European Journal of Immunology最新文献_第2页

Beyond Negative Regulation: IL-1R8 and IL-1R2 as Novel Immune Checkpoints 超越负调控：IL-1R8和IL-1R2作为新的免疫检查点

IF 3.7 3区医学

European Journal of Immunology Pub Date : 2025-09-05 DOI: 10.1002/eji.70050

Domenico Supino, Roberto Garuti, Cecilia Garlanda

{"title":"Beyond Negative Regulation: IL-1R8 and IL-1R2 as Novel Immune Checkpoints","authors":"Domenico Supino, Roberto Garuti, Cecilia Garlanda","doi":"10.1002/eji.70050","DOIUrl":"https://doi.org/10.1002/eji.70050","url":null,"abstract":"IL-1 family members and their signaling receptors are key drivers of inflammation in sterile or infectious conditions, as well as polarization of the innate and adaptive immunity. Deregulated or excessive activation of the IL-1 system is associated with detrimental inflammatory reactions. Beside signaling receptors, IL-1-family receptors comprise decoy or negative regulatory receptors, which regulate cell activation mediated by IL-1 family ligands. IL-1-family negative regulatory receptors, which include IL-1R8 and IL-1R2, have peculiar structural features and functions essential to the self-regulation of the IL-1 system. IL-1R8 and IL-1R2 emerge as regulatory molecules whose function is context-dependent, spanning from negative regulation of inflammation in infections or conditions of sterile inflammation and cell damage, including cancer-related inflammation, to skewing of myeloid and lymphoid cells, modulation of anti-tumor immunity, and immune checkpoint activity. This review reports new insights into the physio-pathological roles of these two negative regulatory IL-1 family members, emphasizing their mechanisms of action and potential for innovative therapeutic interventions.","PeriodicalId":165,"journal":{"name":"European Journal of Immunology","volume":"55 9","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/eji.70050","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144990729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Cover Story: Eur. J. Immunol. 9'25 封面故事：欧元。[j] .免疫学杂志。9'25 .

IF 3.7 3区医学

European Journal of Immunology Pub Date : 2025-09-03 DOI: 10.1002/eji.70053

引用次数: 0

Bacterial Vaginosis-Associated Prevotella timonensis Enhances Dendritic Cell–T Cell Clustering and Subsequent T Cell Proliferation 细菌性阴道病相关的蒙古普氏菌增强树突状细胞- T细胞聚集和随后的T细胞增殖

IF 3.7 3区医学

European Journal of Immunology Pub Date : 2025-09-03 DOI: 10.1002/eji.70051

Marleen Y. van Smoorenburg, Julia L. Nerwinska, John L. van Hamme, Ester B. M. Remmerswaal, Celia Segui-Perez, Karin Strijbis, Teunis B. H. Geijtenbeek

{"title":"Bacterial Vaginosis-Associated Prevotella timonensis Enhances Dendritic Cell–T Cell Clustering and Subsequent T Cell Proliferation","authors":"Marleen Y. van Smoorenburg, Julia L. Nerwinska, John L. van Hamme, Ester B. M. Remmerswaal, Celia Segui-Perez, Karin Strijbis, Teunis B. H. Geijtenbeek","doi":"10.1002/eji.70051","DOIUrl":"https://doi.org/10.1002/eji.70051","url":null,"abstract":"Dysbiosis of the vaginal microbiome is associated with increased inflammation in the female genital tract. Microbiota associated with bacterial vaginosis (BV), such as Gardnerella vaginalis, Megasphaera elsdenii, and Prevotella timonensis, replace the health-associated bacterium Lactobacillus crispatus and cause inflammation affecting mucosal integrity and immunity. However, it remains unclear how these BV-associated bacteria modulate immune cells and enhance inflammation. Here, we investigated whether BV-associated bacteria directly affected dendritic cell (DC) function. Notably, P. timonensis but not M. elsdenii induced cell–cell clustering between monocytic cell lines and, importantly, between primary DCs and primary CD4 T cells. Our data indicate that this increased clustering is independent of LFA-1. Moreover, P. timonensis enhanced DC-mediated CD4 T cell proliferation. Altogether, these results suggest that P. timonensis-induced cell–cell clustering contributes to the elevated mucosal inflammation observed during bacterial vaginosis.","PeriodicalId":165,"journal":{"name":"European Journal of Immunology","volume":"55 9","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/eji.70051","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144930044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Perturbances in Both Circulating B and CD4+ T Cells Discriminate Multiple Sclerosis from Other Central Nervous System Autoimmune Diseases 循环B细胞和CD4+ T细胞的扰动可区分多发性硬化症与其他中枢神经系统自身免疫性疾病

IF 3.7 3区医学

European Journal of Immunology Pub Date : 2025-09-03 DOI: 10.1002/eji.70049

Laurens Bogers, Jasper Rip, Suzanne C. Franken, Kirsten L. Kuiper, Ana M. Marques, Annet F. Wierenga-Wolf, Marie-José Melief, Cato E. A. Corsten, Romy A. M. Klein Kranenbarg, Janet de Beukelaar, Ide Smets, Beatrijs H. Wokke, Maarten J. Titulaer, Joost Smolders, Marvin M. van Luijn

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Cellular Cosmetics: How Innate Lymphoid Cells Can Recontour the Tumour Microenvironment 细胞化妆品：先天淋巴细胞如何重塑肿瘤微环境

IF 3.7 3区医学

European Journal of Immunology Pub Date : 2025-09-03 DOI: 10.1002/eji.70041

Nabina Pun, David R. Withers

{"title":"Cellular Cosmetics: How Innate Lymphoid Cells Can Recontour the Tumour Microenvironment","authors":"Nabina Pun, David R. Withers","doi":"10.1002/eji.70041","DOIUrl":"https://doi.org/10.1002/eji.70041","url":null,"abstract":"The innate lymphoid cell (ILC) family includes natural killer (NK) cells, recognised for over 50 years, as well as several more recently identified populations. Over the past 15 years, ILCs have emerged as key orchestrators of tissue homeostasis and inflammation. To build upon the early promise of cancer immunotherapies, it is essential to better understand the pathways regulating the composition of, and immunosuppressive mechanisms that dominate many solid cancers and effectively curtail or block T cell responses. Given their residence within most tissues, how these cellular sentinels influence tumour development and progression remains an active area of both discovery and more translationally focused research. By defining precisely how different immunosuppressive pathways form, rationalised immunotherapy combinations can be devised to specifically target these. Current evidence indicates that for each ILC subset, both pro- and anti-tumourigenic roles are possible, likely reflecting local cues within different tissues and contexts. Here, we seek to concisely review some of the prevailing data describing ILC contributions to tumour immunity and highlight some of the challenges that still exist in fully dissecting these mechanisms.","PeriodicalId":165,"journal":{"name":"European Journal of Immunology","volume":"55 9","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/eji.70041","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144930045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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STING and Nonnecroptotic MLKL-Mediated Mechanisms Improve Dendritic Cell Maturation and Killing of Cancer Cells STING和非坏死性mlkl介导的机制改善树突状细胞成熟和杀死癌细胞

IF 3.7 3区医学

European Journal of Immunology Pub Date : 2025-09-03 DOI: 10.1002/eji.70044

Trine S. Jensen, Marlene F. Laursen, Lea Schort, Agnieszka J. Banasik, Ralf Agger, Martin R. Jakobsen, Emil Kofod-Olsen

{"title":"STING and Nonnecroptotic MLKL-Mediated Mechanisms Improve Dendritic Cell Maturation and Killing of Cancer Cells","authors":"Trine S. Jensen, Marlene F. Laursen, Lea Schort, Agnieszka J. Banasik, Ralf Agger, Martin R. Jakobsen, Emil Kofod-Olsen","doi":"10.1002/eji.70044","DOIUrl":"https://doi.org/10.1002/eji.70044","url":null,"abstract":"Activation of the cGAS-STING pathway plays an important role in antitumor immunity through maturation of tumor-infiltrating DCs. DCs engulf extracellular DNA released by dying cancer cells, supporting activation of the cGAS-STING pathway and concomitant DC maturation. Extracellular DNA in the tumor microenvironment is primarily derived from cells undergoing uncontrolled necrosis or programmed inflammatory death, such as necroptosis, which can be induced when apoptosis pathways are inhibited. Here, we report that caspase inhibition primes activation of a RIPK1/3, MLKL, and STING signaling axis in DCs, resulting in maturation without the need for any further maturation stimuli such as LPS or TNF-α. Notably, these signaling events do not induce DC death, indicating a nonnecroptotic role of the RIPK1-RIPK3-MLKL pathway and novel crosstalk with the STING pathway. Caspase inhibition in DC/cancer cell co-cultures results in DC maturation, inducing TNF-α secretion, which delivers the co-signal to induce cancer cell necroptosis. In summary, we find a collaborative mechanism of the STING and necroptosis pathway in DC maturation, and that activation of the necroptosis pathway has opposite effects on cancer cells and DCs, proposing a possibility for new targets in cancer immunotherapy.","PeriodicalId":165,"journal":{"name":"European Journal of Immunology","volume":"55 9","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/eji.70044","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144930042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Issue Information: Eur. J. Immunol. 9'25 发行信息：欧元。[j] .免疫学杂志。9'25 .

IF 3.7 3区医学

European Journal of Immunology Pub Date : 2025-09-03 DOI: 10.1002/eji.70052

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Baseline Single-Cell Differences in Polyfunctionality Between Systemic Autoinflammatory Diseases Patients and Healthy Controls 全身性自身炎性疾病患者与健康对照者多功能性单细胞基线差异

IF 3.7 3区医学

European Journal of Immunology Pub Date : 2025-09-03 DOI: 10.1002/eji.70047

Aline Linder, Farah Diab, Loïc de Pontual, Irina Giurgea, Klaus Eyer

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Natural Killer Cells Are Dispensable for Virus Control in Rag2−/− Mice During Primary RSV Infection 自然杀伤细胞在Rag2−/−小鼠原发RSV感染期间的病毒控制中是必不可少的

IF 3.7 3区医学

European Journal of Immunology Pub Date : 2025-09-03 DOI: 10.1002/eji.70045

Joy Nakawesi, Tammie Sow Tao Min, Cecilia Johansson

{"title":"Natural Killer Cells Are Dispensable for Virus Control in Rag2−/− Mice During Primary RSV Infection","authors":"Joy Nakawesi, Tammie Sow Tao Min, Cecilia Johansson","doi":"10.1002/eji.70045","DOIUrl":"https://doi.org/10.1002/eji.70045","url":null,"abstract":"Respiratory syncytial virus (RSV) is one of the major causes of severe lower respiratory tract infections, especially in children, the elderly, and immunocompromised individuals. Complications arising from viral infections in these age groups can present therapeutic challenges, as most of these individuals have impaired adaptive immunity. Using the T- and B cell-deficient Rag2−/− mice, the mechanisms that mediate protection in immunocompromised hosts during RSV infection can be investigated. RSV-infected Rag2−/− mice showed no symptoms of disease or chronic inflammation in the lungs and airways despite the presence of infectious virus in their lungs several months after infection. Interestingly, Natural Killer (NK) cells, the main innate cells with anti-viral cytotoxic effector functions, were recruited 2 days earlier in the lungs of Rag2−/− mice compared with wildtype mice, resulting in early production of IFN-γ. However, depletion of NK cells did not affect disease severity or viral load. Together, these results suggest that the NK cells are largely dispensable for virus control during primary RSV infection in Rag2−/− mice.","PeriodicalId":165,"journal":{"name":"European Journal of Immunology","volume":"55 9","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/eji.70045","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144930097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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2025 German Society for Immunology Prizes 2025年德国免疫学学会奖

IF 3.7 3区医学

European Journal of Immunology Pub Date : 2025-09-03 DOI: 10.1002/eji.70046

Rebecca Katharina Kutscherauer, Philippa Meiser, Adam Wahida, Ali Maisam Afzali, Camilo Faust Akl, Julia Esser-von Bieren, Kaan Boztug, Evelyn Ullrich

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