Journal of metabolic syndrome最新文献

{"title":"Nonalcoholic Fatty Liver Disease Alone Is a Better Predictor of MetabolicSyndrome and Insulin Resistance than Existing ATP-III Criteria","authors":"S. Singh, P. Nath, Ayaskanta Singh, Jimmy Narayan, P. Parida, P. Padhi, G. Pati, Chudamani Meher, Omprakash Agrawal","doi":"10.4172/2167-0943.1000183","DOIUrl":"https://doi.org/10.4172/2167-0943.1000183","url":null,"abstract":"Abstract  \u0000Objective: Metabolic syndrome (MS) also known as insulin resistance syndrome is a surrogate marker of insulin resistance (IR). Traditionally this is being diagnosed by Adult Treatment Panel III (ATP-III) and International Federation of Diabetes (IDF) criteria. Despite mounting evidence in favor of non-alcoholic fatty liver disease (NAFLD), this has not been yet included as a component of either ATP-III or IDF criteria. We conducted this study to evaluate if NAFLD could be used as a criterion for identifying metabolic syndrome. \u0000Methods: Setting: Single center observational study in Gastroenterology OPD at SCB Medical College, Cuttack. Subjects: Consecutive subjects presenting with functional bowel disease were included; these included 68 NAFLD subjects and 200 subjects with normal liver on ultrasonography. Investigations: All 268 subjects were evaluated for the presence of metabolic syndrome by ATP-III and insulin resistance by HOMA IR method. NAFLD subjects were compared with those with metabolic syndrome for presence of insulin resistance \u0000Results: Patients with NAFLD had higher HOMA-IR than those with metabolic syndrome (2.34±1.01 vs. 1.79±1.01; p<0.000). Presence of NAFLD can detect insulin resistance with a sensitivity of 78.0% and specificity of 86.3 % with an odds ratio of 25.55 (95%CI: 11.51-56.70) which is better than that of metabolic syndrome diagnosed by ATP-III criteria (sensitivity 71.43%, specificity 70.32%; OR: 5.92, 95%CI: 2.99-11.74). Multivariate logistic regression analysis showed that fatty liver was an independent predictor for insulin resistance and metabolic syndrome. \u0000Conclusion: NAFLD alone is a better predictor for insulin resistance than existing ATP-III criteria. Hence NAFLD should be used as a surrogate marker for metabolic syndrome.","PeriodicalId":16452,"journal":{"name":"Journal of metabolic syndrome","volume":"64 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2015-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78191796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re-sleeve Gastrectomy for Failure of Weight Loss After Primary Sleeve Gastrectomy; 3 Cases","authors":"Ji-Sun Hong, Sang-Moon Han","doi":"10.4172/2167-0943.1000182","DOIUrl":"https://doi.org/10.4172/2167-0943.1000182","url":null,"abstract":"Laparoscopic sleeve gastrectomy (LSG) is the leading weight loss procedure for treatment of morbid obesity. However, as with all other bariatric procedures, failure of weight loss was observed. We report here 3 cases of resleeve gastrectomy (RSG) for failure of weight loss after primary sleeve gastrectomy (PSG). The first patient, with a body mass index (BMI) of 32.9 kg/m2, underwent PSG in August 2003. She showed an initial drop in BMI to 22.4 kg/m2 in 2007 and regained weight to BMI of 33.1 kg/m2 in 2013, but, after the RSG, her BMI was 21.9 kg/m2 at 12 months. The second patient, with a BMI of 32.6 kg/m2, underwent PSG in May 2004. She showed a drop in BMI of 27.4 kg/m2 in 2005 and regained weight to BMI of 31.4 kg/m2 in 2011, but, after the RSG, her BMI was 24.4 kg/m2 at 24 months. The third patient, with a BMI of 34.0 kg/m2, underwent PSG in July 2013. She had a drop in BMI of 28.0 kg/m2 in January 2014, but her weight did not change until July 2014. Her BMI had dropped to 21.2 at 6 month postoperatively after RSG. Therefore, RSG may be considered as a revision surgery for failure of weight loss after PSG.","PeriodicalId":16452,"journal":{"name":"Journal of metabolic syndrome","volume":"46 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2015-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91530532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Metabolic Syndrome Diagnosed by Three Different Criteria in School-Aged Children from Rural and Urban Areas of Northwest Mexico","authors":"Cecilia Ramírez-Murillo, Elizabeth Guillot-Sánchez, B. ElizabethArtalejo-OchoaQ, A. Robles-Sardin, J. Ponce-Martínez, M. Grijalva-Haro, Graciela Caire‐Juvera, M. Ortega-Vélez, M. Ballesteros-Vásquez","doi":"10.4172/2167-0943.1000181","DOIUrl":"https://doi.org/10.4172/2167-0943.1000181","url":null,"abstract":"The International Diabetes Federation (IDF) does not justify the evaluation of metabolic syndrome (MetS) in children aged less than 10 years, unless they have a family history of risk factors. The prevalence of overweight and obesity in the Northwest of Mexico has increased in recent decades, making it possible to consider that MetS is already present in this group of population. \u0000Objective: The primary objective of this study was to determine the prevalence of metabolic syndrome in children aged 6 to 9 years living in rural (RA) or urban (UA) areas of Northwest of Mexico. A secondary objective was to find adequate criteria to diagnose the prevalence of MS in children. \u0000Methods: Participated 268 school-aged children in a random-selected cross sectional study. Anthropometric and blood pressure measurement were performed, and biochemical indicators were analyzed. MetS was defined as the presence of three or more risk factors and diagnosed using three different criteria. One of them according to what was proposed by the International Diabetes Federation (IDF) for children and two additional criteria proposed by this study considering suitable cutoffs for age for lipids and blood pressure. \u0000Results: The general prevalence of MetS according to the three different criteria used was as follows.1) IDF criteria, 4.1%; 2) using cutoffs suggested for age for lipids and blood pressure and taking into account waist circumference as a criterion for MetS, 6.3%; and 3) cutoffs suggested for age, lipids and blood pressure without considering waist circumference as a criterion for MetS, 10.4%. Children living in the RA with a history of obesity and cardiovascular disease had higher waist circumference, triglycerides, and very low-density lipoprotein-C, and children from the UA had higher systolic and diastolic blood pressure, and higher levels of glucose and insulin. \u0000Conclusion: MetS is present in children aged 6 to 9 years in the northwest region of Mexico, with higher proportions of the syndrome observed in overweight and obese children. The second criteria used in this study could be the most suitable for diagnosis of MetS, and the third criteria, for children at higher risk for cardiovascular disease and type 2 diabetes mellitus associated to heredity factors.","PeriodicalId":16452,"journal":{"name":"Journal of metabolic syndrome","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91157817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Deoxyribonuclease I Gene Polymorphisms with Graves Disease in the Chinese Han Population","authors":"Jingyan Chen, Hua Zeng, Zhixian Zhang, Tingting Li, Lei Bi, H. Ding, Jin Zhang","doi":"10.4172/2167-0943.1000180","DOIUrl":"https://doi.org/10.4172/2167-0943.1000180","url":null,"abstract":"Background: This study aimed to investigate the association between the single nucleotide polymorphism (SNP) rs1053874 in the deoxyribonuclease I (DNASE1) gene and Graves’ disease (GD) in the Han Chinese population. \u0000Methods: Polymerase chain reaction-restriction fragment length polymorphism analysis and direct sequencing were used to identify the distribution of the SNP rs1053874 in the DNASE1 genes from 284 GD patients and 203 healthy controls, and associations between clinical manifestations of GD and the observed genotype and allele frequencies at the DNASE1 gene were analyzed. \u0000Results: In the Han Chinese population, there were significant differences between the GD groups and the controls with respect to genotype and allele frequencies associated with theSNPrs1053874. The risk of GD was greater among carriers of the G allele than non-carriers (OR=0.65, 95% CI: 0.49- 0.86). There were significant differences in genotype and allele frequencies between the GD patients with a history of relapse and the GD patients without history of relapse; furthermore, the G allele of the SNP rs1053874 was associated with relapse in GD patients. \u0000Conclusion: This study confirmed that the DNASE1 gene may be a GD susceptibility gene in the in the Southern Chinese Han population. The G allele at the rs1053874 SNP would be a direct genetic risk factor for GD in this population. Furthermore, this allele may be associated with disease relapse.","PeriodicalId":16452,"journal":{"name":"Journal of metabolic syndrome","volume":"13 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2015-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74376775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral Aspects of Metabolic Disorders","authors":"A. Bohra","doi":"10.4172/2167-0943.1000178","DOIUrl":"https://doi.org/10.4172/2167-0943.1000178","url":null,"abstract":"Metabolism is a complex process that involves a series of chemical reactions in the human body. Alterations in these metabolic processes constitute the disturbances of metabolism causing metabolic disorders. The breakdown of carbohydrate by the oral microorganisms has been the subject of numerous investigations. This review discusses the oral aspects of metabolic diseases.","PeriodicalId":16452,"journal":{"name":"Journal of metabolic syndrome","volume":"15 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2015-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73330678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Cutoff Values of Epicardial Fat in Metabolic Syndrome, Cardiovascular Risk Factors, Coronary and Carotid Stenosis","authors":"L. Roever, E. Resende","doi":"10.4172/2167-0943.1000E116","DOIUrl":"https://doi.org/10.4172/2167-0943.1000E116","url":null,"abstract":"Pierdomenico et. al. studied 174 Caucasian hypertensive patients, aged ≥40 years, with (BM) <25 kg/m2 and waist circumference (WC)<102 cm in men and 88 cm in women, MetS was present 12% patients. EF was significantly higher in patients with MetS than in those without MetS (4.0±0.8 vs. 2.5 ± 0.9 mm, P <0.01). The ROC curve analysis showed that EF significantly improved prediction of MetS when added to BMI and WC. The ROC curve for EF alone indicated that the cutoff value of 3.1 mm had the best performance in predicting MetS(100% sensitivity and 79% specificity) [6].","PeriodicalId":16452,"journal":{"name":"Journal of metabolic syndrome","volume":"20 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2015-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89388019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treating Hyperinsulinemia with Momordica charantia","authors":"F. Comhaire","doi":"10.4172/2167-0943.1000177","DOIUrl":"https://doi.org/10.4172/2167-0943.1000177","url":null,"abstract":"Objectives: To assess the efficacy of a novel nutraceutical mainly containing the extract of bitter gourd (Momordica charantia) and α-lipoic acid for the treatment of patients with hyperinsulinemia. \u0000Methods: Pilot prospective open-label cohort trial including 11 patients with hyperinsulinemia due to insulin resistance. The concentrations of insulin, C-peptide, glucose, haemoglobin A1c, total cholesterol, triglycerids, gamma- glutamyltransferase, and C-reactive protein were measured in blood take between 3 and 4 hours after dinner. \u0000Results: One and 4 months after initiation of treatment there was a significant decrease of the concentrations of Insulin (to average 25% of initial value), C-peptide (to average 44% of initial value), glucose, hemoglobin A1c and gamma-glutamyl transpeptidase. Clinical significance: Treatment of patients with hyperinsulinemia, with or without diabetes or metabolic syndrome, using a novel nutraceutical containing Momordica charantia and α-lipoic acid dramatically reduced insulin resistance and may have improved non-alcoholic fatty liver disease.","PeriodicalId":16452,"journal":{"name":"Journal of metabolic syndrome","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85926269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human Endothelial Progenitor Cell Application in Vascular Diseases Seen inMetabolic Syndrome","authors":"U. Dincer","doi":"10.4172/2167-0943.1000E115","DOIUrl":"https://doi.org/10.4172/2167-0943.1000E115","url":null,"abstract":"Intact endothelial cells and their progenitors receive, integrate and response to physiological and pathological environment and play an important role in cardiovascular disease development and angiogenesis. When Furchgott et al. demonstrated that a healthy intact endothelium is necessary to continuation of vascular function, it truly revealed a different point of view [1]. The new era, vascular adaptation requires intact healthy endothelial cells to response physiological and pathological environment, displayed different therapeutic approaches in cardiovascular diseases. Generation of more information such as endothelial cells release a short-lived vasodilator agent which called nitric oxide via eNOS also was shook down the previous approaches in vascular disease management [1]. Furthermore, Asahara et al. were isolated endothelial progenitors from human peripheral blood in 1997 and they clearly demonstrated that those progenitors are actually differentiated into endothelial cells in adults [2]. It was completely started to predominant paradigm in previous treatment modalities regarding a new vessel formation probable via their progenitors in adults after embryonic development [2]. Because, until that time it was believed that endothelial differentiation could only occur during embryonic development [2]. Thus, endothelial progenitors are important as intact endothelial cells and the information “during different physiological and pathological stress a larger amount of endothelial progenitors released and mobilized into the peripheral blood furthermore display vasodilatation and generate a new vessel formation to re-establish blood flow” is impressive as intact endothelium necessary to vessel function knowledge.","PeriodicalId":16452,"journal":{"name":"Journal of metabolic syndrome","volume":"27 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2015-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86244482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolically Healthy Obesity and the Fit/Fat Phenotype: Associations with Mortality, Subclinical Cardiovascular Disease and Approach to Treatment","authors":"Ayesha Farooq, Sufian Sorathia, S. Shaharyar, Lara L. Roberson, H. Feiz","doi":"10.4172/2167-0943.1000176","DOIUrl":"https://doi.org/10.4172/2167-0943.1000176","url":null,"abstract":"Obesity is a global epidemic affecting over a third of the adult population. Within the obese, subgroups have been identified, including the metabolically healthy obese (MHO) and the fit/fat phenotypes. The MHO phenotype was traditionally thought to have lower cardiovascular risk than the ‘typically obese’, a notion that is being challenged by recent data. Similarly, the emerging fit/fat phenotype is raising questions about the impact of obesity on mortality and cardiovascular risk. The present narrative review provides an overview of these phenotypes and summarizes current evidence and viewpoints regarding the same. The review then incorporates this data into a format that can be utilized by clinicians and researchers to aid clinical decision-making.","PeriodicalId":16452,"journal":{"name":"Journal of metabolic syndrome","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82222340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Metabolic Syndrome on Fibrosis Progression in Chronic Viral Hepatitis B Infection","authors":"C. Aygun","doi":"10.4172/2167-0943.1000175","DOIUrl":"https://doi.org/10.4172/2167-0943.1000175","url":null,"abstract":"Many factors may increase the risk of fibrosis development in chronic viral hepatitis infections. As the burden of obesity and metabolic syndrome has been increasing in recent years, there is growing concern regarding the association between metabolic factors and chronic viral hepatitis cases. However data regarding the influence of metabolic syndrome on progression of fibrosis in chronic hepatitis B virus (HBV) infection is limited. Metabolic syndrome is a constellation of problems that includes insulin resistance, obesity, hypertension, and hyperlipidemia. Initially, epidemiologic data demonstrated that HBsAg-positive serostatus was positively correlated with a high risk of metabolic syndrome; later on, HBV was considered as a “metabolovirus” because the gene expression of HBV and key metabolic genes in hepatocytes was found to be similarly regulated. Metabolic syndrome is not only found to accelerate the progression of liver disease in patients with chronic HBV infection but also found to induce cirrhosis or even hepatocellular carcinoma development. This review article it is aimed to highlight the association of metabolic syndrome with chronic HBV infection.","PeriodicalId":16452,"journal":{"name":"Journal of metabolic syndrome","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81162837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}