Journal of Nanomedicine & Nanotechnology最新文献

{"title":"Ultrasensitive optical Biosensor for absolute RNA quantificationUsing Gold to Probe Genomic Stability for Cancer and Neurological Disorder Diagnosis","authors":"S. Shawky, A. A. Awad, Arwa A. Abugable, and Sherif F. EL-Khamisy","doi":"10.4172/2157-7439.1000","DOIUrl":"https://doi.org/10.4172/2157-7439.1000","url":null,"abstract":"Nanostructured materials such as metallic oxides, possibly iron (II, III) oxide can play an important role in the fields of life sciences such as biomedicine, agriculture, and environment science. Iron (II, III) Oxide nanoparticles (FeII,IIINPs) an innovative material in recent nanotechnology due to their unique properties, such as like high surface area to volume ratio, bettered solubility, low toxicity, surface tailoring power, Superparamagnetism or magnetic properties, greater surface area, easy separation methodology, biocompatibility and multiple use making them strong candidate for biomedicine. Currently the interest of using FeII, IIINPs such as magnetic nanoparticles (iron oxide), metallic oxides nanoparticles, nanoshells, and nanocages have been continuously used and modified to enable their use as a diagnostic and therapeutic agent. This review summarizes and initiates the chemistry of Iron (II, III) Oxide nanoparticles related with the methods for the preparation of iron oxide NPs, magnetic properties, superparamagnetic nature of FeII, IIINPs and some role of their application in biomedicine with recent biomedical, profitable, and industrial applications. Several physical, chemical, and biological methods have been adopted to synthesize magnetic NPs with suitable surface chemistry. These methods possess specific performance and conditions to develop nanoparticles of different properties like shape, average size, size distribution, crystallinity, magnetic properties, dispersibility, and biocompatibility. Based on their reliability, convenient and cheap method, thermal decomposition and co-precipitation method were considered in this review as profit techniques. As one convenient and cheap method, chemical coprecipitation has the potential to meet the increasing demand for the direct preparation of well dispersed (water-base) Fe3O4 nanoparticles. Chemical co-precipitation can produce fine, high-purity, stoichiometric particles of single and multicomponent metal oxides synthesis techniques. Keeping in mind the current interest in iron (II, III) Oxides nanoparticles, this review is designed to report recent information from synthesis to characterization, and applications of FeII, IIINPs.","PeriodicalId":16532,"journal":{"name":"Journal of Nanomedicine & Nanotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87162055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personalized and precision medicine (PPM) as a model of healthcare of the newest genera-tion: the motivation for biopharma and translational resources to be united and to move ahead","authors":"Sergey Suchkov","doi":"10.4172/2157-7439-c1-066","DOIUrl":"https://doi.org/10.4172/2157-7439-c1-066","url":null,"abstract":"","PeriodicalId":16532,"journal":{"name":"Journal of Nanomedicine & Nanotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78862542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Solvent-free Synthesis and Characterization of MnO2 Nanostructures and Investigation of Optical Properties","authors":"S. Akbari, M. Foroughi, M. Ranjbar","doi":"10.4172/2157-7439.1000498","DOIUrl":"https://doi.org/10.4172/2157-7439.1000498","url":null,"abstract":"This paper reports on a novel processing route for producing MnO2 nanocomposites by solid-state thermal decomposition of manganese (II) acetylacetonate nanostructures from manganese(II) acetylacetonate powder as starting reagents, in the temperature 200°C for 4 h. \u0000Finally, the efficiency of MnO2 nanostructures as an optical investigation using PL spectrum has been evaluated. The as-synthesized nanoproducts were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), photoluminescence (PL) spectroscopy and Infrared Spectroscopy (IR). The sublimation process of the Mn(OAc)2 powder was carried out within the range of 200°C, 210°C, 220°C, and 230°C. MnO2 nanocomposites showed strong photoluminescence excited at 383 nm which showed this structures exhibited optical properties behavior at room temperature. In this study simulation calculations were done by the Taguchi technique for systematic optimizing of the parameter on the size distribution of the MnO2 nanocomposites.","PeriodicalId":16532,"journal":{"name":"Journal of Nanomedicine & Nanotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74562200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nano Technology in Medicine and Future Implications: A Mini Review","authors":"K. Wani, R. Kothari","doi":"10.4172/2157-7439.1000497","DOIUrl":"https://doi.org/10.4172/2157-7439.1000497","url":null,"abstract":"Nanoparticles hold great potential in the field of medicine. In this review we have discuuded some of the diseases that are treated by the use of nanotechnology. Nanotechnology has gained interest in recent years almost in every field with special emphasis on nanomedicine and nanobiology. Nanosystems with different compositions and biological properties have been extensively investigated for drug and gene delivery applications. However, it is important to understand the interactions of nanomaterials with the biological environment, targeting cell-surface receptors, drug release, multiple drug administration, stability of therapeutic agents under consideration.","PeriodicalId":16532,"journal":{"name":"Journal of Nanomedicine & Nanotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85302626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanoemulsions of Essential Oil Constituents","authors":"M. JoyceNirmala, A. Rakesh, R. Nagarajan","doi":"10.4172/2157-7439.1000495","DOIUrl":"https://doi.org/10.4172/2157-7439.1000495","url":null,"abstract":"","PeriodicalId":16532,"journal":{"name":"Journal of Nanomedicine & Nanotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77503701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Platanus orientalis Leaf Mediated Rapid Synthesis of Catalytic Gold and Silver Nanoparticles","authors":"Shriya Shende, Komal A. Joshi, A. Kulkarni, Chaitanya Charolkar, V. Shinde, V. S. Parihar, Rohini Kitture, K. Banerjee, Narayan Kamble, J. Bellare, Sougata Ghosh","doi":"10.4172/2157-7439.1000494","DOIUrl":"https://doi.org/10.4172/2157-7439.1000494","url":null,"abstract":"In an attempt to synthesize novel catalytic gold (AuNPs) and silver nanoparticles (AgNPs) we have used Platanus orientalis leaf extract for both reduction and capping. The synthesis was rapid which completed by 5 h as indicated by change in colour and development of prominent peak at 540 nm for AuNPs and 440 nm for AgNPs, as revealed by UV-visible spectroscopy. The phytogenic nanoparticles showed exotic shapes which included triangles, spheres, hexagons and pentagons as analyzed by high resolution transmission electron microscopy. The optimized processing parameters like salt concentration (1 mM concentration of HAuCl4 and 4 mM of AgNO3) and the reaction temperature (50°C) led to faster nanoparticles synthesis. Energy dispersive spectra and X-ray diffraction studies confirmed the elemental gold and silver in AuNPs and AgNPs. Detailed phytochemical characterization using biochemical techniques and gas chromatography mass spectrometry indicated the predominance of ascorbic acid, citric acid, reducing sugars and even starch which may together lead to simultaneous synthesis and capping. Further, AuNPs and AgNPs catalyzed the reduction of 4-nitrophenol (4-NP) to 4-aminophenol (4-AP) using NaBH4 with apparent rate constants of 1.908 × 10-4 min-1 and 3.071 × 10-4 min-1, respectively.","PeriodicalId":16532,"journal":{"name":"Journal of Nanomedicine & Nanotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80004667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biosynthesis of Silver Nanoparticle by Amphiroa anceps (Lamarck) Decaisne and Its Biomedical and Ecological Implications","authors":"Suparna Roy, P. Anantharaman","doi":"10.4172/2157-7439.1000492","DOIUrl":"https://doi.org/10.4172/2157-7439.1000492","url":null,"abstract":"The present study synthesized silver nanoparticles by using seaweed extract and tested it against clinical bacterial pathogens and also with seeds to assess its friendly potential to germination. The biosynthesized Silver Nanoparticles was characterized with UV-Visible Spectrophotometer, Fourier-Transform Infrared Spectroscopy (FT-IR), Scanning Electron Microscopy (SEM), Dynamic Light Scattering (DLS) and X-ray Diffraction study. Antibacterial activity was evaluated using agar disc diffusion and the seed germination test was done with standard protocol. The nanoparticles exhibited highest antibacterial activity against Escherichia coli (0.95 ± 0.057 cm), followed by Klebsiella pneumoniae (0.63 ± 0.05 cm), as compared to antibiotic Chloramphenicol (5 mg/ml). The per cent seed germination was 75% and 80% respectively in Abelmoschus esculentus and Raphanus sativus var. longipinnatus treated with nanoparticles, while it was only in a range of 20 to 40% in control seeds treated with normal water, seaweed extract and seaweed liquid bio-fertilizer. The antibacterial activity of the biosynthesized Silver Nanoparticle is needed more detailed investigation for its biomedical application. The potential of bio-nano-fertilizer is to be assessed for the whole plant life cycle up to quality and quantity of vegetable yield.","PeriodicalId":16532,"journal":{"name":"Journal of Nanomedicine & Nanotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74880441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Physical Stability and Drug Release of Mefenamic Acid Amorphous Solid Dispersions in Topical Administration","authors":"Yizheng Cao, Kho P. Verian","doi":"10.4172/2157-7439.1000491","DOIUrl":"https://doi.org/10.4172/2157-7439.1000491","url":null,"abstract":"Mefenamic acid (MFA) has been used as a pain reliever for a long time. However, as a Biopharmaceutics Classification System II drug, the low solubility remains a major issue. Recently an article has featured the efforts in generating amorphous solid dispersions of MFA for topical administration. Despite the novelty and some successful results from the polyvinylpyrrolidone dispersions, there are a few key points that are worth a thorough discussion, including the experimental methodology for the characterization, evaluation of the physical stability, and data interpretation for the drug release.","PeriodicalId":16532,"journal":{"name":"Journal of Nanomedicine & Nanotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74465883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Lot of Promise for ZnO-5FU Nanoparticles Cytotoxicity against Breast Cancer Cell Lines","authors":"M. Sanad, Shimaa Nabih, Goda Ma","doi":"10.4172/2157-7439.1000486","DOIUrl":"https://doi.org/10.4172/2157-7439.1000486","url":null,"abstract":"In this study we present an approach for new modification of 5-FU drug, which widely used for treatment of cancer by inhibiting essential biological processes. Recently understanding of the treating mechanism of 5-FU has led to the development of new ways that raises its activity. Herein, we modify the drug function by combination with ZnO which get a lot of attention in the past 10 years in the field of anticancer drug development. Anticancer activity of ZnO reveals to production of Reactive Oxygen and ions. Zinc Oxide were designed by Sol-Gel. X-ray, High resolution transition electron microscope and scanning electron microscope used to characterize the structure and morphology of samples. DPPH, SOD and GPx radical scavenging activity applied to investigate the antioxidant activity. Cytotoxicity of MCF-7 was determined by MTT assay, flow cytometry and RT-PCR which confirms that (ZnO-5-FU) will be promising efficient drug for treatment of breast cancer.","PeriodicalId":16532,"journal":{"name":"Journal of Nanomedicine & Nanotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90826804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biosynthesis, Characterization and Antibacterial Capability of Silver and Copper Nanoparticles Using Aqueous Leaf Extract of Salacia chinensis L","authors":"J. Chavan, D. M. Ghadage","doi":"10.4172/2157-7439.1000484","DOIUrl":"https://doi.org/10.4172/2157-7439.1000484","url":null,"abstract":"Salacia chinensis L. is highly valued taxa having several medicinal implications. The study aimed to synthesize and characterize the silver (AgNPs) and copper nanoparticles (CuNPs) using the aqueous leaf extract of S. chinensis and their test against pathogenic bacteria. The silver and copper nanoparticles were synthesized using different concentrations of aqueous AgNO3 and CuNO3 solutions; however 4 mM was found optimal concentration. The synthesized nanoparticles were characterized using UV-Vis spectroscopy; scanning electron microscopy and the antibacterial capability of nanoparticles were evaluated using agar well diffusion method. The AgNPs and CuNPs were formed within an hour of the reaction and showed maximum UV-Vis absorption at 445 nm and 630 nm respectively. SEM analysis revealed the size (50-200 nm) and diverse shapes (spherical, road) of the synthesized nanoparticles. The efficiency of synthesized AgNPs and CuNPs against the bacterial species viz. Escherichia coli, Bacillus subtilis, Staphylococcus aureus and Pseudomonas averogenosa validated the action of these nanoparticles against infections microbes. The study illustrated the capacity of leaves of S. chinensis towards the synthesis of silver and copper nanomaterial and AgNPs were found with enhanced antibacterial capability against test microbes.","PeriodicalId":16532,"journal":{"name":"Journal of Nanomedicine & Nanotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78828020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}