Journal of Orthopaedic Surgery最新文献

{"title":"Relationships of PedsQL 4.0 generic core scales with other validated HRQoL instruments in braced idiopathic scoliosis patients: An age and curve severity-specific analysis.","authors":"Kai Chun Augustine Chan, Kai Him Ambrose Chan, See Laam Wong, Jason Pui Yin Cheung, Prudence Wing Hang Cheung","doi":"10.1177/10225536251321122","DOIUrl":"10.1177/10225536251321122","url":null,"abstract":"<p><p><b>Purpose:</b> This study aims to investigate if the addition of PedsQL 4.0 generic core scales (PedsQL) with other validated instruments in day-to-day clinical context is feasible. <b>Methods:</b> Patients with idiopathic scoliosis who were undergoing brace treatment and aged 8-18 were asked to fill in the PedsQL 4.0 generic core scales, SRS-22r and EQ5D questionnaires at the spine specialist outpatient clinic and were followed up at 6 months by phone consultation. Questionnaire scores at baseline and follow-up were compared. Correlation of score changes of different questionnaires were tested. <b>Results:</b> A total of 232 patients (58 males, 174 females) were included. PedsQL school functioning scores and total scores at follow-up were lower than at baseline (<i>p</i> < 0.001), with greatest reductions in school functioning domain (range: -2.8 ± 7.0 to -5.1 ± 3.6). For those aged 13-18 years, changes of PedsQL school functioning correlated with changes of SRS total score (<i>r</i> = 0.20; <i>p</i> = 0.042). For patients with baseline major Cobb angle >30°, changes in PedsQL physical functioning correlated with SRS domain score changes in function (<i>r</i> = 0.25; <i>p</i> = 0.017), pain (<i>r</i> = 0.24; <i>p</i> = 0.021) and SRS total score (<i>r</i> = 0.26; <i>p</i> = 0.016). Both changes in PedsQL school functioning (<i>r</i> = 0.23; <i>p</i> = 0.032) and total score (<i>r</i> = 0.22; <i>p</i> = 0.043) correlated with SRS total score changes. <b>Conclusion:</b> PedsQL was sensitive to changes of HRQoL together with SRS-22r and EQ-5D-Y-5L questionnaires. Changes in PedsQL scores were related to changes in SRS-22r scores in patients of 13-18 years with more severe curves (>30°). PedsQL is recommended to be used in conjunction with validated instruments like SRS-22r with its ability to assess changes of patient's school functioning and overall HRQoL. The short-term nature of our study highlighted the need for future research with a larger cohort and longer duration to investigate long-term HRQoL outcomes assessed by individual questionnaires.</p>","PeriodicalId":16608,"journal":{"name":"Journal of Orthopaedic Surgery","volume":"33 1","pages":"10225536251321122"},"PeriodicalIF":1.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chondroblastoma in 28 cases: The risk of local recurrence increases with larger tumor size.","authors":"Di Yang, Zhongliang Wang","doi":"10.1177/10225536251328099","DOIUrl":"10.1177/10225536251328099","url":null,"abstract":"<p><p><b>Introduction:</b> Chondroblastoma (CBL) is a rare benign bone tumor with potentially local recurrence and metastases. At present, the local recurrence risk factors are controversial. The purpose of this study is to analysis local recurrence factors in our medical center. <b>Methodology:</b> A retrospective analysis was conducted on 18 male and 10 female patients who presented at our hospital between 2016 and 2023. The clinical data included radiological images, histological results, treatment modalities, functional outcomes, and local recurrence rates. Surgical interventions comprised curettage, followed by bone grafting and adjunctive techniques. Furthermore, all patients were stratified into two groups based on tumor volume, with a threshold of 25 cm³, to explore the relationship between tumor volume and recurrence. <b>Results:</b> Among the 28 patients, with an average age of 13 years (range: 9 to 16 years) and an average follow-up duration of 33 months (range: 8 to 91 months). The mean Musculoskeletal Tumor Society (MSTS) score was 27 points (range: 14 to 30). Notably, recurrence was observed in 3 pediatric patients. A statistically significant difference in recurrence rates was found between tumors with volumes less than 25 cm³ and those greater than 25 cm³ (<i>p</i> < .05). <b>Conclusion:</b> Curettage, combined with alcohol as an adjuvant, resulted in local control and good outcomes in most pediatric patients. It was noteworthy that a larger tumor size correlated with an increased likelihood of recurrence.</p>","PeriodicalId":16608,"journal":{"name":"Journal of Orthopaedic Surgery","volume":"33 1","pages":"10225536251328099"},"PeriodicalIF":1.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic impact of oligometastases in orthopaedic surgery for metastatic bone disease.","authors":"Wolfram Weschenfelder, Friederike Weschenfelder, Christian Spiegel, Karin Gabriela Schrenk, Thomas Ernst, Gunther Olaf Hofmann","doi":"10.1177/10225536251315983","DOIUrl":"10.1177/10225536251315983","url":null,"abstract":"<p><strong>Introduction: </strong>The rising number of cancer patients with metastatic bone disease (MBD) reflects advancements in treatment. The concept of oligometastatic disease, associated with improved prognosis, has emerged. This study evaluated prognostic factors, including oligometastases, in patients undergoing urgent orthopaedic surgery for MBD to inform preoperative decision-making and reduce morbidity and mortality from immobilization.</p><p><strong>Materials and methods: </strong>We retrospectively analysed records of patients who underwent surgery for MBD between 2005 and 2022. Data included medical history, tumour type, metastatic status, surgical method, lesion location, imaging, and survival outcomes. Multivariate survival analyses were conducted.</p><p><strong>Results: </strong>The number of metastases and presence of visceral metastases significantly influenced survival. Patients with single metastases had a median survival of 65 months, oligometastases 25 months, and polymetastases 11 months. Visceral metastases were associated with a median survival of 9 months versus 27 months without. Tumour type also impacted prognosis, with thyroid cancer patients having the highest median survival and lung cancer patients the lowest. Pathological fractures reduced survival significantly (11 months vs 36 months without fractures).</p><p><strong>Conclusion: </strong>Oligometastatic disease is a strong prognostic factor for MBD patients undergoing orthopaedic surgery, with better outcomes compared to polymetastatic disease. Other key factors include tumour type, visceral metastases, and pathological fractures. Improved staging, risk assessment, and early interdisciplinary collaboration could mitigate pathological fractures and improve outcomes.</p>","PeriodicalId":16608,"journal":{"name":"Journal of Orthopaedic Surgery","volume":"33 1","pages":"10225536251315983"},"PeriodicalIF":1.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anxiety and depression as risk factors for postoperative complications and pain in lumbar spine surgery: A national database study","authors":"Ruimin Wu, Pengcheng Gao, Shuxia Liu, Qinfeng Yang, Jian Wang, Fangguo Liang, Yuhang Chen, Lin Yang","doi":"10.1177/10225536241280190","DOIUrl":"https://doi.org/10.1177/10225536241280190","url":null,"abstract":"Objective: To investigate the potential association between anxiety and depression and surgical outcomes in patients undergoing LSS. By analyzing data from the Nationwide Inpatient Sample (NIS) database, we aim to identify whether anxiety and depression serve as predictors for postoperative complications and pain-related symptoms. Methods: A retrospective analysis was conducted via the NIS database. Those undergoing LSS from 2010 to 2019 were divided into four groups: those with a diagnosis of anxiety, depression, both depression and anxiety, and neither depression nor anxiety. The chi-squared test, rank sum test, the Student-Newman-Keuls, least significant difference, and Bonferroni tests were used to identify differences between these groups. Logistic regression analysis was utilized to determine if anxiety and depression were predictors for postoperative complications and pain-related symptoms. Results: From 2010 to 2019, 832,099 patients undergoing LSS were identified. Patients with either anxiety or depression were associated with heavier economic burdens ($85,375, $76,840, $88,542 in the anxiety, depression, and comorbid group, respectively, p &lt; 0.001) and prolonged hospital stay ( p &lt; 0.001). They were identified to experience higher risks of various complications especially thrombophilia (OR = 1.82, and 1.55 in the anxiety and the depression group, respectively, p &lt; 0.01). Multiple pain-related symptoms, but face reduced risks of inpatient mortality (OR = 0.71, 0.75, and 0.63 in the anxiety, depression, and comorbid group, respectively, p &lt; 0.01). Conclusions: The overall morbidities of depression and anxiety were relatively high. Psychiatric comorbidities were closely correlated with the negative outcomes after LSS. The psychological health of patients receiving LSS requires necessary attention to ensure pain control and prevent complications postoperatively.","PeriodicalId":16608,"journal":{"name":"Journal of Orthopaedic Surgery","volume":"65 1","pages":"10225536241280190"},"PeriodicalIF":1.6,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142247831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging evaluation of extraarticular posterior loose bodies in varus ankle osteoarthritis","authors":"Tae Hun Song, Jun Young Choi, Jin Soo Suh, Yu Min Suh, Kyung Ah Chun","doi":"10.1177/10225536241284507","DOIUrl":"https://doi.org/10.1177/10225536241284507","url":null,"abstract":"Purpose: Multiple loose bodies (LBs) are often found in patients with varus ankle osteoarthritis (OA). This study aimed to investigate the characteristics of extra-articular posterior ankle LBs in patients with varus ankle OA. We also sought to determine whether there were variations in the characteristics of LBs according to the degree of ankle OA. Methods: We retrospectively reviewed 50 patients who had appeared posterior extraarticular LBs on preoperative ankle imaging among the patients who underwent operative treatment for varus ankle OA from March 2011 to February 2023. We categorized the entire patient cohort into four groups according to the degree of ankle arthritis (Takakura stage II, IIIA, IIIB, and IV). Size, number, and location of LBs were evaluated using preoperative computed tomography and magnetic resonance imaging. Results: 142 LBs were identified (mean size: 11.5 mm); 76.8% were located within the flexor hallucis longus (FHL) tendon sheath, 20.4% in the posterior recess, and 2.8% in the flexor digitorum longus tendon sheath. Average LB size was significantly larger in Takakura stage IIIB and IV patients ( p &lt; .05), and the LB number was significantly lower in stage II patients ( p = .013). Conclusion: Extra-articular posterior LBs in varus ankle OA are predominantly located within the FHL tendon sheath and were larger in Takakura stages IIIB and IV patients.Level of Evidence: Level III. Retrospective comparative study.","PeriodicalId":16608,"journal":{"name":"Journal of Orthopaedic Surgery","volume":"39 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142247834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"China-made robot-assisted unicompartmental knee arthroplasty can enhance the precision of prosthesis placement and yield better short-term efficacy.","authors":"Rongxin Sun, Wusiman Yilihamujiang, Abulaiti Aierxiding, Gang Cheng, Zhoujun Zhu, Zhang Lei, Jian Gao, Guangjun Zhong, Maimaitiyiming Mieradili, Yeersheng Releken, Kan Jiang","doi":"10.1177/10225536241298040","DOIUrl":"10.1177/10225536241298040","url":null,"abstract":"<p><strong>Background: </strong>The purpose of this study was to assess whether China-made robot-assisted medial UKA can improve prosthesis placement accuracy and yield superior short-term outcomes compared with conventional UKA.</p><p><strong>Methods: </strong>50 patients who underwent initial medial UKA were included in this single-center, prospective, parallel, randomized, controlled trial. Preoperatively, patients were randomly categorized the robot-assisted UKA group and conventional UKA group. The operation time, intraoperative blood loss, postoperative pain scores (VAS scores at 24 h, 72 h, and 3 months post-surgery), KSS scores (clinical and functional scores), and knee range of motion (ROM) were compared between the two groups. The coronal deviation values of the femoral component, tibial component, and knee joint line height change were also compared between the two groups.</p><p><strong>Results: </strong>The deviations in tibial component coronal plane alignment, femoral component coronal plane alignment, and joint line height change were significantly smaller in the robot-assisted group compared to those in the conventional group (<i>p</i> < 0.05). The operation time of the robot-assisted group was longer than that of the conventional group (<i>p</i> < 0.05). At 24 h and 72 h postoperatively, patients in the robot-assisted group reported lower VAS scores compared to those in the conventional group (<i>p</i> < 0.05). No significant differences were observed between the two groups regarding intraoperative bloodloss, the VAS scores at 3 months postoperatively, the KSS scores (clinical scores and functional scores) at 3 months postoperatively, and the Knee range of motion at 3 months postoperatively.</p><p><strong>Conclusions: </strong>The China-made UKA robot can enhance the precision of prosthesis placement, yielding favorable short-term therapeutic outcomes.</p>","PeriodicalId":16608,"journal":{"name":"Journal of Orthopaedic Surgery","volume":"32 3","pages":"10225536241298040"},"PeriodicalIF":1.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Cemented and Cementless Fixation in Total Knee Arthroplasty: A Meta-Analysis and Systematic Review of RCTs.","authors":"Zirui Liu, Lei Wen, Libo Zhou, Zhongcheng Liu, Yi Chen, Bin Geng, Yayi Xia","doi":"10.1177/10225536241267270","DOIUrl":"10.1177/10225536241267270","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to compare infection, aseptic loosening, revision, operation time, function scores, and the radiographic radiolucent line (RLL) between cementless and cemented fixation in total knee arthroplasty (TKA).</p><p><strong>Methods: </strong>Articles reporting the outcomes of cemented and cementless TKA were searched in Medline, EMBASE, Web of Science, and the Cochrane Library. The search was conducted from articles published from January 1996 to May 2024. Odds Ratios (OR) and confidence intervals (CI) were used to measure the results. Cochrane Collaboration's Review Manager software was used to perform the meta-analysis.</p><p><strong>Results: </strong>Sixteen randomized controlled trials containing 2358 participants were included in this meta-analysis. Pooled data found that, in TKA, there were no significant differences between cemented fixation and cementless fixation for a prosthesis in infection, aseptic loosening and revision. The subgroup analysis and sensitivity analysis results of the knee society score (KSS) showed a significant difference favoring cementless fixation in a follow-up of less than 5 years (MD = -2.30, 95%CI -3.85 -0.74, <i>p</i> = .001) while favoring cemented fixation in a follow-up over 5 years (MD = 2.79, 95%CI 0.95 4.63, <i>p</i> = .003). The operation time of cementless was less than that of cemented (MD = 12.03, 95%CI 8.30 15.77, <i>p</i> < .00001). No significant difference was detected in knee society function score, Western Ontario and McMaster Universities osteoarthritis index, and RLL. There was no heterogeneity across studies (<i>p</i> > .1), and most studies have a low risk of bias.</p><p><strong>Conclusions: </strong>Within a follow-up period of less than 5 years, cementless TKA had better KSS, while over 5 years, KSS was better in cemented TKA, and cementless TKA required less operation time.</p>","PeriodicalId":16608,"journal":{"name":"Journal of Orthopaedic Surgery","volume":"32 3","pages":"10225536241267270"},"PeriodicalIF":1.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The status of acetabulum in bipolar HIP replacements in orthopaedics oncology cases.","authors":"Vivek Ajit Singh, Ooi Ying Jing, Rupini Devi Santharalinggam, Nor Faissal Yasin","doi":"10.1177/10225536241306917","DOIUrl":"https://doi.org/10.1177/10225536241306917","url":null,"abstract":"<p><p><b>Background:</b> Bipolar hip endoprosthesis replacement is a commonly employed procedure in orthopaedic oncology that requires the resection and reconstruction of the proximal femur. With improving survival rates, issues of implant durability and acetabular wear have become increasingly important. The decision to replace the acetabulum in bipolar hip endoprosthesis replacement procedures remains a topic of debate. <b>Aim:</b> This study aimed to assess the prevalence of secondary osteoarthritis following bipolar hip replacement, the need for revision to total joint replacement post-procedure, the functional status of patients in relation to radiological findings of joint degeneration, and the survivorship of bipolar hip replacements. <b>Methods:</b> Patients with orthopaedic oncology cases who underwent bipolar hip endoprosthesis replacement between 2006 and October 2021, with a minimum follow-up of six months, were included. Both clinical and radiological evaluations were carried out. The clinical evaluation utilised the Musculoskeletal Tumor Society (MSTS), Toronto Extremity Salvage Score (TESS), and modified Harris Hip Score (mHHS) systems. The radiological assessment focused on identifying acetabular erosion. <b>Results:</b> Forty eligible patients were identified. Radiological assessments revealed 21 patients (52.5%) with grade 0, 17 patients (42.5%) with grade 1, and 2 patients (5.0%) with grade 2 acetabular erosion. No patients exhibited grade 3 acetabular erosion. One patient (2.5%) required revision surgery from proximal femoral bipolar replacement to total hip replacement due to recurrent postoperative hip dislocation. There was no statistically significant difference in MSTS and mHHS scores but a significant difference in TESS scores. The ten-year implant survival rate was 77.8%, while the overall patient survivorship at ten years was 72.1%. <b>Conclusion:</b> Bipolar hip replacement is a durable limb-preserving reconstruction that can outlast patients' lifespans and is well-tolerated by oncology patients. The incidence of acetabular erosion and revision surgery is low. Despite radiological evidence of hip degeneration, functional status in patients is not significantly impacted.</p>","PeriodicalId":16608,"journal":{"name":"Journal of Orthopaedic Surgery","volume":"32 3","pages":"10225536241306917"},"PeriodicalIF":1.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does high body mass index affect short-term clinical and radiologic outcomes in robotic-assisted total knee arthroplasty?","authors":"MingYang Li, Han Zhang, HaoXiang Zhu, YongTao Zhang","doi":"10.1177/10225536241276158","DOIUrl":"https://doi.org/10.1177/10225536241276158","url":null,"abstract":"<p><strong>Background: </strong>The purpose of this study was to determine whether high BMI affect short-term clinical and radiologic outcomes of robotic-assisted total knee arthroplasty (TKA) by comparing the clinical outcomes, radiologic outcomes and complications between high BMI and normal patients.</p><p><strong>Methods: </strong>We retrospectively compared the short-term clinical and radiological outcomes of 424 knees (408 patients). The patients were divided into four groups: BMI < 24.9 kg/m² (normal); BMI between 25.0 and 29.9 kg/m² (overweight); BMI between 30.0 and 34.9 kg/m² (obese class I) and BMI between 35.0 and 39.9 kg/m² (obese class II). Clinical and radiologic outcomes were evaluated.</p><p><strong>Results: </strong>There was no significant difference in radiologic outcomes between those groups (<i>p</i> > .05). Furthermore, there was no significant difference in operation time, drainage volume, fall in hemoglobin, post-operative CRP and complications, including periprosthetic fracture and periprosthetic joint infection (PJI), between those groups.</p><p><strong>Conclusion: </strong>High BMI does not affect short-term clinical and radiologic outcomes in robot-assisted TKA.</p>","PeriodicalId":16608,"journal":{"name":"Journal of Orthopaedic Surgery","volume":"32 3","pages":"10225536241276158"},"PeriodicalIF":1.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142468047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative abaloparatide plus zoledronate treatment accelerates femoral bone healing in rats following osteotomy.","authors":"Takashi Kataoka, Yuta Tsubouchi, Ryota Takase, Takefumi Otsu, Tatsuya Iwasaki, Masashi Kataoka, Nobuhiro Kaku","doi":"10.1177/10225536241293486","DOIUrl":"https://doi.org/10.1177/10225536241293486","url":null,"abstract":"<p><p><b>Purpose:</b> We investigated the potential efficacy of abaloparatide (Abalo) and zoledronate (ZA) combination therapy for accelerating femoral union in a rat osteotomy model. <b>Methods:</b> Nine-week-old male Sprague-Dawley rats were randomly divided into four groups (<i>n</i> = 14 per group): control, abaloparatide (Abalo, 30 μg/kg via subcutaneous injection [s.c.] 5 times per week for 6 weeks), zoledronate (ZA; 0.1 mg/kg via s.c., single dose), and Abalo + ZA. Rats were then subjected to unilateral osteotomy of the femoral shaft, followed by osteosynthesis with intramedullary nailing to establish bone healing models. At 2 and 4 weeks after osteotomy, both femurs were removed from seven rats per group for soft X-ray imaging to evaluate bone union and microcomputed tomography (micro-CT) for bone morphometric evaluation. Blood samples were collected from all rats every 2 week starting 6 weeks pre- to 4 weeks postosteotomy. Toluidine blue staining was used for histopathological evaluation of the undecalcified specimens. <b>Results:</b> Soft X-ray imaging revealed accelerated callus formation, callus maturation, and fracture line closure in Abalo and Abalo + ZA groups compared to ZA and control groups. Micro-CT demonstrated greater cortical bone and trabecular bone to total volume ratios in contralateral (left) femurs of the Abalo + ZA group compared to the Abalo group. Both trabecular and cortical bone mineral densities were also greater in contralateral femurs of the Abalo + ZA group compared to Abalo and ZA groups. <b>Conclusion:</b> These findings suggest substantial additive or synergistic efficacy of abaloparatide plus zoledronate combination therapy for accelerating bone healing following osteotomy and for maintaining normal bone health.</p>","PeriodicalId":16608,"journal":{"name":"Journal of Orthopaedic Surgery","volume":"32 3","pages":"10225536241293486"},"PeriodicalIF":1.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142468048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}