Evaluation of the Physical Stability and Drug Release of Mefenamic Acid Amorphous Solid Dispersions in Topical Administration

Mefenamic acid (MFA) has been used as a pain reliever for a long time. However, as a Biopharmaceutics Classification System II drug, the low solubility remains a major issue. Recently an article has featured the efforts in generating amorphous solid dispersions of MFA for topical administration. Despite the novelty and some successful results from the polyvinylpyrrolidone dispersions, there are a few key points that are worth a thorough discussion, including the experimental methodology for the characterization, evaluation of the physical stability, and data interpretation for the drug release.