Journal of Nepal Chemical Society最新文献

Formulation and Evaluation of Herbal Antioxidant Tablets of Urtica Dioica Extract 荨麻提取物草本抗氧化剂片剂的配制与评估

Journal of Nepal Chemical Society Pub Date : 2024-02-21 DOI: 10.3126/jncs.v44i1.62686

Jony Timalsina, Sunena Dhukuchhu, Jina Dhukuchhu, Alisha Bhattarai, Rajan Shrestha, R. Gyawali

{"title":"Formulation and Evaluation of Herbal Antioxidant Tablets of Urtica Dioica Extract","authors":"Jony Timalsina, Sunena Dhukuchhu, Jina Dhukuchhu, Alisha Bhattarai, Rajan Shrestha, R. Gyawali","doi":"10.3126/jncs.v44i1.62686","DOIUrl":"https://doi.org/10.3126/jncs.v44i1.62686","url":null,"abstract":"This study explores the formulation and assessment of herbal antioxidant tablets derived from Urtica dioica (stinging nettle) extracts for arthritis and osteoarthritis treatment. Various extraction methods were compared, revealing that 100% dehydrated ethanol at 45 degrees Celsius for four hours in a Soxhlet apparatus resulted in an 89% phenolic extraction. Although ethyl acetate yielded the highest phenolic extract (187%), its toxicity led to the selection of ethanol for further extraction. The Folin-Ciocalteu method determined the total phenolic content. The DPPH assay demonstrated positive antioxidant activity of the Urtica dioica ethanolic extract, with an IC50 value of 37.5761201 μg/mL, compared to the standard ascorbic acid with an IC50 value of 21.23506 μg/ml. Herbal tablets were formulated using the direct compression method. The findings highlight the potential of Urtica dioica extracts as effective herbal antioxidants for arthritis and osteoarthritis treatment. This research enhances our understanding of natural remedies and their therapeutic applications. Future investigations should delve into the clinical efficacy and safety of these herbal antioxidant tablets, paving the way for their potential integration into clinical settings. This study contributes valuable insights into the development of alternative therapies for managing arthritic conditions, emphasizing the importance of exploring nature's remedies in healthcare.","PeriodicalId":16483,"journal":{"name":"Journal of Nepal Chemical Society","volume":"144 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140443666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study of Antimicrobial Activity of ZnO Nanoparticles Dopped Natural Hydroxyapatites 氧化锌纳米颗粒掺杂天然羟基磷灰石的抗菌活性研究

Journal of Nepal Chemical Society Pub Date : 2024-02-21 DOI: 10.3126/jncs.v44i1.62677

Dirgha Raj Karki, Sushant Bhujel, Kshama Parajuli, Ramesh Raj Pant, M. L. Sharma

引用次数: 0

Index Based Irrigation Suitability of Ramsar Sites (Rara and Ghodaghodi) in Western Nepal 尼泊尔西部拉姆萨尔遗址（Rara 和 Ghodaghodi）的灌溉适宜性指数

Journal of Nepal Chemical Society Pub Date : 2024-02-21 DOI: 10.3126/jncs.v44i1.62685

R. Bhatta, S. Gurung, Rajendra Joshi, Shrija Tuladhar, Dikshya Regmi, Lekhendra Tripathee, Rukumesh Paudyal, Junming Guo, Shichang Kang, Chhatra Mani Sharma

{"title":"Index Based Irrigation Suitability of Ramsar Sites (Rara and Ghodaghodi) in Western Nepal","authors":"R. Bhatta, S. Gurung, Rajendra Joshi, Shrija Tuladhar, Dikshya Regmi, Lekhendra Tripathee, Rukumesh Paudyal, Junming Guo, Shichang Kang, Chhatra Mani Sharma","doi":"10.3126/jncs.v44i1.62685","DOIUrl":"https://doi.org/10.3126/jncs.v44i1.62685","url":null,"abstract":"The present study highlights the water quality of two important Ramsar sites of western Nepal (Ghodaghodi and Rara lakes) in terms of irrigation use. Based on land use patterns and location accessibility, 13 sites in Ghodaghodi and 18 in Rara were considered and the samplings were performed in the pre-monsoon and post-monsoon seasons. Different physicochemical parameters such as pH, electrical conductivity (EC), total dissolved solids (TDS), total hardness (TH), major cations, and anion (Na+, K+, Ca2+, Mg2+, and HCO3-) were measured. The calculated indices were permeability index percentage (PI), sodium percentage (%Na), sodium adsorption ratio (SAR), magnesium hazard ratio (MAR), residual sodium carbonate (RSC), and Kelly’s index (KI). Major ions were analyzed using ion chromatography including field and procedural blanks to maintain quality standards, whereas on-site parameters were measured by using standard multi-meter probes. The studied irrigation water quality parameters (pH, EC, TDS, TH) and indices (PI, MAR, RSC, KI, SAR, and %Na) fall within the permissible limit in both lakes, indicating the suitability of such water for irrigation purposes. In addition, based on the SAR vs. EC plot, all the results from both lakes fall in the S1 category, signifying low sodium hazard. Concerning EC, most of the samples demonstrate the C1 category and few are in the C2 category (in Ghodaghodi) whereas the C1 category predominates for Rara. According to IWQI, all water samples in both lakes fall in the class I category, which supports the results of other indices indicating the suitability of water for irrigation purposes.","PeriodicalId":16483,"journal":{"name":"Journal of Nepal Chemical Society","volume":"216 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140443792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of heavy metals in different brands of chocolates marketed in Kathmandu, Nepal, and their associated health risks 评估尼泊尔加德满都市场上销售的不同品牌巧克力中的重金属及其相关健康风险

Journal of Nepal Chemical Society Pub Date : 2024-02-21 DOI: 10.3126/jncs.v44i1.62680

Jasana Maharjan, P. Shakya

{"title":"Evaluation of heavy metals in different brands of chocolates marketed in Kathmandu, Nepal, and their associated health risks","authors":"Jasana Maharjan, P. Shakya","doi":"10.3126/jncs.v44i1.62680","DOIUrl":"https://doi.org/10.3126/jncs.v44i1.62680","url":null,"abstract":"Chocolates are among the sweet food items consumed by all age groups particularly children in Nepal. However, this foodstuff may be contaminated with heavy metals from the raw ingredients, production, and packaging methods, which could bring serious health issues. Therefore, this study aimed to determine cadmium (Cd), nickel (Ni), and lead (Pb) by Flame Atomic Absorption Spectrophotometer (FAAS) in a total of thirty-seven different brands of milk-based, cocoa-based, and sugar-based chocolates available in local grocery shops of Kathmandu city, Nepal and to evaluate associated health risks in children and adults using USEPA deterministic approaches. The results revealed concentrations of Cd, Ni, and Pb in the range of 0.021 – 0.585, 1.90 – 7.24, and 0.57 – 4.29 mg/kg respectively in studied chocolates and an overall mean concentration of 0.199, 4.22, and 1.94 mg/kg respectively. The observed concentrations exceeded the maximum permissible limits set by FAO/WHO (2001). A higher concentration of all studied metals was found in cocoa-based chocolate compared to milk-based and sugar-based chocolates. The positive and significant correlations (p < 0.05) among Cd, Ni, and Pb in studied chocolates indicate the possibility of contamination from common sources. Similarly, the estimated ADDing values were higher for all metals in cocoa-based chocolate for both children and adults. However, children were more prone to metals exposure than adults since their dietary intake was higher than adults. Cocoa-based chocolate in this study posed a non-carcinogenic risk to both children and adults since their hazard index (HI) values exceeded the acceptable limit (>1.0). In addition, Cd and Ni posed carcinogenic risks to both receptor groups through the consumption of all three categories of chocolate. Therefore, this study suggested the use of less contaminated raw materials in chocolates as well as regular monitoring of the production chain as an attempt to ensure the quality and safety of the food products.","PeriodicalId":16483,"journal":{"name":"Journal of Nepal Chemical Society","volume":"22 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140444115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study of Anti-Corrosion Properties of Sodium Dodecyl Sulphate and Cetyl Pyridinium Chloride 十二烷基硫酸钠和十六烷基氯化吡啶的防腐蚀性能研究

Journal of Nepal Chemical Society Pub Date : 2024-02-21 DOI: 10.3126/jncs.v44i1.62690

Chandradip Kumar Yadav, Tulasi Prasad Niraula, S. Neupane, Amar Prasad Yadav, A. Bhattarai

引用次数: 0

The interfacial tension at the liquid junction of petrol and Sodium dodecyl sulphate solution 汽油和十二烷基硫酸钠溶液液体交界处的界面张力

Journal of Nepal Chemical Society Pub Date : 2024-02-21 DOI: 10.3126/jncs.v44i1.62687

A. Bhattarai, Man Singh

引用次数: 0

Assessment of Microplastics in Hanumante River of Kathmandu Valley 加德满都谷地哈努曼特河的微塑料评估

Journal of Nepal Chemical Society Pub Date : 2024-02-21 DOI: 10.3126/jncs.v44i1.62684

Khageshwari Bhatta, Gauri Devi Sharma, K. Bohara, Mahesh Kumar Joshi

{"title":"Assessment of Microplastics in Hanumante River of Kathmandu Valley","authors":"Khageshwari Bhatta, Gauri Devi Sharma, K. Bohara, Mahesh Kumar Joshi","doi":"10.3126/jncs.v44i1.62684","DOIUrl":"https://doi.org/10.3126/jncs.v44i1.62684","url":null,"abstract":"Plastic debris is one of the most significant organic pollutants in the aquatic environment. Researchers are currently focusing on the impact of micro and nano-scale plastic waste on aquatic systems. In this study, we investigated the distribution of plastic pellets and fragments present in the freshwater ecosystem. The goal was to assess microplastic (MP) abundance in the Hanumante River, a tributary of the Bagmati River, and analyze their properties. Sample collection involved the bottle sampling method. Filtration, wet peroxide oxidation, density separation, gravimetric analysis, and microscopic examination were performed to study the characteristics of microplastics. The study was conducted by following the guidelines of the National Oceanic and Atmospheric Administration (NOAA) protocol. Gravimetric analysis was applied to calculate the reduced mass of the sample after total organic carbon reduction. Results showed that the maximum amount of reduced sample was obtained from the sample taken from sample taken from Madhyapur Thimi area (~3.593g) and the minimum amount of reduced sample was obtained from the sample taken from the Shiva temple Jagati area (~2.130g). Microscopic inspection showed that samples taken from different locations were composed of an average of 14–23 microplastics per liter of sample. FT-IR analysis was performed to analyze the characteristics of microplastics and the type of polymers present in the sample which showed the abundance of polymer materials like polyethylene, polypropylene, and polycarbonates. The findings imply that appropriate plastic waste management measures be implemented in the communities to safeguard the ecosystem benefits derived from the river.","PeriodicalId":16483,"journal":{"name":"Journal of Nepal Chemical Society","volume":"12 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140442900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microwave-Accelerated Synthesis of Flavanones through Oxidative Cyclization of 2'-Hydroxychalcones Using Acetic Acid as a Sole Catalyst 以乙酸为单一催化剂通过 2'-Hydroxychalcones 氧化环化微波加速合成黄烷酮类化合物

Journal of Nepal Chemical Society Pub Date : 2024-02-21 DOI: 10.3126/jncs.v44i1.62688

Gan B. Bajracharya, Rabina Dhakal, Sulochana Timalsina

引用次数: 0

Phytochemical Screening and In Vitro Antioxidant Activity of Three Nepalese Plants 三种尼泊尔植物的植物化学筛选和体外抗氧化活性

Journal of Nepal Chemical Society Pub Date : 2024-02-21 DOI: 10.3126/jncs.v44i1.62681

Samiksha Poudel, Sabina Adhikari, Anil Tiwari, Shiva Acharya, Sumit Bahadur Baruwal Chhetri, Rupesh Adhikari, Prakash Poudel, Deepa Khatri

{"title":"Phytochemical Screening and In Vitro Antioxidant Activity of Three Nepalese Plants","authors":"Samiksha Poudel, Sabina Adhikari, Anil Tiwari, Shiva Acharya, Sumit Bahadur Baruwal Chhetri, Rupesh Adhikari, Prakash Poudel, Deepa Khatri","doi":"10.3126/jncs.v44i1.62681","DOIUrl":"https://doi.org/10.3126/jncs.v44i1.62681","url":null,"abstract":"Nepal is rich in plant resources and holds the 49th spot in the world’s biodiversity. The variation in altitude, climatic conditions, and geographical features across Nepal make it a rich source of Medicinal and Aromatic Plants (MAPs). The study was carried out to perform the preliminary phytochemical screening and assess antioxidant properties in Ficus neriifolia, Rubus treutleri, and Periploca calophylla. Plants were selected based on their ethnomedical use and scant scientific research. Ethanol (70%) and aqueous extracts were prepared by using the cold maceration method and preliminary phytochemical screening was conducted using the previously established method to test the presence of biologically active phytoconstituent. In vitro, antioxidant activity was examined by DPPH free radical scavenging assay. The results revealed the variation in phytoconstituents among the 70% ethanol and aqueous extracts of all three plant samples. Among the samples, the 70% ethanol extract of P. calophylla exhibited the highest antioxidant activity with an IC50 value of 94.36 μg/mL, while the aqueous extract of F. neriifolia showed the minimum antioxidant activity with an IC50 value of 902.23 μg/mL. This study indicates that these plant samples possess potent natural antioxidants capable of scavenging free radicals that cause cellular damage and contribute to various diseases in our bodies.","PeriodicalId":16483,"journal":{"name":"Journal of Nepal Chemical Society","volume":"58 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140442385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design of Hydrogel for the Drug Delivery of Less Permeable Ursolic Acid Isolated from Rhododendron arboreum Flower in Animal Skin Membrane 从杜鹃花中提取的渗透性较低的熊果酸在动物皮膜中的给药水凝胶设计

Journal of Nepal Chemical Society Pub Date : 2024-02-21 DOI: 10.3126/jncs.v44i1.62683

Bigyan Joshi, N. L. Bhandari, S. Shyaula, Uttam Budathoki, R. Gyawali, Panna Thapa

{"title":"Design of Hydrogel for the Drug Delivery of Less Permeable Ursolic Acid Isolated from Rhododendron arboreum Flower in Animal Skin Membrane","authors":"Bigyan Joshi, N. L. Bhandari, S. Shyaula, Uttam Budathoki, R. Gyawali, Panna Thapa","doi":"10.3126/jncs.v44i1.62683","DOIUrl":"https://doi.org/10.3126/jncs.v44i1.62683","url":null,"abstract":"Ursolic acid (UA) is a pentacyclic triterpene that has antioxidant, anticancer, and anti-inflammatory properties. As it belongs to the biopharmaceutical classification system IV due to its poor water solubility and permeability restricts its use in clinical application. So, the research is focused on the development of hydrogel containing encapsulated liposomes of ursolic acid to increase its permeability. The ursolic acid liposomal gel was prepared with a 0.5%, 1%, and 1.5% mixture of carbopol 934P and HPMC K4M as gelling agents. The pH and spreadability of liposomal gel were found to be in the range of (6.93±0.035 to 7.12±0.03) and (15.41±0.36 to 24.47±0.90) g.cm/sec respectively. The drug content was found to be in (19.77±0.02 to 20.11±0.02)%. The study of drug release kinetics showed Higuchi release followed by a non-Fickian diffusion mechanism. The result of the permeation study by Franz diffusion cell showed 1.55 times higher compared to the plain gel at the 5th hour of the study with a flux value of 0.455(mg/cm2/hr). It resolved the fast and enhanced delivery of liposomal ursolic acid through the skin membrane.","PeriodicalId":16483,"journal":{"name":"Journal of Nepal Chemical Society","volume":"15 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140444189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0