European Journal of Heart Failure最新文献

{"title":"Transcatheter tricuspid valve replacement using the LuX‐Valve Plus system: 1‐year compassionate use outcomes","authors":"Lukas Stolz, Neil Fam, Geraldine Ong, Pedro Villablanca, Ahmad Jabri, Ole de Backer, Jacob Eifer Mølller, Didier Tchétché, Omar Oliva, Kent Chak‐Yu So, Yat‐Yin Lam, Azeem Latib, Andrea Scotti, Augustin Coisne, Arnaud Sudre, Julien Dreyfus, Mohammed Nejjari, Ignacio Cruz‐Gonzalez, Rodrigo Estévez‐Loureiro, Manuel Barreiro‐Perez, Guillaume Leurent, Erwan Donal, Guillaume Bonnet, Thomas Modine, Raj Makkar, Dhairya Patel, Karl‐Patrik Kresoja, Philipp Lurz, Jörg Hausleiter","doi":"10.1002/ejhf.70010","DOIUrl":"https://doi.org/10.1002/ejhf.70010","url":null,"abstract":"","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":"36 1","pages":""},"PeriodicalIF":18.2,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144899237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heart failure-attributed mortality in Europe, 2012-2021.","authors":"Marco Zuin, Pier Luigi Temporelli, Marco Metra, Gianluigi Savarese, Gianluca Rigatelli, Claudio Bilato, Fabrizio Oliva","doi":"10.1002/ejhf.70001","DOIUrl":"https://doi.org/10.1002/ejhf.70001","url":null,"abstract":"<p><strong>Aims: </strong>Heart failure (HF) is a leading cause of cardiovascular mortality worldwide. However, comprehensive and updated assessments of HF-attributable mortality trends across Europe are limited. The aim of this study was to evaluate HF-attributed mortality trends in Europe between 2012 and 2021, examining variations by age, sex, and European region.</p><p><strong>Methods and results: </strong>We extracted HF-attributed mortality data from the World Health Organization (WHO) mortality dataset for 2012-2021. Age-adjusted mortality rates (AAMRs) were analysed using joinpoint regression modelling, expressed as average annual percent change (AAPC) with 95% confidence intervals (CIs). A parallelism test compared trend differences across groups. To explore contributors to HF-attributable mortality, we analysed the mean alcohol consumption and the age-adjusted prevalence and trends of smoking habit, arterial hypertension (HTN), obesity and type 2 diabetes mellitus (DM) using the WHO non-communicable diseases dataset (2012-2021). From 2012 to 2021, 4 872 634 individuals (2 084 521 men and 2 788 113 women) died due to HF, equating to 11 522 deaths per 100 000 population. Overall, the AAMR increased (AAPC: +0.4% [95% CI 0.3-0.5], p < 0.001), with a significantly greater increase in men compared to women (p for parallelism = 0.02). HF-attributable mortality trend had a higher increase among patients aged less than 70 years compared to those aged 70 years or older (p for parallelism = 0.001). Regionally, AAMRs increased in Western (AAPC: +1.2% [95% CI 1.0-1.4], p < 0.001), Eastern (AAPC: +0.9% [95% CI 0.7-1.0], p < 0.001) and Northern Europe (AAPC: +0.5 [95% CI 0.3-0.6], p < 0.001) while plateaued in Southern Europe (AAPC: +3.2% [95% CI -3.2 to 10.1], p = 0.28). A similar increase was observed in the trend for AAMR in HF-attributable mortality among subjects died due to HF with reduced or preserved ejection fraction (p for parallelism = 0.18). During the same period, the age-adjusted prevalence of overweight, obesity and DM rose, while HTN, smoking habit and alcohol consumption decreased.</p><p><strong>Conclusions: </strong>Heart failure-attributed mortality in Europe increased between 2012 and 2021. Substantial disparities persist across European regions and countries.</p>","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":" ","pages":""},"PeriodicalIF":10.8,"publicationDate":"2025-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144870597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying and overcoming barriers to referral in advanced heart failure. A scientific statement of the Heart Failure Association (HFA) of the ESC.","authors":"Guillaume Baudry, Maria Generosa Crespo-Leiro, Clément Delmas, Federica Guidetti, Marta Jimenez-Blanco Bravo, Federica Valente, Maja Cikes, Nicolas Girerd, Finn Gustafsson, Gianluigi Savarese, Linda W van Laake, Loreena Hill, Anne Kathrine Skibelund, Andreas Zuckermann, Marco Metra, Kevin Damman","doi":"10.1002/ejhf.70003","DOIUrl":"https://doi.org/10.1002/ejhf.70003","url":null,"abstract":"<p><p>The identification of patients with advanced heart failure (HF) remains challenging, often leading to delayed referrals and suboptimal use of advanced therapies such as long-term mechanical circulatory support (MCS) or heart transplantation (HT). This delay contributes to worse outcomes and missed opportunities for timely intervention. Many eligible patients are not recognized early enough in their clinical trajectory, either due to the complexity of the condition, overlapping HF phenotypes, or limited awareness of referral criteria among non-specialist clinicians. In this context, the aim of this scientific statement from the Heart Failure Association (HFA) of the ESC is to systematically identify and address the multifaceted barriers that hinder early recognition and referral for advanced HF care. These barriers span across different stakeholders-patients, caregivers, referring physicians, HF specialists, the academic community, and health authorities. The document proposes practical, stakeholder-specific solutions to improve awareness, standardize referral criteria, integrate digital decision-support tools, and structure care networks. Ultimately, the goal is to enable earlier access to specialized evaluation, ensure equitable use of HT and MCS when appropriate, and improve both survival and quality of life for patients living with advanced HF.</p>","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":" ","pages":""},"PeriodicalIF":10.8,"publicationDate":"2025-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144870598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to 'Healthcare system deficiencies should never be employed as justification for delivering sub-standard care to heart failure patients'.","authors":"Alberto Palazzuoli,Pierpaolo Pellicori,John G F Cleland","doi":"10.1002/ejhf.3770","DOIUrl":"https://doi.org/10.1002/ejhf.3770","url":null,"abstract":"","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":"96 1","pages":""},"PeriodicalIF":18.2,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144850906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clustering in dilated cardiomyopathy at initial evaluation: An effective tool for clinical stratification.","authors":"Ilaria Gandin,Maria Perotto,Alessia Paldino,Giovanni Baj,Denise Zaffalon,Andrea Pezzato,Cinzia Crescenzi,Fabiana Romeo,Annamaria Martino,Francesca Fanisio,Federica Toto,Maddalena Rossi,Marta Gigli,Matteo Dal Ferro,Leonardo Calò,Gianfranco Sinagra,Marco Merlo","doi":"10.1002/ejhf.3780","DOIUrl":"https://doi.org/10.1002/ejhf.3780","url":null,"abstract":"AIMSDilated cardiomyopathy (DCM) has a highly variable presentation and disease course. Current stratification strategies are complex and require multimodality evaluation. Using machine learning (ML) on a large dataset obtained at first cardiological evaluation, this study aims to identify specific DCM subgroups.METHODS AND RESULTSIn a retrospective cohort of DCM patients, baseline clinical, genetic, and outcome data were collected. Unsupervised clustering was performed and then simplified to identify patient subgroups. The subgroups were characterized based on outcomes, including all-cause mortality/heart transplantation (HT)/left ventricular assist device implantation (LVAD), sudden cardiac death/major ventricular arrhythmias (SCD/MVA) and heart failure-related death/HT/LVAD. These findings were then validated in an external population. In the derivation cohort of 409 patients (mean age 46 ± 14 years, 71% male), two cluster-subgroups were identified: CL1 (82%) and CL2 (18%), mainly differentiated by electrocardiogram (ECG) characteristics. A lower yield of pathogenic/likely pathogenic variants was found in CL2 versus CL1 (15% vs. 47%, p < 0.001). A simplified clustering using only three variables (QRS duration, presence of left bundle branch block, intrinsicoid deflection >50 ms) was equally effective and validated in the external cohort of 160 patients (mean age 54 ± 13 years, 68% male). A lower risk for SCD/MVA events was observed for CL2 in the primary (hazard ratio 0.29, 95% confidence interval 0.13-0.67) and validation cohort (p = 0.017).CONCLUSIONSUsing ML, baseline ECG variables were found to effectively identify two DCM subgroups differing in disease progression and genetic background. This approach could serve as a valuable tool for improving risk stratification of DCM patients upon their initial evaluation.","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":"31 1","pages":""},"PeriodicalIF":18.2,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144850904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to 'Impact of misclassification bias on interpretation of finerenone efficacy in chronic obstructive pulmonary disease and heart failure with mildly reduced/preserved ejection fraction: A critical appraisal of the FINEARTS-HF sub-analysis'.","authors":"Jawad H Butt,John J V McMurray","doi":"10.1002/ejhf.3804","DOIUrl":"https://doi.org/10.1002/ejhf.3804","url":null,"abstract":"","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":"19 1","pages":""},"PeriodicalIF":18.2,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144850933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healthcare system deficiencies should never be employed as justification for delivering sub-standard care to heart failure patients. Letter regarding the article 'Serial assessment of left ventricular ejection fraction for the management of heart failure: Unnecessary and unrealistic?'","authors":"Giuseppe M C Rosano,Antoni Bayes-Genis,Koichiro Kinugawa,John R Teerlink,Marco Metra,Andrew J S Coats","doi":"10.1002/ejhf.3772","DOIUrl":"https://doi.org/10.1002/ejhf.3772","url":null,"abstract":"","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":"39 1","pages":""},"PeriodicalIF":18.2,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144850931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The convergence of two epidemics - unravelling the diagnostic complexities at the heart of cardio-oncology.","authors":"Tienush Rassaf, Stefan D Anker, Markus S Anker","doi":"10.1002/ejhf.3774","DOIUrl":"https://doi.org/10.1002/ejhf.3774","url":null,"abstract":"","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":" ","pages":""},"PeriodicalIF":10.8,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144843936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pacing beyond rhythm - improving myocardial function by tickling the heart electrically?","authors":"Christian Sticherling, Gerd Hasenfuss, Felix Mahfoud","doi":"10.1002/ejhf.70009","DOIUrl":"https://doi.org/10.1002/ejhf.70009","url":null,"abstract":"","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":" ","pages":""},"PeriodicalIF":10.8,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144843933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacotherapy post cardiac resynchronization therapy: Long walk home.","authors":"David Žižek, Marta Cvijić, Mitja Lainscak","doi":"10.1002/ejhf.3796","DOIUrl":"https://doi.org/10.1002/ejhf.3796","url":null,"abstract":"","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":" ","pages":""},"PeriodicalIF":10.8,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144843934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}