropical countries with poor socioeconomic development. <i>Ascaris lumbricoides</i>, <i>Trichuris trichiura</i>, and hookworm are the three major STHs. This study aimed to determine the prevalence of STHs and associated risk factors among schoolchildren in selected primary schools around Lake Tana, Northwestern Ethiopia.</p><p><strong>Methods: </strong>A school-based cross-sectional study was conducted from February to May 2021 involving 337 study participants. A systematic random sampling method was utilized to select the study participants from the selected schools. Data related to sociodemographic characteristics of the study participants and risk factors for STH infections were collected using a pretested questionnaire. Stool samples were collected in sterile plastic containers from each participant and processed using Kato-Katz thick fecal smear and Ritchie's concentration techniques. The data were analyzed using the Statistical Package for Social Sciences software tool version 23, and factors with a <i>p</i> < 0.05 were considered as statistically significant.</p><p><strong>Results: </strong>The overall prevalence of STH infection was 38.3% (95% CI: 33.1-43.7). Hookworm infection was the predominant STH infection, which was detected in 26.1% schoolchildren followed by <i>A. lumbricoides</i> (14.8%) and <i>T. trichiura</i> (1.5%). Most of the study subjects (34.1%) had single infections, whereas only 4.2% study subjects had multiple helminthic infections. Among the risk factors considered in the study, lack of shoe wearing habit (adjusted odds ratio [AOR]=29.5; 95% confidence interval [CI]=6.59-132.55; <i>p</i> < 0.001), lack of knowledge on the prevention and control methods (AOR = 5.41; 95% CI = 2.44-11.98; <i>p</i> < 0.001), engagement in irrigation activities (AOR = 2.14; 95% CI = 1.02-4.57, <i>p</i> = 0.049), lack of toilet (AOR = 3.06; 95% CI = 1.31-7.16; <i>p</i> = 0.01), children grades of 5-8 (AOR = 2.62; 95% CI = 1.26-5.43; <i>p</i> = 0.01), playing on soils (AOR = 5.90; 95% CI = 2.79-12.49; <i>p</i> < 0.001), lack of fingernail trimming habit (AOR = 3.21; 95% CI = 1.57-6.55; <i>p</i> = 0.001), and male gender (AOR = 2.28; 95% CI: 1.19-4.39; <i>p</i> = 0.013) were significant explanatory factors for STH infection among schoolchildren in the study area.</p><p><strong>Conclusions: </strong>The present study showed that STHs were common among schoolchildren around Lake Tana. Therefore, education on personal and environmental hygiene should be taken into account to reduce the prevalence of STH infection in the study area.</p>","PeriodicalId":16662,"journal":{"name":"Journal of Parasitology Research","volume":"2022 ","pages":"4603638"},"PeriodicalIF":2.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9810415/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10857025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antischistosomal Activity of Zingiber officinale, Piper nigrum, and Coriandrum sativum Aqueous Plant Extracts on Hamster Infected with Schistosoma mansoni","authors":"M. F. Abou El-Nour, Y. Fadladdin","doi":"10.1155/2021/6628787","DOIUrl":"https://doi.org/10.1155/2021/6628787","url":null,"abstract":"Schistosomiasis continues to affect the health and quality of life of millions of people around the world. Schistosomiasis has been ranked the second disease after malaria in terms of importance as a targeted tropical disease. Praziquantel (PZQ) is the only drug approved by the World Health Organization (WHO) for the treatment of schistosomiasis. Being the only drug, parasite resistance to this drug has developed. Therefore, the search for new alternatives has been the goal of many researchers. In this study, the effects of aqueous extracts of Zingiber officinale, Piper nigrum, and Coriandrum sativum on Schistosoma mansoni infected golden hamsters (Egyptian strain) were evaluated in vitro and in vivo at different doses of 500, 250, 125, 62.5, and 31.25 μg/ml. In vitro, adult worms of S. mansoni were tested in RPMI-1640 medium for 48 hrs. The results showed that the concentrations 500, 250, and 125 μg/ml of Zingiber officinale and Piper nigrum caused dead of 100% of adult worms within 6 and 12 hrs of incubation, respectively. Although, aqueous extract of Coriandrum sativum at concentrations 500, 250, and 125 μg/ml resulted dead of 100% parasites after 12 to 24 hrs of incubation. In conclusion, Zingiber officinale and Piper nigrum showed efficacy against schistosomiasis in both in vitro and biological experiments of Egyptian schistosome strain, while Coriandrum sativum gave less effective results than the previous ones. Therefore, Zingiber officinale and Piper nigrum may become an innovative treatment for schistosomiasis.","PeriodicalId":16662,"journal":{"name":"Journal of Parasitology Research","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2021-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49358158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological Survey of Toxoplasma gondii and Associated Risk Factors in Ruminant Species of the Khyber Pakhtunkhwa Province of Pakistan","authors":"Abid Ali, T. Omer, Asad Ullah, Abdul Haleem, M. Naseem, Mujeeb Ullah, Seemab, F. Shamim, Amna Tehreem, M. Bilal, Muhammad Numan Khan","doi":"10.1155/2021/6653239","DOIUrl":"https://doi.org/10.1155/2021/6653239","url":null,"abstract":"Department of Zoology, Government Degree College Akbarpura Nowshera, Pakistan Genomic Laboratory, Veterinary Research Institute, Livestock Department Peshawar KP, Pakistan Department of Statistics and Computer Science University of Veterinary and Animal Sciences Lahore, Pakistan Department of Zoology, University of Agriculture Faisalabad, Pakistan Department of Zoology, Islamia College Peshawar, Pakistan Department of Zoology, University of Peshawar, Pakistan Department of Zoology, Government College Women University Faisalabad, Pakistan Department of Fisheries and Aquaculture, University of Veterinary and Animal Sciences, Lahore, Pakistan Department of Zoology, Quaid e Azam University Islamabad, Pakistan","PeriodicalId":16662,"journal":{"name":"Journal of Parasitology Research","volume":"2021 1","pages":"1-8"},"PeriodicalIF":2.2,"publicationDate":"2021-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43584817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Soil-Transmitted Helminths and Intestinal Protozoan Infections on Haemoglobin Levels among School-Aged Children in Belo and Bui, North West Cameroon: A Cross-Sectional Study","authors":"F. Cho, Humphrey Ngala Ngala, Ranibell Tung Bongazi, Rogers Sanga Kinsam, Beltha Tahnteng Tata, D. Aji, P. Fru, Patrick Kofon Jokwi","doi":"10.1155/2021/8873555","DOIUrl":"https://doi.org/10.1155/2021/8873555","url":null,"abstract":"Introduction. Soil-transmitted helminths (STH) remain a public health problem worldwide especially in low-income countries. Soil-transmitted helminths are known to affect both growth and haemoglobin levels. In this study, we determine the prevalence of intestinal parasites and explored its association with anaemia in school-aged children (SAC). Methodology. A cross-sectional study was carried out amongst pupils selected from 18 primary schools in four communities of the North West Region. Stool samples were examined using direct wet mount and formol-ether concentration techniques, while finger prick was performed for the measurement of haemoglobin with a haemoglobinometer. Results. The results showed significant variation of STHs, intestinal protozoan prevalence, and anaemia between age, sex, and communities. The prevalence of Ascaris lumbricoides, Trichuris trichiura, and hookworms was 15.1%, 0.8%, and 2%, respectively, with an overall STH prevalence of 18.3% across the four communities. Soil-transmitted helminths were more prevalent in Mbessa (30.2%) in comparison to Nkor (26.7%), Djottin (17.5%), and Kumbo (9.6%) communities. The prevalence of Entamoeba histolytica/dispar was 25.4% and Giardia duodenalis (6.9%), with an overall intestinal protozoa prevalence of 31% across the four communities. The prevalence of anaemia in the study population was 23.1%. Conclusion. Soil-transmitted helminths, intestinal protozoan infections, and anaemia are prevalent in the study area. Anaemia was observed to be associated with STH, intestinal protozoa, and the communities under study. This study recommends continuous deworming and health education on personal sanitation and environmental sanitation.","PeriodicalId":16662,"journal":{"name":"Journal of Parasitology Research","volume":"1 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45986646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Platelet Indices as a Potential Marker for Malaria Severity.","authors":"Biruk Bayleyegn,&nbsp;Fikir Asrie,&nbsp;Aregawi Yalew,&nbsp;Berhanu Woldu","doi":"10.1155/2021/5531091","DOIUrl":"https://doi.org/10.1155/2021/5531091","url":null,"abstract":"<p><strong>Purpose: </strong>Platelet parameter alteration such as platelet count and platelet indices are more common than in other blood cell lines due to diverse causative pathophysiological mechanisms in severe malaria infection. In malaria patients, no more studies evaluated platelet indices in relation to disease severity and prognosis. Therefore, this review assessed the current scientific knowledge on the potential role of platelet indices for the diagnostic marker of severe malaria infection.</p><p><strong>Results: </strong>Hence, after reviewing recent literatures, elevation of mean platelet volume and platelet distribution width in addition to decreased plateletcrit and platelet counts is the known potential risk factor associated with warning signs of severe malaria. Thus, thrombocytopenia < 150 × 10⁹/L, MPV ≥ 9.05 fL, and PDW ≥ 14.550% as well as significantly higher P-LCR and decrease in PCT are shown significant sensitivity and specificity as they are used as diagnostic and prognostic values in severe malaria infection.</p><p><strong>Conclusion: </strong>Platelet indices are useful predictors of malaria severity. Immature platelet fraction (IPF%) is raised in the case of severe malaria, and it was significantly more useful than MPV. Advanced research will further investigate the platelet index abnormality associated with specific age and gender among specific malaria species.</p>","PeriodicalId":16662,"journal":{"name":"Journal of Parasitology Research","volume":"2021 ","pages":"5531091"},"PeriodicalIF":2.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435314/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10405669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}