Journal of Pain and Relief最新文献_第6页

Bimoclomol and Arimoclomol: HSP-co-Inducers for the Treatment of ProteinMisfolding Disorders, Neuropathy and Neuropathic Pain 双氯洛酚和阿利莫洛酚:治疗蛋白质错误折叠障碍、神经病变和神经性疼痛的热休克蛋白共同诱导剂

Journal of Pain and Relief Pub Date : 2016-12-27 DOI: 10.4172/2167-0846.1000279

K. Jm

引用次数: 6

The Use of Methadone in Refractory Headache Pain in an Opiate Naive Patientwith Non Metastatic BurkittÃ¢ÂÂs Lymphoma and HIV - A Case Report 美沙酮治疗初治非转移性BurkittÃ¢ÂÂs淋巴瘤和HIV患者顽固性头痛1例报告

Journal of Pain and Relief Pub Date : 2016-12-26 DOI: 10.4172/2167-0846.1000280

M. Stotland, Helen Rahimzad

{"title":"The Use of Methadone in Refractory Headache Pain in an Opiate Naive Patientwith Non Metastatic BurkittÃ¢ÂÂs Lymphoma and HIV - A Case Report","authors":"M. Stotland, Helen Rahimzad","doi":"10.4172/2167-0846.1000280","DOIUrl":"https://doi.org/10.4172/2167-0846.1000280","url":null,"abstract":"In extreme cases Methadone has been used for severe pain in oncologic patients; frequently cancer patients \u0000 have severe headaches in addition to their pain. This patient is a 50 year old Hispanic female with metastatic \u0000 Burkitt’s Lymphoma and controlled HIV on triple therapy. Throughout her inpatient hospitalizations of chemotherapy \u0000 with R-EPOCH and then salvage chemotherapy in addition to pancytopenia she experienced consistent pain of 9-10 \u0000 out of 10 on the pain scale and headaches of 9-10 in severity out of 10. The patient underwent various methods of \u0000 pain and headache control including PCA of hydromorphone, intravenous and oral hydromorphone, intravenous \u0000 morphine, intravenous Tylenol, Fioricet and oral analgesics. The patient received moderate relief with oral \u0000 Methadone of both her pain and headaches, bringing the pain and headache scale down to a 4-5 out of 10. This is \u0000 the first case of intractable pain and headaches in an opiate naive patient with non-metastatic Burkitt’s Lymphoma \u0000 and HIV that received with 50 percent reduction in symptoms from the addition of oral Methadone that has no prior \u0000 use of opiate abuse or dependence.","PeriodicalId":16641,"journal":{"name":"Journal of Pain and Relief","volume":"74 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74567096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intractable Headaches in a Patient with Alport Syndrome with No Evidence of Brain Lesions-A Case Report 无脑损伤证据的Alport综合征患者顽固性头痛1例报告

Journal of Pain and Relief Pub Date : 2016-12-21 DOI: 10.4172/2167-0846.1000278

Mitchell Stotl

{"title":"Intractable Headaches in a Patient with Alport Syndrome with No Evidence of Brain Lesions-A Case Report","authors":"Mitchell Stotl","doi":"10.4172/2167-0846.1000278","DOIUrl":"https://doi.org/10.4172/2167-0846.1000278","url":null,"abstract":"Alport Syndrome results in a genetic mutation in type IV collagen; one place of major significance is the glomerular basement membrane of nephrons. These patients are at high risk for glomerulonephritis and renal failure in addition to inner ear and eye pathology. This patient is a 25 year old Caucasian female with non-deaf Alport Syndrome who was hospitalized for intractable headaches with pain scale measuring 8-10 out of 10 of severity. This patient received a CT of the head, MRI, MRA and MRV of the brain that demonstrated no evidence of chronic or acute hemorrhage, acute intracranial process, chronic or acute infarction, vasculitis, brain lesions or emboli. This patient’s headaches were refractory to oral Fioricet, Aspirin, Tylenol and NSAIDS. The patient initially refused oral and intravenous analgesics including morphine, oxycodone due to the side effects of nausea, lethargy and drowsiness. The patient’s pain was moderately relieved by small doses of oral oxycodone and intravenous morphine. The patient experienced mild nausea and drowsiness from these medications; however her pain reduced over 60% in severity to a final rating of 3-4 out of 10 from an initial 8-10 out of 10 in severity. This patient was the first patient reported with Alport Syndrome and intractable headaches without evidence of acute or chronic brain lesions on brain MRV, MRI, MRA and CT imaging whose headache pain was reduced by over 60% in severity by oral and intravenous analgesics in the inpatient setting.","PeriodicalId":16641,"journal":{"name":"Journal of Pain and Relief","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89571429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Integral of Pain Relief as an Innovative Method of Pain Measurement 疼痛缓解积分作为一种创新的疼痛测量方法

Journal of Pain and Relief Pub Date : 2016-12-13 DOI: 10.4172/2167-0846.1000277

I. Wilderman

引用次数: 5

Audio-Analgesia a Complementary Pain Relief Application within the Confines of Epidural Anesthesia 音频镇痛在硬膜外麻醉范围内的辅助镇痛应用

Journal of Pain and Relief Pub Date : 2016-11-28 DOI: 10.4172/2167-0846.1000276

Wesley Lapommeray

{"title":"Audio-Analgesia a Complementary Pain Relief Application within the Confines of Epidural Anesthesia","authors":"Wesley Lapommeray","doi":"10.4172/2167-0846.1000276","DOIUrl":"https://doi.org/10.4172/2167-0846.1000276","url":null,"abstract":"Childbirth is an dynamic experience fraught with medical complications. The field of Anesthesiology has alleviated excruciating pain throughout modernity. The development of new medication and procedures have reduced adverse fatalities. Furthermore, epidural anesthesia have afforded rather painless childbirth. Before the advent of modern anesthesiology (epidural anesthesia), women were bereft of painless births. “Childbirth is painful, and we are in an era when most American women consider some chemical means of pain relief an accepted part of the delivery process” [1]. The advent of anesthesiology has remarkable reduced possible death of the fetus and the mother. However, complications arise not withstanding the fact of the proper implementation of standard protocol. Aspiration of vomitus in obstetric anesthesiology is ubiquitous in the hospital setting. A sizeable amount of pregnant, expectant mothers have vomited during or immediately after following inhalation of anesthesia. In addition, death from epidural anesthesia or spinal anesthesia may result from hypotension. A physiological response to the implementation of an epidural anesthesia is hypotension associated with sympathetic blockade. Effectively managing the blood pressure of an expectant, pregnant mother is an ongoing issue of the utmost importance. Diligent Anesthesiologists adequately resolve the factors leading to hypovolemic state of the patients. There are intrinsic psychosomatic factors that may exacerbate the precarious hypovolemic state blood in expectant, pregnant women.","PeriodicalId":16641,"journal":{"name":"Journal of Pain and Relief","volume":"931 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2016-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85595261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prolonged Pulsed Radiofrequency Ablation of Genicular Nerves of Knee for Intractable Pain from Knee Osteoarthritis: A Case Report 长时间脉冲射频消融术治疗膝关节骨性关节炎顽固性疼痛1例

Journal of Pain and Relief Pub Date : 2016-11-18 DOI: 10.4172/2167-0846.1000275

Arif Ahmed

引用次数: 6

Topical Analgesics: Critical Issues Related to Formulation and Concentration 局部镇痛药:与配方和浓度相关的关键问题

Journal of Pain and Relief Pub Date : 2016-11-11 DOI: 10.4172/2167-0846.1000274

K. Jm

{"title":"Topical Analgesics: Critical Issues Related to Formulation and Concentration","authors":"K. Jm","doi":"10.4172/2167-0846.1000274","DOIUrl":"https://doi.org/10.4172/2167-0846.1000274","url":null,"abstract":"Topical analgesics are in need to be differentiated from transdermal formulations of analgesics. Topical analgesics are characterized by local analgesic effects in the absence of systemic effects, and do not require a transdermal delivery formulation. There are two key issues in the development of topical analgesics. 1. For optimal clinical effects specific characteristics for the vehicle (a cream base or gel base) are required, depending on the physicochemical characteristics of the pharmaceutical active ingredient in the carrier. 2. One cannot and should not skip well designed phase II dose-finding studies, and this unfortunately happens often, as we will discuss in this paper. In fact, we will demonstrate underdosing is one of the major hurdles to detect meaningful and statistically relevant clinical effects of topical analgesics. In the case of gels or creams containing ketamine, amitriptyline and baclofen, the dose-finding most probably needs to start at 10% for ketamine and amitriptyline and 2.5% for baclofen, while the doses tested were much lower: 4%, 2% and 1% respectively. Topical analgesics are promising inroads for the treatment of neuropathic pain, once sufficient attention is given to aspects such as formulation and concentration.","PeriodicalId":16641,"journal":{"name":"Journal of Pain and Relief","volume":"36 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2016-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89780257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

The impact of chronic musculoskeletal pain on male reproductive hormones and sperm quality 慢性肌肉骨骼疼痛对男性生殖激素和精子质量的影响

Journal of Pain and Relief Pub Date : 2016-10-28 DOI: 10.4172/2167-0846.C1.012

F. Dardmeh

引用次数: 1

Posturology: A new discipline involving art, well-being, physiology, pain management and prevention of musculoskeletal disorders 姿势学:一门涉及艺术、健康、生理学、疼痛管理和肌肉骨骼疾病预防的新学科

Journal of Pain and Relief Pub Date : 2016-10-28 DOI: 10.4172/2167-0846.C1.010

M. Romoli

引用次数: 0

Pregabalin Versus Acetaminophen for a Treatment of Chronic Neuropathic Painon Extremities after Cervical Surgery: A Prospective Randomized, Open-LabelPreliminary Study 普瑞巴林与对乙酰氨基酚治疗颈椎术后四肢慢性神经性疼痛:一项前瞻性随机、开放标签的初步研究

Journal of Pain and Relief Pub Date : 2016-10-24 DOI: 10.4172/2167-0846.1000273

T. Hirai, T. Yoshii, M. Enomoto, Tsuyoshi Yamada, Takashi Taniyama, H. Inose, Tsuyoshi Kato, and Atsushi Okawa

{"title":"Pregabalin Versus Acetaminophen for a Treatment of Chronic Neuropathic Painon Extremities after Cervical Surgery: A Prospective Randomized, Open-LabelPreliminary Study","authors":"T. Hirai, T. Yoshii, M. Enomoto, Tsuyoshi Yamada, Takashi Taniyama, H. Inose, Tsuyoshi Kato, and Atsushi Okawa","doi":"10.4172/2167-0846.1000273","DOIUrl":"https://doi.org/10.4172/2167-0846.1000273","url":null,"abstract":"Therapeutic efficacy of pregabalin (PGL) for reducing neuropathic pain in patients who received a cervical operation is unclear. The purpose of this prospective pilot study was to compare the efficacy and adverse events between PGL and acetaminophen (ACM) for residual neuropathic pain. Thirty-four patients who received cervical spine surgery at our hospital from September 2011 to April 2013 and were diagnosed with residual neuropathic pain in the extremities were enrolled and were randomized to receive PGL (50 mg/day initially as an induction dose for 2 weeks) or ACM (1200 mg/day) for 8 weeks. PGL dosage was adjusted to 50-150 mg/day according to the severity of pain using a visual analog scale (VAS) after a 2-week time point. The Neck Disability Index (NDI) and VAS were used to evaluate subjective pain of the extremities and sleep condition. Short Form-36 (SF-36) and Japanese Orthopedic Association Cervical Myelopathy Evaluation Questionnaire (JOACMEQ) were used to evaluate neurologic function. Thirty-three patients (PGL 19 cases, ACM 14 cases) completed 8 weeks of follow-up. The average VAS for pain and numbness significantly improved in both groups at the final visit. The scale for sleep improved in the PGL group but was unchanged in the ACM group. The proportion of patients with satisfactory improvement in sleep was 31.6% and 0% in the PGL and ACM groups, respectively. There was a significant difference in VAS for sleep only. There were no significant improvements in the NDI and each domain of JOACMEQ in both groups. The number of patients who complained of somnolence tended to be greater in the PGL group. Thus, both PGL and ACM administration improved residual neuropathic pain in patients treated with cervical spine surgery for myelopathy. PGL was more effective in reducing sleep interference related to refractory neuropathic pain compared with ACM.","PeriodicalId":16641,"journal":{"name":"Journal of Pain and Relief","volume":"356 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2016-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76496539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0