Journal of oral rehabilitation最新文献

{"title":"Associations Between Wake-Time and Sleep-Time Masticatory Muscle Activity and Clinical Correlates in Free-Living Adults.","authors":"D Waller, F Firth, H Bennani, M Farella","doi":"10.1111/joor.70325","DOIUrl":"https://doi.org/10.1111/joor.70325","url":null,"abstract":"<p><strong>Aim: </strong>To investigate associations between wake-time and sleep-time masticatory muscle activity (MMA) in free-living adults with high levels of oral behaviours, and to examine associations with tooth wear, masticatory muscle pain, stress, and anxiety.</p><p><strong>Methods: </strong>In this observational repeated-measures study, 30 adults (mean age 31.4 ± 11.2 years) reporting clenching or grinding behaviours were recruited following screening with the Oral Behaviours Checklist. MMA was recorded during 77 sessions (2-3 sessions per participant) under free-living conditions using a wearable electromyography device, capturing wake-time and sleep-time activity. Tooth wear was assessed from intraoral scans and photographs using a standardised index. Stress and anxiety were assessed using validated questionnaires, muscle tenderness by standardised palpation, and pain on awakening by self-report. Associations were analysed using correlation and multivariable models accounting for repeated measures and covariates.</p><p><strong>Results: </strong>Moderate associations were observed between sleep time and wake time MMA for episode frequency, duty time, and rhythmic masticatory muscle activity (RMMA%), and remained significant after adjustment for confounders. Tooth wear showed limited association with MMA after accounting for age and sex, whereas higher sleep-time RMMA was associated with muscle pain on awakening. MMA measures were not associated with perceived stress, anxiety, or oral behaviours.</p><p><strong>Conclusions: </strong>Sleep-time and wake-time masticatory muscle activity showed partial within-individual coupling in free-living adults, suggesting that some quantitative features of MMA may be shared across behavioural states. Tooth wear and self-reported behaviours may not reflect current MMA, whereas pain on awakening may be more informative. Integrating objective MMA assessment across behavioural states may improve clinical evaluation of bruxism and related conditions.</p>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149069805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Among Eating Speed, Dietary Diversity, and Fat-Free Mass Index in Adults.","authors":"Takatoshi Hiroshimaya, Komei Iwai, Marika Marutani, Tetsuji Azuma, Takatoshi Yonenaga, Koichiro Tabata, Kazutoshi Watanabe, Michiya Ohno, Mitsuru Seishima, Takaaki Tomofuji, Naofumi Tamaki","doi":"10.1111/joor.70312","DOIUrl":"https://doi.org/10.1111/joor.70312","url":null,"abstract":"<p><strong>Objective: </strong>Dietary diversity and eating behaviour are recognised as factors influencing body composition; however, their association with fat-free mass index and body fat mass index remains unclear.</p><p><strong>Methods: </strong>This cross-sectional study analysed the relationships among body composition indices (BMI, FFMI, BFMI), self-reported eating speed, and dietary diversity in 10 644 healthy adults aged 18-64 years (4419 women and 6225 men; mean age 41.9 years) who visited hospitals for health checkups.</p><p><strong>Results: </strong>The dietary variety score showed a positive association with muscle mass in men and a significant negative association with body fat mass index in women (fat-free mass index: β = 0.03, 95% confidence interval: 0.01 to 0.05, p = 0.04; body fat mass index: β = -0.07, 95% confidence interval: -0.15 to -0.01, p < 0.01). Regarding eating speed, a consistent trend was observed in both sexes: the fast-eating group showed significantly higher body mass index, fat-free mass index, and body fat mass index values (p < 0.01), whereas the slow-eating group had lower values.</p><p><strong>Conclusions: </strong>These associations were more pronounced in men than in women. Both dietary diversity and eating speed were associated with body composition indices, with notable sex-related differences. These findings suggest that dietary behaviour and diversity may influence body composition.</p>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149069768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Intrinsic Capacity and Edentulism in Middle-Aged and Older Adults: A Longitudinal Cohort Study From CHARLS.","authors":"Shihan Wang, Zhangui Tang, Ming Li, Yuan Wang, Yang Liu, Mingyan Bao","doi":"10.1111/joor.70319","DOIUrl":"https://doi.org/10.1111/joor.70319","url":null,"abstract":"<p><strong>Background: </strong>Intrinsic capacity (IC) serves as a fundamental concept for assessing an individual's comprehensive functional status. This study utilized data from the China Health and Retirement Longitudinal Study (CHARLS) to investigate the association between IC and edentulism among middle-aged and older adults.</p><p><strong>Methods: </strong>Data were sourced from four waves (wave 2011, wave 2013, wave 2015, and wave 2018) of national surveys within CHARLS conducted between 2011 and 2018, culminating in the inclusion of 9110 participants aged 45 and older. IC was evaluated across five domains: cognition, locomotion, vitality, sensory function, and psychological capacity. Each domain was scored as preserved (1 point) or impaired (0 points), resulting in a total score ranging from 0 to 6, with higher scores reflecting better overall functional capacity. Edentulism was ascertained via self-report, with participants responding 'yes' to the question, 'Have you lost all your teeth?' Cox proportional hazards regression was employed to analyse the relationship between IC and edentulism. Additionally, restricted cubic splines (RCS) were used to explore potential non-linear associations. Subgroup analyses were conducted to evaluate interaction effects within different populations. An XGBoost model was utilized to identify key predictive variables and develop a nomogram for predicting the risk of edentulism.</p><p><strong>Results: </strong>After adjusting for multiple confounding factors, higher IC (6 points) was found to be significantly associated with a lower risk of edentulism compared to participants in the lowest IC category (scores 0-1) (HR = 0.609, 95% CI: 0.403-0.919, p = 0.018). When IC was dichotomized using a cut-off of > 5 points (intact vs. impaired), this association remained significant (HR = 0.876, 95% CI: 0.771-0.995, p = 0.041). RCS analysis further indicated a negative linear correlation between IC scores and the prevalence of edentulism. Subgroup analyses revealed no significant interactions for any examined covariates (all interaction p > 0.05). The nomogram developed from age, education level, sleep duration, IC, and residential area exhibited strong predictive capability.</p><p><strong>Conclusion: </strong>Higher IC is associated with a reduced risk of edentulism in middle-aged and older adults. The nomogram created based on key predictors offers a valuable tool for predicting the risk of edentulism.</p>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149039448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Autologous Conditioned Serum and Platelet-Rich Plasma Following Arthrocentesis in Temporomandibular Joint Osteoarthritis: A Randomized Clinical Trial.","authors":"Rojdan Ferman Güneş Uysal, Ibrahim Uysal","doi":"10.1111/joor.70314","DOIUrl":"https://doi.org/10.1111/joor.70314","url":null,"abstract":"<p><strong>Background: </strong>Temporomandibular joint osteoarthritis (TMJ-OA) is a degenerative condition that negatively affects quality of life. Although platelet-rich plasma (PRP) is widely used, its efficacy remains controversial. Autologous conditioned serum (ACS), which targets inflammation via interleukin-1 receptor antagonist (IL-1Ra), has emerged as a novel biological therapy.</p><p><strong>Objective: </strong>To compare the effects of two autologous biological agents, PRP and ACS, used as adjuncts to arthrocentesis, on pain, maximum mouth opening (MMO) and joint sounds in patients with TMJ-OA.</p><p><strong>Methods: </strong>This randomized, single-centre clinical trial with blinded outcome assessment and statistical analysis included 75 patients with TMJ-OA. Participants were allocated to three groups: ACS, PRP and control (n = 25 each). All patients underwent arthrocentesis; the ACS and PRP groups received 1 mL intra-articular injections, while the control group received no additional treatment. Outcomes were assessed at baseline, 1 week, 1 month, 3 months and 6 months by a blinded assessor. Pain was evaluated using a visual analogue scale (VAS), MMO was measured in millimetres and joint sounds were clinically assessed.</p><p><strong>Results: </strong>Baseline characteristics were comparable among the groups. From the first week onward, significant differences in VAS and MMO were observed at all follow-up time points (p < 0.001). Both ACS and PRP groups demonstrated greater improvement compared to the control group. However, no consistent statistically significant differences were observed between the two treatment groups. Joint sounds decreased significantly in both treatment groups, particularly at later follow-up periods.</p><p><strong>Conclusion: </strong>Both ACS and PRP following arthrocentesis improved clinical outcomes in TMJ-OA, with no consistent superiority between treatments.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov: NCT06839326.</p>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149039487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Clenching Intensity and Duration on Pressure Pain Threshold and Masseter-Muscle Stiffness Under Standardised EMG-Based Contraction Exposure.","authors":"Keisuke Miyazono, Hiroyuki Ishiyama, Akira Nishiyama, Kenji Fueki","doi":"10.1111/joor.70317","DOIUrl":"https://doi.org/10.1111/joor.70317","url":null,"abstract":"<p><strong>Background: </strong>Low-intensity, long-duration clenching is considered more harmful to the stomatognathic system than high-intensity, short-duration clenching; however, their physiological effects under standardised EMG-based contraction exposure remain unclear.</p><p><strong>Objective: </strong>To compare the effects of low-intensity, long-duration (LL) and high-intensity, short-duration (HS) clenching on pressure pain threshold (PPT) and masseter muscle stiffness under standardised EMG-based contraction exposure.</p><p><strong>Methods: </strong>Thirty-six participants completed a randomised crossover study. They performed Task LL (10% maximum voluntary contraction [MVC] for 75 s) and Task HS (50% MVC for 15 s) on separate days, with a washout period of ≥ 7 days. Each task comprised 30 sets with 15-s rests, and equivalent prescribed contraction exposure (intensity × duration × sets). PPT and muscle stiffness were assessed at baseline and 0, 10, 20 and 30 min post-task. Data were analysed using mixed-effects models with Bonferroni-adjusted post hoc comparisons and baseline-adjusted ANCOVA; p < 0.05 was considered significant.</p><p><strong>Results: </strong>All participants (mean age 29.0 ± 6.6 years; 50% female) completed the study. PPT immediately after LL was significantly lower than after HS (baseline-adjusted mean difference, -11.5 kPa; p = 0.026). Muscle stiffness showed a significant time effect only after HS (p < 0.001). Immediately after HS, muscle stiffness was lower than baseline (mean difference, -22.4 N/m; p < 0.001) and lower than after LL (baseline-adjusted mean difference, -20.0 N/m; p < 0.001).</p><p><strong>Conclusion: </strong>Under equivalent prescribed EMG-based contraction exposure, PPT was lower after LL than after HS, whereas HS caused transient reductions in muscle stiffness, indicating pattern-dependent responses.</p>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149039527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Anterior Repositioning Splint on Temporomandibular Joint Positional and Morphological Parameters and Facial Symmetry in Patients With Temporomandibular Disorders and Functional Mandibular Deviation: A Prospective Study.","authors":"Juan Wang, Wenhao Weng, Tao Wang, Yuhan Ren, Yifei Xu, Yang Wang, Ruibo Zhu, Jianglin Zhou, Wuci Yi, Menghong Li, Kun Qi","doi":"10.1111/joor.70308","DOIUrl":"https://doi.org/10.1111/joor.70308","url":null,"abstract":"<p><strong>Background: </strong>Anterior repositioning splint (ARS) alleviates temporomandibular disorders (TMD) by sagittal correction of jaw via cusp-to-fossa relation, which can also correct transverse positional deficiency. Therefore, ARS may have therapeutic effects on mandibular deviation (MD) related TMD.</p><p><strong>Objectives: </strong>To investigate the temporomandibular joint (TMJ) positional and morphological parameters and facial symmetry in patients with MD and evaluate the therapeutic effects of ARS treatment on these parameters in patients with TMD and functional MD.</p><p><strong>Methods: </strong>CBCT, MRI, and 3D facial images of patients with or without MD were compared in the case-control study. Effects of ARS treatment were evaluated and compared at pre-treatment (T0), the therapeutic occlusal position (T1) and post-treatment (T2) in the prospective study.</p><p><strong>Results: </strong>Forty patients (20 MD, 20 control) were recruited for the case-control study. Bilateral condylar height of the MD group was smaller than that of the control group, with the deviated side smaller than the contralateral side. Condylion Y-axis and X-axis of the deviated side were larger than those of the contralateral side. Disc-condyle angle and internal distance of the disc of the contralateral side were larger than those of the control group. 18 patients (15.40 ± 4.30 years) were included in the prospective study. Y coordinate of the condyle and disc-condyle angle reduced in T1 compared to T0. External distance of the disc of both sides and Condylion Z-axis and Y coordinate of the condyle of the contralateral side decreased in T2 compared to T0.</p><p><strong>Conclusion: </strong>Mandibular deviation is accompanied by asymmetry in TMJ and facial soft tissues. ARS treatment might contribute to improving TMJ positional symmetry, implying its potential therapeutic value for patients with TMD and functional mandibular deviation.</p>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149025211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex and Psychosocial Correlates of TMD-Related Pain: A Cross-Sectional Study.","authors":"Liangqiuyue Zhong, Chunshen Li, Yunshan Zhao, Yan Liu, Yi Li, Xi Chen","doi":"10.1111/joor.70313","DOIUrl":"https://doi.org/10.1111/joor.70313","url":null,"abstract":"<p><strong>Background: </strong>Previous studies have linked sex, stress, anxiety and depression to temporomandibular disorders (TMD) and orofacial pain, yet their independent associations with pain remain poorly defined.</p><p><strong>Objective: </strong>To explore associations of TMD pain with sex, life stress, anxiety, depression and oral mucosal pain and identify independent psychosocial correlates.</p><p><strong>Methods: </strong>This cross-sectional study enrolled 179 participants. Data on demographics, TMD-related pain, oral mucosal pain, 6-month stressful life events, Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS) scores were collected. TMD-related pain was defined as pain score > 0. Spearman correlation, intergroup comparison, stratified stress analysis and multivariate logistic regression were performed.</p><p><strong>Results: </strong>Overall, 46.9% had TMD-related pain and 31.3% had oral mucosal pain. Females showed a higher prevalence of TMD-related pain. TMD-related pain severity was positively correlated with stress, SAS, SDS and oral mucosal pain. TMD-related pain prevalence increased progressively across stress levels, and each higher stress category was associated with increased odds of TMD-related pain. In the fully adjusted model, female sex and anxiety remained independently associated with TMD-related pain, whereas stress and depression were no longer independently associated.</p><p><strong>Conclusion: </strong>The associations of sex and psychosocial factors with TMD-related pain observed in this study are consistent with previous evidence. After simultaneous adjustment, anxiety was the only psychological dimension that remained independently associated with TMD-related pain, while stress burden showed a graded association with pain likelihood. These findings are compatible with a biopsychosocial approach to TMD assessment and highlight the potential value of incorporating psychosocial evaluation into routine clinical assessment.</p>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149030826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dental Implants in Adults With Intellectual Disabilities: A Multicenter Retrospective Study. Part 2: Prosthesis Outcomes.","authors":"Javier Fernández-Feijoo, Manuel Bratos-Bobo, Manuel Bratos-Morillo, Denise Faulks, Marie-Sophie Bogner, Melanie Derchu, Caroline Eschevins, Emmanuel Nicolas, Pierre Yves Cousson, Chantal Auduc, Yoo Soo-Yeon, Pedro Diz-Dios, Pablo Gasamáns-García, Jacobo Limeres-Posse, P Paolo Appendino, Simone Buttiglieri, F Francesco Della Ferrera, Roberto Rozza, Fabio Brusamolino, Márcio Diniz-Freitas","doi":"10.1111/joor.70315","DOIUrl":"https://doi.org/10.1111/joor.70315","url":null,"abstract":"<p><strong>Background: </strong>Adults with intellectual disabilities often experience tooth loss and face barriers to accessing implant-supported rehabilitation.</p><p><strong>Objective: </strong>To evaluate implant-supported prosthesis outcomes in adults with non-syndromic intellectual disabilities and to identify variables associated with prosthetic success.</p><p><strong>Methods: </strong>A total of 247 implant-supported prostheses placed in 137 patients from 7 dental centers in Spain, France, Italy, and South Korea were analysed. Patient characteristics, oral health, implant features, and prosthesis-related variables were collected. Prosthetic outcomes were categorized as \"undamaged and successful\", \"damaged but successful\", \"loss\", or \"undamaged but unsuccessful\". Success was assessed using an adapted United States Public Health Service (USPHS) clinical rating system.</p><p><strong>Results: </strong>At a mean follow-up of 68.1 months, 94.3% of prostheses were considered successful. Cumulative survival rates were 97% at 5 years, 88% at 10 years, and 85% at 15 years. The most common technical complications were screw loosening (10.4%) and chipping (10%). Fixed prostheses predominated (92.3%), with 65.3% crowns and 34.6% bridges. Screw retention was most common (84.2%), and 94.3% followed a conventional loading protocol. General anaesthesia was used in nearly half of the cases during the impression step, although most framework and delivery procedures were performed without sedation. Among the multinomial mixed-effects models, implant design was significantly associated with the outcome category \"damaged but successful\", whereas age at first implant surgery was significantly associated with the outcome category \"loss\" (OR = 0.93 per additional year; 95% CI: 0.87-0.99; p = 0.031). However, the model showed no overall discriminatory ability (AUC-ROC = 0.500), and these associations should therefore be considered exploratory rather than clinically predictive. Random-effects binomial models showed improved discrimination (AUC-ROC = 0.754), although no statistically significant associations were identified.</p><p><strong>Conclusion: </strong>Implant-supported prosthetic rehabilitation is a viable and successful long-term treatment option for adults with non-syndromic intellectual disabilities, achieving outcomes comparable to those in the general population.</p>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149025180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Clonidine-Associated α-Adrenergic Hypothesis in Sleep Bruxism Pharmacotherapy: An Evidence-Anchored Target Analysis.","authors":"Deshui Li, Shanliang Sun, Hui Chen, Xiaojia Ci, Jiayi Luo, Fulan Wei","doi":"10.1111/joor.70316","DOIUrl":"https://doi.org/10.1111/joor.70316","url":null,"abstract":"<p><strong>Background: </strong>Sleep bruxism (SB) is a centrally regulated, arousal-related motor behaviour, but no pharmacotherapy has demonstrated reliable clinical efficacy. This study aimed to identify pathway-level signals most consistently supported by current polysomnography (PSG)-based pharmacotherapy evidence for SB.</p><p><strong>Methods: </strong>We performed an evidence-anchored bioinformatic analysis of six drugs evaluated in randomized or controlled. Drugs were classified as effective or not-supported according to prespecified clinical efficacy criteria. Human pharmacodynamic targets were curated from GtoPdb and DrugBank, with precursor-derived metabolite targets excluded. Target convergence and Effective-versus-Not-supported contrasts were assessed using enrichment analyses with sensitivity testing across drug classification, enrichment background and retention thresholds.</p><p><strong>Results: </strong>Thirty-one curated pharmacodynamic targets converged on monoaminergic and GABA-A receptor systems, including adrenergic, dopaminergic, serotonergic and GABA-A receptor signalling. The Effective-versus-Not-supported contrast retained 14 Effective-side terms, all driven by α-adrenergic receptors (ADRA1A/1B/1D and ADRA2A/2B/2C). Dopamine-receptor enrichment was present in the broader target profile but was not retained in the efficacy contrast. Precursor-aware curation further showed that levodopa contributed to GPR143 rather than direct dopamine-receptor targets.</p><p><strong>Conclusions: </strong>This efficacy-anchored analysis generated a clonidine-associated α-adrenergic, arousal-related pharmacological signal within the limited available evidence. The findings are more consistent with a central arousal-related hypothesis for SB pharmacotherapy than with a single motor-target or dopamine-driven treatment model, but require confirmation in contemporary PSG-based clinical studies and real-world patient populations.</p>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149025273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Bite Force Measurements Using Sensor-Based Systems: A Feasibility Study.","authors":"Chahak Seth-Johansen, Carsten Thomsen, Merete Bakke, Klaus Gotfredsen","doi":"10.1111/joor.70320","DOIUrl":"https://doi.org/10.1111/joor.70320","url":null,"abstract":"<p><strong>Background: </strong>Digital occlusal analysis systems are increasingly used to assess bite force. However, these systems have not been adequately evaluated.</p><p><strong>Objectives: </strong>The purpose of this clinical study was to evaluate bite force recordings obtained with a digital bite force device (Innobyte), a digital occlusal analysis system (T-Scan) and a miniature, strain gauge, bite force sensor to assess absolute and relative bite force distribution.</p><p><strong>Methods: </strong>Twenty-three healthy adults participated. Dental status, functional units, Diagnostic Criteria for Temporomandibular Disorders (DC/TMD), Jaw Functional Limitation Scale (JFLS-20) and Oral Behavior Checklist (OBC) were recorded. Bite force was investigated with Innobyte, T-Scan and a miniature bite force device. Absolute bite force was measured with Innobyte and the miniature bite force sensor and their association was analysed using Pearson correlation. Relative bite force was assessed for all three devices, and the agreement was evaluated using Bland-Altman analysis.</p><p><strong>Results: </strong>Absolute bite force recorded by Innobyte correlated significantly with the miniature bite force sensor (r = 0.73, R² = 0.53, p < 0.001). Participants with < 10 functional units exhibited markedly reduced bite force values with both devices. Regarding relative bite force, Innobyte and miniature bite force device demonstrated high correlation and agreement in relative occlusal force distribution, whereas lower agreement was observed in comparisons involving T-Scan.</p><p><strong>Conclusions: </strong>Innobyte and the miniature bite force sensor demonstrated high correlation and agreement in bite force measurements, whereas T-Scan showed greater variability in relative occlusal force distribution. Device-specific differences should be considered when interpreting digital occlusal force measurements in clinical practice.</p>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149025196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}