Journal of Neurology最新文献

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The role of 7 T MRI to assess atrophy of the subcortical deep gray matter in relapsing-remitting multiple sclerosis. 7 T 磁共振成像在评估复发缓解型多发性硬化症皮层下深灰质萎缩中的作用。
IF 4.8 2区 医学
Journal of Neurology Pub Date : 2024-10-01 Epub Date: 2024-09-06 DOI: 10.1007/s00415-024-12656-y
Alexis M Callen, Jonathan Zurawski, Renxin Chu, Yanmei Tie, Shahamat Tauhid, Molly Quattrucci, Brian C Healy, Rohit Bakshi
{"title":"The role of 7 T MRI to assess atrophy of the subcortical deep gray matter in relapsing-remitting multiple sclerosis.","authors":"Alexis M Callen, Jonathan Zurawski, Renxin Chu, Yanmei Tie, Shahamat Tauhid, Molly Quattrucci, Brian C Healy, Rohit Bakshi","doi":"10.1007/s00415-024-12656-y","DOIUrl":"10.1007/s00415-024-12656-y","url":null,"abstract":"<p><strong>Background: </strong>Deep gray matter (DGM) atrophy and lesions are found in multiple sclerosis (MS).</p><p><strong>Objective: </strong>To optimize automated segmentation for 7 T DGM volumetrics and assess sensitivity to atrophy and relationship to DGM lesions and disability in relapsing-remitting (RR) MS.</p><p><strong>Methods: </strong>30 RRMS subjects [mean age 44.0 years, median Expanded Disability Status Scale (EDSS) score 2] and 14 healthy controls underwent 7 T MRI with 3D magnetization-prepared 2 rapid gradient-echoes (MP2RAGE) and fluid-attenuated inversion recovery. Customizing an automated pipeline to assess DGM structure volumes required pre-processing combining two MP2RAGE inversion times and uniform T1 images, and noise-suppressed reconstruction. DGM volumes were normalized. Brain DGM lesions and white matter T2 lesion volume (T2LV) were expert-quantified. Spearman correlations and Wilcoxon rank-sum tests were assessed.</p><p><strong>Results: </strong>DGM lesions were found in 77% (n = 23) of MS subjects and no controls, with thalamic lesions most prevalent (73%). An average of 3.6 DGM lesions was found per person with MS. Total DGM volumes were lower in MS vs. controls (p = 0.034), varying by region, most pronounced in the caudate (p = 0.008). DGM volumes inversely correlated with EDSS (total DGM: r = - 0.45, p = 0.014; globus pallidus: r =  - 0.42, p = 0.023; putamen: r = - 0.44, p = 0.016; caudate: r = - 0.37, p = 0.047) and T2LV (total DGM: r = - 0.53, p = 0.003; putamen: r = - 0.40, p = 0.030; thalamus: r = - 0.63, p < 0.001). DGM atrophy was most closely linked to disability among all MRI measures. Thalamic lesion volume correlated inversely with thalamic volume (r = - 0.38, p = 0.045).</p><p><strong>Conclusion: </strong>7 T MRI shows a link between DGM atrophy and both white matter lesions and physical disability in RRMS. Thalamic lesions are associated with thalamic atrophy.</p>","PeriodicalId":16558,"journal":{"name":"Journal of Neurology","volume":" ","pages":"6935-6943"},"PeriodicalIF":4.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142140358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pediatric-onset Multiple Sclerosis treatment: a multicentre observational study comparing natalizumab with fingolimod. 小儿多发性硬化症治疗:纳他珠单抗与芬戈莫德的多中心观察研究比较。
IF 4.8 2区 医学
Journal of Neurology Pub Date : 2024-10-01 Epub Date: 2024-08-23 DOI: 10.1007/s00415-024-12610-y
Antonio Carotenuto, Cristina Di Monaco, Laura Papetti, Giovanna Borriello, Elisabetta Signoriello, Camilla Masciulli, Valentina Tomassini, Giovanna De Luca, Antonio Ianniello, Giacomo Lus, Federica Novarella, Antonio Luca Spiezia, Dario Di Somma, Marcello Moccia, Maria Petracca, Carmine Iacovazzo, Giuseppe Servillo, Emilio Portaccio, Maria Triassi, Maria Pia Amato, Carlo Pozzilli, Massimiliano Valeriani, Vincenzo Brescia Morra, Roberta Lanzillo
{"title":"Pediatric-onset Multiple Sclerosis treatment: a multicentre observational study comparing natalizumab with fingolimod.","authors":"Antonio Carotenuto, Cristina Di Monaco, Laura Papetti, Giovanna Borriello, Elisabetta Signoriello, Camilla Masciulli, Valentina Tomassini, Giovanna De Luca, Antonio Ianniello, Giacomo Lus, Federica Novarella, Antonio Luca Spiezia, Dario Di Somma, Marcello Moccia, Maria Petracca, Carmine Iacovazzo, Giuseppe Servillo, Emilio Portaccio, Maria Triassi, Maria Pia Amato, Carlo Pozzilli, Massimiliano Valeriani, Vincenzo Brescia Morra, Roberta Lanzillo","doi":"10.1007/s00415-024-12610-y","DOIUrl":"10.1007/s00415-024-12610-y","url":null,"abstract":"<p><strong>Background: </strong>Pediatric-onset Multiple Sclerosis (POMS) patients show more inflammatory disease compared with adult-onset MS. However, highly effective treatments are limited with only fingolimod being approved in Italy and natalizumab prescribed as off-label treatment.</p><p><strong>Objectives: </strong>to compare the efficacy of natalizumab versus fingolimod in POMS.</p><p><strong>Methods: </strong>This is an observational longitudinal multicentre study including natalizumab- and fingolimod-treated POMS patients (N-POMS and F-POMS, respectively). We collected Annual Relapse Rate (ARR), Expanded Disability Status Scale (EDSS), Symbol Digit Modality Test (SDMT), and MRI activity at baseline (T0), 12-18 months (T1), and last available observation (T2).</p><p><strong>Results: </strong>We enrolled 57 N-POMS and 27 F-POMS patients from six Italian MS Centres. At T0, N-POMS patients showed higher ARR (p = 0.03), higher EDSS (p = 0.003) and lower SDMT (p = 0.04) at baseline compared with F-POMS. Between T<sub>0</sub> and T<sub>1</sub> ARR improved for both N-POMS and F-POMS (p < 0.001), while EDSS (p < 0.001) and SDMT (p = 0.03) improved only for N-POMS. At T<sub>2</sub> (66.1 ± 55.4 months) we collected data from 42 out of 57 N-POMS patients showing no further ARR decrease.</p><p><strong>Conclusion: </strong>Both natalizumab and fingolimod showed high and sustained efficacy in controlling relapses and natalizumab also associated to a disability decrease in POMS. This latter effect might be partly mediated by the high inflammatory activity at baseline in N-POMS.</p>","PeriodicalId":16558,"journal":{"name":"Journal of Neurology","volume":" ","pages":"6773-6781"},"PeriodicalIF":4.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11446972/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142036084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A multidimensional gender analysis of health technology self-efficacy among people with Parkinson's disease. 帕金森病患者对医疗技术自我效能感的多维性别分析。
IF 4.8 2区 医学
Journal of Neurology Pub Date : 2024-10-01 Epub Date: 2024-08-22 DOI: 10.1007/s00415-024-12635-3
Irene Göttgens, Sirwan K L Darweesh, Bastiaan R Bloem, Sabine Oertelt-Prigione
{"title":"A multidimensional gender analysis of health technology self-efficacy among people with Parkinson's disease.","authors":"Irene Göttgens, Sirwan K L Darweesh, Bastiaan R Bloem, Sabine Oertelt-Prigione","doi":"10.1007/s00415-024-12635-3","DOIUrl":"10.1007/s00415-024-12635-3","url":null,"abstract":"<p><strong>Background: </strong>Digital health technologies (DHT) enable self-tracking of bio-behavioral states and pharmacotherapy outcomes in various diseases. However, the role of gender, encompassing social roles, expectations, and relations, is often overlooked in their adoption and use. This study addresses this issue for persons with Parkinson's disease (PD), where DHT hold promise for remote evaluations.</p><p><strong>Methods: </strong>We conducted a cross-sectional survey study in the Netherlands, assessing the impact of gender identity, roles, and relations on health technology self-efficacy (HTSE) and attitude (HTA). An intersectional gender analysis was applied to explore how gender intersects with education, employment, disease duration, and severity in influencing HTSE and HTA.</p><p><strong>Results: </strong>Among 313 participants (40% women), no significant correlation was found between gender identity or relations and HTSE or HTA. However, individuals with an androgynous (non-binary) gender role orientation demonstrated better HTSE and HTA. The exploratory intersectional analysis suggested that sociodemographic and clinical factors might affect the influence of gender role orientations on HTSE and HTA, indicating complex and nuanced interactions.</p><p><strong>Conclusion: </strong>This study highlights the importance of investigating gender as a multidimensional variable in PD research on health technology adoption and use. Considering gender as a behavioral construct, such as through gender roles and norms, shows more significant associations with HTSE and HTA, although effect sized were generally small. The impact of gender dimensions on these outcomes can be compounded by intersecting social and disease-specific factors. Future studies should consider multiple gender dimensions and intersecting factors to fully understand their combined effects on technology uptake and use among people with PD.</p>","PeriodicalId":16558,"journal":{"name":"Journal of Neurology","volume":" ","pages":"6750-6760"},"PeriodicalIF":4.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11457693/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142017714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evolution from viral encephalitis to autoimmune encephalitis to multiple sclerosis: a case report. 从病毒性脑炎到自身免疫性脑炎再到多发性硬化症的演变:病例报告。
IF 4.8 2区 医学
Journal of Neurology Pub Date : 2024-10-01 Epub Date: 2024-08-31 DOI: 10.1007/s00415-024-12659-9
Katharina Wurdack, Harald Prüss, Carsten Finke
{"title":"Evolution from viral encephalitis to autoimmune encephalitis to multiple sclerosis: a case report.","authors":"Katharina Wurdack, Harald Prüss, Carsten Finke","doi":"10.1007/s00415-024-12659-9","DOIUrl":"10.1007/s00415-024-12659-9","url":null,"abstract":"<p><strong>Background: </strong>There are established associations between viral and autoimmune encephalitis as well as between autoimmune encephalitis and demyelinating central nervous system (CNS) diseases. Here, we report the evolution from varicella zoster virus (VZV) encephalitis to limbic autoimmune encephalitis (AIE) to multiple sclerosis (MS) in one patient.</p><p><strong>Case report: </strong>A woman in her mid-thirties presented with headache, aphasia, and a generalized tonic-clonic seizure. Cerebrospinal fluid (CSF) VZV polymerase chain reaction was positive and treatment with acyclovir was administered for VZV encephalitis. Five months later, the patient presented with cognitive deficits and MRI showed new bilateral hippocampal T2-hyperintensities. CSF analyses revealed pleocytosis and neuropil antibodies in tissue-staining. A diagnosis of limbic AIE was established and treatment with IV steroids and IV immunoglobulins initiated. One year later, the patient developed paresthesia of both legs and magnetic resonance imaging studies now showed new supratentorial and spinal demyelinating lesions. The patient was diagnosed with MS and treatment was changed to rituximab.</p><p><strong>Conclusions: </strong>This unique case report links three important neuroimmunological entities in characterizing the evolution from infectious to autoimmune encephalitis to multiple sclerosis in one patient. Identification of such rare clinical constellations is critical for correct treatment choice and provides important novel insights into the pathophysiology of neuroimmunological disorders including viral triggers and overlap manifestations of autoimmune CNS diseases.</p>","PeriodicalId":16558,"journal":{"name":"Journal of Neurology","volume":" ","pages":"7035-7038"},"PeriodicalIF":4.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11446979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142108347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The contribution of white matter changes to clinical phenotype in progressive supranuclear palsy. 白质变化对进行性核上性麻痹临床表型的影响。
IF 4.8 2区 医学
Journal of Neurology Pub Date : 2024-10-01 Epub Date: 2024-09-02 DOI: 10.1007/s00415-024-12662-0
Maria Francesca Tepedino, Francesco Diana, Filomena Abate, Anna Rosa Avallone, Miriam Caterino, Roberto Erro, Maria Teresa Pellecchia, Renzo Manara, Paolo Barone, Marina Picillo
{"title":"The contribution of white matter changes to clinical phenotype in progressive supranuclear palsy.","authors":"Maria Francesca Tepedino, Francesco Diana, Filomena Abate, Anna Rosa Avallone, Miriam Caterino, Roberto Erro, Maria Teresa Pellecchia, Renzo Manara, Paolo Barone, Marina Picillo","doi":"10.1007/s00415-024-12662-0","DOIUrl":"10.1007/s00415-024-12662-0","url":null,"abstract":"<p><p>White matter hyperintensities (WMH) are considered magnetic brain imaging (MRI) biomarkers of cerebral small vessel disease but their clinical role in neurodegenerative-related disorders is poorly understood. This study describes the distribution of WMH on brain MRI in Progressive Supranuclear Palsy (PSP) in comparison with Parkinson's disease (PD) and explores their possible impact on disease's features. Sixty PSP and 33 PD patients were included. Motor symptoms, cardiovascular risk factors and the age-related white matter changes (ARWMC) score was computed to rate WMH for both groups. Pearson's correlation and linear or logistic regression analysis were used to check for relationships between ARWMC and PSP clinical scores. The mean (standard deviation) ARWMC total score in the PSP cohort was 4.66 (3.25). Any degree of WMH was present in 68% of PSP (ARWMC +). Compared to ARWMC-, ARWMC + did not have greater disease severity or more cardiovascular risk factors. WMH were frequently localized in fronto-parietal lobes and were mild in severity. Linear regression analysis showed that ARWMC total score was related to the PSP-rating scale, irrespective of age, disease duration and the Charlson modified comorbidity index. Logistic regression analysis confirmed that ARWMC total score was related to the use of wheelchair, irrespective of above-mentioned covariates. Vascular risk factors as well as severity and distribution of WMH did not have an impact on the PSP phenotype. No differences were found with PD patients. Our results suggest that WMH in PSP might be markers of neurodegenerative-related pathology rather than being simple expression of atherosclerotic cerebrovascular changes.</p>","PeriodicalId":16558,"journal":{"name":"Journal of Neurology","volume":" ","pages":"6866-6875"},"PeriodicalIF":4.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11447107/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142108351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Switching from inotersen to eplontersen in patients with hereditary transthyretin-mediated amyloidosis with polyneuropathy: analysis from NEURO-TTRansform. 遗传性转甲状腺素介导的淀粉样变性伴多发性神经病患者从依诺替生转为依普隆替生:NEURO-TTRansform分析。
IF 4.8 2区 医学
Journal of Neurology Pub Date : 2024-10-01 Epub Date: 2024-08-13 DOI: 10.1007/s00415-024-12616-6
Isabel Conceição, John L Berk, Markus Weiler, Pedro A Kowacs, Noel R Dasgupta, Sami Khella, Chi-Chao Chao, Shahram Attarian, T Jesse Kwoh, Shiangtung W Jung, Jersey Chen, Nicholas J Viney, Rosie Z Yu, Morie Gertz, Ahmad Masri, Márcia Waddington Cruz, Teresa Coelho
{"title":"Switching from inotersen to eplontersen in patients with hereditary transthyretin-mediated amyloidosis with polyneuropathy: analysis from NEURO-TTRansform.","authors":"Isabel Conceição, John L Berk, Markus Weiler, Pedro A Kowacs, Noel R Dasgupta, Sami Khella, Chi-Chao Chao, Shahram Attarian, T Jesse Kwoh, Shiangtung W Jung, Jersey Chen, Nicholas J Viney, Rosie Z Yu, Morie Gertz, Ahmad Masri, Márcia Waddington Cruz, Teresa Coelho","doi":"10.1007/s00415-024-12616-6","DOIUrl":"10.1007/s00415-024-12616-6","url":null,"abstract":"<p><strong>Background: </strong>The phase 3 NEURO-TTRansform trial showed eplontersen treatment for 65 weeks reduced transthyretin (TTR), halted progression of neuropathy impairment, and improved quality of life (QoL) in adult patients with hereditary TTR-mediated amyloidosis with polyneuropathy (ATTRv-PN), vs. historical placebo.</p><p><strong>Methods: </strong>NEURO-TTRansform enrolled patients with ATTRv-PN. A subset of patients were randomized to receive subcutaneous inotersen 300 mg weekly (Weeks 1-34) and subsequently switched to subcutaneous eplontersen 45 mg every 4 weeks (Weeks 37-81). Change in serum TTR and treatment-emergent adverse events (TEAEs) were evaluated through Week 85. Effects on neuropathy impairment, QoL, and nutritional status were also evaluated.</p><p><strong>Results: </strong>Of 24 patients randomized to inotersen, 20 (83%) switched to eplontersen at Week 37 and four discontinued due to AEs/investigator decision. Absolute change in serum TTR was greater after switching from inotersen (-74.3%; Week 35) to eplontersen (-80.6%; Week 85). From the end of inotersen treatment, neuropathy impairment and QoL were stable (i.e., did not progress) while on eplontersen, and there was no deterioration in nutritional status. TEAEs were fewer with eplontersen (Weeks 37-85; 19/20 [95%] patients) compared with inotersen (up to Week 35; 24/24 [100%] patients). Mean platelet counts decreased during inotersen treatment (mean nadir reduction ‒40.7%) and returned to baseline during eplontersen treatment (mean nadir reduction, ‒3.2%).</p><p><strong>Conclusions: </strong>Switching from inotersen to eplontersen further reduced serum TTR, halted disease progression, stabilized QoL, restored platelet count, and improved tolerability, without deterioration in nutritional status. This supports a positive benefit-risk profile for patients with ATTRv-PN who switch from inotersen to eplontersen.</p>","PeriodicalId":16558,"journal":{"name":"Journal of Neurology","volume":" ","pages":"6655-6666"},"PeriodicalIF":4.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11447117/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141975931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
POLG-related mitochondrial disease mimicking autoimmune encephalitis. 模仿自身免疫性脑炎的 POLG 相关线粒体疾病。
IF 4.8 2区 医学
Journal of Neurology Pub Date : 2024-10-01 Epub Date: 2024-08-24 DOI: 10.1007/s00415-024-12641-5
Michael Bayat, Thomas Harbo, Maryam Anzabi, Allan Bayat, Jan Lykke Scheel Thomsen
{"title":"POLG-related mitochondrial disease mimicking autoimmune encephalitis.","authors":"Michael Bayat, Thomas Harbo, Maryam Anzabi, Allan Bayat, Jan Lykke Scheel Thomsen","doi":"10.1007/s00415-024-12641-5","DOIUrl":"10.1007/s00415-024-12641-5","url":null,"abstract":"","PeriodicalId":16558,"journal":{"name":"Journal of Neurology","volume":" ","pages":"7021-7023"},"PeriodicalIF":4.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142046765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Does repetitive transcranial magnetic stimulation have a beneficial effect on improving unilateral spatial neglect caused by stroke? A meta-analysis. 重复经颅磁刺激对改善中风引起的单侧空间忽略是否有益?一项荟萃分析。
IF 4.8 2区 医学
Journal of Neurology Pub Date : 2024-10-01 Epub Date: 2024-08-28 DOI: 10.1007/s00415-024-12612-w
Ruixuan Lin, Jack Jiaqi Zhang, Lingling Zhong, Sofina S Y Chan, Patrick W H Kwong, Lukas Lorentz, Usman Jawed Shaikh, Tommy L H Lam, David M A Mehler, Kenneth N K Fong
{"title":"Does repetitive transcranial magnetic stimulation have a beneficial effect on improving unilateral spatial neglect caused by stroke? A meta-analysis.","authors":"Ruixuan Lin, Jack Jiaqi Zhang, Lingling Zhong, Sofina S Y Chan, Patrick W H Kwong, Lukas Lorentz, Usman Jawed Shaikh, Tommy L H Lam, David M A Mehler, Kenneth N K Fong","doi":"10.1007/s00415-024-12612-w","DOIUrl":"10.1007/s00415-024-12612-w","url":null,"abstract":"<p><p>This review aimed to assess the effect of repetitive transcranial magnetic stimulation (rTMS) in improving post-stroke unilateral spatial neglect (USN) using a meta-analysis. Further, we aimed to identify any association between rTMS parameters, patient demographics, and treatment effect sizes using subgroup analyses and meta-regression. A literature search was conducted through four databases from inception to March 6, 2024, to retrieve all relevant controlled trials investigating the effects of rTMS on symptoms of USN in post-stroke patients. Overall, rTMS significantly improved post-stroke USN, as measured by the line bisection test (Hedges' g = - 1.301, p < 0.0001), the cancelation test (Hedge's g = - 1.512, p < 0.0001), and the Catherine Bergego Scale (Hedges'g = - 0.770, p < 0.0001), compared to sham stimulation. Subgroup analysis found that generally larger effect sizes following excitatory rTMS across several outcome measures, indicating that excitatory rTMS on the ipsilesional hemisphere may be more effective than inhibitory rTMS on the contralesional hemisphere in ameliorating neglect symptoms. Meta-regression analysis of the line bisection test showed a significant difference in the chronicity of stroke patients, suggesting that rTMS may be more effective for USN in patients at the acute stage (within 3 months since stroke) than in those at the post-acute stage (p = 0.035). In conclusion, rTMS appears to be effective in promoting recovery from post-stroke USN. Excitatory protocols and early intervention may enhance recovery outcomes for neglect behaviors in post-stroke survivors.</p>","PeriodicalId":16558,"journal":{"name":"Journal of Neurology","volume":" ","pages":"6494-6507"},"PeriodicalIF":4.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11446973/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142080553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biplanar MRI significantly improves early detection of transient global amnesia. 双平面磁共振成像大大提高了对短暂性全局失忆症的早期检测能力。
IF 4.8 2区 医学
Journal of Neurology Pub Date : 2024-10-01 Epub Date: 2024-08-31 DOI: 10.1007/s00415-024-12643-3
Omar Alhaj Omar, Anne Mrochen, Norma J Diel, Stefan T Gerner, Hagen B Huttner, Julia Heinrichs, Tobias Braun
{"title":"Biplanar MRI significantly improves early detection of transient global amnesia.","authors":"Omar Alhaj Omar, Anne Mrochen, Norma J Diel, Stefan T Gerner, Hagen B Huttner, Julia Heinrichs, Tobias Braun","doi":"10.1007/s00415-024-12643-3","DOIUrl":"10.1007/s00415-024-12643-3","url":null,"abstract":"","PeriodicalId":16558,"journal":{"name":"Journal of Neurology","volume":" ","pages":"7030-7034"},"PeriodicalIF":4.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11447076/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142108345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to: Fatigue in multiple sclerosis: can we measure it and can we treat it? 更正:多发性硬化症患者的疲劳:我们能测量它并治疗它吗?
IF 4.8 2区 医学
Journal of Neurology Pub Date : 2024-10-01 DOI: 10.1007/s00415-024-12630-8
John DeLuca
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