Journal of neurosurgery. Pediatrics最新文献

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The role of genetics on behavioral outcomes in nonsyndromic sagittal synostosis. 遗传对非综合征矢状突眼行为结果的影响。
IF 2.1 3区 医学
Journal of neurosurgery. Pediatrics Pub Date : 2024-06-14 Print Date: 2024-09-01 DOI: 10.3171/2024.4.PEDS23510
David P Alper, Mariana N Almeida, Kevin G Hu, Jenny F Yang, Andrew T Timberlake, Jinesh Shah, John A Persing, Michael Alperovich
{"title":"The role of genetics on behavioral outcomes in nonsyndromic sagittal synostosis.","authors":"David P Alper, Mariana N Almeida, Kevin G Hu, Jenny F Yang, Andrew T Timberlake, Jinesh Shah, John A Persing, Michael Alperovich","doi":"10.3171/2024.4.PEDS23510","DOIUrl":"10.3171/2024.4.PEDS23510","url":null,"abstract":"<p><strong>Objective: </strong>Previous work identified an association between genetics and neurodevelopmental delays in patients with nonsyndromic craniosynostosis. The authors investigated the role of genetic mutations on behavioral outcomes of patients with treated sagittal synostosis.</p><p><strong>Methods: </strong>Parents of children aged 6-18 years with surgically corrected sagittal synostosis were recruited to complete the Child Behavioral Checklist (overall behavioral problems), Conners 3rd Edition-Parent (attention-deficit/hyperactivity disorder), Social Responsiveness Scale 2nd Edition (autism spectrum disorder [ASD]), and Behavior Rating Inventory of Executive Function 2nd Edition (executive function). Genomic analysis was completed, and patients were identified if they had mutations in high probability of loss of function intolerant (pLI) genes (high pLI vs nonhigh pLI). Genetic burden was assessed relative to controls. Multivariate linear regression determined the association of mutations in high pLI genes with behavioral scores, while controlling for sociodemographic factors, age at surgery, surgery type, and IQ.</p><p><strong>Results: </strong>Sixteen of 45 patients were in the high pLI group. There were no differences between the groups in terms of sociodemographic factors. A greater proportion of children in the high pLI group scored at or above borderline clinical levels for aggression (18.8% vs 0.0%, p = 0.05) and externalizing problems (31.3% vs 3.7%, p = 0.02). Among children in the nonhigh pLI group, older age at surgery was associated with worse scores on the rule-breaking, aggression, and externalizing problems domains and four out of five ASD domains.</p><p><strong>Conclusions: </strong>Children with treated nonsyndromic sagittal synostosis and mutations in high pLI genes had worse behavioral problems in externalizing behaviors and aggression, whereas older age at surgery was a significant predictor of worse behavioral outcomes in patients without mutations in high pLI genes.</p>","PeriodicalId":16549,"journal":{"name":"Journal of neurosurgery. Pediatrics","volume":" ","pages":"234-245"},"PeriodicalIF":2.1,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141321036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
White matter characteristics in children with cerebral palsy prior to selective dorsal rhizotomy: a multicenter diffusion tensor imaging study. 选择性背根切断术前脑瘫患儿的白质特征:一项多中心弥散张量成像研究。
IF 2.1 3区 医学
Journal of neurosurgery. Pediatrics Pub Date : 2024-06-07 Print Date: 2024-09-01 DOI: 10.3171/2024.4.PEDS23589
Weihong Yuan, Charles B Stevenson, Paolo Moretti, Francesco T Mangano, Marco Pavanello, Armando Cama, Domenico Tortora, Chiara Tacchino, Amy F Bailes, Kelly R Greve, Jilda N Vargus-Adams, Jonathan A Dudley, Karen Harpster, Brad G Kurowski, Alexis Mitelpunkt, Bruce Aronow
{"title":"White matter characteristics in children with cerebral palsy prior to selective dorsal rhizotomy: a multicenter diffusion tensor imaging study.","authors":"Weihong Yuan, Charles B Stevenson, Paolo Moretti, Francesco T Mangano, Marco Pavanello, Armando Cama, Domenico Tortora, Chiara Tacchino, Amy F Bailes, Kelly R Greve, Jilda N Vargus-Adams, Jonathan A Dudley, Karen Harpster, Brad G Kurowski, Alexis Mitelpunkt, Bruce Aronow","doi":"10.3171/2024.4.PEDS23589","DOIUrl":"10.3171/2024.4.PEDS23589","url":null,"abstract":"<p><strong>Objective: </strong>The aims of this study were to 1) assess and quantify white matter (WM) microstructural characteristics derived from diffusion tensor imaging (DTI) in children with cerebral palsy (CP) prior to selective dorsal rhizotomy (SDR), and 2) investigate potential associations between WM diffusion properties and gross motor function and spasticity in children with spastic CP who underwent SDR.</p><p><strong>Methods: </strong>This study is a multisite study based on DT images acquired prior to SDR as well as postoperative outcome data. DTI data collected from two sites were harmonized using the ComBat approach to minimize intersite scanner difference. The DTI abnormalities between children with spastic CP and controls were analyzed and correlated with the severity of impaired mobility based on the Gross Motor Function Classification System (GMFCS). The improvement in gross motor function and spasticity after SDR surgery was assessed utilizing the Gross Motor Function Measure-66 (GMFM-66), the Modified Tardieu Scale (MTS), and the modified Ashworth scale (MAS). Alterations in these outcome measures were quantified in association with DTI abnormalities.</p><p><strong>Results: </strong>Significant DTI alterations, including lower fractional anisotropy (FA) in the genu of the corpus callosum (gCC) and higher mean diffusivity (MD) in the gCC and posterior limb of the internal capsule (PLIC), were found in children in the SDR group when compared with the age-matched control group (all p < 0.05). Greater DTI alterations (FA in gCC and MD in gCC and PLIC) were associated with lower mobility levels as determined based on GMFCS level (p < 0.05). The pre- to post-SDR improvement in motor function based on GMFM-66 was statistically significant (p = 0.006 and 0.002 at 6-month and 12-month follow-ups, respectively). The SDR efficacy was also identified as improving spasticity in lower-extremity muscle groups assessed with the MTS and MAS. Partial correlation analysis presented a significant association between pre- to post-SDR MTS alteration and DTI abnormalities.</p><p><strong>Conclusions: </strong>The findings in the present study provided initial quantitative evidence to establish the WM microstructural characteristics in children with spastic CP prior to SDR surgery. The study generated data for the association between baseline DTI characteristics and mobility in children with CP prior to SDR surgery. The study also demonstrated SDR efficacy in improving motor function and spasticity based on the GMFM-66, MTS, and MAS, respectively, in association with DTI data.</p>","PeriodicalId":16549,"journal":{"name":"Journal of neurosurgery. Pediatrics","volume":" ","pages":"268-277"},"PeriodicalIF":2.1,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141288202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter to the Editor. Ventriculogallbladder shunts as treatment alternative for infants with necrotizing enterocolitis. 致编辑的信。将脑室-膀胱分流术作为治疗坏死性小肠结肠炎婴儿的替代方案。
IF 2.1 3区 医学
Journal of neurosurgery. Pediatrics Pub Date : 2024-06-07 DOI: 10.3171/2024.3.PEDS24114
Hector E James
{"title":"Letter to the Editor. Ventriculogallbladder shunts as treatment alternative for infants with necrotizing enterocolitis.","authors":"Hector E James","doi":"10.3171/2024.3.PEDS24114","DOIUrl":"10.3171/2024.3.PEDS24114","url":null,"abstract":"","PeriodicalId":16549,"journal":{"name":"Journal of neurosurgery. Pediatrics","volume":" ","pages":"303-304"},"PeriodicalIF":2.1,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141288201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of cervical spine clearance scores in children younger than 3 years with blunt trauma. 评估三岁以下钝伤儿童的颈椎清创评分。
IF 2.1 3区 医学
Journal of neurosurgery. Pediatrics Pub Date : 2024-05-31 Print Date: 2024-08-01 DOI: 10.3171/2024.4.PEDS2413
Tej D Azad, Kelly Jiang, Carly Weber-Levine, Ryan P Lee, Amit Jain, Paul Sponseller, Mari Groves, Nicholas Theodore, Isam W Nasr, Eric M Jackson
{"title":"Evaluation of cervical spine clearance scores in children younger than 3 years with blunt trauma.","authors":"Tej D Azad, Kelly Jiang, Carly Weber-Levine, Ryan P Lee, Amit Jain, Paul Sponseller, Mari Groves, Nicholas Theodore, Isam W Nasr, Eric M Jackson","doi":"10.3171/2024.4.PEDS2413","DOIUrl":"10.3171/2024.4.PEDS2413","url":null,"abstract":"<p><strong>Objective: </strong>The PEDSPINE I and PEDSPINE II scores were developed to determine when patients require advanced imaging to rule out cervical spine injury (CSI) in children younger than 3 years of age with blunt trauma. This study aimed to evaluate these scores in an institutional cohort.</p><p><strong>Methods: </strong>The authors identified patients younger than 3 years with blunt trauma who received cervical spine MRI from their institution's prospective database from 2012 to 2015. Patient demographics, injury characteristics, and imaging were compared between patients with and without CSI using chi-square and Wilcoxon rank-sum tests.</p><p><strong>Results: </strong>Eighty-eight patients were identified, 8 (9%) of whom had CSI on MRI. The PEDSPINE I system had a higher sensitivity (50% vs 25%) and negative predictive value (93% vs 92%), whereas PEDSPINE II had a higher specificity (91% vs 65%) and positive predictive value (22% vs 13%). Patients with CSI missed by the scores had mild, radiologically significant ligamentous injuries detected on MRI. Both models would have recommended advanced imaging for the patient who required halo-vest fixation (risk profile: no CSI, 81.9%; ligamentous, 10.1%; osseous, 8.0%). PEDSPINE I would have prevented 52 (65%) of 80 uninjured patients from receiving advanced imaging, whereas PEDSPINE II would have prevented 73 (91%). Using PEDSPINE I, 10 uninjured patients (13%) could have avoided intubation for imaging. PEDSPINE II would not have spared any patients intubation.</p><p><strong>Conclusions: </strong>Current cervical spine clearance algorithms are not sensitive or specific enough to determine the need for advanced imaging in children. However, these scores can be used as a reference in conjunction with physicians' clinical impressions to reduce unnecessary imaging.</p>","PeriodicalId":16549,"journal":{"name":"Journal of neurosurgery. Pediatrics","volume":" ","pages":"138-144"},"PeriodicalIF":2.1,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141183793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Autologous rib graft for posterior cervical fusion in pediatric patients: efficacy and safety in the early postoperative period. 自体肋骨移植用于小儿颈椎后路融合术:术后早期的有效性和安全性。
IF 2.1 3区 医学
Journal of neurosurgery. Pediatrics Pub Date : 2024-05-31 Print Date: 2024-08-01 DOI: 10.3171/2024.3.PEDS2424
Hudin Jackson, Rita Snyder, Jacob R Lepard, David F Bauer
{"title":"Autologous rib graft for posterior cervical fusion in pediatric patients: efficacy and safety in the early postoperative period.","authors":"Hudin Jackson, Rita Snyder, Jacob R Lepard, David F Bauer","doi":"10.3171/2024.3.PEDS2424","DOIUrl":"10.3171/2024.3.PEDS2424","url":null,"abstract":"<p><strong>Objective: </strong>The objective was to describe the indications, technique, and initial outcomes of autologous rib graft with recombinant human bone morphogenetic protein (rhBMP) in pediatric patients undergoing posterior cervical fusion.</p><p><strong>Methods: </strong>A retrospective study was performed of all pediatric patients who underwent autologous rib grafting with extra-small rhBMP-2 for posterior craniocervical or cervical arthrodesis at a single institution between May 2020 and July 2023. Patients with less than 3 months of postoperative follow-up and no postoperative CT data were excluded. Primary outcomes included presence of fusion on CT, 30-day perioperative complications, and rib harvest complications.</p><p><strong>Results: </strong>Twenty-eight sequential patients met inclusion criteria. Thirteen were male, 15 were female, and the average age was 9 years. There were no surgical site infections or instances of postoperative seroma or unplanned return to the operating room. All patients had solid fusion on postoperative CT at 3 months. The average follow-up was 14.5 months, with a range of 4 months to 3 years. There were no complications associated with the rib harvest, including no instances of harvest site pain, and all patient incisions healed well.</p><p><strong>Conclusions: </strong>The authors' preliminary results demonstrate that autologous rib graft with extra-small rhBMP-2 is an effective strategy to achieve a high rate of fusion in pediatric patients undergoing posterior instrumented craniocervical or cervical fusion. In this series, the authors found an acceptable safety profile, without seroma, surgical site infection, unplanned return to the operating room, or rib harvest complications.</p>","PeriodicalId":16549,"journal":{"name":"Journal of neurosurgery. Pediatrics","volume":" ","pages":"145-152"},"PeriodicalIF":2.1,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141183751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ventriculoperitoneal shunt placement following endoscopic third ventriculostomy failure in the treatment of pediatric hydrocephalus. 内窥镜第三脑室造口术治疗小儿脑积水失败后的脑室腹腔分流术置入术。
IF 2.1 3区 医学
Journal of neurosurgery. Pediatrics Pub Date : 2024-05-31 Print Date: 2024-08-01 DOI: 10.3171/2024.4.PEDS23572
Alexander R Evans, Lance Villeneuve, Ira Bowen, Lacey Carter, Sixia Chen, Marianne Kimmell, Joanna Gernsback, Karl Balsara, Andrew Jea, Virendra R Desai
{"title":"Ventriculoperitoneal shunt placement following endoscopic third ventriculostomy failure in the treatment of pediatric hydrocephalus.","authors":"Alexander R Evans, Lance Villeneuve, Ira Bowen, Lacey Carter, Sixia Chen, Marianne Kimmell, Joanna Gernsback, Karl Balsara, Andrew Jea, Virendra R Desai","doi":"10.3171/2024.4.PEDS23572","DOIUrl":"10.3171/2024.4.PEDS23572","url":null,"abstract":"<p><strong>Objective: </strong>The goal of this study was to evaluate the impact of endoscopic third ventriculostomy (ETV) failure on subsequent risk of ventriculoperitoneal shunt (VPS) placement.</p><p><strong>Methods: </strong>A retrospective chart review was performed to identify pediatric patients receiving ETV followed by a VPS at Oklahoma Children's Hospital between January 1, 2016, and December 31, 2021. A control group of patients receiving a VPS alone was also gathered. Complication and shunt failure rates were compared between the 2 groups at 12 months postoperatively.</p><p><strong>Results: </strong>A total of 222 patients were included in this study. The VPS placement after ETV failure (VPSEF) group included 21 patients; 53% were male and 47% were female, with a mean age of 2.2 years and standard deviation of 4.3 years. The etiology of hydrocephalus was chiefly intraventricular hemorrhage (43%) and neural tube defects (19%). At 12 months after VPS placement, the complication rate was 24%, predominantly including infection (19%) or CSF leakage (10%). The VPS-only (VPSO) group included 201 patients; 51% were male and 49% were female, with a mean age of 4.2 years and standard deviation of 6.5 years. The etiology of hydrocephalus was chiefly intraventricular hemorrhage (26%) and neural tube defects (30%). At 12 months postoperatively, the complication rate was 10%, predominantly including infection (6%) or catheter-associated hemorrhage (3%). The difference in complication rates between the VPSEF and VPSO groups was not significant at 12 months postoperatively (p = 0.07); however, on subgroup analysis there was a significantly higher rate of CSF leakage at 12 months in the VPSEF group compared to the VPSO group (p = 0.0371).</p><p><strong>Conclusions: </strong>There was no difference in overall complication rates for the treatment of pediatric hydrocephalus by VPS following failed ETV compared to VPS placement alone, yet prior ETV may predispose patients to a higher rate of CSF leaks within 12 months of VPS placement. Further study is indicated to determine whether a prior ETV procedure predisposes patients to a higher complication rate on VPS placement.</p>","PeriodicalId":16549,"journal":{"name":"Journal of neurosurgery. Pediatrics","volume":" ","pages":"176-181"},"PeriodicalIF":2.1,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141183796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter to the Editor. Sensitivity, specificity, and abusive head injury. 致编辑的信。灵敏度、特异性和虐待性头部损伤。
IF 2.1 3区 医学
Journal of neurosurgery. Pediatrics Pub Date : 2024-05-24 DOI: 10.3171/2024.2.PEDS2484
Joseph Piatt
{"title":"Letter to the Editor. Sensitivity, specificity, and abusive head injury.","authors":"Joseph Piatt","doi":"10.3171/2024.2.PEDS2484","DOIUrl":"10.3171/2024.2.PEDS2484","url":null,"abstract":"","PeriodicalId":16549,"journal":{"name":"Journal of neurosurgery. Pediatrics","volume":" ","pages":"301-303"},"PeriodicalIF":2.1,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141093759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Examining barriers to care: a retrospective cohort analysis investigating the relationship between hospital volume and outcomes in pediatric patients with cerebral arteriovenous malformations. 检查护理障碍:一项回顾性队列分析,调查脑动静脉畸形儿科患者的住院量与预后之间的关系。
IF 2.1 3区 医学
Journal of neurosurgery. Pediatrics Pub Date : 2024-05-24 Print Date: 2024-08-01 DOI: 10.3171/2024.3.PEDS23534
Michael G Brandel, Hernan Gonzalez, David D Gonda, Michael L Levy, Edward R Smith, Sandi K Lam, William T Couldwell, Jeffrey Steinberg, Vijay M Ravindra
{"title":"Examining barriers to care: a retrospective cohort analysis investigating the relationship between hospital volume and outcomes in pediatric patients with cerebral arteriovenous malformations.","authors":"Michael G Brandel, Hernan Gonzalez, David D Gonda, Michael L Levy, Edward R Smith, Sandi K Lam, William T Couldwell, Jeffrey Steinberg, Vijay M Ravindra","doi":"10.3171/2024.3.PEDS23534","DOIUrl":"10.3171/2024.3.PEDS23534","url":null,"abstract":"<p><strong>Objective: </strong>Comprehensive data on treatment patterns of pediatric cerebral arteriovenous malformations (AVMs) are lacking. The authors' aim was to examine national trends, assess the effect of hospital volume on outcomes, and identify variables associated with treatment at high-volume centers.</p><p><strong>Methods: </strong>Pediatric AVM admissions (for ruptured and unruptured lesions) occurring in the US in 2016 and 2019 were identified using the Kids' Inpatient Database. Demographics, treatment methods, costs, and outcomes were recorded. The effect of hospital AVM volume on outcomes and factors associated with treatment at higher-volume hospitals were analyzed.</p><p><strong>Results: </strong>Among 2752 AVM admissions identified, 730 (26.5%) patients underwent craniotomy, endovascular treatment, or a combination. High-volume (vs low-volume) centers saw lower proportions of Black (8.7% vs 12.9%, p < 0.001) and lowest-income quartile (20.7% vs 27.9%, p < 0.001) patients, but were more likely to provide endovascular intervention (19.5%) than low-volume institutions (13.7%) (p = 0.001). Patients treated at high-volume hospitals had insignificantly lower numbers of complications (mean 2.66 vs 4.17, p = 0.105) but significantly lower odds of nonroutine discharge (OR 0.18 [95% CI 0.06-0.53], p = 0.009) and death (OR 0.13 [95% CI 0.02-0.75], p = 0.023). Admissions at high-volume hospitals cost more than at low-volume hospitals, regardless of whether intervention was performed ($64,811 vs $48,677, p = 0.001) or not ($64,137 vs $33,779, p < 0.001). Multivariable analysis demonstrated that Hispanic children, patients who received AVM treatment, and those in higher-income quartiles had higher odds of treatment at high-volume hospitals.</p><p><strong>Conclusions: </strong>In this largest study of US pediatric cerebral AVM admissions to date, higher hospital volume correlated with several better outcomes, particularly when patients underwent intervention. Multivariable analysis demonstrated that higher income and Hispanic race were associated with treatment at high-volume centers, where endovascular care is more common. The findings highlight the fact that ensuring access to appropriate treatment of patients of all races and socioeconomic classes must be a focus.</p>","PeriodicalId":16549,"journal":{"name":"Journal of neurosurgery. Pediatrics","volume":" ","pages":"153-162"},"PeriodicalIF":2.1,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141093786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing pediatric neurosurgery capacity in La Paz, Bolivia: an illustrative institutional experience of a lower-middle-income country in South America. 评估玻利维亚拉巴斯的小儿神经外科能力:南美一个中低收入国家的机构经验示例。
IF 2.1 3区 医学
Journal of neurosurgery. Pediatrics Pub Date : 2024-05-24 Print Date: 2024-08-01 DOI: 10.3171/2024.3.PEDS24126
Victor M Lu, Jorge Daniel Brun, Toba N Niazi, Jorge David Brun
{"title":"Assessing pediatric neurosurgery capacity in La Paz, Bolivia: an illustrative institutional experience of a lower-middle-income country in South America.","authors":"Victor M Lu, Jorge Daniel Brun, Toba N Niazi, Jorge David Brun","doi":"10.3171/2024.3.PEDS24126","DOIUrl":"10.3171/2024.3.PEDS24126","url":null,"abstract":"<p><strong>Objective: </strong>The current pediatric neurosurgery capacity in lower-middle-income countries (LMICs) in South America is poorly understood. Correspondingly, the authors sought to interrogate the neurosurgical inpatient experience of the sole publicly funded pediatric hospital in one of the largest regional departments of Bolivia to better understand this capacity.</p><p><strong>Methods: </strong>A retrospective review of all neurosurgical procedures performed at the Children's Hospital of La Paz, Bolivia (Hospital del Niño \"Dr. Ovidio Aliaga Uria\") between 2019 and 2023 was conducted after institutional approval using a recently implemented national electronic medical record system.</p><p><strong>Results: </strong>A total of 475 neurosurgical admissions satisfied inclusion for analysis over the 5-year span. The majority of admissions were from within the La Paz Department (87%) via the emergency department (77%), without private insurance (83%). The most common indications for neurosurgical intervention were trauma (35%), followed by hydrocephalus (28%), congenital disease (12%), infection (5%), and craniosynostosis (3%). Overall, the median age at time of surgery was 2.0 years, and the median operating time was 1.5 hours with a minority of intraoperative complications (2%). The most common inpatient complication was unplanned return to the operating room (19%), most commonly seen in congenital indications. At final discharge, the median postoperative length of stay was 10 days. Twenty-seven (6%) of the 475 patients died during hospitalization, most commonly seen in tumor indications. Of the 448 patients who were discharged, 299 (67%) returned for at least one follow-up appointment.</p><p><strong>Conclusions: </strong>There is restricted breadth in neurosurgical indications and outcomes achievable at the Children's Hospital of La Paz, Bolivia. As such, the capacity of pediatric neurosurgery at institutions in LMICs in South America such as this one is very limited. Identifying and prioritizing actionable interventions to improve this capacity is institution- and LMIC-dependent, and as such, future efforts will need to be tailored appropriately.</p>","PeriodicalId":16549,"journal":{"name":"Journal of neurosurgery. Pediatrics","volume":" ","pages":"190-198"},"PeriodicalIF":2.1,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141093775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The utility of biomarkers in traumatic brain injuries in children: opportunities and challenges. 生物标志物在儿童脑外伤中的应用:机遇与挑战。
IF 2.1 3区 医学
Journal of neurosurgery. Pediatrics Pub Date : 2024-05-17 DOI: 10.3171/2024.3.PEDS2446
Andrew Reisner, Youssef M Zohdy, Joshua J Chern, Laura S Blackwell, Jacob R Lepard, Ali Alawieh, Meena S Verma, Firas Kobeissy, Makda G Mulugeta, Joseph A Tyndall, Brendan J Klein, Olubunmi A Fariyike, Rebekah Mannix, Jennifer C Munoz Pareja, Kevin K Wang
{"title":"The utility of biomarkers in traumatic brain injuries in children: opportunities and challenges.","authors":"Andrew Reisner, Youssef M Zohdy, Joshua J Chern, Laura S Blackwell, Jacob R Lepard, Ali Alawieh, Meena S Verma, Firas Kobeissy, Makda G Mulugeta, Joseph A Tyndall, Brendan J Klein, Olubunmi A Fariyike, Rebekah Mannix, Jennifer C Munoz Pareja, Kevin K Wang","doi":"10.3171/2024.3.PEDS2446","DOIUrl":"10.3171/2024.3.PEDS2446","url":null,"abstract":"","PeriodicalId":16549,"journal":{"name":"Journal of neurosurgery. Pediatrics","volume":" ","pages":"199-203"},"PeriodicalIF":2.1,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140957934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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