A Lot of Promise for ZnO-5FU Nanoparticles Cytotoxicity against Breast Cancer Cell Lines

Abstract

In this study we present an approach for new modification of 5-FU drug, which widely used for treatment of cancer by inhibiting essential biological processes. Recently understanding of the treating mechanism of 5-FU has led to the development of new ways that raises its activity. Herein, we modify the drug function by combination with ZnO which get a lot of attention in the past 10 years in the field of anticancer drug development. Anticancer activity of ZnO reveals to production of Reactive Oxygen and ions. Zinc Oxide were designed by Sol-Gel. X-ray, High resolution transition electron microscope and scanning electron microscope used to characterize the structure and morphology of samples. DPPH, SOD and GPx radical scavenging activity applied to investigate the antioxidant activity. Cytotoxicity of MCF-7 was determined by MTT assay, flow cytometry and RT-PCR which confirms that (ZnO-5-FU) will be promising efficient drug for treatment of breast cancer.