Human Endothelial Progenitor Cell Application in Vascular Diseases Seen inMetabolic Syndrome

Intact endothelial cells and their progenitors receive, integrate and response to physiological and pathological environment and play an important role in cardiovascular disease development and angiogenesis. When Furchgott et al. demonstrated that a healthy intact endothelium is necessary to continuation of vascular function, it truly revealed a different point of view [1]. The new era, vascular adaptation requires intact healthy endothelial cells to response physiological and pathological environment, displayed different therapeutic approaches in cardiovascular diseases. Generation of more information such as endothelial cells release a short-lived vasodilator agent which called nitric oxide via eNOS also was shook down the previous approaches in vascular disease management [1]. Furthermore, Asahara et al. were isolated endothelial progenitors from human peripheral blood in 1997 and they clearly demonstrated that those progenitors are actually differentiated into endothelial cells in adults [2]. It was completely started to predominant paradigm in previous treatment modalities regarding a new vessel formation probable via their progenitors in adults after embryonic development [2]. Because, until that time it was believed that endothelial differentiation could only occur during embryonic development [2]. Thus, endothelial progenitors are important as intact endothelial cells and the information “during different physiological and pathological stress a larger amount of endothelial progenitors released and mobilized into the peripheral blood furthermore display vasodilatation and generate a new vessel formation to re-establish blood flow” is impressive as intact endothelium necessary to vessel function knowledge.