Journal of Oral Pathology & Medicine最新文献

{"title":"Correction to “Synergistic Effect of Honokiol and 5-Fluorouracil on Apoptosis of Oral Squamous Cell Carcinoma Cells”","authors":"","doi":"10.1111/jop.13648","DOIUrl":"10.1111/jop.13648","url":null,"abstract":"<p>Ning Ji, Lu Jiang, Peng Deng, Hao Xu, Fangman Chen, Jinli Liu, Jing Li, Ga Liao, Xin Zeng, Yuchun Lin, Mingye Feng, Longjiang Li, Qianming Chen, “Synergistic effect of honokiol and 5-fluorouracil on apoptosis of oral squamous cell carcinoma cells.” <i>Journal of Oral Pathology &amp; Medicine</i> 46, no. 3 (2017): 201–207, https://doi.org/10.1111/jop.12481.</p><p>The authors regret careless mistakes in the incorrect images were used for the Lipo-Ki67, Lipo-TUNEL and HNK-TUNEL groups in Figure 4. The corrected versions of Figure 4 is provided together with this corrigendum. The authors confirm that the conclusions of the article are not affected by this correction and apologize for any inconvenience this may have caused.</p><p>We apologize for these errors.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"54 6","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jop.13648","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “RNAi-Mediated Downregulation of Oral Cancer Overexpressed 1 (ORAOV1) Inhibits Vascular Endothelial Cell Proliferation, Migration, Invasion, and Tube Formation”","authors":"","doi":"10.1111/jop.13649","DOIUrl":"10.1111/jop.13649","url":null,"abstract":"<p>X. Zhao, D. Liu, L. Wang, R. Wu, X. Zeng, H. Dan, N. Ji, L. Jiang, Y. Zhou, and Q. Chen, “RNAi-Mediated Downregulation of Oral Cancer Overexpressed 1 (ORAOV1) Inhibits Vascular Endothelial Cell Proliferation, Migration, Invasion, and Tube Formation,” <i>Journal of Oral Pathology &amp; Medicine</i> 45 (2016): 256–261, https://doi.org/10.1111/jop.12371.</p><p>The authors regret careless mistakes of the incorrect images which were used for the HSC-3 and SCC-25 Blank control groups in Figure 6A. The corrected versions of Figure 6A are provided together with this corrigendum. The authors confirm that the conclusions of the article are not affected by this correction and apologize for any inconvenience this may have caused.</p><p>We apologize for the error.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"54 6","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jop.13649","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Expression of HHLA2, TMIGD2, and GITR in Salivary Gland Adenoid Cystic Carcinoma and Mucoepidermoid Carcinoma”","authors":"","doi":"10.1111/jop.13645","DOIUrl":"10.1111/jop.13645","url":null,"abstract":"<p>M.-J. Zhang, S. Wang, C.-C. Wu, L. Wu, and Z. Sun, “Expression of HHLA2, TMIGD2, and GITR in Salivary Gland Adenoid Cystic Carcinoma and Mucoepidermoid Carcinoma,” <i>Journal of Oral Pathology &amp; Medicine</i> 51, no. 4 (2022): 379–387, https://doi.org/10.1111/jop.13289.</p><p><b>Figure 4(A)</b> Typical immunohistochemical staining of signaling oncogenes, epithelial-mesenchymal transition proteins, and stem cell-like molecules (first to third columns) was performed with tissue microarrays. TGF-β1 (column 1), p-Erk_1/2(column 2), and CD8 (column 3) expression in the AdCC, MEC, PMA, and NSG samples. Representative NSG (first row), PMA (second row), AdCC (third row), and MEC (fourth row) results are shown. Scale bar = 50 μm.</p><p>We apologize for these errors.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"54 6","pages":"480-482"},"PeriodicalIF":2.7,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jop.13645","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biological Consequences and Assessment Methods Analysis of Fixed Orthodontic Appliances on Oral Epithelial Cells: A Systematic Review","authors":"Francesco Paolo Modugno,&nbsp;Elisabetta Kuhn,&nbsp;Chiara Luisa Bianchi,&nbsp;Letterio Runza,&nbsp;Matteo Pellegrini,&nbsp;Federica Pulicari,&nbsp;Francesco Spadari","doi":"10.1111/jop.13643","DOIUrl":"10.1111/jop.13643","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Fixed orthodontic appliances (OAs) expose the oral mucosa to mechanical traumas and metal ions throughout the whole orthodontic therapy. This review aims to understand the cytological and genetic changes consequent to fixed orthodontic therapy, their clinical implications, and how they can be assessed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>A comprehensive search was conducted in PubMed (MEDLINE), Scopus, and Web of Science using MeSH terms related to cytology, DNA damage, mutagenicity, and orthodontic appliances. The PICO model and PRISMA guidelines were followed. The risk of bias was assessed using the ROBINS-I tool, and study quality was evaluated with the NHLBI Quality Assessment Tools. Two independent evaluators assessed the methodological quality of the included studies using the Joanna Briggs Institute (JBI) levels of evidence; inter-reviewer agreement was measured using Cohen's kappa coefficient (<i>κ</i> = 0.80).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Nineteen prospective and cross-sectional studies were included in the analysis. The findings suggest the presence of higher metal cellular content, as well as cytological changes, nuclear alterations, and cytotoxic and genotoxic effects. Different appliance compositions and treatment durations may influence the biological consequences. The analysis shows a tendency toward regression, especially for nuclear alterations. No dysplastic changes have been observed in any of the studies included.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>OAs cause cellular alterations, which tend to be reversible and do not seem to evolve into dysplastic changes. Future research should focus on longitudinal studies with standardized methodologies to better understand the persistence and reversibility of the changes associated with OAs, as well as exploring alternative materials that pose less risk during orthodontic treatment.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"54 6","pages":"413-434"},"PeriodicalIF":2.7,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jop.13643","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-Dimensional Stereophotogrammetry Facial Morphologic Signatures of Temporomandibular Disorders","authors":"Li Mei,&nbsp;Carmen Au,&nbsp;Stacy Foo,&nbsp;Cui Gao,&nbsp;Sichao Zhu,&nbsp;Guangzhao Guan","doi":"10.1111/jop.13644","DOIUrl":"10.1111/jop.13644","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To utilize stereophotogrammetry to investigate changes in three-dimensional (3D) facial morphology in both TMD-free individuals and TMD patients, both before and after treatment, and to classify subjects as either TMD-free or TMD patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>40 participants (TMD and TMD-free, mean age of 38.9 ± 15.3 years) were recruited from the Oral Medicine Clinic at the Faculty of Dentistry, University of Otago. Participants were given a questionnaire, and 3D images of their faces at maximum mouth opening and in occlusion were recorded using the 3dMDtrio craniofacial scanner. Participants were followed up after 3 months and 6 months. The 3D images captured were analysed using the 3dMD Vultus software.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Significant changes were observed between baseline and 3-month follow-up measurements in TRAR-GoR(C), GoR-GN(C) and LS-PG(O) (<i>p</i> &lt; 0.05). At the 6-month follow-up, additional significant differences were found in G-PG(R), TRAL-SN(C), TRAR-GoR(C), GoR-GN(C), LS-PG(O), and maximum mouth opening (MMO) (<i>p</i> &lt; 0.05). TRAR-GoR(C), LS-PG(O), TRAL-GoL(C), MMO, and TRAR-SN(C) exhibited significant correlations. LS-PG(R) was the most reliable predictor. Discriminant analysis revealed an 85% sensitivity and 90% specificity in classifying individuals with and without TMD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Significant 3D morphological changes were detected in TMD patients' post-treatment, with notable mouth opening and masseter muscle volume reduction.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"54 6","pages":"470-479"},"PeriodicalIF":2.7,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jop.13644","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient Education and Levels of Disease-Specific Information Needs Among Individuals With Oral Epithelial Dysplasia","authors":"Waleed Alamoudi,&nbsp;Abdullah Alsoghier,&nbsp;Richeal Ni Riordain,&nbsp;Stefano Fedele,&nbsp;Stephen Porter","doi":"10.1111/jop.13642","DOIUrl":"10.1111/jop.13642","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Oral epithelial dysplasia (OED) is a histological diagnosis that carries an increased risk of the individual developing oral squamous cell carcinoma. We assessed the information needs (IN) and explored the sources of education used by individuals with OED using a validated OED-specific measurement.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 102 adults with OED from the oral medicine clinic of a dental hospital in Central London were selected using convenience sampling. A cross-sectional survey was conducted in which participants completed the 33-item Oral Epithelial Dysplasia Informational Needs Questionnaire (ODIN-Q), which assessed IN and gathered perspectives on patient education.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Approximately two-thirds of the participants (<i>n</i> = 66, 64%) reported meeting the IN, whereas the remaining participants (<i>n</i> = 36, 35%) did not. The mean and median total scores from the questionnaire were 2.43 (± 0.38) and 2.6, respectively, indicating a low sufficient level of IN. Most participants (<i>n</i> = 80, 78%) preferred one-on-one meetings as the primary mode of obtaining information, followed by written materials (<i>n</i> = 64, 62%), audiovisual resources (<i>n</i> = 24, 23%), and group discussions (<i>n</i> = 8, 0.7%).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Some topics were insufficiently met, necessitating additional educational efforts, such as risk factors and lifestyle modifications, physical and psychological impacts, awareness of potential complications, and seeking medical and psychological support. Sex and degree of dysplasia were associated with the levels of IN. These findings may guide future longitudinal research on OED IN assessment, support the creation of tailored educational tools, and facilitate further evaluation of the psychometric properties of the ODIN-Q.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"54 6","pages":"459-469"},"PeriodicalIF":2.7,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jop.13642","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral Health in Individuals with Severe Mental Illness on Second-Generation Antipsychotics—A Scoping Review","authors":"Dileep Sharma,&nbsp;Oliver Higgins,&nbsp;Aleksander Sawicki,&nbsp;Poornima Ramamurthy,&nbsp;Belinda Field,&nbsp;Paul Hussein,&nbsp;Kiran Singh,&nbsp;Sarbin Ranjitkar","doi":"10.1111/jop.13639","DOIUrl":"10.1111/jop.13639","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>There has been a significant increase in antipsychotic usage, particularly belonging to second-generation antipsychotics (SGAs), in the management of severe mental illnesses (SMIs) over the past few decades, but their impact on oral health is unclear. This review evaluated the oral side effects of the SGAs used in managing SMIs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A PRISMA-guided scoping review was conducted, using predefined criteria and relevant word combination in Medline (PubMed), Embase, Scopus and Cochrane databases. Eligible studies were assessed for study type, population demographics, antipsychotic medication usage, oral diseases and conditions, and their outcomes. Primary outcomes were explicitly studied oral conditions or diseases, and secondary outcomes were broader oral or general “treatment-emergent adverse effects.”</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Twelve studies met the inclusion criteria for the primary outcomes and 13 for the secondary outcomes. The most reported primary outcomes were salivary gland dysfunction (hypofunction, three studies; hypersalivation, two studies), dental caries (positive association, three studies; no association, one study), and periodontal disease (five studies). Secondary outcomes included dysgeusia and oral hypoesthesia (six studies).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Discussion</h3>\u0000 \u0000 <p>SGAs significantly compromise oral health, particularly through salivary gland and sensory dysfunction, highlighting the need for up-to-date guidelines on routine oral screening and preventive care.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"54 6","pages":"401-412"},"PeriodicalIF":2.7,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jop.13639","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burning Mouth Syndrome: Unlocking the Future of Pharmacological Treatment","authors":"Daniela Adamo","doi":"10.1111/jop.13641","DOIUrl":"https://doi.org/10.1111/jop.13641","url":null,"abstract":"","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"54 5","pages":"251-262"},"PeriodicalIF":2.7,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143950158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the Edmonton-33: A Patient-Reported Outcome Instrument in Head and Neck Oncology at Baseline and Subacute Phases Post-Treatment","authors":"K. Zhang,&nbsp;H. Khan,&nbsp;H. Seikaly,&nbsp;A. Nichols,&nbsp;K. Fung,&nbsp;S. D. MacNeil,&nbsp;A. Mendez","doi":"10.1111/jop.13640","DOIUrl":"10.1111/jop.13640","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Patient-reported outcomes (PRO), which prioritize patient perspectives, are highly valuable for patient-centered care in Head and Neck Oncology. The objective of this study was to explore the longitudinal validity of the Edmonton-33 (E-33), a PRO instrument for assessing head and neck functions in swallowing, chewing, dry mouth, and speech.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study involved 59 adult patients (18 female, 41 male) with squamous cell carcinoma (SCC) of the oral cavity. Participants provided consent and completed the E-33 and other PRO instruments before and after surgical and radiation treatment at months 3 (<i>n</i> = 18), 6 (<i>n</i> = 18), and 9 (<i>n</i> = 16). Data were collected (from June 2021 to August 2024) and analyzed for correlation between domains of the E-33 and their domain-specific, previously validated counterparts before treatment (baseline) and after treatment (Months 3, 6, and 9).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>There were statistically significant correlations (<i>p</i> &lt; 0.05) between all E-33 domains and their domain-specific counterparts at baseline and at post-treatment month 6. At Months 3 and 9 post-treatment, there were partial correlations between E-33 domains and some domain-specific counterparts.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The E-33 demonstrates validity pre-treatment and post-treatment at subacute timepoint (Months 6) for capturing data on swallowing, chewing, dry mouth, and speech, similar to other previously validated instruments. This validity is limited at the more acute timepoint of 3 months post-treatment and the later timepoint of 9 months post-treatment. Additional data are needed to further explore the long-term validity at further longitudinal timepoints at 1 and 2 years post-treatment.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"54 6","pages":"455-458"},"PeriodicalIF":2.7,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jop.13640","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of LncRNA UCA1 in OSCC CAFs: PD-L1 Upregulation and Tumor Progression","authors":"Nisha Zhu,&nbsp;Mengxiang Zhao,&nbsp;Yong Fu,&nbsp;Xingxing Zhao,&nbsp;Sufeng Zhao,&nbsp;Antonio Celentano,&nbsp;Liang Ding,&nbsp;Qingang Hu,&nbsp;Yanhong Ni","doi":"10.1111/jop.13631","DOIUrl":"10.1111/jop.13631","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Characterize LncUCA1 expression in OSCC cancer-associated fibroblasts (CAFs), investigate immune regulation by high LncUCA1 CAFs, and assess their impact on tumor malignancy in vitro.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Transcriptome sequencing identified upregulated genes in matched CAFs and normal fibroblasts (NFs) from OSCC patients. Clinical outcomes were evaluated in 21 OSCC patients. LncUCA1's effect on PD-L1 expression in CAFs was assessed by flow sorting and qRT-PCR. Co-culture experiments evaluated CAFs' impact on CD8⁺ T cell proliferation and immunosuppression. Matrigel contraction and CCK8 assays explored CAFs' matrix contraction and proliferation. Direct co-culture analyzed CAFs' effect on OSCC proliferation. Transwell assays examined CAFs' impact on tumor cell migration and invasion.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>LncUCA1 was significantly upregulated in CAFs compared to NFs. Higher LncUCA1 expression correlated with advanced tumor stage and shorter overall survival. LncUCA1 positively correlated with PD-L1 expression and activated the JAK2/STAT3 pathway in CAFs. Co-culture experiments showed high LncUCA1 CAFs inhibited CD8⁺ T cell proliferation and enhanced immunosuppression. LncUCA1 overexpression enhanced matrix contraction but significantly promoted proliferation, migration, and invasion of OSCC cells.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>LncUCA1 upregulation in CAFs drives PD-L1 expression, inhibits CD8⁺ T cell proliferation, and promotes immunosuppression. High LncUCA1 CAFs also enhance OSCC proliferation, migration, and invasion.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"54 6","pages":"445-454"},"PeriodicalIF":2.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144000150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}