Journal of Neuropsychiatry and Clinical Neurosciences最新文献

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The Multifaceted Phenomenon of Anosognosia in Dementia and Its Relationship to Premorbid Personality Traits. 痴呆病感失认症的多面性现象及其与病前人格特质的关系。
IF 3.3 4区 医学
Journal of Neuropsychiatry and Clinical Neurosciences Pub Date : 2026-07-22 DOI: 10.1176/appi.neuropsych.20260047
Victor Calil, Gabriel Bernardes, Natalia Oliveira, Alana Batista, Joana Bondarovsky, Isabella Fialho Bertelli, Luciano Mariano, Karen Luíza Oliveira Meira, Elisa Resende, Paulo Caramelli, Leonardo Cruz de Souza, Paulo Mattos
{"title":"The Multifaceted Phenomenon of Anosognosia in Dementia and Its Relationship to Premorbid Personality Traits.","authors":"Victor Calil, Gabriel Bernardes, Natalia Oliveira, Alana Batista, Joana Bondarovsky, Isabella Fialho Bertelli, Luciano Mariano, Karen Luíza Oliveira Meira, Elisa Resende, Paulo Caramelli, Leonardo Cruz de Souza, Paulo Mattos","doi":"10.1176/appi.neuropsych.20260047","DOIUrl":"https://doi.org/10.1176/appi.neuropsych.20260047","url":null,"abstract":"<p><strong>Objective: </strong>Anosognosia, the unawareness of a person's own neurological or psychiatric symptoms, is a common manifestation of dementia. Anosognosia may involve different cognitive or behavioral domains and may be influenced by factors such as premorbid personality traits. In this study, the authors investigated the relationship between premorbid personality traits and different anosognosia subtypes. Another objective was to assess the interrelationships among the anosognosia subtypes.</p><p><strong>Methods: </strong>The authors evaluated individuals with mild cognitive impairment (MCI) and mild-to-moderate dementia. Anosognosia was evaluated by using differences in scores between questionnaires completed by the participants and by their informants (with positive indices indicating worse anosognosia). Several questionnaires were used to assess distinct cognitive domains. Premorbid personality traits were evaluated with the Big Five Inventory 2-short version.</p><p><strong>Results: </strong>Data for 67 individuals with MCI or mild-to-moderate dementia were included. Agreeableness and the socioemotional anosognosia subtype were strongly and negatively correlated with each other (r=-0.627), and a strong positive correlation was detected between neuroticism and the behavioral anosognosia subtype (r=0.569) (both p<0.01, Bonferroni corrected). No significant correlation was observed between premorbid personality traits and functional, memory, and general cognition anosognosia subtypes. Correlations were moderate to strong for the functionality and memory (r=0.488) and socioemotional and behavioral (r=0.569) anosognosia subtypes (both p<0.01, Bonferroni corrected).</p><p><strong>Conclusions: </strong>The observed correlations of several anosognosia subtypes with predementia-onset personality traits and the absence of significant interrelationships among the anosognosia subtypes assessed suggest that cognitive-functional and behavioral-socioemotional anosognosias represent two relatively independent clusters, possibly driven by different neural and environmental mechanisms.</p>","PeriodicalId":16559,"journal":{"name":"Journal of Neuropsychiatry and Clinical Neurosciences","volume":" ","pages":"appineuropsych20260047"},"PeriodicalIF":3.3,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148549411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prospective Study of Different Diagnostic Criteria for Catatonia and Delirium in Internal Medicine and Neurology Admissions. 内科和神经内科住院患者紧张症和谵妄不同诊断标准的前瞻性研究。
IF 3.3 4区 医学
Journal of Neuropsychiatry and Clinical Neurosciences Pub Date : 2026-07-22 DOI: 10.1176/appi.neuropsych.20250095
Natalia Gutiérrez Ochoa, Juan Diego Corzo Casadiego, Gabriela Castresana Zúñiga, Carolina Zapata, María Botero Urrea, María Carolina González, Valery Briñez Prada, Paula T Trzepacz, José G Franco
{"title":"Prospective Study of Different Diagnostic Criteria for Catatonia and Delirium in Internal Medicine and Neurology Admissions.","authors":"Natalia Gutiérrez Ochoa, Juan Diego Corzo Casadiego, Gabriela Castresana Zúñiga, Carolina Zapata, María Botero Urrea, María Carolina González, Valery Briñez Prada, Paula T Trzepacz, José G Franco","doi":"10.1176/appi.neuropsych.20250095","DOIUrl":"https://doi.org/10.1176/appi.neuropsych.20250095","url":null,"abstract":"<p><strong>Objective: </strong>The authors prospectively examined the relationship between catatonia and delirium in consecutive hospital admissions. Potentially confounding neuropsychiatric conditions for catatonia symptoms were also assessed.</p><p><strong>Methods: </strong>In this cross-sectional study of 223 geriatric inpatients with or without delirium, the authors rated symptoms with Bush-Francis Catatonia Rating Scale (BFCRS) items to diagnose catatonia according to the BFCRS, <i>DSM-5-TR</i>, and Research Diagnostic Criteria for Catatonia (RDCC). The Delirium Rating Scale-Revised-98 (DRS-R-98) and other tools were used to assess neuropsychiatric conditions. The BFCRS item relationships were analyzed with exploratory factor analysis (EFA) and correlation analyses.</p><p><strong>Results: </strong>Catatonia prevalence in the patient cohort was 10% and 1% per BFCRS and <i>DSM-5-TR</i> criteria, respectively, and significantly higher in the delirium group; no patient had catatonia per the RDCC. EFA identified three BFCRS factors, with immobility/stupor, mutism, and staring loading together onto the first factor. However, EFA explained only 48% of the variance, possibly attributable to catatonia symptom overlap with other conditions. EFA supported akinesia as a core catatonia feature. Many correlations between BFCRS items and scores for apathy, parkinsonism, dementia, depression, neuroleptic use, and drowsiness suggested confounding. Few correlations were observed between BFCRS and DRS-R-98 items, notably excitement with psychosis and motor agitation, as well as mitgehen with items representing the three core delirium domains and psychosis.</p><p><strong>Conclusions: </strong>Comorbidity of catatonia with delirium was rare or absent when using <i>DSM-5-TR</i> criteria or the RDCC. The BFCRS criteria yielded a 10% catatonia rate, but BFCRS items were confounded by other conditions. Rigorous differential diagnosis of catatonia is needed among geriatric patients.</p>","PeriodicalId":16559,"journal":{"name":"Journal of Neuropsychiatry and Clinical Neurosciences","volume":" ","pages":"appineuropsych20250095"},"PeriodicalIF":3.3,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148549456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Survey on the Application Timeline for Behavioral Neurology & Neuropsychiatry Fellowship Programs. 行为神经病学和神经精神病学奖学金项目申请时间调查。
IF 3.3 4区 医学
Journal of Neuropsychiatry and Clinical Neurosciences Pub Date : 2026-07-22 DOI: 10.1176/appi.neuropsych.20240254
Sylvia Josephy-Hernandez, James R Bateman, Roy H Hamilton
{"title":"Survey on the Application Timeline for Behavioral Neurology & Neuropsychiatry Fellowship Programs.","authors":"Sylvia Josephy-Hernandez, James R Bateman, Roy H Hamilton","doi":"10.1176/appi.neuropsych.20240254","DOIUrl":"https://doi.org/10.1176/appi.neuropsych.20240254","url":null,"abstract":"<p><p>Behavioral neurology & neuropsychiatry (BNNP) fellowship programs do not have a coordinated application timeline. The authors conducted a survey to analyze the opinions of BNNP fellowship program directors (PDs) and incoming and current neuropsychiatry & neurology fellows regarding the application process and their willingness to coordinate application timelines. A one-time survey was distributed to all United Council for Neurological Subspecialties-accredited BNNP fellowship PDs, who were asked to forward the survey to current and incoming fellows. Complete responses were received from 22 PDs and from 11 current and six incoming fellows, within a span of 17 months between the first application opening (August postgraduate year 3) and the last position offering (December postgraduate year 4). Overall, 86% of the PDs agreed that the different application deadlines can negatively affect their ability to recruit applicants (p<0.001), and 95% were open to having an agreed-upon date before which no offers would be made (p<0.001). Although not a statistically significant finding, 41% of the fellows reported that different application timelines prevented them from completing interviews for all their desired programs, and 88% agreed with a unified timeline (p=0.002). Although not a statistically significant observation, 59% of the fellows reported experiencing anxiety or stress while navigating different application timelines, and 53% had anxiety and stress when trying to keep offers open while awaiting later interviews. Most participants recognized challenges because of differing timelines and agreed on unifying one or more aspects of the application process.</p>","PeriodicalId":16559,"journal":{"name":"Journal of Neuropsychiatry and Clinical Neurosciences","volume":" ","pages":"appineuropsych20240254"},"PeriodicalIF":3.3,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148549443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Neuropsychiatric Phenotype of Klüver-Bucy Syndrome: A Systematic Review of Reported Cases. kl<s:1> ver- bucy综合征的神经精神表型:对报告病例的系统回顾。
IF 2.9 4区 医学
Journal of Neuropsychiatry and Clinical Neurosciences Pub Date : 2026-06-12 DOI: 10.1176/appi.neuropsych.20250144
Jose Fernando Muñoz, Jesús Ramírez-Bermúdez, Jordi Peña-Casanova, Diana Restrepo, Clara Gómez-Henk, José Ricardo Muñoz, Miguel Restrepo-Martínez
{"title":"The Neuropsychiatric Phenotype of Klüver-Bucy Syndrome: A Systematic Review of Reported Cases.","authors":"Jose Fernando Muñoz, Jesús Ramírez-Bermúdez, Jordi Peña-Casanova, Diana Restrepo, Clara Gómez-Henk, José Ricardo Muñoz, Miguel Restrepo-Martínez","doi":"10.1176/appi.neuropsych.20250144","DOIUrl":"https://doi.org/10.1176/appi.neuropsych.20250144","url":null,"abstract":"<p><p>Klüver-Bucy syndrome (KBS) is a neuropsychiatric condition characterized by hypersexuality, hyperorality, hyperphagia, visual agnosia, hypermetamorphosis, and emotional changes such as placidity and loss of fear. Distinct diagnostic criteria are used to define both complete and partial KBS, but clinicians often face challenges due to symptom variability and unvalidated criteria. In this systematic review, the authors searched the PubMed, Embase, PsycNet, Latin America and the Caribbean Literature on Health Sciences, and OpenGrey literature databases from their inception to January 24, 2025, focusing on KBS case reports and series. Inclusion criteria required patients to meet at least three of the six classic KBS features (partial KBS) or all six features (complete KBS). Studies involving orbitofrontal syndrome were excluded. Data were independently extracted and summarized. In total, 141 articles describing 157 cases that met the inclusion criteria were included. Hypersexuality (84%), hyperorality (84%), and hyperphagia (73%) were most common in KBS, whereas hypermetamorphosis (52%) and visual agnosia (47%) were less frequent. Cognitive changes, such as attentional and memory disturbances, were also common. Neuroimaging showed bilateral temporal lobe lesions in 73% of KBS cases. Major KBS causes included central nervous system infections (27%), traumatic brain injuries (14%), and autoimmune conditions (12%). Most reports lacked standardized symptom assessment, risking underreporting of features such as visual agnosia and hypermetamorphosis. This review highlights variability in KBS and its neuropsychiatric features. A new diagnostic framework with defined certainty levels is proposed. Future research should validate these criteria and explore targeted therapies to improve the understanding and management of this syndrome.</p>","PeriodicalId":16559,"journal":{"name":"Journal of Neuropsychiatry and Clinical Neurosciences","volume":" ","pages":"appineuropsych20250144"},"PeriodicalIF":2.9,"publicationDate":"2026-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148225980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diffusion Tensor Imaging Correlates of Financial Capacity Instrument-Short Form Completion Time in Mild Cognitive Impairment. 弥散张量成像与轻度认知障碍患者财务能力量表-短表格完成时间的相关性。
IF 2.9 4区 医学
Journal of Neuropsychiatry and Clinical Neurosciences Pub Date : 2026-06-12 DOI: 10.1176/appi.neuropsych.20250087
Daniel A Stevens, Kylie Alm, Arnold Bakker, Vidyulata Kamath, Kevin J Manning, George W Rebok, Paul B Rosenberg, Milap A Nowrangi
{"title":"Diffusion Tensor Imaging Correlates of Financial Capacity Instrument-Short Form Completion Time in Mild Cognitive Impairment.","authors":"Daniel A Stevens, Kylie Alm, Arnold Bakker, Vidyulata Kamath, Kevin J Manning, George W Rebok, Paul B Rosenberg, Milap A Nowrangi","doi":"10.1176/appi.neuropsych.20250087","DOIUrl":"https://doi.org/10.1176/appi.neuropsych.20250087","url":null,"abstract":"<p><strong>Objective: </strong>The capacity to complete financial tasks accurately and efficiently is fundamental to financial independence; however, early declines in the progression of Alzheimer's disease may contribute to personal financial loss, risk for elder abuse, and increased caregiver burden. Slower performance on measures of financial capacity may reflect early disease-related changes, foreshadowing subsequent cognitive decline. The authors investigated the relationship between the time needed to complete financial tasks and white matter tract diffusion characteristics among older individuals with or without mild cognitive impairment (MCI).</p><p><strong>Methods: </strong>Fifteen participants with MCI and 15 healthy control participants completed diffusion MRI scans, a neuropsychological assessment, and the Financial Capacity Instrument-Short Form (FCI-SF). In analyses of data adjusted for demographic characteristics, Geriatric Depression Scale scores, and FCI-SF total score, the authors used diffusion tensor imaging to investigate correlations between the time needed to complete financial tasks and diffusion characteristics of white matter tracts terminating in the angular and fusiform gyri.</p><p><strong>Results: </strong>FCI-SF completion times were significantly prolonged among participants with MCI compared with healthy control participants. The two groups did not significantly differ in diffusion metrics across the selected white matter tracts. FCI-SF total completion time was significantly correlated with multiple diffusion metrics in the arcuate, vertical occipital, and inferior longitudinal fasciculi of individuals with MCI.</p><p><strong>Conclusions: </strong>Completion time measures of the FCI-SF may reflect early disease-related changes in white matter tracts implicated in reading and arithmetic performance.</p>","PeriodicalId":16559,"journal":{"name":"Journal of Neuropsychiatry and Clinical Neurosciences","volume":" ","pages":"appineuropsych20250087"},"PeriodicalIF":2.9,"publicationDate":"2026-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148226044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A 3-Week Intensive Outpatient Program for Patients With Persistent Neuropsychiatric Symptoms After Remote TBI. 远程脑外伤后持续性神经精神症状患者的3周强化门诊治疗方案
IF 2.9 4区 医学
Journal of Neuropsychiatry and Clinical Neurosciences Pub Date : 2026-05-22 DOI: 10.1176/appi.neuropsych.20250116
Alicia K Vose, Vaughn E Bryant, Jade Hannan, Jiang Bian, Hao Dai, Michael Sorna, Ramon Bautista, Scott Silliman
{"title":"A 3-Week Intensive Outpatient Program for Patients With Persistent Neuropsychiatric Symptoms After Remote TBI.","authors":"Alicia K Vose, Vaughn E Bryant, Jade Hannan, Jiang Bian, Hao Dai, Michael Sorna, Ramon Bautista, Scott Silliman","doi":"10.1176/appi.neuropsych.20250116","DOIUrl":"https://doi.org/10.1176/appi.neuropsych.20250116","url":null,"abstract":"<p><strong>Objective: </strong>The authors evaluated changes associated with a 3-week interdisciplinary intensive outpatient program that delivers integrated neuropsychiatric rehabilitation for veterans and first responders with persistent postconcussive and co-occurring symptoms after remote traumatic brain injury.</p><p><strong>Methods: </strong>In this retrospective cohort study, 128 patients completed patient-reported measures, including the Neurobehavioral Symptom Inventory (NSI), PTSD Checklist for DSM-5 (PCL-5), and Life Satisfaction Questionnaire-11 (LiSat-11), and objective assessments, comprising Addenbrooke's Cognitive Examination-III (ACE-III), gait speed, computerized dynamic posturography (for conducting the Sensory Organization Test [SOT]), and Modified Clinical Test of Sensory Interaction in Balance (mCTSIB). Paired t tests were used to compare intake with discharge measures, and a linear mixed-effects model was used to examine NSI scores over time with covariate adjustment.</p><p><strong>Results: </strong>The NSI total score decreased by 15.6 points (41%, Cohen's d=1.11); ACE-III scores improved by 6.8 points (Cohen's d=1.41); and forward and backward gait speeds, SOT composite scores, and mCTSIB condition 4 scores showed significant improvements (Cohen's d=0.68-0.87). The proportion of patients screening at or above a common PTSD threshold on the PCL-5 declined from 51% at intake to 20% at discharge, and higher baseline PCL-5 scores were associated with higher NSI scores across time points (p<0.001).</p><p><strong>Conclusions: </strong>These findings are consistent with multidomain benefits of intensive, interdisciplinary neuropsychiatric rehabilitation in this population. These results support the potential of integrated care models to reduce symptom burden and improve cognitive, mobility, vestibular, and life satisfaction outcomes over 3 weeks, while underscoring the close linkage between posttraumatic stress severity and neurobehavioral symptom burden.</p>","PeriodicalId":16559,"journal":{"name":"Journal of Neuropsychiatry and Clinical Neurosciences","volume":" ","pages":"appineuropsych20250116"},"PeriodicalIF":2.9,"publicationDate":"2026-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147987903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Case Study 12: A 57-Year-Old Man With Seizures, Paranoid Psychosis, and Catatonia. 案例研究12:一名患有癫痫、偏执型精神病和紧张症的57岁男性。
IF 2.9 4区 医学
Journal of Neuropsychiatry and Clinical Neurosciences Pub Date : 2026-05-14 DOI: 10.1176/appi.neuropsych.20250141
Nathan Praschan, Stanley Lyndon, Seth A Gale, David Silbersweig, Kirk Daffner, Barbara Schildkrout, Scott M McGinnis
{"title":"Case Study 12: A 57-Year-Old Man With Seizures, Paranoid Psychosis, and Catatonia.","authors":"Nathan Praschan, Stanley Lyndon, Seth A Gale, David Silbersweig, Kirk Daffner, Barbara Schildkrout, Scott M McGinnis","doi":"10.1176/appi.neuropsych.20250141","DOIUrl":"https://doi.org/10.1176/appi.neuropsych.20250141","url":null,"abstract":"","PeriodicalId":16559,"journal":{"name":"Journal of Neuropsychiatry and Clinical Neurosciences","volume":" ","pages":"appineuropsych20250141"},"PeriodicalIF":2.9,"publicationDate":"2026-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147930489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Outcomes of Integrated Practice Unit Treatment for Mild Traumatic Brain Injury and Co-occurring Conditions Among Veterans. 退伍军人轻度创伤性脑损伤及并发疾病综合实践单元治疗的效果。
IF 2.9 4区 医学
Journal of Neuropsychiatry and Clinical Neurosciences Pub Date : 2026-05-14 DOI: 10.1176/appi.neuropsych.20250283
Anneliese T Elmer, David B Arciniegas, Catharine H Johnston-Brooks, Christopher M Filley, James P Kelly, Jeffrey R Hebert
{"title":"Outcomes of Integrated Practice Unit Treatment for Mild Traumatic Brain Injury and Co-occurring Conditions Among Veterans.","authors":"Anneliese T Elmer, David B Arciniegas, Catharine H Johnston-Brooks, Christopher M Filley, James P Kelly, Jeffrey R Hebert","doi":"10.1176/appi.neuropsych.20250283","DOIUrl":"https://doi.org/10.1176/appi.neuropsych.20250283","url":null,"abstract":"<p><strong>Objective: </strong>Persistent cognitive, emotional, and somatic symptoms after mild traumatic brain injury (mTBI) and co-occurring health conditions require multimodal treatment approaches. In this study, the authors assessed the efficacy of an integrated practice unit (IPU) approach to treat veterans with chronic post-mTBI symptoms and co-occurring conditions.</p><p><strong>Methods: </strong>Patient-reported outcomes were retrospectively assessed with scores on the Neurobehavioral Symptom Inventory (NSI), PTSD Checklist for DSM-5 (PCL-5), Life Satisfaction Questionnaire-11 (LiSaT-11), Participation of Recombined Tools-objective (PART-O), and Patient Global Impression of Change (PGIC) instruments during and after participation in an intensive outpatient program. Unadjusted analyses were conducted with paired t tests between time points, and linear mixed models that were controlled for demographic factors were used to evaluate changes in NSI and PCL-5 scores between time points.</p><p><strong>Results: </strong>Records from 219 participants (88% men), mean±SD age=45.8±9.6 years, were included. Total NSI, PCL-5, and LiSaT-11 scores improved from admission to discharge and to 1 month after discharge; observed effect sizes were medium to very large. Average PART-O total scores did not significantly improve between admission and 1 month postdischarge. The observed improvements in total NSI and PCL-5 scores remained statistically significant after analyses were adjusted for demographic factors. Responder analyses indicated clinically meaningful improvements in mTBI and posttraumatic stress symptoms. Nearly all participants endorsed positive PGIC statements at discharge and 1 month postdischarge.</p><p><strong>Conclusions: </strong>The IPU approach to the evaluation and management of persistent post-mTBI symptoms and co-occurring conditions suggests significant symptom reduction and improvement in wellness in a veteran population.</p>","PeriodicalId":16559,"journal":{"name":"Journal of Neuropsychiatry and Clinical Neurosciences","volume":" ","pages":"appineuropsych20250283"},"PeriodicalIF":2.9,"publicationDate":"2026-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147930550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rates of Comorbid Psychiatric Conditions Among Adults With Hydrocephalus at a Hydrocephalus Specialty Center. 在脑积水专科中心的成人脑积水共病精神状况的比率。
IF 2.9 4区 医学
Journal of Neuropsychiatry and Clinical Neurosciences Pub Date : 2026-04-24 DOI: 10.1176/appi.neuropsych.20250270
Philip C Huang, Michael J C Bray, Sazal Sthapit, Christopher C Cranston, Mark G Luciano, Matthew E Peters
{"title":"Rates of Comorbid Psychiatric Conditions Among Adults With Hydrocephalus at a Hydrocephalus Specialty Center.","authors":"Philip C Huang, Michael J C Bray, Sazal Sthapit, Christopher C Cranston, Mark G Luciano, Matthew E Peters","doi":"10.1176/appi.neuropsych.20250270","DOIUrl":"https://doi.org/10.1176/appi.neuropsych.20250270","url":null,"abstract":"<p><strong>Objective: </strong>The relationship between hydrocephalus and comorbid psychiatric conditions among adults remains unclear. The authors characterized the prevalence of psychiatric conditions among adult patients with hydrocephalus and compared the rates of these conditions among hydrocephalus subtypes.</p><p><strong>Methods: </strong>A retrospective study of patients ages ≥18 years from a tertiary hydrocephalus specialty center was conducted by reviewing electronic health record data. Participants (N=2,668) were required to have an <i>ICD-10</i> diagnosis of hydrocephalus (G91) or congenital hydrocephalus (Q03) in their active problem list. Hierarchical logistic regression analysis was performed to compare psychiatric outcomes among hydrocephalus subtypes after analyses had been adjusted for age at the last visit, gender, and number of hydrocephalus center encounters.</p><p><strong>Results: </strong>Overall, 31% of the study participants had at least one comorbid psychiatric condition, most commonly depression (15%), anxiety disorder (10%), dementia (7%), or a substance use disorder (5%). Female gender was significantly associated with depression and anxiety disorder. Older age was linked to increased odds of dementia and a history of psychiatric encounters, and younger age was associated with anxiety disorders, substance use disorders, intellectual disability, developmental disorders, and childhood-onset behavioral and emotional disorders. Congenital hydrocephalus was associated with higher odds of intellectual disability, and no significant difference in psychiatric outcomes was detected between communicating and obstructive hydrocephalus.</p><p><strong>Conclusions: </strong>Comorbid psychiatric conditions affect a substantial proportion of adult patients with hydrocephalus. Age and gender differences in psychiatric diagnoses resemble trends in the general population. These findings highlight a need to improve psychiatric screening among adult patients with hydrocephalus.</p>","PeriodicalId":16559,"journal":{"name":"Journal of Neuropsychiatry and Clinical Neurosciences","volume":" ","pages":"appineuropsych20250270"},"PeriodicalIF":2.9,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Case Study 11: A 67-Year-Old Man With Behavioral Disturbances and Frequent Falls. 案例研究11:一名行为障碍和经常跌倒的67岁男性。
IF 3.3 4区 医学
Journal of Neuropsychiatry and Clinical Neurosciences Pub Date : 2026-04-24 DOI: 10.1176/appi.neuropsych.20250213
Syed Kamal, Naomi Kennel, Alice M Li, Seth A Gale, Elizabeth L Hennessey, Bianca N Rodriguez, Mel B Feany, Andrew M Stern, Vijay S Ganesh, Barbara Schildkrout, Kirk Daffner, David A Silbersweig, Tarun Singhal, Isaiah Kletenik, Michael B Miller
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