Journal of Neurology最新文献

{"title":"Longitudinal description of health-related quality of life and depressive symptoms in polyQ spinocerebellar ataxia patients.","authors":"Audrey Iskandar, Maresa Buchholz, Iris Blotenberg, Tanja Schmitz-Hübsch, Jennifer Faber, Heike Jacobi, Feng Xie, Marcus Grobe-Einsler, Thomas Klockgether, Bernhard Michalowsky","doi":"10.1007/s00415-025-13024-0","DOIUrl":"https://doi.org/10.1007/s00415-025-13024-0","url":null,"abstract":"<p><strong>Introduction: </strong>Due to limited treatment options, managing symptoms has dominated care for Spinocerebellar Ataxia (SCA). Little attention has been given to health-related quality of life (HRQoL) and depressive symptoms experienced by patients across disease duration.</p><p><strong>Objective: </strong>To investigate the course of HRQoL and the severity of depressive symptoms in SCA from disease onset to 26 years after onset and identify influencing factors.</p><p><strong>Methods: </strong>We analyzed data from two longitudinal SCA cohorts, the EUROSCA (European Spinocerebellar Ataxia Registry) and ESMI study (European Spinocerebellar Ataxia Type 3/Machado-Joseph Disease Initiative). Multilevel mixed-effects models were employed to demonstrate the course of HRQoL and depressive symptoms severity to investigate the role of disease progression with disease duration as a predictor of interest, along with time-varying clinical variables and time-fixed covariates.</p><p><strong>Results: </strong>Seven hundred seventy four participants (M_age = 50.8 ± 13.4; 48.6% female) were included. HRQoL consistently decreased throughout disease duration across all SCA subtypes, but the decline was smallest in SCA6. The decrease in HRQoL was explained by ataxia and depression severity and driven by increasing problems with self-care, usual activities and mobility. Depressive symptoms significantly increased in SCA2 and 3 only, with a trend toward slight improvement in SCA6.</p><p><strong>Conclusions: </strong>The trend direction of HRQoL and its significant association with the severity of ataxia symptoms align with the literature. The rapid worsening of self-care problems, the differential associations between depression and HRQoL sub-dimensions in different SCA subtypes, and the unexplainable resilience may warrant a deeper look at patient-specific intra- and interpersonal factors.</p>","PeriodicalId":16558,"journal":{"name":"Journal of Neurology","volume":"272 5","pages":"323"},"PeriodicalIF":4.8,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tenecteplase compared to alteplase before mechanical thrombectomy enhances 1-h recanalization and reduces disability in large-vessel occlusion.","authors":"Lu Wang, Jialu Li, Xiao Wu, Lulan Li, Xueqiao Jiao, Fengyuan Che, Hongxing Han, Liyong Zhang, Weidong Liu, Peifu Wang, Fuxia Yang, Fangfang Zhang, Xunming Ji, Xiuhai Guo","doi":"10.1007/s00415-025-13084-2","DOIUrl":"https://doi.org/10.1007/s00415-025-13084-2","url":null,"abstract":"<p><strong>Background: </strong>The comparative efficacy of tenecteplase versus alteplase in achieving early recanalization (ER) before mechanical thrombectomy (MT) for large-vessel occlusion (LVO) remains uncertain.</p><p><strong>Methods: </strong>This study was a retrospective analysis of prospectively collected data of consecutive patients with LVO underwent intravenous thrombolysis (IVT) and brain angiography between January 2022 and December 2023. ER was defined as ≥ 50% reperfusion or absence of retrievable thrombus on initial angiography.</p><p><strong>Results: </strong>146 patients received tenecteplase and 307 received alteplase. Tenecteplase shortened door-to-IVT time (33 vs. 39 min, P < 0.001) and door-to-puncture time (97 vs. 109 min, P = 0.039) compared to alteplase. Overall ER rates did not differ significantly (17.1% vs. 12.1%, P = 0.223). However, a significant interaction was observed between thrombolytic agent and IVT-to-puncture time (P_interaction = 0.034): tenecteplase achieved higher ER rates when IVT-to-puncture time was < 60 min (17.2% vs. 5.0%, aOR, 4.13 [95% CI 1.24-13.74]). With IVT-to-puncture time ≥ 60 min, ER rates were similar (17.2% vs. 16.8%, aOR 0.91 [95% CI 0.43-1.91]). No ER differences were noted across occlusion sites, clot burden, NIHSS, sex, and age. At 3 months, tenecteplase reduced disability rates (mRS 0-3: 73.5% vs. 65.7%, P = 0.041). Functional independence (mRS 0-2) was 57.4% with tenecteplase and 53.1% with alteplase (P = 0.301).</p><p><strong>Conclusions: </strong>Real-world observations reveal tenecteplase has increased ER rates compared to alteplase within 1 h of IVT and reduced disability in LVO patients. Further randomized trials are warranted to evaluate the effect of tenecteplase rapid bridging mechanical thrombectomy.</p>","PeriodicalId":16558,"journal":{"name":"Journal of Neurology","volume":"272 5","pages":"324"},"PeriodicalIF":4.8,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Motor, affective, cognitive, and perceptual symptom changes over time in individuals with Parkinson's disease who develop freezing of gait.","authors":"Michelle V Faerman, Cayli Cole, Karen Van Ooteghem, Benjamin F Cornish, Erika E Howe, Verena Siu, Pershia Norouzian, Alanna Black, Julia E Fraser, David A Grimes, Mandar Jog, Donna Kwan, Anthony E Lang, Jane M Lawrence-Dewar, Brian Levine, Connie Marras, Mario Masellis, William E McIlroy, Paula M McLaughlin, Manuel Montero-Odasso, J B Orange, Alicia J Peltsch, Frederico Pieruccini-Faria, Angela C Roberts, Yanina Sarquis-Adamson, Thomas D L Steeves, Brian Tan, Angela K Troyer, Kaylena A Ehgoetz Martens","doi":"10.1007/s00415-025-13034-y","DOIUrl":"https://doi.org/10.1007/s00415-025-13034-y","url":null,"abstract":"<p><p>Freezing of gait (FOG) affects up to 80% of individuals living with advanced Parkinson's disease and approximately 20% in early stages. Associated with motor, affective, cognitive, and sensory difficulties, FOG is challenging to treat due to its unknown etiology. Approaches and findings in research studies predicting FOG remain inconsistent. To help address discrepant methods and results, this prospective, longitudinal study evaluated motor, affective, cognitive, and perceptual predictors of FOG. Data from 120 individuals with idiopathic Parkinson's disease from the Ontario Neurodegenerative Disease Research Initiative cohort were analyzed across two years to evaluate the strongest FOG predictors. Over this period, 25 individuals developed FOG (transitional freezers), 71 remained non-freezers, and the remaining 24 participants experienced freezing at baseline and follow-up (continuous freezers). Two-way Time*Group ANOVAs and non-parametric equivalents assessed data longitudinally. Separate logistic regression models evaluated FOG predictors one and two years prior to onset. Transitional freezers showed lower baseline immediate verbal recall z-scores than non-freezers. Transitional freezers' dyskinesia severity, postural instability/gait difficulty, and depression increased, and attentional set-shifting and delayed visuospatial memory declined. Motor symptoms and longer disease duration predicted FOG two years prior, with affective and cognitive measures predictive one year prior. Models had high specificity (2 years: 97.0%, 1 year: 90.4%) but not sensitivity (2 years: 43.8%, 1 year: 52.9%), with accuracies of 86.7% and 81.2%, respectively. These findings highlight the change in FOG predictors relative to its onset time, which might explain conflicting findings to date. Future work should consider whether predictors vary by disease stage or FOG 'subtype'.</p>","PeriodicalId":16558,"journal":{"name":"Journal of Neurology","volume":"272 5","pages":"321"},"PeriodicalIF":4.8,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A cross-sectional survey on the health status of patients with Charcot-Marie-Tooth disease in a Chinese national patient group.","authors":"Shimiao Dai, Jiayin Zheng, Yuqing Chen, Junying Zhu, Xinling Wang, Yuxuan Peng, Yuping Luo, Tian Lin, Yao Li, Miaomiao Ma, Zhan Shi, Xinru Meng, Litao Sun, Ji-Chang Zhou","doi":"10.1007/s00415-025-13063-7","DOIUrl":"https://doi.org/10.1007/s00415-025-13063-7","url":null,"abstract":"<p><strong>Background: </strong>Charcot-Marie-Tooth disease (CMT) is a rare inherited peripheral neuropathy, and the health status of CMT patients in China is not well understood without a national disease registry system. We aimed to obtain the related epidemiological data to support effective work on CMT.</p><p><strong>Methods: </strong>The online cross-sectional study included patients definitively diagnosed with CMT nationwide. Descriptive analyses were conducted on CMT's disease characteristics, diagnostic results, walking condition, rehabilitation status, comorbidities, family history, etc. RESULTS: CMT1A, CMT2A, CMTX1, CMT2S, CMT1E, and CMT1B were the top six types accounting for 64.4% of the 523 eligible patients. PMP22, MFN2, GJB1, MPZ, GDAP1, and IGHMBP2 ranked as the top six genes among the collected 44 pathogenic genes. The median ages of symptom onset and diagnosis were 7.3 and 18.7 years, respectively, with a median interval of 3.8 years between symptom onset and genetic confirmation. Only 8.3% exhibited unaffected walking speed and balance, the remaining experienced varying degrees of motor impairment, and 42.1% employed rehabilitation. Moreover, 26.8% experienced initial misdiagnosis, and 47.0% were estimated to suffer from depression. Of comorbidities complained by the 94 patients, gastrointestinal was most common (17/94) followed by hypertension (13/94), and hiatal hernia (2/94) was first reported. Family history was documented in 35.2% of the surveyed patients.</p><p><strong>Conclusion: </strong>Chinese patients with CMT were in complicated and poor health status with predominant disease types and pathogenic genes generally as anticipated. A national CMT registry system is highly wanted to collect comprehensive information to guide further research and improve patients' health status.</p>","PeriodicalId":16558,"journal":{"name":"Journal of Neurology","volume":"272 5","pages":"322"},"PeriodicalIF":4.8,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HyperCKemia and rhabdomyolysis following lacosamide initiation: two case reports.","authors":"Guido Bonelli, Gianni Cutillo, Sebastiano Galantucci, Marco Vabanesi, Jacopo Lanzone, Anna Bellini, Federico Pedroni, Davide G Curti, Maria R Pecoraro, Camilla Ferri, Giovanna F Fanelli, Massimo Filippi","doi":"10.1007/s00415-025-13079-z","DOIUrl":"https://doi.org/10.1007/s00415-025-13079-z","url":null,"abstract":"","PeriodicalId":16558,"journal":{"name":"Journal of Neurology","volume":"272 5","pages":"319"},"PeriodicalIF":4.8,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural correlates of β-lactam exposure in intensive care unit patients: an observational, prospective cohort study.","authors":"Arnaud Zalta, Agnès Trébuchon, Géraldine Daquin, Lionel Velly, Marc Leone, Olivier Blin, Stanislas Lagarde, Romain Guilhaumou","doi":"10.1007/s00415-025-13067-3","DOIUrl":"https://doi.org/10.1007/s00415-025-13067-3","url":null,"abstract":"<p><strong>Background: </strong>β-lactam-induced neurotoxicity in critical care patients can compromise clinical outcomes. Despite the growing use of therapeutic drug monitoring (TDM) for β-lactams, clear toxicity thresholds remain undefined, leaving clinicians uncertain about dosing adjustments when adverse effects occur. Identifying a relevant and easily detectable neurophysiological biomarker for β-lactam exposure would improve monitoring and prevent serious complications.</p><p><strong>Methods: </strong>In a prospective multicenter, non-interventional study, we analyzed electroencephalographic (EEG) signals of 56 patients hospitalized in intensive care units (ICUs) receiving continuous infusions of five β-lactams (meropenem, piperacillin/tazobactam, cefepime, cefotaxime, or ceftazidime). We applied a time frequency decomposition on these EEG data to investigate quantitatively the power of neural dynamics across frequencies ranging from 1 to 45 Hz. We used a multivariate pattern decoding method to correlate the β-lactam exposure and Sepsis-related Organ Failure Assessment (SOFA) scores with the neural activity.</p><p><strong>Results: </strong>β-lactam exposure correlated with increased β-low γ neural dynamics (20-40 Hz) (p < 0.001, FDR corrected), independent of other clinical factors or medications. β-neural activity was most pronounced in central electrodes (C3: r = 0.20, p < 0.01; C4: r = 0.26, p < 0.01) and the right frontal electrode (Fp2: r = 0.12, p = 0.02). Lower θ-α activity (3.5-5 Hz and 12-18 Hz) was associated with higher SOFA scores (p < 0.001, FDR corrected). No significant correlations were observed between other drugs (opioids, anti-seizure medications, and psychotropics) and β or θ-α dynamics.</p><p><strong>Conclusions: </strong>These results suggest that β neural dynamics represent a potential biomarker for β-lactam exposure in ICU patients. They highlight the potential of quantitative EEG and advanced multivariate decoding methods to identify subtle neurophysiological features that are otherwise difficult to detect.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov ID NCT03339869. Registered 14 September 2017.</p>","PeriodicalId":16558,"journal":{"name":"Journal of Neurology","volume":"272 5","pages":"320"},"PeriodicalIF":4.8,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biological frameworks for Parkinson's disease: the heterogeneity SAAgged.","authors":"Annamaria Landolfi, Cristiano Sorrentino, Paolo Barone, Roberto Erro","doi":"10.1007/s00415-025-13049-5","DOIUrl":"https://doi.org/10.1007/s00415-025-13049-5","url":null,"abstract":"<p><p>Recent biological frameworks of Parkinson's disease (PD) rely on the new advances in α-synuclein detection in biological tissues, mostly through α-synuclein seed amplification assays, and are mainly aimed at intercepting pre-clinical or early phases of disease to be subjected to disease-modifying therapies targeting α-synuclein. However, α-synuclein pathology alone is insufficient to explain the observed clinical heterogeneity of PD. Indeed, it has been demonstrated that a number of additional elements, such as genetics, comorbidities, co-pathology, and environmental factors, may influence PD phenotype and progression. Such factors have been partially accounted for or completely overlooked by both biological frameworks and would instead represent features which could explain, at least partially, the clinical and pathophysiologic diversities of PD and further represent potential druggable targets. Recognizing that the clinical heterogeneity of PD is a window to understand the pathophysiologic complexity of the disease might turn useful for a refinement of the current biological frameworks and move the field to satisfy the unmet need of establishing a precision medicine framework for this prevalent disorder.</p>","PeriodicalId":16558,"journal":{"name":"Journal of Neurology","volume":"272 4","pages":"318"},"PeriodicalIF":4.8,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights into primary progressive aphasia.","authors":"Sabbiha Nadia Majumder, Marc Edwards, Robin Corkill","doi":"10.1007/s00415-025-13075-3","DOIUrl":"https://doi.org/10.1007/s00415-025-13075-3","url":null,"abstract":"","PeriodicalId":16558,"journal":{"name":"Journal of Neurology","volume":"272 4","pages":"317"},"PeriodicalIF":4.8,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Limited added value of systematic spinal cord MRI vs brain MRI alone to classify patients with MS as active or inactive during follow-up.","authors":"Jérémy Hong, Malo Gaubert, Mathilde Lefort, Jean Christophe Ferré, Emmanuelle Le Page, Laure Michel, Pierre Labauge, Jean Pelletier, Jérôme de Seze, Françoise Durand-Dubief, François Cotton, Gilles Edan, Elise Bannier, Benoit Combès, Anne Kerbrat","doi":"10.1007/s00415-025-13068-2","DOIUrl":"10.1007/s00415-025-13068-2","url":null,"abstract":"<p><strong>Background: </strong>The utility of systematic spinal cord (SC) MRI for monitoring disease activity after a multiple sclerosis (MS) diagnosis remains a topic of debate.</p><p><strong>Objectives: </strong>To evaluate the frequency of disease activity when considering brain MRI alone versus both brain and SC MRI and to identify factors associated with the occurrence of new SC lesions.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of clinical and imaging data prospectively collected over 5 years as part of the EMISEP cohort study. A total of 221 intervals (with both brain and spinal cord MRI scans available at 2 consecutive time-points) from 68 patients were analysed. For each interval, brain (3D Fluid-Attenuated Inversion Recovery (FLAIR, axial T2 and axial PD) and SC MRI (sagittal T2 and phase-sensitive inversion recovery, axial T2*w and 3D T1) were reviewed to detect new lesions. Each interval was classified as symptomatic (with relapse) or asymptomatic. The baseline brain and SC lesion numbers were computed.</p><p><strong>Results: </strong>SC MRI activity without clinical relapse and/or brain MRI activity was rare (4 out of 221 intervals, 2%). The occurrence of a new SC lesion was associated with the number of brain lesions at baseline (OR = 1.002 [1.000; 1.0004], p = 0.015) and the occurrence of a new brain lesion during the interval (OR = 1.170 [1.041; 1.314], p = 0.009), but not with the baseline SC lesion number (p = 0.6).</p><p><strong>Conclusion: </strong>These findings support the current guidelines recommending routine disease monitoring with brain MRI alone, even in patients with a high SC lesion load.</p>","PeriodicalId":16558,"journal":{"name":"Journal of Neurology","volume":"272 4","pages":"316"},"PeriodicalIF":4.8,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11972184/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recall vaccination increases detectable B-cell reactivity in persons with multiple sclerosis treated with ocrelizumab.","authors":"Lucia Moiola, Alessandra Mandelli, Maciej Tarkowski, Annamaria Finardi, Arianna Gabrieli, Chiara Zanetta, Vittorio Viti, Irene Gattuso, Federica Esposito, Rosetta Pedotti, Erwan Muros-Le Rouzic, Catarina Raposo, Maria A Rocca, Massimo Locatelli, Chiara Bonini, Roberto Furlan, Agostino Riva, Massimo Filippi","doi":"10.1007/s00415-025-13027-x","DOIUrl":"https://doi.org/10.1007/s00415-025-13027-x","url":null,"abstract":"<p><strong>Background: </strong>Utility of repeated boosts of anti-SARS-CoV-2 vaccination in persons with MS (pwMS) treated with ocrelizumab is questioned.</p><p><strong>Objective: </strong>Investigate antiviral antibody and T-cell responses after mRNA vaccination for SARS-CoV-2 in ocrelizumab-treated pwMS.</p><p><strong>Methods: </strong>Peripheral blood mononuclear cells were stimulated with SARS-CoV-2 peptide pools and T-cell reactivity was assessed by ELISPOT for IFN-γ detection, and by multiparametric flow cytometry analyses for assessment and characterization of T-cell activation. Anti-SARS-CoV-2 spike and nucleocapsid antibodies were analyzed in plasma of pwMS using two commercial platforms.</p><p><strong>Results: </strong>ELISPOT assay against the spike protein of SARS-CoV-2 showed that COVID vaccination with mRNA results in the development of a robust specific T-cell reactivity that is sustained over repeated cycles of vaccination and tends to decline 2 years after last boost. Flow cytometry analysis following stimulation with SARS-CoV-2 peptide pools confirmed the presence of CD8⁺ T memory stem cells. CD8⁺ T memory stem cells, in particular, increased after repeated boosts of vaccination, as occurred for anti-SARS-CoV-2 antibodies.</p><p><strong>Conclusions: </strong>Repeated cycles of vaccination increase T and B-cell reactivity against SARS-CoV-2.</p>","PeriodicalId":16558,"journal":{"name":"Journal of Neurology","volume":"272 4","pages":"314"},"PeriodicalIF":4.8,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}