European Journal of Heart Failure最新文献

{"title":"Heart failure hospitalizations and clinical outcomes in patients undergoing tricuspid transcatheter edge-to-edge repair: Insights from EuroTR.","authors":"Daniela Tomasoni,Marianna Adamo,Jörg Hausleiter,Elisa Pezzola,Karl-Patrik Kresoja,Jennifer von Stein,Vera Fortmeier,Christoph Pauschinger,Wolfgang Rottbauer,Mohammad Kassar,Bjoern Goebel,Paolo Denti,Paul Achouh,Tienush Rassaf,Manuel Barreiro-Perez,Peter Boekstegers,Andreas Rück,Monika Zdanyte,Flavien Vincent,Philipp Schlegel,Ralph-Stephan von Bardeleben,Mirjam G Wild,Christian Besler,Stephanie Brunner,Stefan Toggweiler,Julia Grapsa,Tiffany Patterson,Holger Thiele,Tobias Kister,Giuseppe Tarantini,Giulia Masiero,Marco De Carlo,Alessandro Sticchi,Mathias H Konstandin,Eric Van Belle,Tobias Geisler,Rodrigo Estévez-Loureiro,Peter Luedike,Nicole Karam,Francesco Maisano,Philipp Lauten,Fabien Praz,Mirjam Kessler,Daniel Kalbacher,Volker Rudolph,Christos Iliadis,Philipp Lurz,Lukas Stolz,Marco Metra, ","doi":"10.1002/ejhf.3757","DOIUrl":"https://doi.org/10.1002/ejhf.3757","url":null,"abstract":"AIMSTo assess the prevalence, prognostic significance, and predictors of heart failure hospitalization (HFH) before and after tricuspid transcatheter edge-to-edge repair (T-TEER) in a large real-world cohort of patients with tricuspid regurgitation (TR).METHODS AND RESULTSData from the European Registry of Transcatheter Repair for Tricuspid Regurgitation (EuroTR registry) were analysed. Among 1000 patients undergoing T-TEER for symptomatic TR, 361 (36.1%) had no HFH, 459 (45.9%) had one single HFH, and 180 (18.0%) had multiple HFH the year before T-TEER. Patients with any HFH had more severe heart failure compared with those without. Procedural success (residual TR ≤2) did not differ between patients with single, multiple, or no HFHs before T-TEER. Multivariable analysis showed that a history of HFH was associated with an increased mortality risk (adjusted hazard ratio [HR] 1.51, 95% confidence interval [CI] 1.11-2.06 for single vs. no HFH; adjusted HR 1.63, 95% CI 1.15-2.31 for multiple vs. no HFH), and a higher risk of the combined endpoint of all-cause mortality or HFH. HFH risk decreased by 72% in the 1 year following T-TEER compared to the previous year. Procedural success was the sole independent predictor for reducing HFHs.CONCLUSIONSIn the EuroTR cohort, a history of HFH was highly prevalent and associated with worse clinical outcomes. Among high-risk patients with symptomatic TR, T-TEER significantly lowered HFH risk, with residual TR grade ≤2 being the key predictor for reduced HFH incidence.","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":"677 1","pages":""},"PeriodicalIF":18.2,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144652801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in cardiac structure and function are associated with health-related quality of life in heart failure patients with reduced ejection fraction: Results from the EVALUATE-HF trial.","authors":"Sahmin Lee, Brian L Claggett, James C Fang, Gary F Mitchell, Jonathan H Ward, Scott D Solomon, Hicham Skali, Akshay S Desai, Sheila M Hegde","doi":"10.1002/ejhf.3760","DOIUrl":"https://doi.org/10.1002/ejhf.3760","url":null,"abstract":"<p><strong>Aims: </strong>This analysis aims to investigate the relationship between changes in cardiac structure and function and changes in health-related quality of life in patients with heart failure with reduced ejection fraction (HFrEF).</p><p><strong>Methods and results: </strong>The association between echocardiographic measures and Kansas City Cardiomyopathy Questionnaire (KCCQ)-12 scores was examined in HFrEF patients of the EVALUATE-HF trial who were randomized to sacubitril-valsartan or enalapril for 12 weeks followed by 12 weeks of open-label sacubitril-valsartan for both groups. We used linear regression models adjusted for age, sex, treatment assignment at randomization, baseline KCCQ-12 score, baseline echo measurements, and other clinical variables. Among 406 patients (median age 67 years; 25% women), the KCCQ-12 overall summary score (KCCQ-12-OSS) improved by +9 points (95% confidence interval +7 to +11 points) over 24 weeks. Increases in mitral e' velocities correlated with KCCQ-12-OSS improvement (+2.5 and +2.3 points per standard deviation [SD] increase in septal and lateral e' velocities, respectively, p < 0.05 for each). Decreases in septal E/e' ratio and left atrial volume index (LAVi) also correlated with KCCQ-12-OSS improvement (+3.2 and +2.0 points per SD decrease in septal E/e' ratio and LAVi, respectively, p < 0.05 for each). Changes in left ventricular size, ejection fraction, longitudinal strain, and right ventricular function were not associated with changes in KCCQ-12-OSS. Similar associations were observed for other KCCQ-12 domains.</p><p><strong>Conclusions: </strong>In the EVALUATE-HF trial, increases in mitral e' velocities and decreases in septal E/e' ratio and LAVi were associated with improved KCCQ-12 scores over 24 weeks, after adjusting for treatment assignment. These findings suggest that reductions in left ventricular filling pressures and left atrial size are closely coupled with improved physical function and quality of life in HFrEF patients, which may provide insights into the early benefits of sacubitril-valsartan.</p><p><strong>Clinical trial registration: </strong>ClinicalTrials.gov Identifier: NCT02874794.</p>","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":" ","pages":""},"PeriodicalIF":16.9,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144657905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to the letter regarding the article 'Employment of artificial intelligence for an unbiased evaluation regarding the recovery of right ventricular function after mitral valve transcatheter edge-to-edge repair'.","authors":"Vera Fortmeier,Márton Tokodi,Mark Lachmann","doi":"10.1002/ejhf.3766","DOIUrl":"https://doi.org/10.1002/ejhf.3766","url":null,"abstract":"","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":"7 1","pages":""},"PeriodicalIF":18.2,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144652799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to the letter regarding the article 'Liver stiffness measurement for non-invasive assessment of central venous pressure in patients with heart failure: A multicentre pilot study'.","authors":"Nicolas Girerd,Laurent Sandrin,Victor de Lédinghen,Alexandre Mebazaa","doi":"10.1002/ejhf.3785","DOIUrl":"https://doi.org/10.1002/ejhf.3785","url":null,"abstract":"","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":"281 1","pages":""},"PeriodicalIF":18.2,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144645877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter regarding the article 'Liver stiffness measurement for non-invasive assessment of central venous pressure in patients with heart failure: A multicentre pilot study'.","authors":"Yi Wang,Zongyu Yang,Songjie Liao","doi":"10.1002/ejhf.3784","DOIUrl":"https://doi.org/10.1002/ejhf.3784","url":null,"abstract":"","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":"96 1","pages":""},"PeriodicalIF":18.2,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144645878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics and outcomes of patients with heart failure and history of malignancy: Data from Swedish Heart Failure Registry and the National Cancer Register.","authors":"Pietro Ameri,Paolo Costa,Lina Benson,Davide Stolfo,Nabil V Sayour,Charlotta Ljungman,Javed Butler,Stefan D Anker,Nicolas Girerd,Kalliopi Keramida,Gerasimos Filippatos,Lars H Lund,Felix Lindberg,Gianluigi Savarese","doi":"10.1002/ejhf.3775","DOIUrl":"https://doi.org/10.1002/ejhf.3775","url":null,"abstract":"AIMSWhether a history of malignancy affects heart failure (HF) management and prognosis is unclear. In HF randomized controlled trials, enrolment has been limited to patients with a cancer diagnosis at least 2 years before screening. We investigated clinical profile, HF treatment patterns, and outcomes of patients with a history of cancer of >2 years.METHODS AND RESULTSAmong 53 314 patients included in the Swedish HF Registry between 2000 and 2020, 9066 (17%) had previous cancer (diagnosed >2 years prior to index date), most frequently of prostate (26%), breast (15%), colon (11%), and haematologic system (11%). Previous cancer was associated with older age, female sex, comorbidity burden, and less likely specialized follow-up. Over a median follow-up of 2.4 (0.0-5.0) years, mortality rates were 24 (95% confidence interval [CI] 23-25) and 18 (95% CI 18-19) per 100 subject-years in patients with versus without previous cancer, respectively. Cancer accounted for 16% of deaths in the previous cancer group and for 5.6% in the no-cancer group. Previous cancer was independently associated with higher risk of all-cause death (adjusted hazard ratio [HR] 1.14, 95% CI 1.11-1.18), non-cardiovascular death (adjusted HR 1.38, 95% CI 1.31-1.44), and first all-cause hospitalization (adjusted HR 1.11, 95% CI 1.09-1.14). The risk of non-cardiovascular death declined with increasing time from cancer diagnosis. In patients with HF and reduced ejection fraction (HFrEF), previous cancer was associated with less frequent use of mineralocorticoid receptor antagonists, triple pharmacotherapy, and HF devices.CONCLUSIONSPrevious cancer was common among patients with HF, and it was associated with comorbidity burden, non-cardiovascular outcomes and, in HFrEF, with lower use of guideline-recommended therapies.","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":"49 1","pages":""},"PeriodicalIF":18.2,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144645882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coordinated expression of BMP10/ALK1/endoglin—proteins that drive embryonic cardiac and vascular morphogenesis—in patients with heart failure: The EMPEROR Program","authors":"Milton Packer, Javed Butler, João Pedro Ferreira, Tariq Jamal Siddiqi, James L. Januzzi, Naveed Sattar, Sandra González Maldonado, Marina Panova‐Noeva, Jürgen H. Prochaska, Mikhail Sumin, Serge Masson, Stuart J. Pocock, Gerasimos Filippatos, Stefan D. Anker, Faiez Zannad","doi":"10.1002/ejhf.3764","DOIUrl":"https://doi.org/10.1002/ejhf.3764","url":null,"abstract":"AimsBone morphogenetic protein 10 (BMP10), activin receptor‐like kinase 1 (ALK1) and endoglin form a single transforming growth factor‐β family signalling complex that is the principal driver of cardiac and vascular morphogenesis and maturation during hypoxic embryonic development. These proteins are down‐regulated with the onset of normoxia at birth, but are up‐regulated following experimental cardiac injury. Yet, little is known about the expression of this protein complex in patients with heart failure.Methods and resultsIn the EMPEROR Program, we measured serum levels of BMP10 by electrochemiluminescence immunoassay in 1127 patients in Cohort 1 (<jats:italic>n</jats:italic> = 1127) and plasma levels of BMP10, ALK1 and endoglin by proximity extension assay in a distinct Cohort 2 (<jats:italic>n</jats:italic> = 1120). In both cohorts, patients were characterized at baseline and were followed for the occurrence of major adverse heart failure events. Levels of BMP10, ALK1 and endoglin at baseline and changes in these levels during follow‐up were closely correlated with each other. Higher levels of BMP10, ALK1 and endoglin were associated with worse functional class, higher likelihood of atrial fibrillation and higher levels of natriuretic peptides and troponin T (<jats:italic>p</jats:italic> for trend &lt;0.001 for all). Increasing levels of BMP10, ALK1 and endoglin were associated with progressively higher risks of major adverse outcomes (<jats:italic>p</jats:italic> for trend &lt;0.001 for all three proteins and for all heart failure endpoints). The hazard ratios for the risks associated with tertiles of the three proteins in Cohort 2 were remarkably similar to those seen with BMP10 in Cohort 1. Treatment with empagliflozin had a modest effect to reduce BMP10 in both cohorts.ConclusionsThe coordinated circulating expression of proteins critical to foetal cardiac and vascular development tracks closely with the severity of heart failure, as reflected by symptoms, cardiac injury and stress, prevalence of atrial fibrillation and other comorbidities, and prognosis, suggesting a role of BMP10/ALK1/endoglin signalling in the progression of heart failure.","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":"47 1","pages":""},"PeriodicalIF":18.2,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144629450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to ‘Sodium chloride supplementation in acute heart failure: A closer look at SOLVRED‐AHF’","authors":"Jan Biegus, Gracjan Iwanek, Piotr Ponikowski","doi":"10.1002/ejhf.3771","DOIUrl":"https://doi.org/10.1002/ejhf.3771","url":null,"abstract":"","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":"23 1","pages":""},"PeriodicalIF":18.2,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144629883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sodium chloride supplementation in acute heart failure: A closer look at SOLVRED‐AHF. Letter regarding the article ‘Sodium chloride versus glucose solute as a volume replacement therapy for more effective decongestion in acute heart failure (SOLVRED‐AHF): A prospective, randomized, mechanistic study’","authors":"Tomoya Okazaki, Yu Yaegashi","doi":"10.1002/ejhf.3767","DOIUrl":"https://doi.org/10.1002/ejhf.3767","url":null,"abstract":"","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":"109 1","pages":""},"PeriodicalIF":18.2,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144629885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computational modelling of myocardial metabolism in patients with advanced heart failure","authors":"Niklas Beyhoff, Vera M. Braun, Marieluise Kirchner, Lucy E.M. Finnigan, Christoph Knosalla, István Baczkó, Evgenij Potapov, Ulrich Kintscher, Tilman Grune, Titus Kuehne, Hermann‐Georg Holzhütter, Philipp Mertins, Damian J. Tyler, Hendrik Milting, Betty Raman, Oliver J. Rider, Stefan Neubauer, Nikolaus Berndt","doi":"10.1002/ejhf.3746","DOIUrl":"https://doi.org/10.1002/ejhf.3746","url":null,"abstract":"AimsPerturbations of myocardial metabolism and energy depletion are well‐established hallmarks of heart failure (HF), yet methods for their systematic assessment remain limited in humans. This study aimed to determine the ability of computational modelling of patient‐specific myocardial metabolism to assess individual bioenergetic phenotypes and their clinical implications in HF.Methods and resultsBased on proteomics‐derived enzyme quantities in 136 cardiac biopsies, personalized computational models of myocardial metabolism were generated in two independent cohorts of advanced HF patients together with sex‐ and body mass index‐matched non‐failing controls. The bioenergetic impact of dynamic changes in substrate availability and myocardial workload were simulated, and the models' ability to predict the myocardial response following left ventricular assist device (LVAD) implantation was assessed. Compared to controls, HF patients had a reduced ATP production capacity (<jats:italic>p</jats:italic> &lt; 0.01), although there was remarkable interindividual variance. Utilization of glucose relative to fatty acids was generally higher in HF patients, depending on substrate availability and myocardial workload. The ratio of fatty acid to glucose utilization was associated with reverse cardiac remodelling after LVAD implantation and highly predictive of an improvement in left ventricular ejection fraction ≥10% (C‐index 0.94 [0.81–1.00], <jats:italic>p</jats:italic> &lt; 0.01). System‐level simulations identified fatty acid administration and carnitine supplementation in those with low mitochondrial carnitine content as potential pharmacological interventions to restore myocardial substrate utilization.ConclusionsComputational modelling identified a subset of advanced HF patients with preserved myocardial metabolism despite a similar degree of systolic dysfunction. Substrate preference was associated with the myocardial response after LVAD implantation, which suggests a role for substrate manipulation as a therapeutic approach. Computational assessment of myocardial metabolism in HF may improve understanding of disease heterogeneity, individual risk stratification, and guidance of personalized clinical decision‐making in the future.","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":"13 1","pages":""},"PeriodicalIF":18.2,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144629610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}