Journal of Ophthalmic Inflammation and Infection最新文献

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The prevalence and potential associations of anti-drug antibodies against adalimumab in patients with non-infectious uveitis: a cross-sectional study. 非感染性葡萄膜炎患者抗阿达木单抗的患病率和潜在关联:一项横断面研究
IF 2
Journal of Ophthalmic Inflammation and Infection Pub Date : 2025-12-25 DOI: 10.1186/s12348-025-00567-6
Ashwin Madhavan, Sophie L Rogers, Julian J Bosco, Laura Ross, Priya D Samalia, Anthony J Hall, Lyndell L Lim
{"title":"The prevalence and potential associations of anti-drug antibodies against adalimumab in patients with non-infectious uveitis: a cross-sectional study.","authors":"Ashwin Madhavan, Sophie L Rogers, Julian J Bosco, Laura Ross, Priya D Samalia, Anthony J Hall, Lyndell L Lim","doi":"10.1186/s12348-025-00567-6","DOIUrl":"10.1186/s12348-025-00567-6","url":null,"abstract":"<p><p>BACKGROUND: Adalimumab is effective in treating non-infectious uveitis (NIU), but some patients develop anti-drug antibodies against adalimumab (ADA-A), which can reduce its effectiveness, resulting in active inflammation and vision loss. We sought to determine the prevalence of ADA-A in adults receiving adalimumab for NIU, and investigate factors associated with the presence of ADA-A. BODY: In this cross-sectional study, eighty-one (46 female) consecutive adult patients receiving adalimumab for NIU at The Royal Victorian Eye and Ear Hospital, and Eye Surgery Associates in Melbourne, Australia were recruited from March 2023 to February 2024 inclusive. The median age of patients was 45 years (range 18, 87) with median disease duration of 5.3 years (range 0.4, 25.3), and median duration of adalimumab therapy of 2.3 years (range 0.2, 13.1). Panuveitis (N = 27, 33%) was the commonest anatomical form of uveitis treated, and most patients had bilateral uveitis (N = 73, 90%). The most common diagnoses were presumed idiopathic uveitis (N = 27, 33%) and sarcoidosis (N = 13, 16%). Most patients (N = 50, 62%) were concurrently treated with conventional immunosuppression, most commonly using methotrexate (N = 32, 40%). ADA-A were present in 5/81 patients (6.2%, 95%CI 2.7, 13.6), and their presence was associated with higher Body Mass Index [median 34.9 kg/m2 (IQR 32.5, 38.0) vs. 28.4 kg/m2 (IQR 24.4, 31.9), p = 0.010], higher C-reactive protein [median 7.4 mg/L (IQR 5.5, 7.9) vs. 2.0 mg/L (IQR 0.0, 6.0), p = 0.030], lower patient-reported health [median 5/10 (IQR 5, 6) vs. 8/10 (IQR 6, 8), p = 0.024], and lower serum adalimumab levels [median 0.0 µg/mL (IQR 0.0, 0.0) vs. 5.0 µg/mL (IQR 2.8, 7.8), p = 0.002]. There was no association between ADA-A and the duration of adalimumab therapy, use of concurrent conventional immunosuppression, presence of systemic inflammatory disease, uveitis activity, visual acuity or adverse effects to adalimumab. CONCLUSION: ADA-A were uncommon, and their presence may be associated with obesity, increased C-reactive protein, and poorer patient-reported health. Within the limitations of our statistical power, the presence of ADA-A was not associated with systemic inflammatory disease, uveitis activity, nor adalimumab monotherapy. </p>","PeriodicalId":16600,"journal":{"name":"Journal of Ophthalmic Inflammation and Infection","volume":" ","pages":"6"},"PeriodicalIF":2.0,"publicationDate":"2025-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12847475/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145827927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bilateral acute intermediate uveitis following intrauterine Chitosan tamponade: a case series. 宫内壳聚糖填塞后双侧急性中间葡萄膜炎一例。
IF 2
Journal of Ophthalmic Inflammation and Infection Pub Date : 2025-12-24 DOI: 10.1186/s12348-025-00548-9
David Beckers, Uwe Pleyer, Lena Beckers, Holger Maul, Mascha Lüder, Ulrich Schaudig, Birthe Stemplewitz
{"title":"Bilateral acute intermediate uveitis following intrauterine Chitosan tamponade: a case series.","authors":"David Beckers, Uwe Pleyer, Lena Beckers, Holger Maul, Mascha Lüder, Ulrich Schaudig, Birthe Stemplewitz","doi":"10.1186/s12348-025-00548-9","DOIUrl":"10.1186/s12348-025-00548-9","url":null,"abstract":"<p><p>BACKGROUND: Postpartum hemorrhage is a leading cause of maternal morbidity and mortality, with intrauterine tamponade techniques increasingly employed in its management. Chitosan-based products, such as Celox®, have been introduced for their hemostatic properties. However, their potential systemic effects remain insufficiently understood. This case series describes six patients who developed acute bilateral intermediate uveitis shortly after receiving intrauterine Chitosan tamponade during obstetric care. MAIN BODY: A retrospective review was conducted on six postpartum patients who developed acute bilateral intraocular inflammation following the use of intrauterine Chitosan tamponade. Clinical data, laboratory findings, and ophthalmological assessments were analyzed. All six women presented with bilateral anterior and posterior segment inflammation within 48 to 72 h after tamponade placement. Common ocular findings included limbal corneal infiltrates, anterior chamber cells, vitritis, and decreased visual acuity. Three patients also experienced non-ocular symptoms, including perichondritis and auditory disturbances. Comprehensive evaluations, including infectious and autoimmune workups, were unremarkable in all cases. None of the patients had a prior history of uveitis or known systemic inflammatory conditions. Prompt initiation of topical and systemic corticosteroids led to the resolution of inflammation and recovery of visual function in all individuals. The uniform timing, bilateral occurrence of inflammation, and lack of alternative explanations indicate a possible association with the use of the Chitosan-based tamponade. The underlying mechanism remains uncertain, but an immunologic or toxic reaction is suspected. CONCLUSION: This case series highlights a possible association between intrauterine Chitosan tamponade and the onset of bilateral intermediate uveitis in postpartum patients. Although causality cannot be definitely established, the temporal clustering and consistent clinical presentation warrant caution and further investigation into the systemic immunogenic potential of Chitosan-based products. </p>","PeriodicalId":16600,"journal":{"name":"Journal of Ophthalmic Inflammation and Infection","volume":" ","pages":"5"},"PeriodicalIF":2.0,"publicationDate":"2025-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12847582/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145827944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intriguing choroidal lesions in Birdshot chorioretinopathy: a diagnostic and clinical dilemma. 鸟射型脉络膜视网膜病变中有趣的脉络膜病变:诊断和临床困境。
IF 2.3
Journal of Ophthalmic Inflammation and Infection Pub Date : 2025-12-22 DOI: 10.1186/s12348-025-00557-8
Yann Bertolani, Tetiana Goncharova, Eric Kirkegaard-Biosca, Laura Distefano
{"title":"Intriguing choroidal lesions in Birdshot chorioretinopathy: a diagnostic and clinical dilemma.","authors":"Yann Bertolani, Tetiana Goncharova, Eric Kirkegaard-Biosca, Laura Distefano","doi":"10.1186/s12348-025-00557-8","DOIUrl":"10.1186/s12348-025-00557-8","url":null,"abstract":"<p><strong>Purpose: </strong>To report a case of intriguing choroidal lesions in a patient with Birdshot chorioretinopathy.</p><p><strong>Case presentation: </strong>A case report of a 51-year-old female with previous medical history of Birdshot chorioretinopathy presenting with de novo choroidal lesions, diffuse choroidal thickening and serous retinal detachment in the right eye is presented. Several medical evaluation visits were conducted, including ophthalmological and hematological follow-up. The multimodal imaging was suggestive of a lymphoproliferative process, presumably uveal lymphoid hyperplasia and the patient was referred to Hematology. A systemic work-up was conducted to rule out systemic malignancy and the choroidal biopsy was declined by the patient. The patient was treated with a short course of steroids due to an unrelated Bell's palsy, with complete resolution of the choroidal thickening and the neurosensory detachment. After a 4-year follow-up, the patient remained asymptomatic with no signs of relapse in the multimodal imaging.</p><p><strong>Conclusion: </strong>As underline by this case report, uveal lymphoid hyperplasia may be considered in patients with Birdshot chorioretinopathy, emphasizing the importance of individualized management and long-term follow-up in such complex clinical scenarios.</p>","PeriodicalId":16600,"journal":{"name":"Journal of Ophthalmic Inflammation and Infection","volume":"15 1","pages":"94"},"PeriodicalIF":2.3,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12722620/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145805005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Etiologies of intermediate uveitis in a tertiary center: an age-oriented medical assessment? 三级中心中级葡萄膜炎的病因:以年龄为导向的医学评估?
IF 2
Journal of Ophthalmic Inflammation and Infection Pub Date : 2025-12-13 DOI: 10.1186/s12348-025-00563-w
P Mansuy, T El-Jammal, R Jacquot, T Mathis, L Kodjikian, Pascal Sève
{"title":"Etiologies of intermediate uveitis in a tertiary center: an age-oriented medical assessment?","authors":"P Mansuy, T El-Jammal, R Jacquot, T Mathis, L Kodjikian, Pascal Sève","doi":"10.1186/s12348-025-00563-w","DOIUrl":"10.1186/s12348-025-00563-w","url":null,"abstract":"<p><p>PURPOSE: To analyze the distribution of intermediate uveitis (IU) etiologies by age in order to guide the diagnostic approach. METHODS: We conducted a monocentric retrospective study of 126 adult patients referred to an internal medicine department at a tertiary center with a diagnosis of intermediate uveitis of unknown cause between July 2002 and April 2023. RESULTS: Among the 126 patients, most were women (n = 77; 61%), with a median age of 49 [33;62] years; 113 (90%) were Caucasian. Idiopathic IU was the most common etiology across all age groups. In patients under 30 years old (n = 20), idiopathic IU was observed in 10 cases (50%), followed by pars planitis in 7 cases (35%) and multiple sclerosis in 2 cases (10%). In the 30–60-year group (n = 71), idiopathic IU remained the most frequent (n = 34, 48%), followed by sarcoidosis (n = 15, 21%) and lymphoma (n = 5, 7%). Other etiologies included pars planitis (n = 3), multiple sclerosis (n = 3), and infections (n = 2). After 60 years (n = 35), idiopathic IU was again the most prevalent (n = 22, 63%), followed by lymphoma (n = 6, 17%) and sarcoidosis (n = 5, 14%). Infectious diseases were observed in 2 cases. CONCLUSIONS: The etiologic distribution of IU varies with age. Before 30, idiopathic IU, pars planitis, and multiple sclerosis are the most common etiologies. After 30, idiopathic IU, sarcoidosis, and lymphoma become more prevalent, with lymphoma appearing after 45. After 60, lymphoma is more common than sarcoidosis. These findings support the use of an age-stratified diagnostic approach in the evaluation of IU. </p>","PeriodicalId":16600,"journal":{"name":"Journal of Ophthalmic Inflammation and Infection","volume":" ","pages":"97"},"PeriodicalIF":2.0,"publicationDate":"2025-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12748337/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145751824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Primary tubercular osteomyelitis of lateral orbital wall: a rare presentation. 原发性眼眶外侧壁结核性骨髓炎:罕见的表现。
IF 2
Journal of Ophthalmic Inflammation and Infection Pub Date : 2025-12-11 DOI: 10.1186/s12348-025-00518-1
Vandana Sharma, Vikasdeep Gupta, Harmeet Kaur, Anuradha Raj
{"title":"Primary tubercular osteomyelitis of lateral orbital wall: a rare presentation.","authors":"Vandana Sharma, Vikasdeep Gupta, Harmeet Kaur, Anuradha Raj","doi":"10.1186/s12348-025-00518-1","DOIUrl":"10.1186/s12348-025-00518-1","url":null,"abstract":"<p><p>Osteomyelitis of facial bones is a very rare presentation. Primary presentation of tubercular osteomyelitis in facial bones is even rarer. We are reporting a case of zygomatic tubercular osteomyelitis presenting in a very innocuous way. Identification of such cases in early stage can help in timely intervention. A 30 years old female presented to Ophthalmology Out Patient Department (OPD) with complain of a mildly painful nodule over left lower eyelid, turning into an ulcer. After appropriate investigation, diagnosis of primary tubercular osteomyelitis of left zygomatic bone was made and patient underwent debridement and anti-tubercular treatment. Patient has healed satisfactorily, with no sinus formation, no residual bony on filtration and good cosmetic results. Early diagnosis and timely management of such cases can avoid extensive involvement of bone, thereby reducing the subsequent morbidity of the patients.</p>","PeriodicalId":16600,"journal":{"name":"Journal of Ophthalmic Inflammation and Infection","volume":" ","pages":"4"},"PeriodicalIF":2.0,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12804508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145723922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Implications of peripapillary retinal nerve fiber layer thickening by optical coherence tomography in children with pars planitis. 光学相干断层扫描对小儿足底炎乳头周围视网膜神经纤维增厚的意义。
IF 2
Journal of Ophthalmic Inflammation and Infection Pub Date : 2025-12-10 DOI: 10.1186/s12348-025-00564-9
Diala Abu Al-Halawa, Radgonde Amer
{"title":"Implications of peripapillary retinal nerve fiber layer thickening by optical coherence tomography in children with pars planitis.","authors":"Diala Abu Al-Halawa, Radgonde Amer","doi":"10.1186/s12348-025-00564-9","DOIUrl":"10.1186/s12348-025-00564-9","url":null,"abstract":"<p><p>PURPOSE: To assess retinal nerve fiber layer thickness by optical coherence tomography (OCT-RNFLT) in children with pars planitis and to examine its associations with visual acuity, binocular indirect ophthalmoscopy score (BIO), ocular signs and medical therapies. METHODS: This was a retrospective study. Demographic, clinical and imaging data were collected. RESULTS: Included were 29 children (50 eyes) with a mean age of 7.9 ± 2.9 years. Presenting OCT-RNFLT (28 eyes) was 209.6 ± 179 μm. Twenty-two eyes (78.6%) had OCT-RNFLT ≥ 130 μm and it was significantly associated with higher BIO score (2.02 ± 1.21 vs. 0.42 ± 0.80 in eyes with OCT-RNFLT < 130 μm), anterior uveitis, papillitis, conventional disease-modifying antirheumatic drugs and biologic therapy. Following the initiation of therapy, improvement in BIO score was observed promptly, preceding the improvement in OCT-RNFLT. In the univariate general linear model, BIO group classification demonstrated the strongest association with RNFLT (F = 16.69, p < 0.001). Papillitis was also significantly associated with higher RNFL values (F = 6.47, p = 0.015). Anterior uveitis did not show a significant association with RNFLT (F = 0.02, p = 0.883), suggesting that posterior segment findings could be more relevant indicators of RNFLT in this cohort. CONCLUSION: To date, this is the first longitudinal study that investigated OCT-RNFLT in pediatric pars planitis patients. OCT-RNFLT strongly correlated with disease severity and eyes with OCT-RNFLT ≥130 µm required at a higher rate the institution of intensive immunosuppressive regimen. The reduction in OCT-RNFLT with resolving inflammation highlights its potential role as a tool for monitoring therapeutic response over time. </p>","PeriodicalId":16600,"journal":{"name":"Journal of Ophthalmic Inflammation and Infection","volume":" ","pages":"3"},"PeriodicalIF":2.0,"publicationDate":"2025-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12804509/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145714763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
JAK inhibitors in autoimmune ocular inflammatory diseases - A systematic review of case reports and series. 自身免疫性眼部炎症疾病中的JAK抑制剂-病例报告和系列的系统综述
IF 2.3
Journal of Ophthalmic Inflammation and Infection Pub Date : 2025-12-10 DOI: 10.1186/s12348-025-00537-y
Salem Almerri, Hamad Alshatti, Yousef Taleb Ali, Raed Behbehani
{"title":"JAK inhibitors in autoimmune ocular inflammatory diseases - A systematic review of case reports and series.","authors":"Salem Almerri, Hamad Alshatti, Yousef Taleb Ali, Raed Behbehani","doi":"10.1186/s12348-025-00537-y","DOIUrl":"10.1186/s12348-025-00537-y","url":null,"abstract":"<p><strong>Background: </strong>Autoimmune inflammatory ocular diseases, including uveitis, scleritis, and ocular mucous membrane pemphigoid, can cause severe, vision-threatening complications and are often associated with systemic autoimmune conditions. Standard therapies involve corticosteroids, conventional disease-modifying antirheumatic drugs (cDMARDs), and biologics, yet some cases remain refractory. Janus kinase (JAK) inhibitors have emerged as a promising therapeutic option for such refractory cases and are increasingly being explored as potential primary or secondary line therapies.</p><p><strong>Main body: </strong>This systematic review synthesized evidence from case reports and case series describing the use of JAK inhibitors in non-infectious ocular inflammation. A comprehensive search of PubMed and MEDLINE (from inception to March 2025) identified 22 studies (12 case reports, 10 case series) involving 43 patients (64 eyes). Patients ranged from 13 to 85 years (mean = 41) with a female predominance (69.7%). Reported ocular conditions included scleritis (46.5%), uveitis (34.9%), ocular mucous membrane pemphigoid (7.0%), keratitis (4.7%), keratoconjunctivitis (4.7%), and non-specific orbital inflammation (2.3%). Most patients had failed prior therapies with corticosteroids, cDMARDs (80%), and biologics (51%) before initiating JAK inhibitors. Tofacitinib (62.8%) was the most frequently used agent. The median follow-up was approximately 2.5 months (range: 1-78 months). Complete remission was achieved in 69.7% of patients, while 27.9% experienced partial or marked improvement. More than half of the patients were able to taper or discontinue corticosteroids. No relapses were reported during follow-up. Reported adverse events were mild and included elevated transaminases, leukopenia, neutropenia, and herpes virus reactivation.</p><p><strong>Conclusion: </strong>JAK inhibitors demonstrate promising efficacy and an acceptable safety profile in refractory autoimmune ocular inflammatory diseases, enabling high rates of remission and reduced steroid dependence. These findings highlight their potential role in treatment algorithms and underscore the need for further prospective studies to define their long-term efficacy, safety, and optimal use.</p>","PeriodicalId":16600,"journal":{"name":"Journal of Ophthalmic Inflammation and Infection","volume":" ","pages":"93"},"PeriodicalIF":2.3,"publicationDate":"2025-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12701197/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145714688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-term outcomes of intravitreal 0.19 mg fluocinolone acetonide implant in uveitic macular edema after prior local corticosteroid treatments. 既往局部皮质类固醇治疗后,玻璃体内0.19 mg醋酸氟西诺酮植入治疗葡萄膜性黄斑水肿的远期疗效。
IF 2
Journal of Ophthalmic Inflammation and Infection Pub Date : 2025-12-08 DOI: 10.1186/s12348-025-00558-7
Ana Margarida Ferreira, Marta Inês Silva, Sónia Torres-Costa, Cláudia Oliveira-Ferreira, Ana Catarina Pedrosa, Luís Figueira, Joana Rodrigues Araújo
{"title":"Long-term outcomes of intravitreal 0.19 mg fluocinolone acetonide implant in uveitic macular edema after prior local corticosteroid treatments.","authors":"Ana Margarida Ferreira, Marta Inês Silva, Sónia Torres-Costa, Cláudia Oliveira-Ferreira, Ana Catarina Pedrosa, Luís Figueira, Joana Rodrigues Araújo","doi":"10.1186/s12348-025-00558-7","DOIUrl":"10.1186/s12348-025-00558-7","url":null,"abstract":"<p><p>BACKGROUND: This study evaluates the long-term efficacy and safety of intravitreal 0.19 mg fluocinolone acetonide implant (FAi) in non-infectious UME, comparing it with prior sub-Tenon’s triamcinolone acetonide (STTA) and/or intravitreal dexamethasone implant (DEXAi). METHODS: A retrospective review of patients with chronic non-infectious UME who received intravitreal FAi after STTA and/or DEXAi. RESULTS: Thirteen eyes from 7 patients (69.2% female) were included, with a mean age of 65 ± 11 years. The median follow-up was 54 months before FAi (IQR: 43–65) and 47 months after FAi (IQR: 23–60). All eyes received at least one STTA, and 11 eyes received at least one DEXAi before FAi. The median number of injections before FAi was 4 (range: 2–8). A significant reduction in recurrences per year was observed after FAi (4.62 ± 1.9 before vs. 0.31 ± 0.5 after, Wilcoxon test, p = 0.001). Macular edema relapsed in 4 eyes (30.8%) between months 28 and 36. Central retinal thickness significantly decreased after FAi (474 ± 96 μm before vs. 305 ± 58 μm after, Wilcoxon test, p = 0.002). Ten eyes (76.9%) showed BCVA improvement (1–4 lines), and none lost visual acuity. All eyes were pseudophakic prior to FAi. At FAi, four of seven patients were on systemic anti-inflammatory therapy; 3 discontinued it, and none started new treatment after FAi. Five eyes were on topical IOP-lowering medication at the time of FAi; 2 required and increase in treatment, and 2 later underwent trabeculectomy. After FAi, only two eyes started IOP-lowering medication. CONCLUSIONS: In this case series with long-term follow-up, FAi for non-infectious UME was effective, safe, and reduced recurrences compared to other local corticosteroids. </p>","PeriodicalId":16600,"journal":{"name":"Journal of Ophthalmic Inflammation and Infection","volume":"15 1","pages":"92"},"PeriodicalIF":2.0,"publicationDate":"2025-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12686286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145701147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multifocal necrotising scleritis post-MIVS in oligoarticular JIA : exploring plausible deniability. 少关节JIA中mivs后多灶性坏死性巩膜炎:探讨合理的否认。
IF 2
Journal of Ophthalmic Inflammation and Infection Pub Date : 2025-12-06 DOI: 10.1186/s12348-025-00562-x
Gaurav M Kohli, Luxmi Singh, Anam Masood, Pratik Shenoy, Digvijay Chaudhary
{"title":"Multifocal necrotising scleritis post-MIVS in oligoarticular JIA : exploring plausible deniability.","authors":"Gaurav M Kohli, Luxmi Singh, Anam Masood, Pratik Shenoy, Digvijay Chaudhary","doi":"10.1186/s12348-025-00562-x","DOIUrl":"10.1186/s12348-025-00562-x","url":null,"abstract":"<p><p>AIM: To report and discuss the clinical features and management strategies for paediatric surgically induced necrotizing scleritis (SINS) following microincision vitrectomy surgery (MIVS), in a patient with underlying seronegative oligoarticular juvenile idiopathic arthritis (JIA). METHODS: Case report and review of literature. RESULTS: A 10-year-old boy presented with multifocal areas of painless scleral necrosis following three-port 25-gauge pars plana vitrectomy. The area of scleral necrosis remained localized to the temporal sclerotomy sites, which were closed with 6 − 0 polyglactin sutures. There were no associated clinical signs of suppuration or discharge suggestive of an infectious etiology; the smear from the base of the scleral necrosis showed no microbial growth. Scleral melt remained progressive despite immunosuppressive therapy with intravenous methylprednisolone and cyclophosphamide. Systemically, the patient reported a recent onset of multiple joint pains without any visible joint swelling. The blood investigation returned negative for rheumatoid factor, ANA, and ANCA antibodies. Non-specific inflammatory markers (CRP) were significantly raised. The scleral necrosis stabilized following removal of the polyglactin suture. Scleral patch graft with conjunctivo-tenon flap helped to preserve the globe integrity. No recurrence or further necrosis was observed over twelve months of follow-up. CONCLUSION: This is the first report on the clinical presentation of paediatric SINS associated with JIA following MIVS. Prior surgeries, underlying autoimmunity and use of polyglactin suture could have precipitated SINS which was recalcitrant to conventional immunosuppressants. A combined medical and surgical approach was helpful to achieve disease remission. </p>","PeriodicalId":16600,"journal":{"name":"Journal of Ophthalmic Inflammation and Infection","volume":" ","pages":"1"},"PeriodicalIF":2.0,"publicationDate":"2025-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12796035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145696209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Retinal and choroidal detachment following corneal wasp sting: a case report and literature review. 纠正:角膜黄蜂蜇伤后视网膜和脉络膜脱离:1例报告和文献复习。
IF 2.3
Journal of Ophthalmic Inflammation and Infection Pub Date : 2025-11-28 DOI: 10.1186/s12348-025-00528-z
Shaofei Xue, Jiang Yao, Daniel Hillarion Scotland, Yuanyuan Qi
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