Ophthalmologica Indonesiana最新文献_第4页

Quality of Life Comparisons in Strabismic Children Managed Surgically or Conservatively 手术或保守治疗的斜视儿童生活质量比较

Ophthalmologica Indonesiana Pub Date : 2024-02-12 DOI: 10.35749/q1bs2e20

ESTER GRACESILLYA APRINONA G, Maya Sari Wahyu Kuntorini, MD, Elsa Gustianty, MD, Feti Karfiati Memed, MD, Irawati Irfani, MD, Primawati Oktarima Amiruddin, MD, Sesy Caesarya, MD

{"title":"Quality of Life Comparisons in Strabismic Children Managed Surgically or Conservatively","authors":"ESTER GRACESILLYA APRINONA G, Maya Sari Wahyu Kuntorini, MD, Elsa Gustianty, MD, Feti Karfiati Memed, MD, Irawati Irfani, MD, Primawati Oktarima Amiruddin, MD, Sesy Caesarya, MD","doi":"10.35749/q1bs2e20","DOIUrl":"https://doi.org/10.35749/q1bs2e20","url":null,"abstract":"Abstract \u0000Introduction & Objectives : Strabismus causes visual impairment due to ocular misalignment, interferes cosmetic appearance, results in negative self-image and impacts quality of life. Studies in adults have shown that successful strabismus surgery improves quality of life, but awareness of strabismus surgery and its benefits are still lacking. Studies regarding the impact of conservative treatment on quality of life are limited, so further study is required. \u0000Methods : This was an observational study comparing 2 unpaired groups. The method used in this study was cross-sectional and samples were obtained purposefully according to medical records and consecutively based on outpatient visits. \u0000Results : Thirty-six subjects in group A, who had undergone strabismus surgery and 33 subjects in group B who were still managed conservatively were included in this study. Both groups had similar demographic characteristics, except parental education background (p=0.048). Comparative test of2 unpaired groups in this study showed higher quality of life scores in group A (p=0.0001). \u0000Conclusion : The quality of life in subjects who had undergone strabismus surgery was better than that in those who were still managed conservatively.","PeriodicalId":165753,"journal":{"name":"Ophthalmologica Indonesiana","volume":"96 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139784379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COMPARISON OF ANGLE OPENING DISTANCE AND TRABECULAR IRIS SPACE AREA BEFORE AND AFTER LASER PERIPHERAL IRIDOTOMY IN ANGLE CLOSURE DISEASE 角膜闭合症患者激光周边虹膜切开术前后开角距离和小梁虹膜空间面积的比较

Ophthalmologica Indonesiana Pub Date : 2024-02-12 DOI: 10.35749/05vxs382

R. Ramdhani, R. M. Rifada, Irawati Irfani, Elsa Gustianty, Sonie Umbara

{"title":"COMPARISON OF ANGLE OPENING DISTANCE AND TRABECULAR IRIS SPACE AREA BEFORE AND AFTER LASER PERIPHERAL IRIDOTOMY IN ANGLE CLOSURE DISEASE","authors":"R. Ramdhani, R. M. Rifada, Irawati Irfani, Elsa Gustianty, Sonie Umbara","doi":"10.35749/05vxs382","DOIUrl":"https://doi.org/10.35749/05vxs382","url":null,"abstract":"Introduction & ObjectivesLaser peripheral iridotomy (LPI) is the standard first-line therapy in angle closure disease toincrease anterior chamber angle width. Spectral Domain Anterior Segment Optical CoherenceTomography (SD AS-OCT) is an instrument that has a quantitative parameter to measure anteriorchamber angle. Angle opening distance (AOD) and trabecular iris space area (TISA) are quantitativeparameters in SD AS-OCT. The purpose of this study is to compare AOD and TISA before and oneweek after LPI in angle closure disease. \u0000MethodsThis is an analytical prospective study with a cross-sectional study design. Twenty-two eyes withangle closure disease that met inclusion and exclusion criteria underwent LPI and SD AS-OCT beforeand one week after LPI. Analysis was performed using SD AS-OCT parameters, such as AOD(AOD500, AOD750) and TISA (TISA500, TISA750) in the temporal, nasal quadrants, and average. \u0000ResultsTwenty-two eyes with angle closure are divided into nine eyes with primary angle closure suspect,seven eyes with primary angle closure, and six eyes with primary angle closure glaucoma. The meanage of participants was 57.86±7.63 years. There was a significant increase in AOD500, AOD750,TISA500, and TISA750 in the temporal and nasal quadrants, as well as in the average (P=0.0001)based on a paired t test or Wilcoxon as an alternative. Average AOD750 had the highest T-value (T=6.329) with a mean 0.20±0.096 before LPI and 0.31±0.144 one week after LPI. \u0000ConclusionThere was a significant increase in AOD and TISA after one week LPI in angle closure disease.","PeriodicalId":165753,"journal":{"name":"Ophthalmologica Indonesiana","volume":"80 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139784497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A RARE CASE : HOMONYMOUS HEMIANOPIA IN CHILDREN 罕见病例儿童同侧半身不遂

Ophthalmologica Indonesiana Pub Date : 2024-02-12 DOI: 10.35749/vkcy5658

RAHAYU WIDHYASTI1, Antonia Kartika Indriati, Rusti Hanindya Sari, Dianita Veulina Ginting, Prettyla Yollamanda

{"title":"A RARE CASE : HOMONYMOUS HEMIANOPIA IN CHILDREN","authors":"RAHAYU WIDHYASTI1, Antonia Kartika Indriati, Rusti Hanindya Sari, Dianita Veulina Ginting, Prettyla Yollamanda","doi":"10.35749/vkcy5658","DOIUrl":"https://doi.org/10.35749/vkcy5658","url":null,"abstract":"Abstract \u0000Introduction : Homonymous hemianopia (HH) is a visual field loss in the same halves of the visual field of each eye that is caused by numerous lesion affecting the retrochiasmal visual pathway. Homonymous hemianopia in children is a rare disabling condition and might be found as an initial presentation of brain tumors. \u0000Case Illustration : A 12 years old boy came with chief complaint of partially vision loss on the left side of vision accompanied by intermittent headache. Ophthalmological examination showed visual acuity of 1.0 on both eyes. Visual field examination revealed left homonymous hemianopia (figure 1). These findings were relevant to the result of his brain Computed Tomography (CT) scan, which showed vascular mass in the right occipital lobe caused by suspected arteriovenous malformation mixed diffuse type (figure 2). The patient was referred to neurosurgeon for further management. \u0000Discussion : Visual field defect depends on location of the lesion and can be used to recognize optic pathway diseases. Homonymous hemianopia occurs in retrochiasmal lesions that could happened either in adult or children. Unusual presentation of HH in children caused by brain tumor such as arteriovenous malformation. It might occur in up to 27% and can be detected radiologically with either brain CT scan or Magnetic Resonance Imaging (MRI). \u0000Conclusion : Visual field loss in pediatric patient might be challenging. Proper and prompt diagnosis is important to detect underlying condition and determine further management of the patient.","PeriodicalId":165753,"journal":{"name":"Ophthalmologica Indonesiana","volume":"81 15","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139784587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MULTIPLE GIANT CHALAZIA IN HYPERIMMUNOGLOBULINEMIA E SYNDROME: A CASE REPORT 高免疫球蛋白血症 E 综合征中的多发性巨大霰粒肿：病例报告

Ophthalmologica Indonesiana Pub Date : 2024-02-12 DOI: 10.35749/6c6g4758

Lily Raudah Putri, Florentina Priscilia, Dany Petra Pranata Barus, Annisa Windyani, Muhammad Shafiq Advani, Lukman Edwar

{"title":"MULTIPLE GIANT CHALAZIA IN HYPERIMMUNOGLOBULINEMIA E SYNDROME: A CASE REPORT","authors":"Lily Raudah Putri, Florentina Priscilia, Dany Petra Pranata Barus, Annisa Windyani, Muhammad Shafiq Advani, Lukman Edwar","doi":"10.35749/6c6g4758","DOIUrl":"https://doi.org/10.35749/6c6g4758","url":null,"abstract":"Abstract \u0000Introduction : Hyperimmunoglobulinemia E syndrome (HIES) is a rare primary immunodeficiency disorder that manifests as elevated level of serum immunoglobulin E (IgE) higher than 1.000 IU/mL and multisystem disorder characterized by recurrent skin and pulmonary abscesses caused by autosomal dominant or recessive disorder with gene mutation. We present a case of multiple giant chalazion ina patient with HIES. \u0000Case Illustration : A 15-year-old boy was referred to Ophthalmology Department with multiple giant lumps on the left eyelid for the last 2 weeks. He had a history of recurrent multiple lumps on the left lower eyelid in the last 1 year. He was diagnosed with HIES since 8 years ago. He had normal visual acuity of both eyes. Multiple giant chalazion were observed on the left upper and lower eyelid. The patient also presented with scalp and neck infection. Laboratory studies showed elevated total serum IgE level of 53,032 IU/mL and eosinophilia. \u0000Discussion : Ocular manifestations in HIES patients are not common. Some cases reported chalazia, keratoconus, and blepharitis. Surgical incision drainage was performed in our patient. Medications and surgical intervention had produced only transient improvement. The patient was treated conservatively. Riskof chalazia recurrence remains unknown as reported cases presented with diverse clinical presentation and follow-up serum IgE evaluation is not routinely performed. \u0000Conclusion : Recurrent multiple giant chalazia may occur as an ophthalmic feature of HIES. HIES should be considered and investigated in patients presenting with recurrent giant chalazia.","PeriodicalId":165753,"journal":{"name":"Ophthalmologica Indonesiana","volume":"83 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139784599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Kearns–Sayre Syndrome with Bilateral Ptosis and External Ophthalmoplegia: A Rare Case Report 伴有双侧上睑下垂和外侧眼肌麻痹的卡恩斯-赛尔综合征：罕见病例报告

Ophthalmologica Indonesiana Pub Date : 2024-02-12 DOI: 10.35749/dyz23y26

Philipus Putra Raharjo, Yunia Mansyur, Batari Todja Umar

{"title":"Kearns–Sayre Syndrome with Bilateral Ptosis and External Ophthalmoplegia: A Rare Case Report","authors":"Philipus Putra Raharjo, Yunia Mansyur, Batari Todja Umar","doi":"10.35749/dyz23y26","DOIUrl":"https://doi.org/10.35749/dyz23y26","url":null,"abstract":"Abstract \u0000Introduction : Kearns-Sayre syndrome (KSS) is a rare genetic disorder caused by a deletion of mitochondrial DNA (mtDNA) segment, typically characterized by a triad of symptoms includes external ophthalmoplegia, pigmentary retinopathy and appeared before the age of 20. The prevalence rate is about 1–3 per 100.000 individuals. It was diagnosed based on clinical features and supported by biochemical, radiological, histologic, and molecular genetic tests. \u0000Case Illustration : 26-year-old male with bilateral ptosis, chronic progressive external ophthalmoplegia, pigmentary retinopathy was shown from ophthalmology examination and associated with hearing loss. Physical examination showed short stature, wasting, and weakness of limb muscles. MRI examination revealed focal brain atrophy on bilateral parietal regions. \u0000Discussion : Mitochondrial DNA defect led to dysfunction of the central nervous system, endocrine system, extraocular muscle, myocardium, skeletal muscle, and other multiple systems. The clinical findings in this patient are appropriate for classical signs and symptoms of KSS. Central nervous involvementis shown by the neuroimaging result. There is no cardiac involvement suggested by normal cardiology examination. Although muscle pathology and molecular genetic analysis can play a great role to diagnose KSS, the classical triad of clinical signs plus one of the other symptoms could establish KSS diagnosis. \u0000Conclusion : KSS is a rare genetic disorder and challenging to diagnose. However, if a patient presents with the classic triad of symptoms, clinicians should have a high level of suspicion for the disorder. Additionally, It is important to perform a thorough evaluation to rule out other conditions that can cause similar symptoms.","PeriodicalId":165753,"journal":{"name":"Ophthalmologica Indonesiana","volume":"68 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139784803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characteristics of Premature Retinopathy Patients who underwent surgery at dr. Kariadi General Hospital Semarang 在三宝垄卡瑞迪综合医院接受手术的早发性视网膜病变患者的特征

Ophthalmologica Indonesiana Pub Date : 2024-02-12 DOI: 10.35749/997v9e35

CANDA ARDITYA, Arnila Novitasari Saubig

{"title":"Characteristics of Premature Retinopathy Patients who underwent surgery at dr. Kariadi General Hospital Semarang","authors":"CANDA ARDITYA, Arnila Novitasari Saubig","doi":"10.35749/997v9e35","DOIUrl":"https://doi.org/10.35749/997v9e35","url":null,"abstract":"Abstract \u0000Introduction & Objectives : Introduction: Retinopathy of prematurity (ROP) represents a leading cause of childhood blindness. The management of ROP can be challenging in preterm babies, those with very low birth weight and multiple risk factors. The characteristic and risk factors of ROP is essential to acknowledge. Objective: To describe the characteristic of patients with ROP who underwent surgery in Dr. Kariadi Hospital and to identify the risk factors of the disease \u0000Methods : A retrospective study held from the medical record of patients with diagnosis ROP from January 2020-January 2023 in Dr. Kariadi Hospital, Semarang. The clinical characteristics: sex, gestation age, birth weight, maternal risk factors, neonatal risk factors, and ROP Stage. Type of surgery: laser, intravitreal injection, vitrectomy were also collected. \u0000Results : There were 19 ROP patients with 8 (42.1%) gestational age between 29-30 weeks, 8 (42.1%) birth weight 1000-1500gr, 7 (36.8%) had maternal risk: hypertension, 12 (63), 15%) of patients with ROP stage 3, 8 (42,1%) had a combined management of laser surgery and intravitreal injection. Among all the patients at risk had at least one neonatal risk factor with history of oxygenation being the most common (100%). \u0000Conclusion : Characteristics of ROP patients underwent surgery at Dr. Kariadi General Hospital are mostly patients with gestational age between 29-30 weeks and have the most oxygenation history factors. The most common type of surgical procedure performed is a combination of laser and intravitreal injection.","PeriodicalId":165753,"journal":{"name":"Ophthalmologica Indonesiana","volume":"20 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139784859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recurrence of Malignant Glaucoma After Vitrectomy Intervention: A Challenging Case Series 玻璃体切除术后恶性青光眼复发：具有挑战性的病例系列

Ophthalmologica Indonesiana Pub Date : 2024-02-12 DOI: 10.35749/571xr814

Mazidah Zulfa, Satya Hutama P, Arief Wildan, F. L. Rahmi, Denti Puspasari, Maharani

{"title":"Recurrence of Malignant Glaucoma After Vitrectomy Intervention: A Challenging Case Series","authors":"Mazidah Zulfa, Satya Hutama P, Arief Wildan, F. L. Rahmi, Denti Puspasari, Maharani","doi":"10.35749/571xr814","DOIUrl":"https://doi.org/10.35749/571xr814","url":null,"abstract":"Introduction : Malignant glaucoma most commonly occurs after glaucoma filtration surgery. Most cases require surgical intervention such as vitrectomy. However, even after successful treatment, it can reoccur in some cases. We present two cases of recurrent malignant glaucoma. \u0000Case Illustration : The first case involved a 48-year-old female with primary angle closure glaucoma who developed malignant glaucoma 1-week after undergoing combined glaucoma surgery. The second case involved a 70-year-old man with primary angle closure glaucoma and pseudophakia who developed malignant glaucoma 4-month after trabeculectomy. They received total vitrectomy treatment. We observed anterior chamber deepening in these 2 cases, but intraocular pressure remained increased 2-week after intervention. \u0000Discussion : We found improvement in anatomy by deepening the anterior chamber, but the intraocular pressure increased in the 2 weeks. Although the problem of releasing aqueous accumulations from the vitreous has been resolved after vitrectomy, but there is no permanent passage between the anterior chamber and the vitreous cavity. So, recurrences can occur. It is possible to manage this condition by restoring aqueous flow from the anterior vitreous to the anterior chamber. YAG laser capsulo- hyaloidotomy or vitrectomy combined with hyaloido-zonula-iridectomy are frequently effective in treating underlying causes. \u0000Conclusion : Vitrectomy can help to improve the deepening anterior chamber, but intraocular pressure may remain increased after 2-week follow-up. The recurrence of malignant glaucoma may be related to incomplete resolution of the underlying condition.","PeriodicalId":165753,"journal":{"name":"Ophthalmologica Indonesiana","volume":"123 21","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139784975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phacodonesis in Angle-Closure Glaucoma: Phacomorphic or Other Lens- Induced? 闭角型青光眼中的法眼色素沉着：幻视还是其他透镜诱导？

Ophthalmologica Indonesiana Pub Date : 2024-02-12 DOI: 10.35749/pr0ygp29

Alyssa Claudia, Aquirina Caesaria, Niken Indah Noerdiyani, Dianawati Koesoemowardani

{"title":"Phacodonesis in Angle-Closure Glaucoma: Phacomorphic or Other Lens- Induced?","authors":"Alyssa Claudia, Aquirina Caesaria, Niken Indah Noerdiyani, Dianawati Koesoemowardani","doi":"10.35749/pr0ygp29","DOIUrl":"https://doi.org/10.35749/pr0ygp29","url":null,"abstract":"Introduction : Glaucoma is defined as progressive optic neuropathies characterized by optic disk cupping, reduced visual field, and visual loss. As a “silent thief of sight”, glaucoma ranked second worldwide and third in Indonesia as the cause of blindness. The cause of glaucoma varies, one of which is lens-induced which presents as loss of vision and red eye. \u0000Case Illustration : A 53-year-old female complained about blurred and pained red eyes. Examination of the right eye revealed VOD 1/300, cloudy-milky lens, phacodonesis, and IOP 26.3 mmHg. She was diagnosed with angle-closure glaucoma suspected as phacomorphic or other lens-induced and was treated by topical hypotensive agents and phacoemulsification with IOL implantation procedure. Right eye examination on day one post operation showed VA 2/60 and IOP 13.6 mmHg. Improvement on two weeks follow- up revealed VA 6/15 with best VA of 6/6, IOP 15.7 mmHg, CD ratio 0.5, and negative glaucoma optic neuropathy (GON) finding. \u0000Discussion : When accompanied by phacodonesis, angle-closure glaucoma is mainly caused by a secondary process. It involves zonule of Zinn fragility, which usually occurs in subluxation but also appear in hypermature cataract. Dilated eye examination showed no sign of subluxation, therefore the final diagnosis was phacomorphic glaucoma and hypermature cataract. Cataract surgery as the definitive treatment must be done at an appropriate time as was done for this patient with a favorable outcome. \u0000Conclusion : The presence of phacodonesis in angle-closure glaucoma should be thoroughly evaluated. Meticulous decisions on definitive treatment can be planned afterward.","PeriodicalId":165753,"journal":{"name":"Ophthalmologica Indonesiana","volume":"59 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139842063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transglutaminase-induced Cornea Collagen Crosslinking Effect on Central Corneal Thickness and Keratocyte Cell Density 转谷氨酰胺酶诱导的角膜胶原交联对角膜中央厚度和角膜细胞密度的影响

Ophthalmologica Indonesiana Pub Date : 2024-02-12 DOI: 10.35749/b8s0fh73

PUSPITA HAPSARI SITORASMI, Yuniar Sarah Ningtiyas, Indri Wahyuni, Yulia Primatasari

{"title":"Transglutaminase-induced Cornea Collagen Crosslinking Effect on Central Corneal Thickness and Keratocyte Cell Density","authors":"PUSPITA HAPSARI SITORASMI, Yuniar Sarah Ningtiyas, Indri Wahyuni, Yulia Primatasari","doi":"10.35749/b8s0fh73","DOIUrl":"https://doi.org/10.35749/b8s0fh73","url":null,"abstract":"Abstract \u0000Introduction & Objectives : This research is aimed to evaluate the effect of transglutaminase-induced corneal collagen crosslinking (CXL) on central corneal thickness (CCT) and keratocyte cell density in vivo. \u0000Methods : Twenty-eight white New Zealand rabbits were divided into four groups: the transglutaminase- induced CXL group, the epithelial-off CXL group, the transepithelial CXL group, and the control group. The ocular surface was treated with a 1 U/mL microbial transglutaminase solution, and both the epithelial-off and transepithelial groups were exposed to clinical ultraviolet A-riboflavin (UVA/RF). The efficacy of each group was evaluated on the 14th day after the procedures. Central corneal thickness was evaluated with Corneal Visualization Scheimpflug Technology (Corvis ST) and keratocyte cell density wad evaluated with histopathology examination. \u0000Results : Transglutaminase-induced CXL group exhibited the highest mean biomechanical CCT (370.14 ± 38.85) in comparison to the UVA/RF epithelial-off group (368.00 ± 25.48), the UVA/RF transepithelial group (369.86 ± 23.43), and the control group (365.14 ± 28.74). Still, there was no significant differences in both biomechanical CCT (p=0.990). Transglutaminase-induced CXL group had the highest mean of keratocyte cell density (43.26 ± 10.65) compared to UVA/RF epithelial-off (29.99 ± 4.79), UVA/RF transepithelial group (42.03 ± 6.55), and control group (34.36 ± 6.76). There was a significant difference between the group, with a p-value of 0.008. \u0000Conclusion : Transglutaminase shown that it produces favorable results for CCT and keratocyte density after CXL, which are two factors contributing to corneal rigidity. The outcomes are equivalent to riboflavin used as a conventional element in CXL.","PeriodicalId":165753,"journal":{"name":"Ophthalmologica Indonesiana","volume":"33 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139842263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

UNILATERAL CMV RETINITIS IN HIV/AIDS PATIENT WITH MULTIPLE OPPORTUNISTIC INFECTIONS 伴有多种机会性感染的艾滋病毒/艾滋病患者的单侧 cmv 视网膜炎

Ophthalmologica Indonesiana Pub Date : 2024-02-12 DOI: 10.35749/n3kv9x42

Daya Banyu Bening, Muhammad Firmansjah, Ismi Zuhria

{"title":"UNILATERAL CMV RETINITIS IN HIV/AIDS PATIENT WITH MULTIPLE OPPORTUNISTIC INFECTIONS","authors":"Daya Banyu Bening, Muhammad Firmansjah, Ismi Zuhria","doi":"10.35749/n3kv9x42","DOIUrl":"https://doi.org/10.35749/n3kv9x42","url":null,"abstract":"Introduction : CMV Retinitis is the most common opportunistic infection in HIV/AIDS patient. Ocular manifestations in HIV/AIDS have similar clinical features though the management therapies are different. \u0000Case Illustration : A 47-year-old man was presented with blurred vision on LE since 4 months. Patient was diagnosed with HIV/AIDS since 2 years. Patient only had light perception on LE, and 5/10 on RE. The LE anterior segment showed flare and cell indicating active anterior uveitis. The LE posterior segment revealed extensive hemorrhage and exudate known as ‘pizza pie’ appearance, and cotton wool spot with multiple ischemic areas on RE. Laboratory tests revealed reactive IgG CMV and very low CD4 count (4 cell/?l). Patient was also diagnosed with Tinea Corporis, Scabies, and Pneumocystis carinii pneumonia. Oral Valganciclovir 900 mg was administered twice a day for 3 weeks, along with anti- retroviral therapy. \u0000Discussion : The anterior uveitis and ‘pizza pie’ appearance with positive CMV IgG indicate CMV Retinitis in fulminant form. Cotton wool spot found in the RE leads to retinal microvasculopathy due to HIV invading the vascular endothelium and causing increased plasma viscosity. This patient only had 4 cell/?l CD4 which indicates severe immune deficiency. If not treated immediately, patients with CD4 count <50 are at higher risk of contralateral eye involvement. Oral Valganciclovir was chosen considering the multiple opportunistic infections the patient had. \u0000Conclusion : It is important to distinguish CMV retinitis with other HIV/AIDS ocular manifestations. The choice of therapy needs be considered with the overall condition of patient.","PeriodicalId":165753,"journal":{"name":"Ophthalmologica Indonesiana","volume":"74 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139842379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0