Ultrasensitive optical Biosensor for absolute RNA quantificationUsing Gold to Probe Genomic Stability for Cancer and Neurological Disorder Diagnosis

Abstract

Nanostructured materials such as metallic oxides, possibly iron (II, III) oxide can play an important role in the fields of life sciences such as biomedicine, agriculture, and environment science. Iron (II, III) Oxide nanoparticles (FeII,IIINPs) an innovative material in recent nanotechnology due to their unique properties, such as like high surface area to volume ratio, bettered solubility, low toxicity, surface tailoring power, Superparamagnetism or magnetic properties, greater surface area, easy separation methodology, biocompatibility and multiple use making them strong candidate for biomedicine. Currently the interest of using FeII, IIINPs such as magnetic nanoparticles (iron oxide), metallic oxides nanoparticles, nanoshells, and nanocages have been continuously used and modified to enable their use as a diagnostic and therapeutic agent. This review summarizes and initiates the chemistry of Iron (II, III) Oxide nanoparticles related with the methods for the preparation of iron oxide NPs, magnetic properties, superparamagnetic nature of FeII, IIINPs and some role of their application in biomedicine with recent biomedical, profitable, and industrial applications. Several physical, chemical, and biological methods have been adopted to synthesize magnetic NPs with suitable surface chemistry. These methods possess specific performance and conditions to develop nanoparticles of different properties like shape, average size, size distribution, crystallinity, magnetic properties, dispersibility, and biocompatibility. Based on their reliability, convenient and cheap method, thermal decomposition and co-precipitation method were considered in this review as profit techniques. As one convenient and cheap method, chemical coprecipitation has the potential to meet the increasing demand for the direct preparation of well dispersed (water-base) Fe3O4 nanoparticles. Chemical co-precipitation can produce fine, high-purity, stoichiometric particles of single and multicomponent metal oxides synthesis techniques. Keeping in mind the current interest in iron (II, III) Oxides nanoparticles, this review is designed to report recent information from synthesis to characterization, and applications of FeII, IIINPs.