European Journal of Heart Failure最新文献

{"title":"Endomyocardial biopsy in the diagnosis of cardiac sarcoidosis","authors":"Henriikka Mälkönen, Jukka Lehtonen, Pauli Pöyhönen, Valtteri Uusitalo, Mikko I. Mäyränpää, Markku Kupari","doi":"10.1002/ejhf.3545","DOIUrl":"https://doi.org/10.1002/ejhf.3545","url":null,"abstract":"AimsWe set out to assess the utility of endomyocardial biopsy (EMB) in cardiac sarcoidosis (CS). Historically, EMB sensitivity in CS is only ≤25%, but comprehensive analyses of its current diagnostic performance are not available.Methods and resultsThe data of 260 consecutive patients with <jats:styled-content style=\"fixed-case\">CS</jats:styled-content> (mean age 49 years, 60% female) meeting the Heart Rhythm Society diagnostic criteria were analysed retrospectively. Overall, 216 patients (83%) had undergone <jats:styled-content style=\"fixed-case\">EMB</jats:styled-content>, 47 with repeat procedures. <jats:styled-content style=\"fixed-case\">EMB</jats:styled-content> overall sensitivity was 38%, rising to 49% after repeat biopsies. On logistic regression analysis, positive <jats:styled-content style=\"fixed-case\">EMB</jats:styled-content> was predicted independently by presentation with ventricular tachyarrhythmia with an odds ratio (<jats:styled-content style=\"fixed-case\">OR</jats:styled-content>) of 3.8 (95% confidence interval [CI] 1.2–12.0, <jats:italic>p</jats:italic> = 0.021), left ventricular ejection fraction ≤45% (<jats:styled-content style=\"fixed-case\">OR</jats:styled-content> 3.7, 95% CI 1.5–9.1, <jats:italic>p</jats:italic> = 0.004), elevation of cardiac troponins (<jats:styled-content style=\"fixed-case\">OR</jats:styled-content> 2.7, 95% CI 1.1–6.4, <jats:italic>p</jats:italic> = 0.024), and presence of late gadolinium enhancement in left ventricular mid‐apical septal segments on magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">OR</jats:styled-content> 4.1, 95% CI 1.2–13.8, <jats:italic>p</jats:italic> = 0.024). <jats:styled-content style=\"fixed-case\">EMB</jats:styled-content> sensitivity, counting in repeats, was 16% in patients (<jats:italic>n</jats:italic> = 37) without any independent predictor versus 38%, 60%, 79%, and 88% in those with 1 (<jats:italic>n</jats:italic> = 76), 2 (<jats:italic>n</jats:italic> = 62), 3 (<jats:italic>n</jats:italic> = 33), and 4/4 (<jats:italic>n</jats:italic> = 8) predictors, respectively. The rate of serious complications was 0.7% without mortality or permanent harm. Positive <jats:styled-content style=\"fixed-case\">EMB</jats:styled-content> was not an independent predictor of prognosis.ConclusionThe sensitivity of <jats:styled-content style=\"fixed-case\">EMB</jats:styled-content> in <jats:styled-content style=\"fixed-case\">CS</jats:styled-content> depends on the extent, activity, and location of myocardial involvement, being the higher the more severe <jats:styled-content style=\"fixed-case\">CS</jats:styled-content> is. Its use should rely on weighing the pre‐test likelihood and individual value of positive biopsy against the procedural risks.","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":"27 1","pages":""},"PeriodicalIF":18.2,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142782458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outpatient worsening of heart failure and mortality in transthyretin amyloid cardiomyopathy","authors":"Lawrence Zeldin, Joanna B.S. Eichler, Sergio L. Teruya, Ariel Y. Weinsaft, Alfonsina Mirabal, Margaret O. Cuomo, Kimberly Mateo, Stephen Helmke, Mathew S. Maurer","doi":"10.1002/ejhf.3540","DOIUrl":"https://doi.org/10.1002/ejhf.3540","url":null,"abstract":"Transthyretin cardiomyopathy (ATTR-CM) is characterized by episodes of worsening heart failure (WHF) which can include heart failure (HF) hospitalizations or urgent unplanned visits for administration of intravenous diuretics. WHF characterized by outpatient intensification of oral loop diuretics is common yet its prognostic implications for ATTR-CM patients relative to other WHF events remains unclear. We assessed how WHF characterized by outpatient diuretic intensification (ODI) relates to mortality in this population.","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":"79 1","pages":""},"PeriodicalIF":18.2,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142782457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The global burden of disease attributable to high body mass index in 204 countries and territories from 1990 to 2021 with projections to 2050: An analysis of the Global Burden of Disease Study 2021","authors":"Zenghong Wu, Fangnan Xia, Weijun Wang, Kun Zhang, Mengke Fan, Rong Lin","doi":"10.1002/ejhf.3539","DOIUrl":"https://doi.org/10.1002/ejhf.3539","url":null,"abstract":"Understanding the global burden of disease attributable to high body mass index (BMI) is essential for informing public health strategies and interventions to mitigate the impact of obesity-related conditions.","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":"16 1","pages":""},"PeriodicalIF":18.2,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142782370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diuretic efficiency of a single dose of subcutaneous versus oral furosemide after heart failure hospitalization across diuretic resistance strata: A pilot randomized controlled trial","authors":"Neil Keshvani, Syed Rizvi, Matthew W. Segar, James W. Miller, Juan David Coellar, Kershaw V. Patel, Bethany Roehm, W.H. Wilson Tang, Ambarish Pandey","doi":"10.1002/ejhf.3537","DOIUrl":"https://doi.org/10.1002/ejhf.3537","url":null,"abstract":"Diuretic resistance (DR) in heart failure (HF) is associated with worse outcomes. Furoscix®, a self-administered subcutaneous (sc) furosemide injection administered via on-body infusor, is approved for HF congestion relief. However, its efficacy in patients with DR post-HF hospitalization remains unknown.","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":"69 1","pages":""},"PeriodicalIF":18.2,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142758558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Midterm outcomes of patients with native heart recovery after Impella 5+ for cardiogenic shock","authors":"Marta Bandini, Nicoletta D'Ettore, Walter Iannotti, Tommaso Capobianco, Giulia Maj, Astrid Cardinale, Alina Gallo, Andrea Audo, Federico Pappalardo","doi":"10.1002/ejhf.3544","DOIUrl":"https://doi.org/10.1002/ejhf.3544","url":null,"abstract":"AimsLeft ventricular unloading by percutaneous microaxial flow‐pump devices has been shown to improve survival in patients with cardiogenic shock (CS). The objective of the study is to examine whether Impella 5.0/5.5 (5+) support is effective in facilitating heart recovery, overall survival, and quality of life.Methods and resultsThis single‐centre retrospective study examined midterm (180 days) outcomes of patients with CS supported by Impella 5+ who achieved heart recovery. The primary endpoint was survival at 180 days and freedom from implantable cardioverter‐defibrillator (ICD), heart transplant/left ventricular assist device (LVAD), or readmission for heart failure. Functional status was assessed with New York Heart Association (NYHA) classification. Between June 2022 and April 2024, 20 patients with CS (64 ± 8.9 years, 80% male) received Impella 5+ and discharged with heart recovery. Before Impella placement, mean left ventricular ejection fraction (LVEF) was 19.2 ± 5.2%, 7 (35%) patients were SCAI stage C, 9 (45%) SCAI stage D, and 4 (20%) SCAI stage E, and the mean vasoactive‐inotropic score was 23.2 ± 38.0. The average duration of Impella support was 10.5 ± 8 days. At 180 days, 19 (95%) patients were alive, no patient received a heart transplant/LVAD, 40% were implanted with an ICD and there were two admissions for heart failure. The mean LVEF was 33.5 ± 10.7%, 5 (26.3%) patients were NYHA class I, 9 (47.4%) were NYHA class II, and 5 (26.3%) were NYHA class III. One patient died from a non‐cardiac cause.ConclusionImpella 5+ represents a promising treatment strategy for CS, providing high rates of sustained native heart recovery. A comprehensive platform of mechanical and pharmacological unloading is key.","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":"44 1","pages":""},"PeriodicalIF":18.2,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142758484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prognostic value of the Dandel's index in patients undergoing tricuspid transcatheter edge-to-edge repair","authors":"Mohammad Kassar, Nicolas Brugger, Lukas Stolz, Muhammed Gerçek, Vera Fortmeier, Karl-Patrik Kresoja, Jennifer von Stein, Benedikt Koell, Wolfgang Rottbauer, Bjoern Goebel, Paolo Denti, Paul Achouh, Tienush Rassaf, Manuel Barreiro-Perez, Peter Boekstegers, Andreas Rück, Monika Zdanyte, Marianna Adamo, Flavien Vincent, Philipp Schlegel, Ralph-Stephan von Bardeleben, Mirjam G. Wild, Stefan Toggweiler, Mathias H. Konstandin, Eric Van Belle, Marco Metra, Tobias Geisler, Rodrigo Estévez-Loureiro, Peter Luedike, Nicole Karam, Francesco Maisano, Philipp Lauten, Mirjam Kessler, Daniel Kalbacher, Christos Iliadis, Philipp Lurz, Stephan Windecker, Jörg Hausleiter, Volker Rudolph, Fabien Praz","doi":"10.1002/ejhf.3532","DOIUrl":"https://doi.org/10.1002/ejhf.3532","url":null,"abstract":"Conventional parameters of right ventricular (RV) function are load-dependent and therefore do not accurately reflect contractility in patients with relevant tricuspid regurgitation (TR). RV adaptability to load has been characterized using the Dandel's index in patients with heart failure, but its prognostic value in patients undergoing tricuspid transcatheter edge-to-edge repair (T-TEER) has not been investigated so far.","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":"261 1","pages":""},"PeriodicalIF":18.2,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142758571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of iron deficiency with cardiac function, congestion, exercise capacity and prognosis in heart failure.","authors":"Nicolò De Biase, Lavinia Del Punta, Wouter L'Hoyes, Pierpaolo Pellicori, John G F Cleland, Gabriele Masini, Luna Gargani, Sara Moura-Ferreira, Sarah Hoedemakers, Valerio Di Fiore, Lieven Herbots, Jan Stassen, Alessandro Mengozzi, Silvia Armenia, Stefano Taddei, Stefano Masi, Jan Verwerft, Nicola Riccardo Pugliese","doi":"10.1002/ejhf.3534","DOIUrl":"https://doi.org/10.1002/ejhf.3534","url":null,"abstract":"<p><strong>Aims: </strong>Uncertainty exists about defining true iron deficiency (ID) in heart failure (HF) patients. We assessed the relationship of different ID definitions with cardiac structure and function, congestion, exercise capacity, and prognosis in HF outpatients.</p><p><strong>Methods and results: </strong>Iron deficiency was defined according to guidelines (G-ID: ferritin <100 ng/ml or ferritin 100-299 ng/ml with transferrin saturation [TSAT] <20%). Alternative ID definitions based on TSAT (<20%), iron (≤13 μmol/L), and ferritin (<100 or < 300 ng/ml) were explored. Relationships with rest/exercise measures of cardiac function and congestion using ultrasound, effort intolerance and adverse outcome (HF hospitalizations or all-cause mortality) were assessed. Of 1502 patients (72% with left ventricular ejection fraction [LVEF] ≥50%), 471 (31%) had TSAT <20%, while 728 (48%) had G-ID. Patients with TSAT <20% or G-ID had greater left atrial volume but similar LVEF. Lower TSAT, iron and haemoglobin, but not ferritin, were associated with more signs of congestion by ultrasound. After correcting for multiple clinical variables, including haemoglobin, TSAT was directly associated with peak oxygen uptake (standardized coefficient 0.069, p = 0.041), while ferritin was not. There was no interaction with HF phenotype (HF with preserved vs. reduced LVEF). During a median follow-up of 18 months, TSAT <20% and iron ≤13 μmol/L were associated with worse outcomes in models adjusted for clinical variables, including LVEF and N-terminal pro-B-type natriuretic peptide (hazard ratio 2.48, 95% confidence interval 1.88-3.17 and 1.93, 1.48-2.52, respectively), while G-ID or ferritin <100 or <300 ng/ml were not.</p><p><strong>Conclusion: </strong>In HF outpatients, TSAT <20% is more consistently associated with congestion by ultrasound and poorer functional capacity than other ID definitions, irrespective of LVEF. TSAT <20% and iron ≤13 μmol/L, but not G-ID or ferritin-based ID, predict a worse prognosis in HF outpatients with preserved and reduced LVEF.</p>","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":" ","pages":""},"PeriodicalIF":16.9,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142737892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What's new in heart failure? November 2024","authors":"Mert Tokcan,&nbsp;Julian Hoevelmann,&nbsp;Philipp Markwirth,&nbsp;Insa Emrich,&nbsp;Bernhard Haring","doi":"10.1002/ejhf.3538","DOIUrl":"10.1002/ejhf.3538","url":null,"abstract":"","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":"26 11","pages":"2301-2303"},"PeriodicalIF":16.9,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142737895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to ‘Malnutrition and severe heart failure in real-world study settings’","authors":"Matteo Pagnesi,&nbsp;Marco Metra","doi":"10.1002/ejhf.3525","DOIUrl":"10.1002/ejhf.3525","url":null,"abstract":"","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":"27 1","pages":"181-182"},"PeriodicalIF":16.9,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142724362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relevance of residual tricuspid regurgitation for right ventricular reverse remodelling after tricuspid valve intervention in patients with severe tricuspid regurgitation and right-sided heart failure.","authors":"Ludwig T Weckbach, Lukas Stolz, Philipp M Doldi, Hannah Glaser, Cecilia Ennin, Michael Kothieringer, Thomas J Stocker, Michael Näbauer, Mohammad Kassar, Sara Bombace, Karl-Patrik Kresoja, Philipp Lurz, Fabien Praz, Holger Thiele, Volker Rudolph, Steffen Massberg, Jörg Hausleiter","doi":"10.1002/ejhf.3529","DOIUrl":"https://doi.org/10.1002/ejhf.3529","url":null,"abstract":"<p><strong>Aims: </strong>Right ventricular reverse remodelling (RVRR) is linked to improved survival in patients with severe tricuspid regurgitation (TR) and right-sided heart failure who underwent interventional treatment. However, the role of residual TR on RVRR remains unclear. In this analysis the impact of residual TR on RVRR after interventional TR treatment, which was validated by two independent cohorts at four sites using echocardiography or cardiac magnetic resonance (CMR) imaging, was investigated.</p><p><strong>Methods and results: </strong>Overall, 253 patients who were treated for severe TR and right-sided heart failure using different treatment modalities (tricuspid transcatheter edge-to-edge repair [T-TEER], transcatheter tricuspid valve annuloplasty, orthotopic transcatheter TV replacement [TTVR], heterotopic TTVR) were included. Three-dimensional echocardiographic and CMR-based assessment of RVRR and clinical evaluation of decongestion or exercise capacity were performed at baseline and 30 days after the procedure. Mortality was analysed at 1 year after transcatheter tricuspid valve intervention (TTVI). In patients with residual TR ≤1+ pronounced reduction of right ventricular end-diastolic and end-systolic volumes was observed. In patients with residual TR ≥2+ the effect of RVRR gradually decreased with higher residual TR reinforcing the relevance of optimal procedural results for RVRR. These findings were validated in two independent cohorts. In contrast to RVRR, residual TR ≤1+ and 2+ were associated with similar 1-year survival. RVRR was only observed after T-TEER or orthotopic TTVR, but not after heterotopic TTVR as expected. However, all three treatment modalities were accompanied by significant decongestion and functional improvement at 30-day follow-up.</p><p><strong>Conclusion: </strong>In patients with severe TR and right-sided heart failure undergoing TTVI, superior procedural results were associated with more pronounced RVRR.</p>","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":" ","pages":""},"PeriodicalIF":16.9,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142724361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}