Journal of oral science最新文献_第4页

Orthodontic tooth movement following bone regeneration with modified bone graft materials treated with a biosilane coupling agent. 生物硅烷偶联剂改性骨移植材料骨再生后正畸牙齿移动。

IF 1.7 4区医学

Journal of oral science Pub Date : 2026-01-16 Epub Date: 2025-10-27 DOI: 10.2334/josnusd.25-0193

Ryota Koike, Takenori Sato, Masahiro Takahashi, Katsura Ohashi, Tomotaro Nihei, Tetsutaro Yamaguchi, Keisuke Handa

{"title":"Orthodontic tooth movement following bone regeneration with modified bone graft materials treated with a biosilane coupling agent.","authors":"Ryota Koike, Takenori Sato, Masahiro Takahashi, Katsura Ohashi, Tomotaro Nihei, Tetsutaro Yamaguchi, Keisuke Handa","doi":"10.2334/josnusd.25-0193","DOIUrl":"10.2334/josnusd.25-0193","url":null,"abstract":"Purpose: The impact of bone regeneration using bone graft materials on orthodontic tooth movement (OTM) remains unclear. This study was designed to histologically and biologically evaluate the influence of bone graft materials treated with a biosilane coupling agent on early bone formation and their effect on OTM.Methods: Maxillary first molars of 4-week-old male Wistar rats were extracted, followed by alveolar bone regeneration using either carbonate apatite (Cytrans granules; Cyt) or biosilane-treated Cytrans (DI6M-Cyt). After 2 weeks, nickel-titanium (Ni-Ti) closed-coil springs were applied to exert mesial traction on the second molars, inducing OTM for 14 or 28 days. Bone formation characteristics and tooth movement patterns were evaluated via micro-computed tomography (micro-CT), histological analysis (hematoxylin and eosin [H&E] and tartrate-resistant acid phosphatase [TRAP] staining), and nanoindentation testing.Results: Initial bone formation was noted in the DI6M-Cyt group relative to the untreated group, the rigidity of the newly formed bone approaching that of natural bone, thus inhibiting aberrant tooth movement following OTM. Furthermore, osteoclast activity was appropriately regulated, maintaining balanced bone remodeling.Conclusion: These findings indicate that biosilane-treated bone graft materials enhance bone regeneration and that the newly formed bone does not impede OTM.","PeriodicalId":16646,"journal":{"name":"Journal of oral science","volume":" ","pages":"1-6"},"PeriodicalIF":1.7,"publicationDate":"2026-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145372789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between oral health and nutritional intake among older denture wearers. 老年假牙佩戴者口腔健康与营养摄入之间的关系。

IF 1.7 4区医学

Journal of oral science Pub Date : 2026-01-16 Epub Date: 2025-12-17 DOI: 10.2334/josnusd.25-0291

Takamasa Yoshida, Kensuke Nishio, Yu Yasuda, Shinji Okada, Tomoka Ito, Toshimitsu Iinuma

{"title":"Association between oral health and nutritional intake among older denture wearers.","authors":"Takamasa Yoshida, Kensuke Nishio, Yu Yasuda, Shinji Okada, Tomoka Ito, Toshimitsu Iinuma","doi":"10.2334/josnusd.25-0291","DOIUrl":"10.2334/josnusd.25-0291","url":null,"abstract":"Purpose: This study examined the association between oral health and nutritional intake among older denture wearers.Methods: Oral health parameters were evaluated in 114 denture wearers, including the number of remaining teeth (<20 or ≥20), posterior occlusal support (Eichner classification A1-B3 or B4-C3), objective masticatory assessment (glucose concentration: <100 or ≥100 mg/dL), subjective masticatory assessment (self-reported masticatory problems), and occlusal force (<500 or ≥500 N). Nutritional intake was assessed using a brief self-administered diet history questionnaire. Differences in nutritional intake according to oral health parameters were assessed using multiple regression analysis.Results: Fewer remaining teeth were associated with higher total fat (β = 0.207, P = 0.038) and plant fat (β = 0.242, P = 0.017) intakes, and with lower carbohydrate (β = -0.264, P = 0.026) and cereal (β = -0.320, P = 0.002) intakes. The presence of masticatory problems and absence of posterior occlusal support were associated with lower intakes of plant protein (β = -0.311, P = 0.002) and meat (β = -0.232, P = 0.022), respectively.Conclusion: Among older denture wearers, denture design-related factors, such as the number of remaining teeth and posterior occlusal support, were associated with more nutritional intake items than oral function-related parameters.","PeriodicalId":16646,"journal":{"name":"Journal of oral science","volume":" ","pages":"19-24"},"PeriodicalIF":1.7,"publicationDate":"2026-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145774857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enamel matrix derivative-induced cementoblast differentiation via Wnt/β-catenin signaling in human periodontal ligament cells. 釉质基质衍生物通过Wnt/β-catenin信号传导诱导人牙周韧带细胞成牙骨质分化。

IF 1.7 4区医学

Journal of oral science Pub Date : 2026-01-16 Epub Date: 2025-12-03 DOI: 10.2334/josnusd.25-0217

Ju-Chan Maeng, Su-Kyeong Son, Jung-Sun Moon, Dong-Wook Yang, Sun-Hun Kim, Min-Seok Kim

{"title":"Enamel matrix derivative-induced cementoblast differentiation via Wnt/β-catenin signaling in human periodontal ligament cells.","authors":"Ju-Chan Maeng, Su-Kyeong Son, Jung-Sun Moon, Dong-Wook Yang, Sun-Hun Kim, Min-Seok Kim","doi":"10.2334/josnusd.25-0217","DOIUrl":"10.2334/josnusd.25-0217","url":null,"abstract":"Purpose: Cementum is a specialized calcified tissue produced by cementoblasts, which play a key role in periodontal regeneration. Enamel matrix derivative (EMD) is an agent currently employed for treatment of periodontal disease, although its molecular action mechanism remains unclear. The present study aimed to investigate the effects of EMD on cementoblast differentiation and the involvement of Wnt/β-catenin signaling in human periodontal ligament (hPDL) cells.Methods: Primary hPDL cells were treated with EMD, and the expression of cementum-related markers was evaluated. The role of Wnt/β-catenin signaling was assessed using IWP-2, a Wnt inhibitor. A luciferase reporter assay was conducted to identify regulatory elements within the cementum protein 1 (CEMP1) promoter.Results: EMD upregulated the expression of CEMP1 and cementum attachment protein. This effect was attenuated by IWP-2, indicating Wnt/β-catenin involvement. A T-cell factor binding site was identified within the CEMP1 promoter. EMD increased the expression of osterix and runt-related transcription factor 2 (Runx2) slightly, but decreased the levels of osteocalcin and osteopontin. No mineralization enhancement was observed based on alkaline phosphatase activity and Alizarin Red S stainingConclusion: EMD promotes early-stage cementoblast differentiation via Wnt/β-catenin signaling but has limited effects on late-stage maturation, offering new insights into the regenerative potential of EMD for periodontal therapy.","PeriodicalId":16646,"journal":{"name":"Journal of oral science","volume":" ","pages":"12-18"},"PeriodicalIF":1.7,"publicationDate":"2026-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145668680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of vat polymerization methods on surface and bonding behavior of additive manufactured dental resins. 还原聚合方法对添加剂制牙用树脂表面和粘接性能的影响。

IF 1.7 4区医学

Journal of oral science Pub Date : 2026-01-16 Epub Date: 2025-11-15 DOI: 10.2334/josnusd.25-0161

İrem B Yeşil Kurt, Nursena Öztemel, Almira A Diken Türksayar

{"title":"Influence of vat polymerization methods on surface and bonding behavior of additive manufactured dental resins.","authors":"İrem B Yeşil Kurt, Nursena Öztemel, Almira A Diken Türksayar","doi":"10.2334/josnusd.25-0161","DOIUrl":"10.2334/josnusd.25-0161","url":null,"abstract":"Purpose: To investigate the surface roughness (Ra), shear bond strength (SBS), and Vickers hardness number (VHN) of additive manufactured interim resins manufactured through different vat polymerization techniques.Methods: Samples were divided into four groups; additive manufacturing technology (Stereolithography:S-FL; Digital light processing:D-AS; Liquid crystal display:L-PH) and subtractive manufacturing technology (Polymethylmethacrylate: MP) (n = 10). After polishing, the Ra values were measured and resin material was then applied. Following thermocycling, SBS tests and VHN tests were carried out. The obtained data were evaluated using one-way analysis of variance (ANOVA) (a = 0.05).Results: Significant differences were observed between the groups for SBS (P = 0.02) and VHN (P < 0.001), whereas the Ra values were not statistically significant (P = 0.148). D-AS and L-PH had higher and similar SBS (P = 1.000) while MP had statistically lower SBS. D-AS demonstrated higher VHN than all groups (P < 0.001) with the exception of S-FL (P = 0.831). MP had lower VHN than all groups (P < 0.01) other than L-PH (P = 0.143).Conclusion: All fabrication methods had clinically acceptable SBS values, L-PH and D-AS had higher results. D-AS demonstrated superiority in terms of VHN, all groups exhibited comparable Ra values.","PeriodicalId":16646,"journal":{"name":"Journal of oral science","volume":" ","pages":"7-11"},"PeriodicalIF":1.7,"publicationDate":"2026-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145534744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adjunctive equol supplementation over 24 months for managing painful oral mucous membrane pemphigoid. 辅助补充雌马酚超过24个月治疗疼痛性口腔黏膜类天疱疮。

IF 1.4 4区医学

Journal of oral science Pub Date : 2026-01-01 DOI: 10.2334/josnusd.26-0059

Aki Kawamoto, Naoyuki Sugano, Takashi Onizawa, Jumi Nakata, Noboru Noma, Shuichi Sato

引用次数: 0

Effect of calcium and magnesium ion incorporation on the osteogenic differentiation of human MSCs on SLA-treated titanium implant surfaces. 钙镁离子掺入对sla处理钛种植体表面人间充质干细胞成骨分化的影响。

IF 1.4 4区医学

Journal of oral science Pub Date : 2026-01-01 DOI: 10.2334/josnusd.26-0023

Jae-Min Kim, Young-Kyung Kim, Jin-Woo Park

{"title":"Effect of calcium and magnesium ion incorporation on the osteogenic differentiation of human MSCs on SLA-treated titanium implant surfaces.","authors":"Jae-Min Kim, Young-Kyung Kim, Jin-Woo Park","doi":"10.2334/josnusd.26-0023","DOIUrl":"10.2334/josnusd.26-0023","url":null,"abstract":"Purpose: Calcium (Ca) and magnesium (Mg) ions enhance the osteoconductivity of titanium oral implants, yet their effects on clinically established complex topographies remain under-explored. This study evaluated the effects of Ca and Mg incorporation into sandblasted, large-grit-, acid-etched (SLA) surfaces on the osteogenic differentiation of human mesenchymal stem cells (MSCs).Methods: Ca or Mg ions were incorporated into SLA-treated titanium via wet chemical treatment. Primary human MSC responses on these modified surfaces were assessed, with unmodified SLA surfaces serving as controls.Results: Ion incorporation facilitated successful formation of nanostructured oxide layers while preserving the underlying microscale SLA topography. Both Ca- and Mg-modified surfaces significantly upregulated adhesion-related genes (integrin subunits, ACTA2, and TLN1), osteogenic transcription factors (RUNX2 and CTNNB1) and differentiation markers (ALPL and BGLAP) relative to the control (P < 0.05). Notably, in comparison to Ca modification, Mg modification induced higher expression of the integrin subunit beta gene and BGLAP production than at early time points; overall, however, cellular behaviors in the two groups remained comparable.Conclusion: Surface chemistry modification with Ca or Mg ions enhances the osteogenic capacity of complex-structured titanium implants by modulating early adhesion signaling and accelerating MSC differentiation. Such bioactive surface modifications represent a promising strategy for improving the clinical performance of contemporary oral implants.","PeriodicalId":16646,"journal":{"name":"Journal of oral science","volume":"68 3","pages":"170-176"},"PeriodicalIF":1.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148455483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 1.4 4区医学

Journal of oral science Pub Date : 2026-01-01 DOI: 10.2334/josnusd.26-0121

Yoshimasa Taketani, Jun Takenoya, Hiroshi Nagasaki, Keita Nakagomi, Yusuke Yamane, Mabuki Uchinuma, Makiko Ishii, Reiji Suzuki, Kitetsu Shin, Joichiro Hayashi

{"title":"Oral health-related quality of life and pain after periodontal regenerative therapy.","authors":"Yoshimasa Taketani, Jun Takenoya, Hiroshi Nagasaki, Keita Nakagomi, Yusuke Yamane, Mabuki Uchinuma, Makiko Ishii, Reiji Suzuki, Kitetsu Shin, Joichiro Hayashi","doi":"10.2334/josnusd.26-0121","DOIUrl":"https://doi.org/10.2334/josnusd.26-0121","url":null,"abstract":"Purpose: The use of patient-centered assessments, including oral health-related quality of life (OHRQoL), alongside conventional clinical assessments, such as attachment level, has been recommended in periodontal treatment. This study surveyed OHRQoL to evaluate postoperative patient burden and pain after periodontal regenerative therapy.Methods: The participants were 104 patients who underwent periodontal regenerative therapy using enamel matrix derivative (EMD), fibroblast growth factor-2 (FGF-2), or open flap debridement. OHRQoL was assessed with the General Oral Health Assessment Index (GOHAI). Pain was evaluated using a visual analog scale (VAS).Results: As compared with preoperative values, GOHAI total score was significantly lower on days 3 and 7 in all groups and VAS score was significantly higher on day 3 in all groups. VAS scores on day 14 were significantly higher in the FGF-2 group than in the EMD group.Conclusion: Periodontal regenerative therapy caused a temporary decline in OHRQoL, and postoperative pain was more prolonged in the FGF-2 group than in the EMD group. These results suggest that patient burden needs to be considered when selecting the procedure for periodontal regenerative therapy.","PeriodicalId":16646,"journal":{"name":"Journal of oral science","volume":"68 4","pages":"239-243"},"PeriodicalIF":1.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149220355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of Stevens-Johnson syndrome triggered by Mycoplasma infection. 由支原体感染引发的史蒂文斯-约翰逊综合征1例。

IF 1.4 4区医学

Journal of oral science Pub Date : 2026-01-01 DOI: 10.2334/josnusd.25-0254

Atsushi Uenoyama, Hideaki Hirai, Yuko Saito, Tetsuo Kiguchi, Saori Takashima, Kei Tomihara

引用次数: 0

In vitro evaluation of color stability of non-pigmented maxillofacial silicone elastomer immersed in condiments. 无色素颌面硅弹性体浸泡在调味品中颜色稳定性的体外评价。

IF 1.4 4区医学

Journal of oral science Pub Date : 2026-01-01 DOI: 10.2334/josnusd.25-0309

Bilal L Alkrayem, Mariko Hattori, Ahmed Sameir M Ali, Mihoko Haraguchi, Mai Murase, Noriyuki Wakabayashi

{"title":"In vitro evaluation of color stability of non-pigmented maxillofacial silicone elastomer immersed in condiments.","authors":"Bilal L Alkrayem, Mariko Hattori, Ahmed Sameir M Ali, Mihoko Haraguchi, Mai Murase, Noriyuki Wakabayashi","doi":"10.2334/josnusd.25-0309","DOIUrl":"10.2334/josnusd.25-0309","url":null,"abstract":"Purpose: Maxillofacial silicone prostheses restore facial appearance, and those in the perioral region contact food that may affect their color. This study evaluated how common condiments influence the color stability of silicone elastomers.Methods: Thirty-two non-pigmented silicone specimens were divided into four groups (n = 8) and immersed in water, ketchup, soy sauce, and vegetable sauce. A spectrophotometer measured color at baseline and after 7 and 14 days. ΔE00 values were calculated using the CIEDE2000 formula, and data were analyzed statistically (α = 0.05).Results: At 14 days, ketchup caused the greatest discoloration (ΔE00 = 8.11 ± 0.21), followed by vegetable sauce (2.27 ± 0.28), soy sauce (0.78 ± 0.17), and water (0.34 ± 0.16). The differences between groups were significant (P < 0.001). Ketchup caused more discoloration than the other condiments, while soy sauce and vegetable sauce differed only at 14 days. All condiments differed from water in relation to discoloration. Color changes included darkening and yellowing with ketchup, greenish-blue tinting with soy sauce, and darkening with vegetable sauce; water caused no change in color.Conclusion: Pigments in condiments can affect the aesthetics of maxillofacial prostheses. Patients should thus receive dietary and hygiene guidance to extend the lifespan of prostheses.","PeriodicalId":16646,"journal":{"name":"Journal of oral science","volume":"68 1","pages":"25-29"},"PeriodicalIF":1.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145998333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Defensin-4 as a proposed diagnostic marker for gingivitis and periodontitis. 防御素-4作为牙龈炎和牙周炎的诊断标志物。

IF 1.4 4区医学

Journal of oral science Pub Date : 2026-01-01 DOI: 10.2334/josnusd.25-0335

Ho-Jin Jeong, Young Sun Hwang

{"title":"Defensin-4 as a proposed diagnostic marker for gingivitis and periodontitis.","authors":"Ho-Jin Jeong, Young Sun Hwang","doi":"10.2334/josnusd.25-0335","DOIUrl":"10.2334/josnusd.25-0335","url":null,"abstract":"Purpose: This study aimed to provide evidence supporting defensin-4 (DEFA4) as a potential diagnostic marker for periodontal diseases.Methods: Proteomic analysis of gingival crevicular fluid (GCF) collected from patients with gingivitis and periodontitis was performed using liquid chromatography-tandem mass spectrometry (LC-MS/MS). In addition, immortalized gingival fibroblasts (IGFs) were stimulated with Porphyromonas gingivalis lipopolysaccharide (PG-LPS) and co-cultured with oral bacteria isolated from periodontitis patients.Results: LC-MS/MS analysis of GCF from patients with periodontal disease revealed markedly elevated levels of DEFA4. The expression of DEFA4 in immortalized gingival fibroblasts (IGFs) was significantly increased following stimulation with Porphyromonas gingivalis lipopolysaccharide (PG-LPS) and co-culture with oral bacteria isolated from periodontitis patients. Furthermore, the culture supernatant of IGFs co-cultured with periodontitis-associated oral bacteria showed increased levels of GRO, GRO-α (CXCL1), IL-1α, IL-6, IL-8, and angiogenin.Conclusion: DEFA4 expression is strongly enhanced by the inflammatory environment of gingival cells influenced by oral bacteria, supporting its potential utility as a diagnostic marker for monitoring periodontal diseases.","PeriodicalId":16646,"journal":{"name":"Journal of oral science","volume":"68 1","pages":"35-39"},"PeriodicalIF":1.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145998316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0