European Journal of Heart Failure最新文献

{"title":"Response to the letter by Mapelli et al.","authors":"Daniel I Bromage, Antonio Cannata","doi":"10.1093/ejhf/xuaf028","DOIUrl":"10.1093/ejhf/xuaf028","url":null,"abstract":"","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":" ","pages":"157"},"PeriodicalIF":10.8,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147343213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics and 1-year outcomes of patients with Cardiogenic Shock secondary to myocarditis.","authors":"Raunak Nair, Abhishek Giri, Harsh Patolia, Ankit Aggarwal, Shashank Shekhar, Andrew Higgins, Ran Lee, Venu Menon","doi":"10.1093/ejhf/xuag147","DOIUrl":"https://doi.org/10.1093/ejhf/xuag147","url":null,"abstract":"","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":" ","pages":""},"PeriodicalIF":10.8,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147758399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Chronological Age: Why Frailty Matters in Heart Failure.","authors":"João Pedro Ferreira,Pedro Marques,Pierpaolo Pellicori,Markus S Anker","doi":"10.1093/ejhf/xuag145","DOIUrl":"https://doi.org/10.1093/ejhf/xuag145","url":null,"abstract":"","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":"259 1","pages":""},"PeriodicalIF":18.2,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147754649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discordant ventilatory and efferent sympathetic responsiveness to peripheral and central chemoreflex stimulation in heart failure with reduced ejection fraction.","authors":"Daniel A Keir,Massimo Nardone,Nasimi A Guluzade,Evan Keys,Mark B Badrov,James Duffin,John S Floras","doi":"10.1093/ejhf/xuag127","DOIUrl":"https://doi.org/10.1093/ejhf/xuag127","url":null,"abstract":"","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":"21 1","pages":""},"PeriodicalIF":18.2,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147754648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left Ventricular Assist Device Therapy as Durable Care: Implications for Clinical Practice and Policy.","authors":"Michael J Bonios,Chris J Kapelios,Owais Dar,Themistocles Chamogeorgakis,Gerasimos Filippatos","doi":"10.1093/ejhf/xuag144","DOIUrl":"https://doi.org/10.1093/ejhf/xuag144","url":null,"abstract":"","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":"1 1","pages":""},"PeriodicalIF":18.2,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147754647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to: \"Feasibility, multiplicity, and the interpretation of pilot findings in SAUNA-HFpEF\".","authors":"Tarek Bekfani,Alexander Schmeisser,Stefan D Anker,Ruediger C Braun-Dullaues","doi":"10.1093/ejhf/xuag136","DOIUrl":"https://doi.org/10.1093/ejhf/xuag136","url":null,"abstract":"","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":"27 1","pages":""},"PeriodicalIF":18.2,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147753162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kidney Dysfunction and Pulmonary Vascular Disease in Heart Failure with preserved Ejection Fraction.","authors":"Matthew B Amdahl,Jwan A Naser,Atsushi Tada,Shunichi Doi,Tomonari Harada,Tatsuro Ibe,Jeffrey M Testani,Vojtech Melenovsky,Yogesh N V Reddy,Barry A Borlaug","doi":"10.1093/ejhf/xuag140","DOIUrl":"https://doi.org/10.1093/ejhf/xuag140","url":null,"abstract":"AIMSChronic kidney disease (CKD) is common in patients with heart failure (HF) with preserved ejection fraction (HFpEF), and its presence is associated with more severe echocardiographic abnormalities and poorer outcomes through unclear mechanisms. CKD-associated endothelial dysfunction, inflammation, and activation of profibrotic pathways could worsen pulmonary vascular disease (PVD) in HFpEF, but such relationships have not been explored.METHODSConsecutively evaluated patients with HFpEF undergoing invasive hemodynamic cardiopulmonary exercise testing were stratified by baseline kidney function to characterize potential differences in pulmonary vascular loading, hemodynamics, cardiopulmonary reserve, and outcomes based upon the presence and severity of kidney dysfunction.RESULTSOf 925 patients with HFpEF, 319 (34.5%) had eGFR < 60 ml/min/1.73 m2. Patients with more severe kidney dysfunction were older and more likely to have diabetes, atrial fibrillation, and hypertension.. At rest, reduced kidney function was associated with lower hemoglobin, higher biventricular filling pressures, and lower cardiac output, but the severity of kidney dysfunction was most conspicuously associated with worsening PVD, evidenced by increasing pulmonary arterial (PA) pressures due to marked increases in pulmonary vascular resistance (PVR) as kidney dysfunction progressed (median [IQR] 1.3 [0.86, 1.88] to 2.8 [2.0, 3.8] WU from eGFR ≥ 90 to eGFR < 30, p<0.001), along with progressively lower PA compliance (PAC, 4.7 [3.6, 5.8] to 2.2 [1.8, 3.4] ml/mmHg from eGFR ≥ 90 to eGFR < 30, p<0.001). With exercise, differences in the severity of PVD became even more striking, with more severe elevation in PA pressures and PVR, and lower PA compliance, leading to lower transmural left-sided distending pressures, with no difference in exertional PA wedge pressure. Patients with worse kidney dysfunction displayed the most dramatic cardiac output limitations with exercise, which along with more severe anemia and markedly reduced O2 delivery, caused marked impairment in aerobic capacity. Worsening kidney function was associated with a striking gradient of increased risk of a composite of all-cause death and HF hospitalization [ranging from HR 2.38 (95% CI 1.01-5.59) for eGFR 60-90 to HR 16.77 (95% CI 6.65-42.28) for eGFR < 30 (vs. reference eGFR ≥ 90)].CONCLUSIONSKidney dysfunction in patients with HFpEF is characterized by more severe pulmonary vascular disease at rest and with exercise, leading to reduced cardiac output reserve, impaired exercise capacity, and increased risk for adverse events. Further study is warranted to better understand causal relationships between CKD and PVD, and determine whether novel therapies to improve kidney function might target these impairments to improve clinical status.","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":"153 1","pages":""},"PeriodicalIF":18.2,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147753163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modification of the association between age and mortality in heart failure by frailty status.","authors":"Caroline Hartwell Garred,Mariam Elmegaard,Daniel Mølager Christensen,Clara Friis,Alexander Christian Falkentoft,Morten Malmborg,Deewa Zahir Anjum,Nina Nouhravesh,Jawad Butt,Jesper Ryg,Emil Fosbøl,Pardeep Jhund,John J V McMurray,Mark C Petrie,Lars Køber,Morten Schou","doi":"10.1093/ejhf/xuag137","DOIUrl":"https://doi.org/10.1093/ejhf/xuag137","url":null,"abstract":"AIMSHeart failure (HF) disproportionately affects older patients, yet evidence guiding management in the oldest and frailest patients remains limited. We evaluated the influence of age and frailty on mortality and use of guideline-directed medical therapy (GDMT).METHODS AND RESULTSUsing nationwide Danish registry data, we identified all patients with new-onset HF (2013-2022), stratified by age (<65, 65-79, ≥80 years) and frailty status according to the Hospital Frailty Risk Score (low, intermediate, high). We assessed all-cause and cardiovascular mortality two years after HF diagnosis and evaluated GDMT use across age and frailty groups using logistic regression. Among 79,193 patients with HF, 24% were aged <65 years, 41% 65-79, and 35% ≥80. Frailty significantly modified the association between age and mortality (interaction p<0.001). Patients with high frailty reached comparable two-year mortality risks at younger ages than patients with lower frailty. The following had similar two-year mortality: low-frailty patients aged 80 years (22.1%, 95% CI, 21.4-22.8), intermediate-frailty patients aged 70 years (22.8%, 21.9-23.8), and high-frailty patients aged 47 (22.8%, 18.0-28.4). Similar results were seen for cardiovascular mortality. GDMT use was lower in high frailty than low frailty patients across all age groups. Moreover, within each frailty group, patients aged ≥80 years had lower odds of receiving GDMT compared to those aged <65 (reference).CONCLUSIONFrailty alters mortality risk in HF beyond chronological age, resulting in prognostic heterogeneity regardless of age. Our findings support the need for both frailty-informed and age-based management strategies in HF across all ages.","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":"4 1","pages":""},"PeriodicalIF":18.2,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147753161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological trends in hypertrophic cardiomyopathy in adults - a Swedish nationwide registry study.","authors":"Jonas Silverdal,Tatara Delavaran,J Gustav Smith,Oscar Braun,Carmen Basic,Erik Thunstrom","doi":"10.1093/ejhf/xuag132","DOIUrl":"https://doi.org/10.1093/ejhf/xuag132","url":null,"abstract":"AIMSHypertrophic cardiomyopathy (HCM), entailing increased risk of heart failure and death, affects approximately 200 per 100,000 population, with incidence rates of 4-12 per 100,000 person-years.We investigated the epidemiological changes and mortality trends in HCM, with and without left ventricular outflow tract obstruction, in Sweden between 2003 and 2022.METHODSUsing the Swedish National Patient Register, we analysed data for patients 17-85 years of age diagnosed with HCM in inpatient or specialised outpatient care, categorised by age and by ICD-10 codes for obstructive (oHCM) and non-obstructive (nHCM) disease. Annual age- and sex-adjusted incidence, prevalence and all-cause mortality were calculated. Temporal and group differences were assessed using negative binomial regression.RESULTSIn total, 11,299 patients were analysed (mean age 62.9 years; 58.8% male; 67% nHCM). During the study period, the overall prevalence increased from 14 to 73 per 100,000 population. The incidence increased from 5.1 to 9.3 per 100,000 person-years, largely due to nHCM, and with the steepest rise observed among middle-aged and older adults. Annual all-cause mortality declined from 9.8% to 4.3%, with similar rates for nHCM and oHCM at study end. Prognosis improved across all age groups, most notably among older age groups.DISCUSSIONBetween 2003 and 2022, the prevalence of oHCM nearly quadrupled, while nHCM increased more than six-fold. Contributing factors include a nearly doubled incidence, primarily driven by a rise in nHCM, and halved all-cause mortality. These trends were most pronounced in older adults, consistent with increased detection of individuals with milder phenotypes.","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":"21 1","pages":""},"PeriodicalIF":18.2,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147731302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of multicomponent exercise training in older individuals with and without heart failure with reduced ejection fraction - the role of functional capacity and novel biomarkers.","authors":"Veronika Schmid-Ellinger,Monika Siegrist,Nina Schaller,Julia Isaak,Michael Weiß,Jannis W Wenzke,Isabel Fegers-Wustrow,Bernhard Haller,Martin Halle,Volker Adams","doi":"10.1093/ejhf/xuag133","DOIUrl":"https://doi.org/10.1093/ejhf/xuag133","url":null,"abstract":"BACKGROUND AND AIMSExercise training is recommended for patients with heart failure (HF), however its efficacy in older individuals (≥80 years) with HF is less clear.METHODSFrom the cluster-randomised controlled Bestform-trial (NCT04207307) in older residents of senior care facilities the effects of 6-month multicomponent machine-based exercise training were assessed for those with and without HF. Functional capacity using the Short Physical Performance Battery (SPPB), Chair-Stand-Test (CST), handgrip strength, and 6-Minute-Walk-Test (6MWT) as well as inflammatory, catabolic and anabolic biomarkers were analysed pre- and post-training using linear mixed models.RESULTSA total of 57 participants (mean 84.4±6.7 years) were included in the analysis, of whom 24 had HF. Baseline data revealed significantly lower 6MWT-distance (mean difference [MD] -71.3, 95%-confidence interval [95% CI] -119.5 to -23.2 m) and handgrip strength (MD -4.3, 95%CI -8.4 to -0.3 kg). Moreover, significantly higher GDF-15 concentrations were observed in participants with HF compared to No HF (MD 544.2, 95%CI: 39.1 to 1049.4 pg/mL). Post-training, SPPB (β=0.60, 95%CI 0.22 to 0.98), CST (β=0.37, 95%CI 0.15 to 0.58), and 6MWT-distance (β=15.22, 95%CI 3.47 to 26.97) significantly improved in the whole analysis population. Among biomarkers, TNF-α decreased significantly (β=-0.22, 95%CI -0.43 to -0.01), and P3NP declined (β=-0.23, 95%CI -0.38 to -0.08) with a Time×Group interaction (β=0.41, 95%CI 0.11 to 0.70) indicating a reduction only in the No HF-group.CONCLUSIONSSix months of multicomponent exercise training enhanced functional capacity and reduced circulating TNF-α in older individuals, irrespective of HF status, while P3NP declined only in those without HF.","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":"55 1","pages":""},"PeriodicalIF":18.2,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147731704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}