Journal of Nepal Chemical Society最新文献_第3页

Cytotoxicity of Compounds Isolated from Usnea aciculifera 针叶Usnea acaulifera分离化合物的细胞毒性研究

Journal of Nepal Chemical Society Pub Date : 2023-04-25 DOI: 10.3126/jncs.v43i2.53357

S. Shyaula, Teresa Shah, R. Rathnayaka, S. Samarakoon, Erendra Manandhar, J. Yue, M. Manandhar

引用次数: 0

Chemical Modification of Banana Peels and Banana Pseudostem for the Adsorptive Removal of Chromium (VI) from Aqueous Solution 化学改性香蕉皮和假茎吸附去除水中六价铬的研究

Journal of Nepal Chemical Society Pub Date : 2023-04-25 DOI: 10.3126/jncs.v43i2.53338

Sujata Adhikari, Krishna Subedi, Sabin Dhungana, Ram Lochan Arhyal, H. Paudyal, K. N. Ghimire, B. R. Poudel, M. R. Pokhrel

引用次数: 0

Free and Open Source Codes for Computational Chemistry Research Initiation: A Conspectus 计算化学研究启动的自由和开放源代码:概论

Journal of Nepal Chemical Society Pub Date : 2023-04-25 DOI: 10.3126/jncs.v43i2.53337

Jhashanath Adhikari, R. Adhikari

引用次数: 0

Preparation, spectroscopic analysis, and biological assessment of heteroleptic Zr(II) and Pd(II) complexes from Otc/Sal mixed ligands Otc/Sal混合配体杂性Zr(II)和Pd(II)配合物的制备、光谱分析和生物学评价

Journal of Nepal Chemical Society Pub Date : 2023-04-25 DOI: 10.3126/jncs.v43i2.53356

R. K. Dev, Yuv Raj Sahu, N. Chaudhary, A. Bhattarai

{"title":"Preparation, spectroscopic analysis, and biological assessment of heteroleptic Zr(II) and Pd(II) complexes from Otc/Sal mixed ligands","authors":"R. K. Dev, Yuv Raj Sahu, N. Chaudhary, A. Bhattarai","doi":"10.3126/jncs.v43i2.53356","DOIUrl":"https://doi.org/10.3126/jncs.v43i2.53356","url":null,"abstract":"The two new novel heteroleptic complexes of the type [M(II)L1.L2] (M= Zr(II) & Pd(II), L1= oxytetracycline (Otc), and L2=salicylaldehyde (Sal)) have been synthesized and analyzed by physical measurements such as CHN, pH, and conductivity. The conductivity data revealed the electrolytic nature of Pd(II)Otc/Sal and the non-electrolytic nature of the Zr(II)Otc/Sal metal complex of mixed ligand. The structural characterizations of the metal complex were approved by spectroscopic analysis methods, such as IR, 1H & 13C-NMR, UV/ Visible, and ESI-MS studies. Thermal analysis (TGA/DTA) determines the thermal and kinetic stabilities of the metal complexes using a popular Coats-Redfern equation through which the activation parameters can be calculated easily. SEM can determine the surface morphology of metal complexes. The selected bond lengths, bond angles, final optimized energy, and geometry of complexes were obtained by running an optimization task in the 3D molecular modeling software program via Chem 3D Pro. 12.0.2. The final geometrical energy was found to be 921.7712 for Zr(II)Otc/Sal and 914.6006 Kcal/mol for Pd(II)Otc/Sal complexes. Based on the above study, Zr(II)Otc/Sal complex has tetrahedral geometry and the Pd(II)Otc/Sal complex has square planar geometry. The complexes were tested in vitro for antibacterial susceptibility study against various strains of clinical pathogenic bacteria such as Staphylococcus aureus (Gram-positive), Proteus mirabilis, and Escherichia coli (Gram-negative). For the antibacterial study, the Kirby-Bauer paper disc diffusion technique is applied by using 50, 25, and 12.5 μg/μL concentrations of the metal complex. Good antibacterial sensitivity was found against all tested pathogens in all synthesized complexes.","PeriodicalId":16483,"journal":{"name":"Journal of Nepal Chemical Society","volume":"77 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74193219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study of Phytochemical Constituent and Biological Activities of Methanolic Extract of Rhizomes of Neopicrorhiza scrophulariiflora and Roots of Rheum australe collected from the Alpine Region of Nepal 尼泊尔高寒地区南大黄根与南大黄根甲醇提取物的化学成分及生物活性研究

Journal of Nepal Chemical Society Pub Date : 2023-04-25 DOI: 10.3126/jncs.v43i2.53359

Ganesh Prasad Kumai, M. Baskota, P. Aryal, Bimala Subba

{"title":"Study of Phytochemical Constituent and Biological Activities of Methanolic Extract of Rhizomes of Neopicrorhiza scrophulariiflora and Roots of Rheum australe collected from the Alpine Region of Nepal","authors":"Ganesh Prasad Kumai, M. Baskota, P. Aryal, Bimala Subba","doi":"10.3126/jncs.v43i2.53359","DOIUrl":"https://doi.org/10.3126/jncs.v43i2.53359","url":null,"abstract":"Rhizomes of Neopicrorhiza scrophularii flora and roots of Rheum australe were collected from the alpine regions of the Jumla district of Nepal. The phytochemical analysis of the methanolic extract of these plants revealed the presence of polyphenols, flavonoids, quinones, saponins, and tannins. The total phenolic and flavonoid content in the extracts of N. scrophulariiflora were estimated to be 141.27±1.414 mg GAE/gm and 43.48±5.476 QE/gm respectively and that in the extracts of R. austral were estimated to be 101.54±4.061 mg GAE/gm and 24.97±2.857 mg QE/gm respectively. A brine shrimp lethality test was performed with the extracts of N. scrophulariiflora and R. austral against brine shrimp nauplii and results revealed high toxicity of the extracts towards nauplii with LC50 values 173.78μg/mL and 257.03μg/mL respectively. N. scrophulariiflora showed the strongest DPPH radical scavenging activity with IC50 value of 57.49 μg/mL in comparison to R. austral whose IC50 was determined to be 68.91μg/mL, ascorbic acid taken as standard with IC50 value 49.05μg/ml. In α-amylase inhibition assay, N. scrophulariiflora extract exhibited strong activity with IC50 value 140.67μg/mL while that of R. austral extract showed mild activity with IC50 value 192.88μg/mL. All the biological studies revealed that N. scrophulariiflora extract is more active than that R. austral extract. Column chromatography of the extract of N. scrophulariiflora was performed and 50 % methanolic fraction was further subjected to FTIR and GC-MS analysis. The GC-MS analysis showed various compounds and among them, 13 major compounds were identified.","PeriodicalId":16483,"journal":{"name":"Journal of Nepal Chemical Society","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80139502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Kinetics of Catalytic Oxidation of Carbenicillin: A Degradation Approach for Penicillanic Acid Derivatives (PADs) 卡比西林催化氧化动力学:青霉素酸衍生物的降解方法

Journal of Nepal Chemical Society Pub Date : 2023-04-25 DOI: 10.3126/jncs.v43i2.53814

Yuv Raj Sahu, R. K. Dev, N. Chaudhary, A. Bhattarai

引用次数: 0

Structural, Optical and Antimicrobial Properties of Carbohydrate-Capped Cadmium Sulfide Nanoparticles 碳水化合物包覆的硫化镉纳米颗粒的结构、光学和抗菌性能

Journal of Nepal Chemical Society Pub Date : 2023-04-25 DOI: 10.3126/jncs.v43i2.53336

Subhav Adhikari, K. Parajuli, Guna B. Karki, Shankar P. Khatiwada, R. Adhikari

{"title":"Structural, Optical and Antimicrobial Properties of Carbohydrate-Capped Cadmium Sulfide Nanoparticles","authors":"Subhav Adhikari, K. Parajuli, Guna B. Karki, Shankar P. Khatiwada, R. Adhikari","doi":"10.3126/jncs.v43i2.53336","DOIUrl":"https://doi.org/10.3126/jncs.v43i2.53336","url":null,"abstract":"Cadmium sulfidenanoparticles (CdSNPs) were prepared through the chemical precipitation process where sweet potato starch and glucose-functioned as capping agents. Ultraviolet-Visible (UV-Vis) spectroscopy, Fourier Transform Infrared (FTIR) spectroscopy and X-ray diffraction (XRD) techniques were applied for the analysis of prepared CdSNPs. The absorption peaks in the UV-Vis spectroscopy towards the lower wavelength region compared to the bulk CdS (512 nm) indicated the formation of CdS particles in the nanometer scale range. FTIR spectroscopy showed the characteristic absorption peaks of the CdSNPs along with the functional groups present in starch and glucose, suggesting the possible interaction between CdSNPs and capping agents. The XRD revealed crystallographic information such as the average crystallite size and shape of CdSNPs. Using the Scherrer equation, the average crystallite size of CdSNPs was determined to be 11.48 nm and 16.03 nm for starch-capped and glucose-capped CdSNPs (CdS-St andCdS-Gl)respectively. Antibacterial and antifungal activities of the prepared CdSNPs were found to be highly efficient for various pathogenic bacteria and fungi. Hence in the present study, the new synthetic route of CdSNPs was applied, and antimicrobial activities were performed","PeriodicalId":16483,"journal":{"name":"Journal of Nepal Chemical Society","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76796471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemical and biological analysis of extracts of Acorus calamus L. 菖蒲提取物的化学和生物学分析。

Journal of Nepal Chemical Society Pub Date : 2023-04-25 DOI: 10.3126/jncs.v43i2.53813

Aaradhana Pokharel, Arjun Thapa, H. Karki, R. Yadav, Samjhana Bharati, Timila Shrestha, P. L. Homagai, Binita Maharjan, R. L. Shrestha

引用次数: 0

Synthesis, Cytotoxicity, Antibacterial and Antioxidant Activity of New 2-Substituted Benzimidazole Containing 1,2,4-Triazoles 含1,2,4-三唑类新2-取代苯并咪唑的合成、细胞毒性、抗菌及抗氧化活性

Journal of Nepal Chemical Society Pub Date : 2023-04-25 DOI: 10.3126/jncs.v43i2.53339

Prateek Aryal, B. Shakya

{"title":"Synthesis, Cytotoxicity, Antibacterial and Antioxidant Activity of New 2-Substituted Benzimidazole Containing 1,2,4-Triazoles","authors":"Prateek Aryal, B. Shakya","doi":"10.3126/jncs.v43i2.53339","DOIUrl":"https://doi.org/10.3126/jncs.v43i2.53339","url":null,"abstract":"The development of a potent new drug with high biological activity is a challenge in drug design and is of strategic importance. Due to the increasing resistance of pathogens on the available drugs, there is always a demand for designing a potent drug with high biological activity. The pharmacological effects have been observed in compounds containing different moieties of pharmaceutical importance such as triazole, Schiff’s base, benzimidazole.Triazole thione, Schiff’s bases, and two new compounds containing three pharmacophores viz. triazole, benzimidazole, and Schiff base incorporated in a single compound were prepared by applying different synthetic reactions. Different spectroscopic methods, including FT-IR, UV-vis, 1H-NMR, and 13C-NMR, were used to confirm the structure of the prepared compounds. All compounds exhibited moderate antibacterial activity against Staphylococcus aureus (ATCC 6538P) and Staphylococcus epidermidis (ATCC 1228). Antioxidant activity was carried out by DPPH radical scavenging test and among the tested five compounds, the IC50 value of 4-amino-3-(2-hydroxyphenyl)-1H-1,2,4-triazole-5(4H)-thione was found to be 32.364 μg.mL-1 which is closer to the ascorbic acid that was found to be 28.546 μgmL-1. All tested compounds were toxic against brine shrimp where 2-(5-((1H-benzo[d]imidazol-2-yl)thio)-4-((4-chlorobenzylidene) amino)-4H-1,2,4-triazol-3-yl) was comparatively more toxic (LC50= 26.827 μgmL-1).","PeriodicalId":16483,"journal":{"name":"Journal of Nepal Chemical Society","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81714962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Hydrochemical characterization of the Ramsar-listed Koshi Tappu Wetland, Nepal 尼泊尔拉姆萨尔湿地Koshi Tappu湿地的水化学特征

Journal of Nepal Chemical Society Pub Date : 2023-04-25 DOI: 10.3126/jncs.v43i2.53354

Shristi Neupane, R. Pant, L. Thapa, D. Shah, Birendra Gautam, Barsha Adhikari, Barsha Khanal, Anueva Acharya, K. Bishwakarma, S. Adhikari

{"title":"Hydrochemical characterization of the Ramsar-listed Koshi Tappu Wetland, Nepal","authors":"Shristi Neupane, R. Pant, L. Thapa, D. Shah, Birendra Gautam, Barsha Adhikari, Barsha Khanal, Anueva Acharya, K. Bishwakarma, S. Adhikari","doi":"10.3126/jncs.v43i2.53354","DOIUrl":"https://doi.org/10.3126/jncs.v43i2.53354","url":null,"abstract":"Nepal abounds a vast array of freshwater bodies, from sub-tropical lowlands to glacier-fed highlands with varying water quality. This study evaluated the spatial variations in water quality at the Koshi Tappu Wetland, the first Ramsar site of Nepal, located in the eastern Tarai region within the Koshi Tappu Wildlife Reserve. Nineteen water quality parameters were chosen and analyzed from twenty-one different sampling points within the wetland. Parameters including pH, EC, TDS, turbidity, and DO were analyzed on-site, whereas HCO3-, Cl-, NH4+, NO3-, SO42- PO43-, K+, TH, Ca2+, Mg2+, CaH, MgH, Na+, and Fe3+ were analyzed in the laboratory. Multivariate methods such as hierarchical agglomerative cluster analysis (CA) and principal component analysis (PCA), and geochemical indices such as piper and mixing diagrams were applied to assess the spatial variation in water quality. Findings indicated Ca2+ as the principal cation and HCO3- as the principal anion regulating the hydrochemistry of the wetland. Based on CA, three spatial clusters were observed, which depicted variations in chemical composition with the PCA results highlighting the primary contamination sources and controlling factors of the sampling locations with 84.13% of the total variance. Findings from the PCA and ionic relationship analyses elucidated that the hydrochemistry of the Koshi Tappu wetland is mainly controlled by carbonate weathering processes with a minor contribution of silicate weathering and anthropogenic activities.","PeriodicalId":16483,"journal":{"name":"Journal of Nepal Chemical Society","volume":"96 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76022374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0