Journal of Medical Toxicology最新文献_第7页

Navigating a Startup Journey: The Journal of Medical Toxicology. 领航创业之旅：医学毒理学杂志》。

IF 2.9 4区医学

Journal of Medical Toxicology Pub Date : 2024-04-01 Epub Date: 2024-03-06 DOI: 10.1007/s13181-024-01002-3

Christian Tomaszewski

引用次数: 0

Welcome to the 2024 ACMT Annual Scientific Meeting. 欢迎参加 2024 ACMT 年度科学会议。

IF 2.9 4区医学

Journal of Medical Toxicology Pub Date : 2024-04-01 Epub Date: 2024-02-26 DOI: 10.1007/s13181-024-00992-4

Michael Toce, Charlotte E Goldfine, Maryann Mazer-Amirshahi, Alison Meyn

引用次数: 0

Ensuring the Efficacy and Safety of Approved Medications. 确保批准药物的有效性和安全性。

IF 2.9 4区医学

Journal of Medical Toxicology Pub Date : 2024-04-01 Epub Date: 2024-02-23 DOI: 10.1007/s13181-024-00998-y

Maryann Mazer-Amirshahi, Jon B Cole, Andrew I Stolbach, Jeanmarie Perrone, Lewis S Nelson

引用次数: 0

Glucagon-Like Peptide-1 Receptor Agonist Cases Reported to United States Poison Centers, 2017-2022. 2017-2022 年向美国毒物中心报告的胰高血糖素样肽-1 受体激动剂病例。

IF 2.5 4区医学

Journal of Medical Toxicology Pub Date : 2024-04-01 Epub Date: 2024-02-29 DOI: 10.1007/s13181-024-00999-x

Christopher E Gaw, Hannah L Hays, Cydney A Kemp, Sandhya Kistamgari, Henry A Spiller, Natalie I Rine, Allison L Rhodes, Motao Zhu, Gary A Smith

{"title":"Glucagon-Like Peptide-1 Receptor Agonist Cases Reported to United States Poison Centers, 2017-2022.","authors":"Christopher E Gaw, Hannah L Hays, Cydney A Kemp, Sandhya Kistamgari, Henry A Spiller, Natalie I Rine, Allison L Rhodes, Motao Zhu, Gary A Smith","doi":"10.1007/s13181-024-00999-x","DOIUrl":"10.1007/s13181-024-00999-x","url":null,"abstract":"Introduction: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are a class of medications for management of diabetes and obesity. The objective of this study is to characterize the epidemiology of GLP-1RA cases reported to US poison centers.Methods: We analyzed cases involving a GLP-1RA reported to the National Poison Data System during 2017-2022.Results: There were 5,713 single-substance exposure cases reported to US poison centers involving a GLP-1RA. Most cases were among females (71.3%) and attributable to therapeutic errors (79.9%). More than one-fifth (22.4%) of cases were evaluated in a healthcare facility, including 0.9% admitted to a critical care unit and 4.1% admitted to a non-critical care unit. Serious medical outcomes were described in 6.2% of cases, including one fatality. The rate of cases per one million US population increased from 1.16 in 2017 to 3.49 in 2021, followed by a rapid increase of 80.9% to 6.32 in 2022. Trends for rates of serious medical outcomes and admissions to a healthcare facility showed similar patterns with 129.9% and 95.8% increases, respectively, from 2021 to 2022.Conclusions: Most GLP-1RA cases reported to US poison centers were associated with no or minimal effects and did not require referral for medical treatment; however, a notable minority of individuals experienced a serious medical outcome or healthcare facility admission. The rate of reported cases increased during the study period, including an 80.9% increase from 2021 to 2022. Opportunities exist to improve provider and patient awareness of the adverse effects of these medications.","PeriodicalId":16429,"journal":{"name":"Journal of Medical Toxicology","volume":" ","pages":"193-204"},"PeriodicalIF":2.5,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10959851/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139990325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Food Poisoning by Oleander Skewers: Investigation of a Toxicologic Urban Legend. 夹竹桃串食物中毒：毒理学都市传说调查。

IF 2.9 4区医学

Journal of Medical Toxicology Pub Date : 2024-04-01 Epub Date: 2024-02-07 DOI: 10.1007/s13181-024-00993-3

Jeffrey R Suchard, Jerald Lim, Kenneth Schmitt

引用次数: 0

Smartphone and Wearable Device-Based Digital Phenotyping to Understand Substance use and its Syndemics. 基于智能手机和可穿戴设备的数字表型分析，以了解药物使用及其综合症。

IF 2.5 4区医学

Journal of Medical Toxicology Pub Date : 2024-04-01 Epub Date: 2024-03-04 DOI: 10.1007/s13181-024-01000-5

Jasper S Lee, Emma Browning, Joanne Hokayem, Hannah Albrechta, Georgia R Goodman, Krishna Venkatasubramanian, Arlen Dumas, Stephanie P Carreiro, Conall O'Cleirigh, Peter R Chai

{"title":"Smartphone and Wearable Device-Based Digital Phenotyping to Understand Substance use and its Syndemics.","authors":"Jasper S Lee, Emma Browning, Joanne Hokayem, Hannah Albrechta, Georgia R Goodman, Krishna Venkatasubramanian, Arlen Dumas, Stephanie P Carreiro, Conall O'Cleirigh, Peter R Chai","doi":"10.1007/s13181-024-01000-5","DOIUrl":"10.1007/s13181-024-01000-5","url":null,"abstract":"Digital phenotyping is a process that allows researchers to leverage smartphone and wearable data to explore how technology use relates to behavioral health outcomes. In this Research Concepts article, we provide background on prior research that has employed digital phenotyping; the fundamentals of how digital phenotyping works, using examples from participant data; the application of digital phenotyping in the context of substance use and its syndemics; and the ethical, legal and social implications of digital phenotyping. We discuss applications for digital phenotyping in medical toxicology, as well as potential uses for digital phenotyping in future research. We also highlight the importance of obtaining ground truth annotation in order to identify and establish digital phenotypes of key behaviors of interest. Finally, there are many potential roles for medical toxicologists to leverage digital phenotyping both in research and in the future as a clinical tool to better understand the contextual features associated with drug poisoning and overdose. This article demonstrates how medical toxicologists and researchers can progress through phases of a research trajectory using digital phenotyping to better understand behavior and its association with smartphone usage.","PeriodicalId":16429,"journal":{"name":"Journal of Medical Toxicology","volume":" ","pages":"205-214"},"PeriodicalIF":2.5,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10959908/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140022051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Voice of Medical Toxicology: Celebrating 20 Years of the Journal of Medical Toxicology. 医学毒理学之声：庆祝《医学毒理学杂志》创刊 20 周年。

IF 2.9 4区医学

Journal of Medical Toxicology Pub Date : 2024-04-01 Epub Date: 2024-03-04 DOI: 10.1007/s13181-024-01001-4

Anthony F Pizon, Louise Kao, Paul M Wax

引用次数: 0

QT-Interval Prolongation Associated with Supratherapeutic Guanfacine Concentration: A Case Report. QT间期延长与治疗浓度过高的关法辛有关：病例报告。

IF 2.9 4区医学

Journal of Medical Toxicology Pub Date : 2024-04-01 Epub Date: 2024-01-17 DOI: 10.1007/s13181-023-00986-8

Fumiya Inoue, Yuji Okazaki, Kenichiro Kashiwa, Toshihisa Ichiba, Akira Namera

{"title":"QT-Interval Prolongation Associated with Supratherapeutic Guanfacine Concentration: A Case Report.","authors":"Fumiya Inoue, Yuji Okazaki, Kenichiro Kashiwa, Toshihisa Ichiba, Akira Namera","doi":"10.1007/s13181-023-00986-8","DOIUrl":"10.1007/s13181-023-00986-8","url":null,"abstract":"Introduction: Guanfacine, an alpha-2 adrenergic agonist, is used to treat attention deficit hyperactivity disorder (ADHD). Although cardiovascular effects including hypotension and bradycardia are common adverse effects of guanfacine, the effect of guanfacine on QT intervals remains unclear. The association between the serum concentration of guanfacine and its toxicity has also not been fully investigated.Case report: This is a case of a 21-year-old woman with ADHD who developed repeated presyncope 1 day before admission. She was taking 3 mg of extended-release guanfacine and 50 mg of sertraline. On admission, she had bradycardia and hypotension. An electrocardiogram (ECG) showed a QT interval of 0.68 s and a QTcF interval of 0.648 s. The QT intervals were manually measured and corrected by the Fridericia formula (QTcF = QT/RR1/3). Although she denied taking an overdose of guanfacine and other drugs, we suspected guanfacine toxicity. The serum guanfacine concentration was 13.0 ng/mL on admission and decreased to 3.2 ng/mL on day 1 and 0.4 ng/mL on day 2. Changes in QTcF intervals and her vital signs correlated with serum guanfacine concentrations.Conclusion: Supratherapeutic serum guanfacine concentrations may induce QT prolongation.","PeriodicalId":16429,"journal":{"name":"Journal of Medical Toxicology","volume":" ","pages":"218-221"},"PeriodicalIF":2.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10959869/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139478406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toxicity Following Tranexamic Acid Overdose. 氨甲环酸过量引起的中毒。

IF 2.9 4区医学

Journal of Medical Toxicology Pub Date : 2024-04-01 Epub Date: 2024-02-09 DOI: 10.1007/s13181-024-00989-z

James Chenoweth, Stacy Marshall, Justin Lewis, Timothy Albertson

引用次数: 0

2024 ACMT Annual Scientific Meeting Abstracts - Washington, DC. 2024 ACMT 年度科学会议摘要 - 华盛顿特区。

IF 2.9 4区医学

Journal of Medical Toxicology Pub Date : 2024-03-08 DOI: 10.1007/s13181-024-00990-6

引用次数: 0