Evelyn Asante-Kwatia, Lord Gyimah, Arnold Donkor Forkuo, William Kofi Anyan, Makafui Adzo Gbemu, Francis Ackah Armah, Abraham Yeboah Mensah
{"title":"加纳阿散蒂地区Atwima-Nwabiagya地区用于治疗血吸虫病的药用植物的民族植物学调查和杀虫活性筛选","authors":"Evelyn Asante-Kwatia, Lord Gyimah, Arnold Donkor Forkuo, William Kofi Anyan, Makafui Adzo Gbemu, Francis Ackah Armah, Abraham Yeboah Mensah","doi":"10.1155/2023/6707157","DOIUrl":null,"url":null,"abstract":"<p><p>This study focused on documenting and evaluating the cercaricidal activity of medicinal plants used for schistosomiasis treatment in an endemic area in Ghana. Through semistructured questionnaires, personal interviews with herbalists in communities surrounding the Barekese dam in the Atwima-Nwabiagya district, where the disease is endemic, were carried out. Thirty medicinal plants distributed in 19 families were reported to be used for schistosomiasis treatment in the survey. Information on the plants, including scientific names, common names, families, and the used plant part were recorded. The families Apocynaceae and Euphorbiaceae recorded the highest number of plants (14% each), followed by Asteraceae (10%), Loranthaceae (7%), and Rubiaceae (7%). <i>In vitro</i> cercaricidal activity of methanol extracts of nine out of the thirty plants was performed by exposing human <i>Schistosoma mansoni</i> cercariae obtained from <i>Biomphalaria pfeifferi</i> to various concentrations of extracts over a duration of 240 minutes. All the plants tested demonstrated time- and concentration-dependent cercaricidal activity. With lethality being set at <1000 <i>μ</i>g/mL, the cercaricidal activity in order of decreasing potency was as follows: <i>Withania somnifera</i> (LC<sub>50</sub> = 1.29) > <i>Balanites aegyptiaca</i> (LC<sub>50</sub> = 7.1) > <i>Xylia evansii</i> (LC<sub>50</sub> = 11.14) <i>> Jathropha multifida</i> (LC<sub>50</sub> = 12.9) <i>> Justicia flava</i> (LC<sub>50</sub> = 22.9) <i>> Anopyxis klaineana</i> (LC<sub>50</sub> = 182.81) > <i>Ximenia americana</i> (LC<sub>50</sub> = 194.98) <i>> Loranthus lecardii</i> (LC<sub>50</sub> = 223.87) <i>> Bridelia tenufolia</i> (LC<sub>50</sub> = 309.03) > <i>Zanthoxylium zanthoxyloides</i> (LC<sub>50</sub> = 851.94). Phytochemicals, including alkaloids, tannins, triterpenes, saponins, phytosterols, and flavonoids were identified in the plants. The result of this study gives scientific credence to the traditional use of these plants in the treatment of schistosomiasis and proves that the rich botanical knowledge of medicinal plants provides an incredible starting point for the discovery of new anti-schistosomal drugs for the local population.</p>","PeriodicalId":16662,"journal":{"name":"Journal of Parasitology Research","volume":"2023 ","pages":"6707157"},"PeriodicalIF":1.4000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372336/pdf/","citationCount":"0","resultStr":"{\"title\":\"Ethnobotanical Survey and Cercaricidal Activity Screening of Medicinal Plants Used for Schistosomiasis Treatment in Atwima-Nwabiagya District, Ashanti Region, Ghana.\",\"authors\":\"Evelyn Asante-Kwatia, Lord Gyimah, Arnold Donkor Forkuo, William Kofi Anyan, Makafui Adzo Gbemu, Francis Ackah Armah, Abraham Yeboah Mensah\",\"doi\":\"10.1155/2023/6707157\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>This study focused on documenting and evaluating the cercaricidal activity of medicinal plants used for schistosomiasis treatment in an endemic area in Ghana. Through semistructured questionnaires, personal interviews with herbalists in communities surrounding the Barekese dam in the Atwima-Nwabiagya district, where the disease is endemic, were carried out. Thirty medicinal plants distributed in 19 families were reported to be used for schistosomiasis treatment in the survey. Information on the plants, including scientific names, common names, families, and the used plant part were recorded. The families Apocynaceae and Euphorbiaceae recorded the highest number of plants (14% each), followed by Asteraceae (10%), Loranthaceae (7%), and Rubiaceae (7%). <i>In vitro</i> cercaricidal activity of methanol extracts of nine out of the thirty plants was performed by exposing human <i>Schistosoma mansoni</i> cercariae obtained from <i>Biomphalaria pfeifferi</i> to various concentrations of extracts over a duration of 240 minutes. All the plants tested demonstrated time- and concentration-dependent cercaricidal activity. With lethality being set at <1000 <i>μ</i>g/mL, the cercaricidal activity in order of decreasing potency was as follows: <i>Withania somnifera</i> (LC<sub>50</sub> = 1.29) > <i>Balanites aegyptiaca</i> (LC<sub>50</sub> = 7.1) > <i>Xylia evansii</i> (LC<sub>50</sub> = 11.14) <i>> Jathropha multifida</i> (LC<sub>50</sub> = 12.9) <i>> Justicia flava</i> (LC<sub>50</sub> = 22.9) <i>> Anopyxis klaineana</i> (LC<sub>50</sub> = 182.81) > <i>Ximenia americana</i> (LC<sub>50</sub> = 194.98) <i>> Loranthus lecardii</i> (LC<sub>50</sub> = 223.87) <i>> Bridelia tenufolia</i> (LC<sub>50</sub> = 309.03) > <i>Zanthoxylium zanthoxyloides</i> (LC<sub>50</sub> = 851.94). Phytochemicals, including alkaloids, tannins, triterpenes, saponins, phytosterols, and flavonoids were identified in the plants. The result of this study gives scientific credence to the traditional use of these plants in the treatment of schistosomiasis and proves that the rich botanical knowledge of medicinal plants provides an incredible starting point for the discovery of new anti-schistosomal drugs for the local population.</p>\",\"PeriodicalId\":16662,\"journal\":{\"name\":\"Journal of Parasitology Research\",\"volume\":\"2023 \",\"pages\":\"6707157\"},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372336/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Parasitology Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1155/2023/6707157\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"PARASITOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Parasitology Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1155/2023/6707157","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PARASITOLOGY","Score":null,"Total":0}
Ethnobotanical Survey and Cercaricidal Activity Screening of Medicinal Plants Used for Schistosomiasis Treatment in Atwima-Nwabiagya District, Ashanti Region, Ghana.
This study focused on documenting and evaluating the cercaricidal activity of medicinal plants used for schistosomiasis treatment in an endemic area in Ghana. Through semistructured questionnaires, personal interviews with herbalists in communities surrounding the Barekese dam in the Atwima-Nwabiagya district, where the disease is endemic, were carried out. Thirty medicinal plants distributed in 19 families were reported to be used for schistosomiasis treatment in the survey. Information on the plants, including scientific names, common names, families, and the used plant part were recorded. The families Apocynaceae and Euphorbiaceae recorded the highest number of plants (14% each), followed by Asteraceae (10%), Loranthaceae (7%), and Rubiaceae (7%). In vitro cercaricidal activity of methanol extracts of nine out of the thirty plants was performed by exposing human Schistosoma mansoni cercariae obtained from Biomphalaria pfeifferi to various concentrations of extracts over a duration of 240 minutes. All the plants tested demonstrated time- and concentration-dependent cercaricidal activity. With lethality being set at <1000 μg/mL, the cercaricidal activity in order of decreasing potency was as follows: Withania somnifera (LC50 = 1.29) > Balanites aegyptiaca (LC50 = 7.1) > Xylia evansii (LC50 = 11.14) > Jathropha multifida (LC50 = 12.9) > Justicia flava (LC50 = 22.9) > Anopyxis klaineana (LC50 = 182.81) > Ximenia americana (LC50 = 194.98) > Loranthus lecardii (LC50 = 223.87) > Bridelia tenufolia (LC50 = 309.03) > Zanthoxylium zanthoxyloides (LC50 = 851.94). Phytochemicals, including alkaloids, tannins, triterpenes, saponins, phytosterols, and flavonoids were identified in the plants. The result of this study gives scientific credence to the traditional use of these plants in the treatment of schistosomiasis and proves that the rich botanical knowledge of medicinal plants provides an incredible starting point for the discovery of new anti-schistosomal drugs for the local population.
期刊介绍:
Journal of Parasitology Research is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies in all areas of basic and applied parasitology. Articles covering host-parasite relationships and parasitic diseases will be considered, as well as studies on disease vectors. Articles highlighting social and economic issues around the impact of parasites are also encouraged. As an international, Open Access publication, Journal of Parasitology Research aims to foster learning and collaboration between countries and communities.