Journal of Neuropsychiatry and Clinical Neurosciences最新文献

{"title":"Tactile-Induced Catalepsy for Motor FND: A Feasibility Single-Case Experimental Study and Standardized Protocol.","authors":"Anne G Lever, Franny C Moene, Else M Ludden-Loman, Roxanne Alink, Jeanette M Gelauff, Timothy R Nicholson, Lineke M Tak","doi":"10.1176/appi.neuropsych.20260149","DOIUrl":"https://doi.org/10.1176/appi.neuropsych.20260149","url":null,"abstract":"<p><strong>Objective: </strong>Functional neurological disorder (FND) is a common and potentially disabling condition for which accessible, evidence-based treatments remain limited. Tactile-induced catalepsy is a novel intervention that temporarily induces increased muscle tone and postural fixation through noninvasive patterned tactile stimulation, potentially facilitating motor retraining. The authors evaluated the feasibility, acceptability, and safety of tactile-induced catalepsy in motor FND.</p><p><strong>Methods: </strong>A nonconcurrent multiple-baseline single-case experimental design study was conducted with three adults with motor FND. After a 2- to 4-week baseline phase, participants received 12 weekly sessions of tactile-induced catalepsy delivered by an FND-specialized physiotherapist. Physical functioning was assessed twice weekly by using the physical functioning subscale of the 36-item Short-Form Health Survey. Phase and time effects were analyzed with linear mixed-effects models, supplemented by reliable change indices and minimal clinically important difference thresholds.</p><p><strong>Results: </strong>Two participants showed statistically significant and clinically meaningful improvements in physical functioning during the treatment, and one had a smaller, nonsignificant improvement. No adverse events were reported, and the intervention was feasible to deliver in an outpatient setting.</p><p><strong>Conclusions: </strong>Tactile-induced catalepsy was found to be feasible and associated with improved physical functioning among most participants, supporting further evaluation in larger controlled studies as a potentially accessible and scalable intervention for managing motor FND.</p>","PeriodicalId":16559,"journal":{"name":"Journal of Neuropsychiatry and Clinical Neurosciences","volume":" ","pages":"appineuropsych20260149"},"PeriodicalIF":3.3,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149224350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain Stimulation as a Treatment for Apathy: A Scoping Review of Effects and Safety.","authors":"Parneet Grewal, Michael B Seidman, Joseph Chasen, Daniel Lench, Ivy Dickens, Emily A Brennan, Federico Rodriguez-Porcel, John Kindred, Mark S George, Steve Kautz, Kevin A Caulfield, Lisa M McTeague","doi":"10.1176/appi.neuropsych.20250297","DOIUrl":"https://doi.org/10.1176/appi.neuropsych.20250297","url":null,"abstract":"<p><strong>Objective: </strong>Apathy is a neuropsychiatric syndrome characterized by impairment of goal-directed behavior, cognition, and emotional responsiveness. In this scoping review, the authors evaluated the literature on brain stimulation for the treatment of patients with apathy across diagnostic categories and provide recommendations to guide future research and practice.</p><p><strong>Methods: </strong>The authors searched PubMed, Scopus, and PsycInfo for studies involving brain stimulation for apathy as a primary or secondary outcome.</p><p><strong>Results: </strong>From 1,209 records, 52 studies evaluating brain stimulation were included; of these, 10 systematic reviews or meta-analyses were synthesized separately. Modalities included repetitive transcranial magnetic stimulation (rTMS; N=26), deep brain stimulation (DBS; N=7), transcranial direct current stimulation (tDCS; N=6), electroconvulsive therapy (N=1), transcranial alternating current stimulation (N=1), and transcranial pulsating electromagnetic field therapy (N=1). Populations included patients with schizophrenia (N=477), Parkinson's disease (PD; N=289), depression (N=288), Alzheimer's disease (AD) and mild cognitive impairment (MCI) (N=210), Huntington's disease (N=42), PD with MCI (N=28), traumatic brain injury (N=28), stroke (N=14), COVID-19 (N=12), and dementia with Lewy bodies (N=6) (total N=1,366). rTMS improved apathy measures, most consistently in AD, with positive trends in depression, MCI, stroke, and schizophrenia. tDCS showed variable effects, with some benefits for schizophrenia. DBS showed mixed results, varying with stimulation location. Observed adverse events were mild and modality specific.</p><p><strong>Conclusions: </strong>Investigations into brain stimulation as a treatment for apathy show some promise. Conclusions were limited by small sample sizes, heterogeneous study designs, and variable outcome measures. Randomized trials with common validated apathy instruments, standardized stimulation parameters, and harmonized diagnostic measures may help advance the field.</p>","PeriodicalId":16559,"journal":{"name":"Journal of Neuropsychiatry and Clinical Neurosciences","volume":" ","pages":"appineuropsych20250297"},"PeriodicalIF":3.3,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149224382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Irritability Among Veterans With Chronic Mild Traumatic Brain Injury: Psychological and Sensory Neurophysiological Factors.","authors":"Jeffrey R Hebert, Jessica M Ketchum, Christopher M Filley, Kayla L Crowder, David Rubinstein, Ramesh Karki, Isabelle Buard, Shaylin A Schundler, Ashley V McCann, David B Arciniegas","doi":"10.1176/appi.neuropsych.20260132","DOIUrl":"https://doi.org/10.1176/appi.neuropsych.20260132","url":null,"abstract":"<p><strong>Objective: </strong>The etiology of irritability among persons with chronic mild traumatic brain injury (mTBI) is poorly understood. The authors investigated relationships among irritability, posttraumatic stress (PTS), and multiple sensory processing indices among veterans with or without mTBI.</p><p><strong>Methods: </strong>In this cross-sectional study (N=124), military veterans with chronic mTBI (experimental group; N=61) and veterans without a history of TBI (control group; N=63) completed the Brief Irritability Test (BITe; primary outcome) and Irritability Questionnaire (IRQ; secondary outcome). The Posttraumatic Stress Disorder Checklist for DSM-5 was used to measure PTS symptoms, with scores ≥33 indicating probable posttraumatic stress disorder (PTSD). Pain, computerized postural control, and functional hearing (signal-to-noise ratio [SNR] loss) were also assessed.</p><p><strong>Results: </strong>Compared with the control group, the experimental group had significantly greater irritability as indicated by BITe and IRQ scores (Cohen's d=0.75-1.21, p<0.001), higher PTS symptom burden (Cohen's d=0.99, p<0.001), greater pain (Cohen's d=1.00, p<0.001), worse postural control (Cohen's d=0.37-0.65, p≤0.044), and greater SNR loss (Cohen's d=0.51, p=0.005). Probable PTSD (partial eta-squared [η²] effect size=0.27-0.32) and pain (η²=0.05-0.06) correlated with irritability most strongly; mTBI status remained independently associated with BITe scores (η²=0.08) but not with IRQ scores. Greater SNR loss was independently associated with BITe scores (η²=0.04) and marginally associated with IRQ scores (η²=0.028-0.029).</p><p><strong>Conclusions: </strong>Irritability was a prominent symptom among veterans with chronic mTBI and was strongly associated with PTSD and pain, with additional contributions from auditory processing. These findings suggest that irritability in chronic mTBI is multifactorial, reflecting both psychological and sensory neurophysiological factors.</p>","PeriodicalId":16559,"journal":{"name":"Journal of Neuropsychiatry and Clinical Neurosciences","volume":" ","pages":"appineuropsych20260132"},"PeriodicalIF":3.3,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148982752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Antidepressants on the Relationship Between Disease Duration and Depressive Symptoms in Multiple Sclerosis.","authors":"David E Freedman, Jiwon Oh, Anthony Feinstein","doi":"10.1176/appi.neuropsych.20260024","DOIUrl":"https://doi.org/10.1176/appi.neuropsych.20260024","url":null,"abstract":"<p><strong>Objective: </strong>Studies have not shown an association between multiple sclerosis (MS) disease duration and depression among people with MS. However, whether antidepressant use influences this possible relationship remains unknown. The authors evaluated whether antidepressant use moderates the association between disease duration and clinically significant depressive symptoms among individuals with MS.</p><p><strong>Methods: </strong>A consecutive sample of 1,076 adults with MS received psychometric testing during clinical care at a tertiary neuropsychiatry clinic in Toronto from 2020 to 2025. Demographic and disease-related data were gathered via retrospective chart review. A logistic regression analysis adjusted for age, sex, education, Expanded Disability Status Scale (EDSS) scores, and Symbol Digit Modalities Test scores was undertaken to evaluate whether the interaction between antidepressant use and disease duration predicted clinically significant depression (Hospital Anxiety and Depression Scale depression subscale score ≥8). Stratified by antidepressant use, secondary regression analyses controlling for the same covariates were used to evaluate whether disease duration was independently associated with depression. Statistical significance was set at p<0.05.</p><p><strong>Results: </strong>Mean participant age was 43.9±11.5 years, 76% were women, the mean length of education was 16.0±3.1 years, and the median EDSS score was 2.0 (interquartile range 1.5-3.5). Antidepressant use significantly moderated the relationship between disease duration and clinically significant depressive symptoms (p=0.017). In the absence of antidepressants, increased disease duration predicted elevated odds of depression (OR=1.02, p=0.038) but not in the presence of antidepressants (OR=0.98).</p><p><strong>Conclusions: </strong>Antidepressant use is associated with a lessened influence of prolonged disease duration on an increased odds of clinically significant depression among people with MS.</p>","PeriodicalId":16559,"journal":{"name":"Journal of Neuropsychiatry and Clinical Neurosciences","volume":" ","pages":"appineuropsych20260024"},"PeriodicalIF":3.3,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148982792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Clinical Prediction Model for Self-Harm After Adolescent Traumatic Brain Injury.","authors":"Maya G T Ogonah, Ioannis Mavroudis, Daniel Whiting, Seena Fazel","doi":"10.1176/appi.neuropsych.20260042","DOIUrl":"https://doi.org/10.1176/appi.neuropsych.20260042","url":null,"abstract":"<p><strong>Objective: </strong>Few prognostic models are available to assess risks of adverse outcomes among traumatic brain injury (TBI) patients beyond acute care. Self-harm is an important adverse outcome with modifiable risk factors. The authors developed and validated a risk model for self-harm after TBI in adolescence.</p><p><strong>Methods: </strong>In this retrospective cohort study, the authors utilized a population-linked dataset based in Wales (the Secure Anonymised Information Linkage Databank). It included adolescents ages 10-24 years who sought health care services with a diagnosis of TBI between January 1, 2009, and October 16, 2023. Cox regression analysis was used to develop a prediction model for the association between risk factors and time to self-harm, with optimism-corrected bootstrapping for internal validation. Model performance was assessed as discrimination and calibration.</p><p><strong>Results: </strong>In total, 34,092 adolescents were in the model development cohort, of whom 538 (1.6%) and 1,202 (3.5%) had recorded self-harm episodes within 1 year and 3 years of the index TBI, respectively. Twelve predictors were included in the risk model, including a history of self-harm, psychiatric conditions, and substance use as strong predictors. The optimism-adjusted area under the receiver operating characteristic curve was 0.74 at 1 year and 0.72 at 3 years post-TBI. The model demonstrated good calibration at both time horizons.</p><p><strong>Conclusions: </strong>A prognostic model based on data from electronic health records could accurately predict self-harm risk after adolescent TBI. Further research is needed to assess the model's clinical utility and transportability. Use of a prognostic model may assist clinical decision making about risk and resource allocation after TBI.</p>","PeriodicalId":16559,"journal":{"name":"Journal of Neuropsychiatry and Clinical Neurosciences","volume":" ","pages":"appineuropsych20260042"},"PeriodicalIF":3.3,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148919689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Presentations and Treatment Experiences of Functional Neurological Disorder in the Perinatal Period.","authors":"Sanne van Rhijn, Roxanne C Keynejad, Alexander Lehn, Jan Coebergh, Helen Galley, Verónica Cabreira, Ingrid Hoeritzauer","doi":"10.1176/appi.neuropsych.20250261","DOIUrl":"https://doi.org/10.1176/appi.neuropsych.20250261","url":null,"abstract":"<p><strong>Objective: </strong>The perinatal period (from conception to 12 months postpartum) is defined by major general medical and psychological transitions that may contribute to functional neurological disorder (FND). The authors examined symptoms and care pathways of FND during the perinatal period and relationships to maternal functioning, obstetric outcomes, and infant care.</p><p><strong>Methods: </strong>Through convenience sampling, data from 41 individuals with FND during the perinatal period were identified in neurology and perinatal mental health service clinical records in the United Kingdom and Australia. Anonymized data on FND symptom course, treatment, delivery mode, and impacts on infant care were extracted from the records.</p><p><strong>Results: </strong>The most prevalent diagnosis was functional seizures only (46%) or combined with motor FND (24%). Worsening of symptoms was most frequently reported in late pregnancy and postpartum (32% in the early postnatal period), but a substantial number of individuals were lost to follow-up. Comorbid depression (51%), anxiety disorder (54%), and posttraumatic stress disorder (39%) were prevalent. Cesarean delivery was common (42%), but neither cesarean nor epidural anesthesia was associated with exacerbation of preexisting FND symptoms. Nearly half of participants reported difficulties with infant care (49%); taking safety precautions was documented for individuals with both motor and seizure presentations. By 6-12 months postpartum, 38% reported a return to prepregnancy functioning, whereas 41% had persistent limitations.</p><p><strong>Conclusions: </strong>FND symptoms fluctuate during the perinatal period and can affect infant caregiving. Prospective observational studies could help inform care pathways for individuals of childbearing age with FND.</p>","PeriodicalId":16559,"journal":{"name":"Journal of Neuropsychiatry and Clinical Neurosciences","volume":" ","pages":"appineuropsych20250261"},"PeriodicalIF":3.3,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148919708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations Between Combat Exposure, Traumatic Brain Injury, and Sleep Outcomes Among Post-9/11 Veterans.","authors":"Leah D Talbert, Fini Chang, Lay Kodama, Elizabeth Valocchi, Catherine Chanfreau-Coffinier, Victoria C Merritt","doi":"10.1176/appi.neuropsych.20260035","DOIUrl":"https://doi.org/10.1176/appi.neuropsych.20260035","url":null,"abstract":"<p><strong>Objective: </strong>The authors examined the relationship between veterans' combat experiences and multiple dimensions of sleep health and how traumatic brain injury (TBI) history may modulate these relationships.</p><p><strong>Methods: </strong>Participants were 17,812 post-9/11 veterans (mean±SD age=46.6±10.8; 80.1% men) enrolled in the U.S. Department of Veterans Affairs (VA) Million Veteran Program (MVP). Combat experiences were assessed with the Combat Exposure Scale (CES) from the Deployment Risk and Resilience Inventory (DRRI), with \"high combat\" defined as a higher frequency of all combat experiences assessed on the CES-DRRI. Sleep health variables included sleep duration, sleep disturbance, and obstructive sleep apnea (OSA) assessed via self-report on MVP surveys. Probable positive or negative TBI history was defined by using the VA TBI Clinical Reminder Screen. Group differences were evaluated with chi-square tests, t tests, analyses of variance, and regression models adjusted for demographic and clinical covariates.</p><p><strong>Results: </strong>High combat exposure and screening positive for TBI were each independently and significantly associated with poorer sleep outcomes, suggesting largely additive effects of these risk factors on sleep health. Pairwise comparisons showed that veterans with high combat exposure and a positive TBI screen had the shortest sleep duration, most significant sleep disturbances, and highest OSA rates, consistent with a cumulative burden among those exposed to both risk factors.</p><p><strong>Conclusions: </strong>These findings support the notion that intensive combat exposure and probable TBI history each contributes to worse sleep health, with their combination conferring the worst outcomes. Incorporating combat exposure profiles alongside TBI screening may enhance risk stratification and support targeted, sleep-focused interventions for post-9/11 veterans.</p>","PeriodicalId":16559,"journal":{"name":"Journal of Neuropsychiatry and Clinical Neurosciences","volume":" ","pages":"appineuropsych20260035"},"PeriodicalIF":3.3,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148829442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlates and Predictors of Metamemory in an Online Sample.","authors":"Jennifer K Hoots, Lawrence Chan, Nathan E Cook, W Curt LaFrance, Ryan Van Patten","doi":"10.1176/appi.neuropsych.20250292","DOIUrl":"https://doi.org/10.1176/appi.neuropsych.20250292","url":null,"abstract":"<p><strong>Objective: </strong>Metamemory is a key component of various neuropsychiatric conditions, including functional cognitive disorder, and is associated with quality of life across such conditions. Improved characterization of correlates and predictors of metamemory in the general population may help inform clinical care. The authors examined psychometric properties of the Multifactorial Memory Questionnaire (MMQ), as well as relationships of metamemory with well-being and health-related factors.</p><p><strong>Methods: </strong>In total, 438 U.S. adults (mean±SD age=32.0±7.0 years) completed an online survey on Amazon's Mechanical Turk platform. Psychometric properties of three MMQ scales were assessed, and hierarchical regressions were used to examine how metamemory relates to well-being and health-related factors (i.e., emotional distress, sleep disturbance, and pain interference).</p><p><strong>Results: </strong>All three MMQ scales showed adequate internal consistency and convergent validity. Only MMQ-ability showed good discriminant validity. Inclusion of MMQ scale scores improved models predicting well-being, beyond demographic characteristics alone (meaning and purpose, R²=0.31; ability to participate, R²=0.22; both p<0.001). Inclusion of health-related factors, particularly emotional distress and sleep disturbance, improved models predicting MMQ-satisfaction, MMQ-ability, and MMQ-strategy scores, beyond demographic characteristics alone (R²=0.40, R²=0.30, and R²=0.14, respectively; all p<0.001).</p><p><strong>Conclusions: </strong>The MMQ is a psychometrically robust measure of metamemory, with scientific and clinical utility in neuropsychiatry. Metamemory was found to be related to well-being in a heterogeneous adult sample from the general population. Health-related variables, particularly emotional distress and sleep disturbance, are associated with memory satisfaction, perceived memory, and strategy use. These findings emphasize the importance of assessing metamemory and incorporating health-related variables into conceptualization and treatment of metamemory in neuropsychiatric conditions.</p>","PeriodicalId":16559,"journal":{"name":"Journal of Neuropsychiatry and Clinical Neurosciences","volume":" ","pages":"appineuropsych20250292"},"PeriodicalIF":3.3,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148829372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lifetime Concussions and Head Impact Exposure During Collegiate Athletics: A CARE Consortium Study.","authors":"Allyssa K Memmini, Chengyun Li, Kelly M Mosesso, Susan M Perkins, Adrian J Boltz, Landon B Lempke, Reid A Syrydiuk, Jie Ren, Jaroslaw Harezlak, Paul F Pasquina, Thomas W McAllister, Michael A McCrea, Steven P Broglio","doi":"10.1176/appi.neuropsych.20250299","DOIUrl":"https://doi.org/10.1176/appi.neuropsych.20250299","url":null,"abstract":"<p><strong>Objective: </strong>Despite a growing interest in the long-term effects of concussion and repetitive head impacts (RHIs) on brain health, understanding is limited regarding the clinical and cognitive changes that may accrue during collegiate athletics.</p><p><strong>Methods: </strong>Collegiate student-athletes enrolled in the Concussion Assessment, Research, and Education Consortium from 2014 to 2021 (N=3,663) completed baseline (at initial enrollment) and exit (at the end of college) assessments. Proxies for RHIs were estimated with sport contact classification (high exposure, low exposure, and unexposed) and total years of primary sport participation. Multivariable linear regressions were used to examine the effects of these variables and the lifetime number of concussions on change scores across somatic, postural stability, and neurocognitive measures.</p><p><strong>Results: </strong>Both low- and high-exposure sport student-athletes had lower (i.e., better) symptom change scores (symptom total: β=-0.62, 95% CI=-1.01, -0.24, p=0.002 [low exposure]; β=-0.80, 95% CI=-1.20, -0.40, p<0.001 [high exposure], and symptom severity: β=-1.58, 95% CI=-2.47, -0.70, p<0.001 [low exposure]; β=-2.17, 95% CI=-3.09, -1.24, p<0.001 [high exposure]), compared with student-athletes in unexposed sports. High-exposure student-athletes had faster reaction time change scores during neurocognitive testing (β=-0.02, 95% CI=-0.03, -0.01, p=0.001). Student-athletes with one or two previous concussions had improved cognitive change scores (β=0.35, 95% CI=0.14, 0.57, p=0.001), compared with those without concussion. A greater number of total years of primary sport participation was associated with lower symptom total change scores (β=-0.06, 95% CI=-0.10, -0.02, p=0.004).</p><p><strong>Conclusions: </strong>These findings suggest that RHIs or lifetime number of concussions have no clinical consequences during university athletics. Further longitudinal investigations are warranted to evaluate brain health later in life.</p>","PeriodicalId":16559,"journal":{"name":"Journal of Neuropsychiatry and Clinical Neurosciences","volume":" ","pages":"appineuropsych20250299"},"PeriodicalIF":3.3,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148684849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression-Experience Decoupling: Disambiguating the Behavioral and Phenomenal Features of Catatonia.","authors":"William J W Choi, Colin J Harrington, Michael J Young","doi":"10.1176/appi.neuropsych.20260107","DOIUrl":"https://doi.org/10.1176/appi.neuropsych.20260107","url":null,"abstract":"","PeriodicalId":16559,"journal":{"name":"Journal of Neuropsychiatry and Clinical Neurosciences","volume":" ","pages":"appineuropsych20260107"},"PeriodicalIF":3.3,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148684791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}