Journal of neurological surgery. Part A, Central European neurosurgery最新文献_第8页

Wilhelm Tönnis and His Network around 1950: His National and International Impact. 1950年前后威廉Tönnis和他的网络：他的国内和国际影响。

IF 0.9 4区医学

Journal of neurological surgery. Part A, Central European neurosurgery Pub Date : 2025-03-01 Epub Date: 2025-05-21 DOI: 10.1055/a-2558-3390

Ulrike Eisenberg

引用次数: 0

Exosomal CircMFN2 Enhances the Progression of Pituitary Adenoma via the MiR-146a-3p/TRAF6/NF-κB Pathway. 外泌体CircMFN2通过MiR-146a-3p/TRAF6/NF-κB途径增强垂体腺瘤的进展。

IF 0.9 4区医学

Journal of neurological surgery. Part A, Central European neurosurgery Pub Date : 2025-03-01 Epub Date: 2023-10-31 DOI: 10.1055/a-2201-8370

Haitong Wan, Xiang Gao, Zexu Yang, Leiguo Wei, Yufei Qu, Qi Liu

{"title":"Exosomal CircMFN2 Enhances the Progression of Pituitary Adenoma via the MiR-146a-3p/TRAF6/NF-κB Pathway.","authors":"Haitong Wan, Xiang Gao, Zexu Yang, Leiguo Wei, Yufei Qu, Qi Liu","doi":"10.1055/a-2201-8370","DOIUrl":"10.1055/a-2201-8370","url":null,"abstract":"Background: Pituitary adenoma (PA) is a common intracranial endocrine tumor, but no precise target has been found for effective prediction and treatment of PA.Methods: Quantitative reverse transcription polymerase chain reaction (qRT‒PCR) analysis showed that circMFN2 could affect the expression of miR-146a-3p in PA samples. Moreover, we used Western blotting to evaluate the expression levels of TRAF6 and NF-κB markers. The EdU assay, scratch wound healing assay, and Matrigel invasion assay were performed to assess the potential function of this pathway in PA cells. Based on the bioinformatic analysis including KEGG, gene ontology (GO) analysis, and microarray analysis, we evaluated the efficacy of circMFN2 as a potential biomarker for diagnosing PA, and we aimed to determine the mechanism of action in PA cells.Results: Our findings indicate that there is a significant increase in the expression of circMFN2 in tissues, serum, and exosomes in the invasive group compared with the noninvasive and normal groups. Furthermore, this difference was statistically significant both preoperatively and postoperatively. To clarify its function, we downregulated this gene, and the experimental results suggested that the motility and proliferative capacity were reduced in vitro. In addition, rescue assays showed that miR-146a-3p could successfully reverse the inhibitory effect of circMFN2 knockdown on motility and proliferation in PA cells. Moreover, downregulation of circMFN2 and miR-146a-3p significantly changed the expression of TRAF6 and NF-κB.Conclusion: This study identified that circMFN2 regulates miR-146a-3p to promote adenoma development partially via the TRAF6/NF-κB pathway and may be a potential therapeutic target for PA.","PeriodicalId":16544,"journal":{"name":"Journal of neurological surgery. Part A, Central European neurosurgery","volume":" ","pages":"135-147"},"PeriodicalIF":0.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11845271/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71424304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Development of German Neurosurgical Health Care from 1945 to 1955. 1945 - 1955年德国神经外科保健的发展。

IF 0.9 4区医学

Journal of neurological surgery. Part A, Central European neurosurgery Pub Date : 2025-03-01 Epub Date: 2025-05-21 DOI: 10.1055/a-2558-3285

Wolf-Ingo Steudel, Hartmut Collmann, Hans-Jürgen Reulen

引用次数: 0

The Impact of the COVID-19 Pandemic and Lockdown on the Outcome of Glioblastoma. COVID-19 大流行和封锁对胶质母细胞瘤治疗结果的影响。

IF 0.9 4区医学

Journal of neurological surgery. Part A, Central European neurosurgery Pub Date : 2025-03-01 Epub Date: 2024-07-03 DOI: 10.1055/s-0044-1779262

Daniele Armocida, Luca D'Angelo, Raffaella De Pietro, Giuseppina Chiarello, Tingting Jiang, Francesca Rizzo, Diego Garbossa, Alessandro Frati, Francesco Marampon, Antonio Santoro

{"title":"The Impact of the COVID-19 Pandemic and Lockdown on the Outcome of Glioblastoma.","authors":"Daniele Armocida, Luca D'Angelo, Raffaella De Pietro, Giuseppina Chiarello, Tingting Jiang, Francesca Rizzo, Diego Garbossa, Alessandro Frati, Francesco Marampon, Antonio Santoro","doi":"10.1055/s-0044-1779262","DOIUrl":"10.1055/s-0044-1779262","url":null,"abstract":"Background: Rapid spread of the SARS-CoV-2 pandemic in 2020 led to an indirect effect on non-COVID patients. Since neuro-oncology cases are unique and brain tumors need a specific therapeutic protocol at proper doses and at the right times, the effects of the pandemic on health care services for patients with glioblastomas (GBs) and their impact on overall survival (OS) and quality of life are not yet known.Methods: We conducted a retrospective study of 142 GB patients who underwent surgery, radiation, and chemotherapy before and after the lockdown period, aiming to determine the differences in access to care, treatment modality, and adjuvant therapies, and how the lockdown changed the prognosis.Results: The number of procedures performed for GB during the pandemic was comparable to that of the prepandemic period, and patients received standard care. There was a significant difference in the volume of lesions measured at diagnosis with a decreased number of \"accidental\" diagnoses and expression of a reduced use by the patient for a checkup or follow-up examinations. Patients expressed a significantly lower performance index in the lockdown period with longer progression-free survival (PFS) in the face of a comparable mean time to OS.Conclusion: Patients treated surgically for GB during the pandemic period had a more pronounced and earlier reduction in performance status than patients treated during the same period the year before. This appears to be primarily due to lower levels of care in the rehabilitation centers and more frequent discontinuation of adjuvant care.","PeriodicalId":16544,"journal":{"name":"Journal of neurological surgery. Part A, Central European neurosurgery","volume":" ","pages":"120-127"},"PeriodicalIF":0.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141498292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Over 70 Years of Neurosurgical Research: A Comparison of the Publication Performance of Two Leading Journals: "Acta Neurochirurgica" and "Zentralblatt für Neurochirurgie". 超过70年的神经外科研究：两个主要期刊的出版表现比较：“Acta neurochirurica”和“Zentralblatt fr Neurochirurgie”。

IF 0.9 4区医学

Journal of neurological surgery. Part A, Central European neurosurgery Pub Date : 2025-03-01 Epub Date: 2025-05-21 DOI: 10.1055/a-2558-3320

Daniel Dubinski, Uwe Hans Wiese

{"title":"Over 70 Years of Neurosurgical Research: A Comparison of the Publication Performance of Two Leading Journals: \"Acta Neurochirurgica\" and \"Zentralblatt für Neurochirurgie\".","authors":"Daniel Dubinski, Uwe Hans Wiese","doi":"10.1055/a-2558-3320","DOIUrl":"https://doi.org/10.1055/a-2558-3320","url":null,"abstract":"The aim of this study is to compare the publication performance of two leading neurosurgical journals, \"Acta Neurochirurgica\" and \"Zentralblatt für Neurochirurgie,\" over a period of over 70 years. Trends in the number of publications as well as the thematic development of neurosurgical research will be analyzed. For this study, the abstracts of publications from the years 1951 and 2023 in the two leading neurosurgical journals \"Acta Neurochirurgica\" and \"Zentralblatt für Neurochirurgie\" were analyzed by the authors. For the sake of clarity, a thematic categorization into thematic blocks has been made. The publication performance in the analyzed journals has significantly increased from one volume with 21 articles for Acta Neurochirurgica in 1951 to 12 volumes in with 506 articles in 2023. A total of one volume with 32 articles was recorded for Zentralblatt für Neurochirurgie in 1951 versus a total of 6 volumes with 90 articles in 2023. Furthermore, new research areas represented include epilepsy surgery, technological innovations such as robotic surgery and virtual reality, hydrocephalus, advancements in neurosurgical education, deep brain stimulation as well as historical and biographical topics. Overall, the results illustrate a significant enhancement in the publication output and thematic richness of neurosurgical research in over more than 70 years. This development underscores the dynamic and evolving nature of the field, driven by continuous scientific and technological advancements. Our comparison highlights the significant role of the journals \"Acta Neurochirurgica\" and \"Zentralblatt für Neurochirurgie\" in disseminating knowledge and promoting scientific progress in neurosurgery in Germany.","PeriodicalId":16544,"journal":{"name":"Journal of neurological surgery. Part A, Central European neurosurgery","volume":"86 S 01","pages":"S23-S26"},"PeriodicalIF":0.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brain Tumor Surgery in Germany around 1950, According to the Tönnis School. 1950年左右德国的脑肿瘤手术，根据Tönnis学校。

IF 0.9 4区医学

Journal of neurological surgery. Part A, Central European neurosurgery Pub Date : 2025-03-01 Epub Date: 2025-05-21 DOI: 10.1055/a-2558-3343

Werner E K Braunsdorf

引用次数: 0

A New Concept for Cervical Expansion Screws Using Shape Memory Alloy: A Feasibility Study. 一种使用形状记忆合金的颈椎膨胀螺钉的新概念——可行性研究。

IF 0.9 4区医学

Journal of neurological surgery. Part A, Central European neurosurgery Pub Date : 2025-03-01 Epub Date: 2023-11-08 DOI: 10.1055/a-2206-2578

Ronny Grunert, Dirk Winkler, Nikolas Knoop, Martin Weidling, Cornelia Matzke, Sebastian Scholz, Juergen Meixensberger, Felix Arlt

{"title":"A New Concept for Cervical Expansion Screws Using Shape Memory Alloy: A Feasibility Study.","authors":"Ronny Grunert, Dirk Winkler, Nikolas Knoop, Martin Weidling, Cornelia Matzke, Sebastian Scholz, Juergen Meixensberger, Felix Arlt","doi":"10.1055/a-2206-2578","DOIUrl":"10.1055/a-2206-2578","url":null,"abstract":"Background: In general, sufficient anchoring of screws in the bone material ensures the intended primary stability.Methods: Shape memory materials offer the option of using temperature-associated deformation energy in a targeted manner to compensate the special situation of osteoporotic bones or the potential lack of anchoring. An expansion screw was developed for these purposes. Using finite element analysis (FEA), the variability of screw configuration and actuator was assessed from shape memory. In particular, the dimensioning of the screw slot, the actuator length, and the actuator diameter as well as the angle of attack in relation to the intended force development were considered.Results: As a result of the FEA, a special configuration of expansion screw and shape memory element could be found. Accordingly, with an optimal screw diameter of 4 mm, an actuator diameter of 0.8 mm, a screw slot of 7.8 mm in length, and an angle of attack of 25 degrees, the best compromise between individual components and high efficiency in favor of maximum strength can be predicted.Conclusion: Shape memory material offers the possibility of using completely new forms of power development. By skillfully modifying the mechanical and shape memory elements, their interaction results in a calculated development of force in favor of a high primary stability of the screw material used. Activation by means of body temperature is a very elegant way of initializing the intended locking and screw strength.","PeriodicalId":16544,"journal":{"name":"Journal of neurological surgery. Part A, Central European neurosurgery","volume":" ","pages":"128-134"},"PeriodicalIF":0.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71521835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Technical Standards in Neurosurgery in Germany around 1950. 1950年前后德国的神经外科技术标准。

IF 0.9 4区医学

Journal of neurological surgery. Part A, Central European neurosurgery Pub Date : 2025-03-01 Epub Date: 2025-05-21 DOI: 10.1055/a-2558-3355

Peter A Winkler

引用次数: 0

Craniotomy versus Decompressive Craniectomy in Acute Subdural Hematoma Management: A Systematic Review and Meta-Analysis. 开颅术与减压开颅术在急性硬膜下血肿治疗中的应用：系统回顾与元分析》。

IF 0.9 4区医学

Journal of neurological surgery. Part A, Central European neurosurgery Pub Date : 2025-03-01 Epub Date: 2024-10-08 DOI: 10.1055/s-0044-1791539

Mohammed Maan Al-Salihi, Maryam Sabah Al-Jebur, Yezan Al-Salihi, Elias Dumour, Ahmed Saleh, Mhran Daie, Firas Hammadi, Ali Ayyad

{"title":"Craniotomy versus Decompressive Craniectomy in Acute Subdural Hematoma Management: A Systematic Review and Meta-Analysis.","authors":"Mohammed Maan Al-Salihi, Maryam Sabah Al-Jebur, Yezan Al-Salihi, Elias Dumour, Ahmed Saleh, Mhran Daie, Firas Hammadi, Ali Ayyad","doi":"10.1055/s-0044-1791539","DOIUrl":"10.1055/s-0044-1791539","url":null,"abstract":"Background: This study aimed to compare the clinical outcomes of decompressive craniectomy (DC) and craniotomy in treating acute subdural hematoma (ASDH) to provide a more precise assessment of the procedures' outcomes.Methods: We searched for relevant articles in PubMed, Web of Science, Embase, Scopus, and Cochrane till August 2023, including cohort studies and randomized controlled trials comparing craniotomy and DC for ASDH. The analysis was conducted using \"Review Manager\" software, using the risk ratio along with a 95% confidence interval (CI) for categorical data, whereas continuous data were analyzed using the mean difference (MD) and 95% CI.Results: Our analysis included 13 studies with a total of 4,689 patients, of whom 1,910 (40.7%) underwent DC and 2,779 (59.3%) underwent craniotomy. The results revealed a statistically significant difference in favor of craniotomy concerning good recovery in delayed GOS (risk ratio [RR] = 1.42; 95% CI [1.12, 1.81]), postoperative mortality (RR = 0.81; 95% CI [0.71, 0.94]), mortality at last follow-up (RR = 0.75; 95% CI [0.62, 0.91]), and hospital stay (MD = -3.71; 95%CI [-5.82, -1.60]). A nonsignificant difference (RR = 1.06; 95% CI [0.52, 2.17]; p = 0.87) was found between the two interventions concerning seizures.Conclusion: Despite craniotomy's favorable clinical outcomes and mortality rates, the significant baseline differences between DC and craniotomy make these data inconclusive. To establish solid evidence regarding the use of DC versus craniotomy in ASDH, it is necessary to conduct well-controlled randomized studies with large sample sizes.","PeriodicalId":16544,"journal":{"name":"Journal of neurological surgery. Part A, Central European neurosurgery","volume":" ","pages":"182-195"},"PeriodicalIF":0.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142391155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Participation of Neurosurgery in the Basic Neurosciences as Documented in the Annual Volumes of the Zentralblatt für Neurochirurgie around 1950. 1950年前后《中央科学协会<e:1>神经外科年鉴》记载的神经外科在基础神经科学中的参与情况。

IF 0.9 4区医学

Journal of neurological surgery. Part A, Central European neurosurgery Pub Date : 2025-03-01 Epub Date: 2025-05-21 DOI: 10.1055/a-2558-3368

Uwe H Wiese

引用次数: 0