Journal of Neurology最新文献

{"title":"Erich Feuchtwanger (1889-1935).","authors":"Lazaros C Triarhou","doi":"10.1007/s00415-025-13341-4","DOIUrl":"https://doi.org/10.1007/s00415-025-13341-4","url":null,"abstract":"","PeriodicalId":16558,"journal":{"name":"Journal of Neurology","volume":"272 10","pages":"664"},"PeriodicalIF":4.6,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"John Newport Langley (1852-1925).","authors":"Andrew J Larner","doi":"10.1007/s00415-025-13413-5","DOIUrl":"https://doi.org/10.1007/s00415-025-13413-5","url":null,"abstract":"","PeriodicalId":16558,"journal":{"name":"Journal of Neurology","volume":"272 10","pages":"667"},"PeriodicalIF":4.6,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of alcohol responsiveness and non-motor symptoms in isolated adult-onset dystonia.","authors":"Johanna Junker, Brian D Berman, Inke R König, Marie Vidailhet, Emmanuel Roze, Joel S Perlmutter, H A Jinnah, Norbert Brüggemann","doi":"10.1007/s00415-025-13383-8","DOIUrl":"10.1007/s00415-025-13383-8","url":null,"abstract":"<p><strong>Objective: </strong>About 30% of patients with isolated adult-onset dystonia report an improvement of their motor symptoms after the consumption of alcohol. In this cross-sectional study, we sought to investigate whether the observed improvement is attributable to the anxiolytic, euphoric, and analgesic properties of alcohol, rather than or in addition to its effect on dystonic movements, as psychiatric symptoms and pain frequently occur in dystonia patients and as emotional stress is a well-established trigger for symptom exacerbation.</p><p><strong>Methods: </strong>We analyzed data from 339 prospectively enrolled participants with recently diagnosed isolated dystonia (mean age: 55.2 ± 12.5 years, 228 female) of the Natural History Project of the Dystonia Coalition, a large international multicenter study. Alcohol responsiveness was determined by patients´ self-report. Symptoms of depression, as well as generalized and social anxiety, were assessed using the Hospital Anxiety and Depression Scale and the Liebowitz Social Anxiety Scale. Severity of pain was measured using question 21 of the RAND 36-Item Health Survey.</p><p><strong>Results: </strong>Participants with more severe pain reported greater response to alcohol than those with less severe pain (p = .004), whereas symptoms of depression (p = .986), generalized anxiety (p = .395) and social anxiety (p = .953) were not associated.</p><p><strong>Conclusion: </strong>Alcohol responsiveness in isolated dystonia is associated with higher levels of pain, whereas self-reported alcohol-related improvements in dystonic movements or tremor do not depend on the euphoric or anxiolytic effects of alcohol. This finding underscores the potential role of pain management in alleviating motor symptoms in dystonia.</p>","PeriodicalId":16558,"journal":{"name":"Journal of Neurology","volume":"272 10","pages":"659"},"PeriodicalIF":4.6,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12477084/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subjective psychiatric symptoms in post-acute autoimmune encephalitis: findings from the Australian autoimmune encephalitis consortium.","authors":"Katherine Y Ko, Christina Kazzi, Nabil Seery, Sarah Griffith, Robb Wesselingh, Tiffany Rushen, Tracie H Tan, Hannah Ford, Catherine Meade, Marie F O'Shea, Laurie McLaughlin, Genevieve Skinner, Mirasol Forcadela, Amy Halliday, Andrew Duncan, Ernest G Butler, Anneke Van Der Walt, Tomas Kalincik, Wendyl D'Souza, Udaya Seneviratne, Katherine Buzzard, Richard Macdonell, Sudarshini Ramanathan, Stefan Blum, Jayashri Kulkarni, Stephen W Reddel, Todd A Hardy, Helmut Butzkueven, Terence J O'Brien, Rubina Alpitsis, Charles B Malpas, Mastura Monif","doi":"10.1007/s00415-025-13353-0","DOIUrl":"10.1007/s00415-025-13353-0","url":null,"abstract":"<p><strong>Background and objectives: </strong>This study examined self-reported psychopathology in patients with autoimmune encephalitis (AE), and explored their relationship with clinical outcomes as measured by the modified Rankin Scale (mRS) and Clinical Assessment Scale in Autoimmune Encephalitis (CASE) scores.</p><p><strong>Methods: </strong>Eighty-seven AE patients (49.43% female, mean age = 54.47 years, SD = 17.84) from the Australian Autoimmune Encephalitis Consortium completed the SPECTRA-Indices of Psychopathology, time-matched with CASE and mRS scores within six months of the assessments.</p><p><strong>Results: </strong>On average, assessments occurred 12 months post-onset. Median CASE and mRS scores were 2, with 84.13% of patients scoring mRS ≤ 2. Mean SPECTRA scores were significantly elevated across multiple domains, indicating greater psychopathology, particularly in depression, post-traumatic stress, suicidal ideation, and cognitive functioning. Patients with seronegative AE exhibited more severe psychopathology compared to those with anti-N-methyl-D-aspartate receptor (NMDAR) and anti-leucine-rich glioma-inactivated 1 (LGI1) subtypes. Psychiatric diagnoses prior to AE onset were associated with worse outcomes, compared to those with no pre-existing psychiatric conditions and those diagnosed post-onset. The mRS and CASE scores each explained only a small amount of variance (7-26%) across SPECTRA domains, and adding the other score to the model provided only little improvement.</p><p><strong>Discussion: </strong>AE patients exhibit significant psychopathology across multiple domains, with significant internalising symptoms-including depression, post-traumatic stress, and suicidal ideation-as well as cognitive concerns, highlighting the considerable psychiatric burden in this population. Our findings highlight the need for systematic, timely assessments of psychological symptoms in AE, and the use of sensitive, comprehensive instruments to capture the full spectrum of their psychopathology.</p>","PeriodicalId":16558,"journal":{"name":"Journal of Neurology","volume":"272 10","pages":"665"},"PeriodicalIF":4.6,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12479715/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"José Ingenieros (1877-1925).","authors":"Martín Enrique Irribaren, Lazaros C Triarhou","doi":"10.1007/s00415-025-13308-5","DOIUrl":"https://doi.org/10.1007/s00415-025-13308-5","url":null,"abstract":"","PeriodicalId":16558,"journal":{"name":"Journal of Neurology","volume":"272 10","pages":"666"},"PeriodicalIF":4.6,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pío del Río-Hortega (1882-1945).","authors":"Lazaros C Triarhou","doi":"10.1007/s00415-025-13388-3","DOIUrl":"https://doi.org/10.1007/s00415-025-13388-3","url":null,"abstract":"","PeriodicalId":16558,"journal":{"name":"Journal of Neurology","volume":"272 10","pages":"662"},"PeriodicalIF":4.6,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Marked neurological recovery in aquaporin-4 neuromyelitis optica spectrum disorder (NMOSD) after delayed anti-complement therapy.","authors":"P Peydro Lavoie, A Attal, A Lannuzel, H Chaumont","doi":"10.1007/s00415-025-13411-7","DOIUrl":"https://doi.org/10.1007/s00415-025-13411-7","url":null,"abstract":"","PeriodicalId":16558,"journal":{"name":"Journal of Neurology","volume":"272 10","pages":"657"},"PeriodicalIF":4.6,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145176084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive stimulation in Parkinson's disease with mild cognitive impairment.","authors":"Jolanda Buonocore, Noemi Iaccino, Giusi Torchia, Francesca Curcio, Fabio Michelangelo Pirrotta, Marianna Contrada, Caterina Pucci, Antonio Gambardella, Aldo Quattrone, Alberto Pilotto, Loris Pignolo, Gennarina Arabia","doi":"10.1007/s00415-025-13374-9","DOIUrl":"10.1007/s00415-025-13374-9","url":null,"abstract":"<p><strong>Background: </strong>Cognitive impairment is among the most frequent and disabling non-motor symptoms of Parkinson's disease (PD), often emerging early and substantially impacting autonomy and quality of life. While cognitive stimulation (CS) is supported in other neurodegenerative conditions, its role in PD is less explored. This study aimed to compare the efficacy of a therapist-guided, home-based CS program, delivered via a virtual reality rehabilitation system, with a conventional in-person CS intervention.</p><p><strong>Methods: </strong>Of 123 individuals screened, 45 patients with PD and mild cognitive impairment (PD-MCI) were randomized to either the tele-rehabilitation group (TRG; n = 25) or the control group (CG; n = 20). Both groups received the same standardized 4-week CS program (20 multi-domain sessions, 5 days/week), targeting memory, attention, executive functions, language, and visuospatial skills. The TRG trained at home via the VRRS platform under remote supervision, while the CG attended outpatient sessions. Neuropsychological and clinical outcomes were assessed at baseline (T1), post-intervention (T2), and 6-month follow-up (T3). Analyses included repeated-measures ANOVA, multivariate linear regression, and categorical comparisons based on predefined clinical cut-offs.</p><p><strong>Results: </strong>All participants completed the intervention with adherence exceeding 90% in both groups. At T2, the TRG showed greater improvements than the CG in global cognition, working memory, and delayed recall. These effects remained significant after adjusting for age, sex, baseline performance, and cognitive reserve index, and were robust to false discovery rate correction. Regression models confirmed these improvements. Categorical analyses also showed a marked reduction in pathological scores in the TRG in the same domains.</p><p><strong>Conclusion: </strong>A short-term, therapist-guided CS program delivered via tele-rehabilitation effectively improved cognitive functioning in PD-MCI, with partial benefits maintained at 6 months, especially in memory and executive domains. The intervention was particularly beneficial for memory and executive functions, highlighting telemedicine as a promising and accessible option for cognitive care in PD.</p>","PeriodicalId":16558,"journal":{"name":"Journal of Neurology","volume":"272 10","pages":"658"},"PeriodicalIF":4.6,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476383/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145181996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ofatumumab treatment in patients with neuromyelitis optica spectrum disorder: a retrospective multicenter cohort study.","authors":"Xiaoxia Yang, Zhen Jia, Xuegan Lian, Rui Zhang, Bin Li, Daishi Tian, Xiuju Gao, Shougang Guo, Baojie Wang, Hongbo Liu, Youming Long, Limei Wang, Jingfen Zhang, Qun Xue, Zhihou Liang, Yongkai Han, Huiyu Feng, Lin Huang, Pin Wang, Naiyuan Shao, Fu-Dong Shi, Chao Zhang","doi":"10.1007/s00415-025-13408-2","DOIUrl":"10.1007/s00415-025-13408-2","url":null,"abstract":"<p><strong>Background: </strong>Ofatumumab is a fully human anti-CD20 monoclonal antibody that selectively and highly depletes B cells. However, limited data on ofatumumab treatment are available in patients with neuromyelitis optica spectrum disorders (NMOSD). In this study, we aimed to evaluate the efficacy and safety of subcutaneous ofatumumab in patients with NMOSD.</p><p><strong>Methods: </strong>We conducted a retrospective multicenter cohort study of patients with NMOSD who received ofatumumab treatment at 15 tertiary hospitals in China. The primary outcome was the annualized relapse rate (ARR). The secondary outcomes included disability measures (Expanded Disability Status Scale score, EDSS; the Aminoff-Logue Disability Scale, ALS), changes in aquaporin-4 IgG (AQP4-IgG) titers, and safety profiles during ofatumumab treatment.</p><p><strong>Results: </strong>A total of 112 patients (88% female, median age 44.0 years with interquartile range [IQR 29.5-57.5]) received ofatumumab treatment for a median of 1.7 years (IQR: 1.1-2.0). The median ARR decreased significantly from 2.0 (IQR 0.7-10.0) before ofatumumab to 0 (IQR 0.0-0.0; p < 0.001) after ofatumumab. Twenty-two patients (20%) experienced 25 relapses, with 20 (80%) occurring within the first year of initiating ofatumumab treatment and 19 (76%) classified as minor. The EDSS score from start to the last follow-up also improved significantly (median: pre-treatment 3.5, IQR 2.0-6.5, post-treatment: 2.0, IQR1.0-3.5, p < 0.001). Among 94 patients, 71 (76%) showed reduced AQP4-IgG titers at last follow-up. Injection-related reactions were reported in 13 (12%) of 112 patients. Twenty-four infections occurred in 20 patients (18%) during the ofatumumab treatment, with 92% (22/24) being grade 1 or 2 (CTCAE version 5.0). Only 2 patients (2%) experienced pneumonia requiring hospitalization and recovered after antibiotic treatment (grade 3). Hypogammaglobulinemia was recorded in 14% (13/95) of patients and was not associated with infection.</p><p><strong>Conclusions: </strong>Subcutaneous ofatumumab treatment significantly reduces the relapse risk, limits worsening of disability, and reduces AQP4-IgG titers in NMOSD. Moreover, the safety profiles were generally acceptable. Further research is necessary to explore the sustained clinical response of ofatumumab in NMOSD.</p>","PeriodicalId":16558,"journal":{"name":"Journal of Neurology","volume":"272 10","pages":"655"},"PeriodicalIF":4.6,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Grey matter atrophy patterns of mobility shared across older adults with and without multiple sclerosis.","authors":"Mark E Wagshul, Siddharth Nayak, Frederick W Foley, Robert W Motl, Manuel E Hernandez, Meltem Izzetoglu, Roee Holtzer","doi":"10.1007/s00415-025-13373-w","DOIUrl":"10.1007/s00415-025-13373-w","url":null,"abstract":"<p><p>Mobility impairment is common in multiple sclerosis, especially in older adults with multiple sclerosis (OAMS). Grey matter (GM) changes are well documented in MS, and GM atrophy is common in older adults. The relationship between GM changes and mobility disability in OAMS is unknown. We sought to identify GM patterns associated with gait speed in OAMS and healthy older controls, using structural covariance network analysis. OAMS (n = 102; 64.8 ± 4.4 years) and healthy controls (n = 106; 68.2 ± 7.3 years) underwent brain MRI and gait assessments; structural covariance networks were constructed to elucidate brain regions with significant associations between GM volume and 25-foot walk gait speed. We used voxel-wise linear regression analyses to elucidate per-network subregions with significant correlations with gait speed. Voxel-wise moderation analysis tested for group differences in these associations. Across the entire cohort, the following networks demonstrated significant gait speed associations: bilateral hippocampus, bilateral caudate/pallidum/putamen, bilateral thalamus/putamen, right middle temporal gyrus and multiple cerebellar regions. There were no significant group-by-network interaction effects. In summary, structural network analysis reveals unique brain patterns of gait speed in older adults, but these patterns are common amongst healthy older adults and OAMS and highlight the importance of cerebellar and subcortical networks in supporting gait speed.</p>","PeriodicalId":16558,"journal":{"name":"Journal of Neurology","volume":"272 10","pages":"656"},"PeriodicalIF":4.6,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12474737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145176073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}