European Journal of Heart Failure最新文献

{"title":"Letter regarding the article \"Effects of Sauna bathing on Exercise Capacity and Muscle Function in HFpEF\".","authors":"Jing Zhao,Jie Gao","doi":"10.1093/ejhf/xuag131","DOIUrl":"https://doi.org/10.1093/ejhf/xuag131","url":null,"abstract":"","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":"24 1","pages":""},"PeriodicalIF":18.2,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147726020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond phenogroups: towards a continuous biology of HFpEF.","authors":"Stefan Störk,Hiroaki Shimokawa","doi":"10.1093/ejhf/xuag130","DOIUrl":"https://doi.org/10.1093/ejhf/xuag130","url":null,"abstract":"","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":"17 1","pages":""},"PeriodicalIF":18.2,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147726023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to: Correspondence on \"Impact of contemporary guideline-directed medical therapy on secondary mitral and tricuspid regurgitation in heart failure with reduced ejection fraction\".","authors":"Jwan A Naser,Sorin V Pislaru,Grace Lin","doi":"10.1093/ejhf/xuag129","DOIUrl":"https://doi.org/10.1093/ejhf/xuag129","url":null,"abstract":"","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":"16 1","pages":""},"PeriodicalIF":18.2,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147726019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemodynamic Changes in Response to GLP-1 Treatment in ICD and CRT Patients: Insights From HeartLogic Sensor Data.","authors":"Frederik Holme Fussing, Lise Witten Davodian, Danny Witten Davodian, Niklas Dyrby Johansen, Preman Kumarathurai, Daniel Modin, Stefan Sattler, Charlotte Larroudé, Niels Risum, Michael Vinther, Lars Køber, Kasper Rossing, Mads Ersbøll, Mikael Kjær Poulsen, Brian Bridal Løgstrup, Katja Fiedler Holm, Ketil J Haugan, Christopher Chien, Brian Claggett, Scott Solomon, Marat Fudim, Adrian Hernandez, Tarek Bekfani, Jens Brock Johansen, Jens Cosedis Nielsen, Craig M Stolen, Tor Biering-Sørensen","doi":"10.1093/ejhf/xuag114","DOIUrl":"https://doi.org/10.1093/ejhf/xuag114","url":null,"abstract":"<p><strong>Background: </strong>Glucagon-like peptide-1 receptor agonist (GLP-1RA) therapy is increasingly used, but the physiological effects in patients with heart failure and reduced ejection fraction (HFrEF) remain uncertain. Continuously collected data from implantable cardiac devices may enable evaluation of drug effects in a real-world setting.</p><p><strong>Methods: </strong>In a nationwide Danish retrospective matched cohort study, GLP-1RA initiators with implantable cardiac devices were matched 1:5 to unexposed device recipients by sex and age. Sensor data were assessed from 30 days before to 30 days after initiation. Primary outcomes were changes in heart rate and thoracic impedance. Analyses were adjusted for baseline sensor value, BMI category, hypertension, and type 2 diabetes. Prespecified subgroup analyses were performed in patients with HFrEF.</p><p><strong>Results: </strong>In 666 patients (111 GLP-1RA initiators, 555 matched controls), semaglutide was used in 95% of initiators. Compared with controls, GLP-1RA initiation was associated with higher night heart rate (adjusted difference 2.12 bpm; 95% CI, 1.38 to 2.87), higher daily heart rate (1.46 bpm; 95% CI, 0.65 to 2.06), and higher thoracic impedance (0.66 Ω; 95% CI, 0.17 to 1.15) (all P<0.01). S1 amplitude decreased (-0.09 mG; 95% CI, -0.14 to -0.04; P<0.01). Heart rate increases followed a stepwise pattern across semaglutide dose levels, with an average increase of 2.5 bpm per dose escalation. Findings were directionally consistent in patients with HFrEF (GLP-1RA n=80), with no evidence of effect modification.</p><p><strong>Conclusion: </strong>GLP-1RA initiation was associated with measurable changes in device-derived physiology. Larger studies are needed to evaluate clinical implications, including in HFrEF.</p><p><strong>Trial registration: </strong>Clinicaltrials.gov (NCT06099158).</p>","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":" ","pages":""},"PeriodicalIF":10.8,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147696951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biochemical triple testing to exclude monoclonal gammopathy for non-biopsy diagnosis of transthyretin amyloid cardiomyopathy.","authors":"Julian D Gillmore,Josephine Mansell,Carol J Whelan,Ana Martinez-Naharro,Lucia Venneri,Muhammad U Rauf,David F Hutt,Yousuf Razvi,Awais Sheikh,Sriram Ravichandran,Jahanzaib Khwaja,Helen J Lachmann,Ashutosh D Wechalekar,Philip N Hawkins,Marianna Fontana","doi":"10.1093/ejhf/xuag120","DOIUrl":"https://doi.org/10.1093/ejhf/xuag120","url":null,"abstract":"","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":"64 1","pages":""},"PeriodicalIF":18.2,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147695164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exercise cardiac magnetic resonance biventricular volumetric reserve in heart failure with preserved ejection fraction.","authors":"Fahime Ghanbari,Deepa M Gopal,Long H Ngo,Jennifer Rodriguez,Aaron B Waxman,Warren J Manning,Reza Nezafat","doi":"10.1093/ejhf/xuag100","DOIUrl":"https://doi.org/10.1093/ejhf/xuag100","url":null,"abstract":"BACKGROUND AND AIMSHeart failure with preserved ejection fraction (HFpEF) is increasingly recognized as a syndrome of reserve dysfunction. However, integrated assessment of biventricular (LV/RV) volumetric reserve under physiological stress remains underexplored. We aimed to investigate whether exercise cardiac magnetic resonance (Ex-CMR) can reveal distinct volumetric reserve profiles across the HFpEF spectrum.METHODSIn this retrospective analysis of a prospective observational, multicentre study, supine ergometer Ex-CMR was performed in HFpEF patients across early to advanced stages (stage B, exercise-induced, stage C), along with healthy controls and a non-cardiac dyspnoea (NCD) group. Percentage changes in LV/RV end-diastolic (ΔEDV%) and end-systolic volumes (ΔESV%) from rest to stress defined EDV reserve and ESV reserve, respectively. Ventricular efficiency index (EI) was defined as ΔEDV%-ΔESV%; biventricular EI as LVEI + RVEI. Group comparisons were performed using ANOVA and post hoc testing. Multivariable general linear model analyses adjusted for age, sex, BMI, and exercise response. A composite phenotyping assessment incorporating all four key reserve parameters was explored.RESULTSAmong 140 participants (40 healthy, 27 NCD, and 73 HFpEF), all HFpEF subgroups showed impaired LVEDV reserve and reduced LVEI (P < .0001). LVESV reserve was impaired only in stage C (P < .0001). Exercise-induced RV dysfunction was a hallmark of HFpEF with pulmonary hypertension (P < .0001). Biventricular EI declined progressively with advancing HFpEF stage (P < .0001) and was significantly lower in NYHA > II (P = .0006). Six distinct reserve phenotypes emerged.CONCLUSIONEx-CMR-based assessment of LV/RV volumetric reserve reveals progressive biventricular dysfunction across HFpEF stages and supports biventricular volumetric reserve-based phenotyping for characterizing HFpEF pathophysiology.KEY QUESTIONCan the integration of left and right ventricular end-diastolic and end-systolic volume reserve under physiological stress reveal distinct profiles across the HFpEF spectrum and enhance our understanding of its haemodynamic heterogeneity?KEY FINDINGSNon-invasive assessment of biventricular volumetric reserve, along with their intra- and interventricular interactions using exercise CMR, revealed a significant, stepwise deterioration across HFpEF subgroups, worsening with NYHA class > II. Exercise CMR enabled composite volumetric reserve-based phenotyping and identified six distinct reserve phenotypes.TAKE HOME MESSAGEBiventricular volumetric reserve assessment is feasible through exercise CMR and may support future precision therapy strategies.","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":"3 1","pages":""},"PeriodicalIF":18.2,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147695163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter regarding the article 'Impact of contemporary guideline-directed medical therapy on secondary mitral and tricuspid regurgitation in heart failure with reduced ejection fraction'.","authors":"Shaoxun Wen,Bin Cao,Rengyun Xiang","doi":"10.1093/ejhf/xuag125","DOIUrl":"https://doi.org/10.1093/ejhf/xuag125","url":null,"abstract":"","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":"10 1","pages":""},"PeriodicalIF":18.2,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147680666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The spectrum of steatotic liver disease (SLD) in cardiology - time to screen for coexisting liver disease.","authors":"Annalisa Cespiati,Jörn M Schattenberg","doi":"10.1093/ejhf/xuag128","DOIUrl":"https://doi.org/10.1093/ejhf/xuag128","url":null,"abstract":"","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":"22 1","pages":""},"PeriodicalIF":18.2,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147680665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subclinical atrial fibrillation and the risk of heart failure: insights from ARTESiA.","authors":"Maria Hee Jung Park Frausing,William F McIntyre,Jeff S Healey,Tanya Kovalova,Jorge A Wong,Søren Zöga Diederichsen,Lucas Yixi Xing,Christopher B Granger,Renato D Lopes,Alexander P Benz,Julia W Erath,Giuseppe Boriani,Philippe Mabo,Cecilia Linde,David J Wright,Valentina Kutyifa,David H Birnie,Juan Benezet-Mazuecos,Andi E Albertsen,Katja Fiedler Holm,Jason G Andrade,Jens Cosedis Nielsen","doi":"10.1093/ejhf/xuag022","DOIUrl":"https://doi.org/10.1093/ejhf/xuag022","url":null,"abstract":"AIMSHeart failure (HF) and clinical atrial fibrillation are closely linked, but the relationship between device-detected subclinical atrial fibrillation (SCAF) and HF is unclear. We aimed to determine incidence and clinical risk factors for HF events among patients with SCAF.METHODSWe included 3986 patients from the ARTESiA (Apixaban for the Reduction of Thromboembolism in Patients with Device-Detected Subclinical Atrial Fibrillation) trial. ARTESiA investigated the effect of apixaban versus aspirin for stroke prevention in patients with episodes of SCAF ≤24 hours. In this secondary analysis, we explored the number and duration of SCAF episodes at baseline as risk markers for HF hospitalization or HF-related death. SCAF progression was analysed as a time-dependent covariate and defined as the development of SCAF >24 hours or clinical atrial fibrillation.RESULTSOver a mean follow-up of 4.1 ± 1.7 years, SCAF progression was observed in 1244 patients (31%). Heart failure hospitalization or HF-related death occurred in 515 (13%) patients at a rate of 3.3 [95% confidence interval (CI) 3.1-3.6] per 100 person-years. A total of 172 HF-related events occurred after SCAF progression (7.2 events, 95% CI 6.2-8.3, per 100 PY). SCAF progression was an independent risk factor for HF hospitalization or HF-related death (hazard ratio 2.72, 95% CI 2.24-3.31).CONCLUSIONHeart failure hospitalization and HF-related death are common in patients with SCAF. Progression to longer SCAF episodes or clinical AF were associated with HF events, but episodes <24 h were not. These findings underscore the need for close surveillance of SCAF patients to detect complications and potentially improve outcomes.","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":"84 1","pages":""},"PeriodicalIF":18.2,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147666580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dyssynchronous heart failure: mitochondrial distribution and functions mirror regional workload and energy demand in a large-animal model of ventricular desynchronization.","authors":"Alexander Dietl,Sabine Iberl,Lisa Marie Köhler,Katja Evert,Maria Heinrich,Esther Dreier,Jan Dudek,Christoph Magnes,Moritz Mayer,Michael Paulus,Christian Riehle,Stefan Wagner,Elmar Zügner,Lars S Maier,Filip Rega,Christoph Maack,Alexander Nickel,Jens-Uwe Voigt,Jürgen Duchenne","doi":"10.1093/ejhf/xuag112","DOIUrl":"https://doi.org/10.1093/ejhf/xuag112","url":null,"abstract":"AIMSIn dyssynchronous heart failure (DHF), left bundle branch block (LBBB) causes inhomogeneous left ventricular (LV) workload and systolic dysfunction. We aimed to investigate underlying metabolic remodelling in an ovine model.METHODS AND RESULTSEleven sheep with dual-chamber-pacemakers for LBBB-like activation (DHF) were studied at baseline and after eight weeks. Six untreated sheep served as controls (CTRL). Regional workload was evaluated using invasive hemodynamics and echocardiography. 18F-fluorodeoxyglucose-tracer positron-emission-tomography/computed tomography visualized regional glucose-uptake. Magnetic resonance imaging assessed fibrosis (late gadolinium enhancement, LGE). Septal and lateral wall tissue was analysed with histology, confocal microscopy, ultra-high-performance liquid chromatography-high resolution mass-spectrometry (UHPLC-HRMS). Dyssynchrony induced low septal and high lateral asymmetry in workload and glucose-uptake. After eight weeks, DHF animals exhibited LV dilation and LVEF decline (31.1±5.1% vs. 59.4±3.5% at baseline, p<0.05). Septal thinning and lateral hypertrophy rebalanced workload and glucose-uptake. No fibrosis was seen on LGE or histology. DHF-animals showed enrichment of mitochondria at the intercalated discs (EMID-sign) - highest in the lateral wall (DHF septal 7.0±4.8% vs. lateral 48.4±12.3%, p<0.05). Mitochondrial redox balance in DHF shifted towards a more oxidised state without evidence of oxidative stress. Metabolomics revealed no differences between septal and lateral walls but severe energy depletion of tricarboxylic acid cycle substrates and phosphocreatine in DHF (fold change DHF/CTRL 0.01, p<0.01).CONCLUSIONExperimental DHF is characterised by non-fibrotic, dilated LV without signs of oxidative stress. Workload increase in the lateral wall leads to hypertrophy and EMID, homogenizing metabolic profiles between wall segments. However, the ventricle enters energy starvation and systolic dysfunction.","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":"13 1","pages":""},"PeriodicalIF":18.2,"publicationDate":"2026-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147663902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}