Taha Şükrü Korkmaz, Semih Can Çetintaş, Süleyman Akkaya, Sureyya Toklu
{"title":"Neurosurgery Residency Training and Beyond in Turkey: A National Survey Study.","authors":"Taha Şükrü Korkmaz, Semih Can Çetintaş, Süleyman Akkaya, Sureyya Toklu","doi":"10.1055/a-2558-5909","DOIUrl":"https://doi.org/10.1055/a-2558-5909","url":null,"abstract":"<p><strong>Study aims: </strong>Training neurosurgery specialists is a challenging and demanding process. This national survey study was conducted to evaluate the infrastructure of neurosurgery residency programs and training clinics in Turkey and to assess how these factors impact specialist practice.</p><p><strong>Material and methods: </strong>A national survey consisting of 32 questions was distributed to neurosurgeons who had been practicing as specialists for at least two years. The survey was divided into four sections: demographic information, residency training process, hospital where they currently work as specialists, and microsurgical experience. Statistical analyses, including chi-square and logistic regression, were conducted to examine factors influencing surgical performance in specialist practice.</p><p><strong>Results: </strong>Regression analyses indicated that performing skin-to-skin surgeries during residency significantly and most effectively increased the likelihood of performing these procedures as a specialist. Additionally, working in anatomy laboratories, attending hands-on cadaver courses, and increased years of practice were all positively associated with surgical performance. It was also found that participants who graduated within the last five years were statistically significantly less likely to have attended hands-on courses or visited another clinic for observerships/fellowships compared to those who graduated more than five years ago.</p><p><strong>Conclusions: </strong>Findings suggest that neurosurgical training in Turkey is affected by disparities in clinical infrastructure and hands-on experience. Standardizing residency experiences and ensuring access to necessary equipment and training resources could enhance neurosurgical competency and consistency in specialist practice.</p>","PeriodicalId":16544,"journal":{"name":"Journal of neurological surgery. Part A, Central European neurosurgery","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lidia Dias, Paulo Nogueira, João Pedro Oliveira, José Cabral
{"title":"Acute Traumatic Subdural Hematomas - When (and why) do we stop? The atSDH-stop survey.","authors":"Lidia Dias, Paulo Nogueira, João Pedro Oliveira, José Cabral","doi":"10.1055/a-2558-5681","DOIUrl":"https://doi.org/10.1055/a-2558-5681","url":null,"abstract":"<p><strong>Objective: </strong>This study investigates the decision-making process among neurosurgeons regarding the surgical management of Acute Subdural Hematomas (ASDH), focusing on the role of non-classical Brain Trauma Foundation (BTF) factors such as brainstem reflexes, hypocoagulation, and patient comorbidity, alongside traditional guidelines.</p><p><strong>Methods: </strong>We conducted an international survey that presented neurosurgeons with real-case scenarios, designed to assess the impact of both traditional and non-traditional prognostic indicators on their surgical decisions. The survey also collected demographic data to examine potential correlations with decision-making preferences.</p><p><strong>Results: </strong>The survey garnered 67 responses from neurosurgeons across 22 countries, revealing a reliance on non-classical BTF factors in decision-making for ASDH cases with a potentially poor prognosis. No significant correlations were found between these decision-making practices and the surgeons' demographic characteristics.</p><p><strong>Conclusion: </strong>The findings highlight the complexity and nuanced nature of surgical decision-making in ASDH management, underlining the importance of non-traditional prognostic factors. The results advocate for further research to refine clinical guidelines, ensuring they encapsulate the breadth of factors considered in practice, thereby enhancing patient-centered care.</p>","PeriodicalId":16544,"journal":{"name":"Journal of neurological surgery. Part A, Central European neurosurgery","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Geraint John Sunderland, Jonathan Ellenbogen, Catherine Gilkes, Ajay Sinha
{"title":"Patient Reported Olfactory and Sinonasal Outcomes Following Endoscopic Transsphenoidal Pituitary Surgery.","authors":"Geraint John Sunderland, Jonathan Ellenbogen, Catherine Gilkes, Ajay Sinha","doi":"10.1055/a-2558-5750","DOIUrl":"https://doi.org/10.1055/a-2558-5750","url":null,"abstract":"<p><strong>Background: </strong>Endoscopic endonasal transsphenoidal surgery (EETS) results in disturbance of nasal mucosa and airflow. Previous studies have demonstrated associated sinonasal morbidity but have not prospectively assessed olfactory function.</p><p><strong>Study aim: </strong>To obtain prospective objective measure of sinonasal morbidity associated with EETS.</p><p><strong>Materials and methods: </strong>We report our prospective patient-reported outcome study of 20 unselected, consecutive patients undergoing EETS. Baseline assessment of olfactory function was performed using the validated University of Pennsylvania Smell Identification Test (UPSIT) alongside quality of life (QoL) assessments using the 22 item Sino-Nasal Outcomes Test (SNOT-22) and Anterior Skull Base Questionnaire (ASBQ) prior to surgery. Repeat olfactory function testing and QoL questionnaires were performed at 3 months and 12 months post operatively. All patients underwent pituitary surgery and there was one extended anterior approach.</p><p><strong>Results: </strong>Mean olfactory function score was worse at 3 months (25.9) compared with baseline (30.5), p= 0.02. This improved back towards baseline at 1 year (29.4). 3 patients (15.8%) had significant residual olfactory impairment at 1 year. There were no significant differences in SNOT-22 score or ASBQ at 3 month or 1 year follow up. EETS is associated with minor disturbances in olfactory and sinonasal QoL.</p><p><strong>Conclusion: </strong>Formal assessment of olfactory function has proven more sensitive in identifying deficiencies in olfaction following surgery however there is little or no correlation with QoL scores.</p>","PeriodicalId":16544,"journal":{"name":"Journal of neurological surgery. Part A, Central European neurosurgery","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F Arlt, D Winkler, N Knoop, M Weidling, F Frank, J Meixensberger, R Grunert
{"title":"The Use of Shape Memory Alloys in Cages for Cervical Spinal Surgery.","authors":"F Arlt, D Winkler, N Knoop, M Weidling, F Frank, J Meixensberger, R Grunert","doi":"10.1055/s-0044-1795156","DOIUrl":"https://doi.org/10.1055/s-0044-1795156","url":null,"abstract":"<p><strong>Background: </strong> Degenerative changes in the cervical spine can include the gradual loss of functionality of the intervertebral disks, development of osteophytes and ligament hypertrophy. Removal of the intervertebral disk and replacement with a cage (anterior discectomy and fusion [ACDF]) is a standardized operative procedure in these patients. The implant should provide structural support, should restore the physiologic lordosis, and enable a solid fusion. In this context, shape memory materials have great potential in the development of implants in spinal surgery.</p><p><strong>Methods: </strong> We designed and developed a cage that automatically adapts to the cross-section of the intervertebral disk space and simultaneously ensures mechanical support for load transfer between the adjacent vertebral bodies. A special mechanism (shape memory alloy [SMA]) should allow the implant to adapt to the geometric configuration of the intervertebral disk space. The cage developed was tested in an artificial cervical spine.</p><p><strong>Results: </strong> The base body of the cage consists of polyether ether ketone (PEEK) with a width of 14 mm, length of 16 mm, and height of 4 mm. A shape memory actuator, made of nickel-titanium alloy, is used to realize the geometry adaptation. Utilizing this, the transformation from martensite to austenite is completed at 35°C. Biomechanical testing with lateral bending and compression was performed. Subsequent cyclic loading results in a constant hysteresis curve, indicating stable implant positioning.</p><p><strong>Conclusions: </strong> We feel confident about having developed an alternative cage for ACDF that can potentially reduce peri- and postoperative morbidity and provide long-term stability by reducing bone removal during cage implantation. Therefore, we are encouraged to proceed with further biomechanical testing in cadaver specimens to eventually reach the goal of in vivo application.</p>","PeriodicalId":16544,"journal":{"name":"Journal of neurological surgery. Part A, Central European neurosurgery","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jin-Sung Kim, Khanathip Jitpakdee, Rohit Akshay Kavishwar
{"title":"Letter to the Editor Regarding \"The Efficacy and Safety of Topical Saline Irrigation with Tranexamic Acid on Perioperative Blood Loss in Patients Treated with Percutaneous Endoscopic Interlaminar Diskectomy: A Retrospective Study\".","authors":"Jin-Sung Kim, Khanathip Jitpakdee, Rohit Akshay Kavishwar","doi":"10.1055/a-2206-2666","DOIUrl":"10.1055/a-2206-2666","url":null,"abstract":"","PeriodicalId":16544,"journal":{"name":"Journal of neurological surgery. Part A, Central European neurosurgery","volume":" ","pages":"217-218"},"PeriodicalIF":0.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71521837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Peter Kurucz, Oliver Ganslandt, Michael Buchfelder, Sasan Darius Adib, Laszlo Barany
{"title":"Anatomy and Microsurgical Relevance of the Outer Arachnoid Envelope around the Olfactory Bulb Based on Endoscopic Cadaveric Observations.","authors":"Peter Kurucz, Oliver Ganslandt, Michael Buchfelder, Sasan Darius Adib, Laszlo Barany","doi":"10.1055/a-2249-7710","DOIUrl":"10.1055/a-2249-7710","url":null,"abstract":"<p><strong>Background: </strong> There is high risk of injury to the olfactory tract and olfactory bulb during surgery of the anterior cranial fossa. The goal of this study was to describe the outer arachnoid envelope around the olfactory bulb, which plays a significant role in approach-related injury of the nerve.</p><p><strong>Methods: </strong> A total of 20 fresh human cadaveric heads were examined. Five cadaveric heads were used to describe a gross overview of the topographic anatomy of the outer arachnoid cover of the olfactory bulb. In 15 cadaveric heads, endoscopic surgical approaches were performed to examine the in situ undisrupted anatomy of the outer arachnoid around the olfactory bulb. Four cadaveric heads were used for the lateral subfrontal approach, 5 heads for the medial subfrontal approach, 3 heads for the median subfrontal approach, and 3 heads for the anterior interhemispheric approach.</p><p><strong>Results: </strong> The outer arachnoid membrane of the frontal lobe attaches the olfactory bulb strongly to the above lying olfactory sulcus. Only the most rostral portion of the olfactory bulb became slightly detached from the frontal lobe. The outer arachnoid forms a decent protrusion around the tip of the olfactory bulbs. The fila olfactoria have their own outer arachnoid cover as a continuation of the same layer of the olfactory bulb. The effect of brain retraction and manipulation forces on the olfactory bulb and the role of the arachnoid membranes located here were visually analyzed and described in detail through the four different neurosurgical approaches we performed.</p><p><strong>Conclusion: </strong> The results of our observations provide important anatomical details for preserving the sense of smell during neurosurgical procedures.</p>","PeriodicalId":16544,"journal":{"name":"Journal of neurological surgery. Part A, Central European neurosurgery","volume":" ","pages":"169-176"},"PeriodicalIF":0.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139502259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Junhua Ye, Mingli Liang, Qizheng Qiu, Wenbo Zhang, Min Ye
{"title":"Decompressive Bone Flap Replacement (Decompressive Cranioplasty): A Novel Technique for Intracranial Hypertension-Initial Experience and Outcome.","authors":"Junhua Ye, Mingli Liang, Qizheng Qiu, Wenbo Zhang, Min Ye","doi":"10.1055/a-2200-3674","DOIUrl":"10.1055/a-2200-3674","url":null,"abstract":"<p><strong>Background: </strong> Intracranial hypertension is a life-threatening condition that can be treated by decompressive craniectomy (DC), which involves removing a part of the skull and intracranial lesions. However, DC has many complications and requires a second surgery to repair the skull. Decompressive bone flap replacement (DBFR) or decompressive cranioplasty is a novel technique that replaces the bone flap with a titanium mesh, providing both decompression and skull integrity.</p><p><strong>Methods: </strong> The materials and methods of DBFR are described in detail. A three-dimensional titanium mesh is fabricated based on the computed tomography (CT) data of previous DC patients. An appropriate titanium mesh is selected based on the preoperative and intraoperative assessments. After removing the intracranial lesions, the titanium mesh is fixed over the bone window.</p><p><strong>Results: </strong> We successfully performed DBFR in three emergent cases. The postoperative CT scan showed adequate decompression in all cases. No reoperation for skull repair was needed, and there were no surgical complications. The cosmetic outcome was excellent. There were no relevant complications in the operative area.</p><p><strong>Conclusions: </strong> DBFR may be a safe and effective alternative to DC in a specific subgroup of patients, in whom complete removal of the bone flap is feasible. DBFR can reduce intracranial pressure while maintaining the integrity of the skull cavity, eliminating the need for additional surgery for skull repair. Possible improvements for DBFR in the future are suggested, such as using a greater curvature of the titanium mesh or a modified DBFR with a hinged titanium mesh.</p>","PeriodicalId":16544,"journal":{"name":"Journal of neurological surgery. Part A, Central European neurosurgery","volume":" ","pages":"156-161"},"PeriodicalIF":0.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61563219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Exosomal CircMFN2 Enhances the Progression of Pituitary Adenoma via the MiR-146a-3p/TRAF6/NF-κB Pathway.","authors":"Haitong Wan, Xiang Gao, Zexu Yang, Leiguo Wei, Yufei Qu, Qi Liu","doi":"10.1055/a-2201-8370","DOIUrl":"10.1055/a-2201-8370","url":null,"abstract":"<p><strong>Background: </strong> Pituitary adenoma (PA) is a common intracranial endocrine tumor, but no precise target has been found for effective prediction and treatment of PA.</p><p><strong>Methods: </strong> Quantitative reverse transcription polymerase chain reaction (qRT‒PCR) analysis showed that circMFN2 could affect the expression of miR-146a-3p in PA samples. Moreover, we used Western blotting to evaluate the expression levels of TRAF6 and NF-κB markers. The EdU assay, scratch wound healing assay, and Matrigel invasion assay were performed to assess the potential function of this pathway in PA cells. Based on the bioinformatic analysis including KEGG, gene ontology (GO) analysis, and microarray analysis, we evaluated the efficacy of circMFN2 as a potential biomarker for diagnosing PA, and we aimed to determine the mechanism of action in PA cells.</p><p><strong>Results: </strong> Our findings indicate that there is a significant increase in the expression of circMFN2 in tissues, serum, and exosomes in the invasive group compared with the noninvasive and normal groups. Furthermore, this difference was statistically significant both preoperatively and postoperatively. To clarify its function, we downregulated this gene, and the experimental results suggested that the motility and proliferative capacity were reduced in vitro. In addition, rescue assays showed that miR-146a-3p could successfully reverse the inhibitory effect of circMFN2 knockdown on motility and proliferation in PA cells. Moreover, downregulation of circMFN2 and miR-146a-3p significantly changed the expression of TRAF6 and NF-κB.</p><p><strong>Conclusion: </strong> This study identified that circMFN2 regulates miR-146a-3p to promote adenoma development partially via the TRAF6/NF-κB pathway and may be a potential therapeutic target for PA.</p>","PeriodicalId":16544,"journal":{"name":"Journal of neurological surgery. Part A, Central European neurosurgery","volume":" ","pages":"135-147"},"PeriodicalIF":0.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11845271/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71424304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Daniele Armocida, Luca D'Angelo, Raffaella De Pietro, Giuseppina Chiarello, Tingting Jiang, Francesca Rizzo, Diego Garbossa, Alessandro Frati, Francesco Marampon, Antonio Santoro
{"title":"The Impact of the COVID-19 Pandemic and Lockdown on the Outcome of Glioblastoma.","authors":"Daniele Armocida, Luca D'Angelo, Raffaella De Pietro, Giuseppina Chiarello, Tingting Jiang, Francesca Rizzo, Diego Garbossa, Alessandro Frati, Francesco Marampon, Antonio Santoro","doi":"10.1055/s-0044-1779262","DOIUrl":"10.1055/s-0044-1779262","url":null,"abstract":"<p><strong>Background: </strong> Rapid spread of the SARS-CoV-2 pandemic in 2020 led to an indirect effect on non-COVID patients. Since neuro-oncology cases are unique and brain tumors need a specific therapeutic protocol at proper doses and at the right times, the effects of the pandemic on health care services for patients with glioblastomas (GBs) and their impact on overall survival (OS) and quality of life are not yet known.</p><p><strong>Methods: </strong> We conducted a retrospective study of 142 GB patients who underwent surgery, radiation, and chemotherapy before and after the lockdown period, aiming to determine the differences in access to care, treatment modality, and adjuvant therapies, and how the lockdown changed the prognosis.</p><p><strong>Results: </strong> The number of procedures performed for GB during the pandemic was comparable to that of the prepandemic period, and patients received standard care. There was a significant difference in the volume of lesions measured at diagnosis with a decreased number of \"accidental\" diagnoses and expression of a reduced use by the patient for a checkup or follow-up examinations. Patients expressed a significantly lower performance index in the lockdown period with longer progression-free survival (PFS) in the face of a comparable mean time to OS.</p><p><strong>Conclusion: </strong> Patients treated surgically for GB during the pandemic period had a more pronounced and earlier reduction in performance status than patients treated during the same period the year before. This appears to be primarily due to lower levels of care in the rehabilitation centers and more frequent discontinuation of adjuvant care.</p>","PeriodicalId":16544,"journal":{"name":"Journal of neurological surgery. Part A, Central European neurosurgery","volume":" ","pages":"120-127"},"PeriodicalIF":0.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141498292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ronny Grunert, Dirk Winkler, Nikolas Knoop, Martin Weidling, Cornelia Matzke, Sebastian Scholz, Juergen Meixensberger, Felix Arlt
{"title":"A New Concept for Cervical Expansion Screws Using Shape Memory Alloy: A Feasibility Study.","authors":"Ronny Grunert, Dirk Winkler, Nikolas Knoop, Martin Weidling, Cornelia Matzke, Sebastian Scholz, Juergen Meixensberger, Felix Arlt","doi":"10.1055/a-2206-2578","DOIUrl":"10.1055/a-2206-2578","url":null,"abstract":"<p><strong>Background: </strong> In general, sufficient anchoring of screws in the bone material ensures the intended primary stability.</p><p><strong>Methods: </strong> Shape memory materials offer the option of using temperature-associated deformation energy in a targeted manner to compensate the special situation of osteoporotic bones or the potential lack of anchoring. An expansion screw was developed for these purposes. Using finite element analysis (FEA), the variability of screw configuration and actuator was assessed from shape memory. In particular, the dimensioning of the screw slot, the actuator length, and the actuator diameter as well as the angle of attack in relation to the intended force development were considered.</p><p><strong>Results: </strong> As a result of the FEA, a special configuration of expansion screw and shape memory element could be found. Accordingly, with an optimal screw diameter of 4 mm, an actuator diameter of 0.8 mm, a screw slot of 7.8 mm in length, and an angle of attack of 25 degrees, the best compromise between individual components and high efficiency in favor of maximum strength can be predicted.</p><p><strong>Conclusion: </strong> Shape memory material offers the possibility of using completely new forms of power development. By skillfully modifying the mechanical and shape memory elements, their interaction results in a calculated development of force in favor of a high primary stability of the screw material used. Activation by means of body temperature is a very elegant way of initializing the intended locking and screw strength.</p>","PeriodicalId":16544,"journal":{"name":"Journal of neurological surgery. Part A, Central European neurosurgery","volume":" ","pages":"128-134"},"PeriodicalIF":0.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71521835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}