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Journal of Medical Toxicology最新文献

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Use of Methylene Blue to Treat Hypotension in Poisoned Patients in the Toxicology Investigators Consortium (ToxIC) Core Registry: 2016-2023. 使用亚甲基蓝治疗中毒患者的低血压，毒理学调查协会（ToxIC）核心注册：2016-2023。
IF 2.6 4区 医学
Journal of Medical Toxicology Pub Date : 2026-01-01 Epub Date: 2025-11-08 DOI: 10.1007/s13181-025-01103-7
John D DelBianco, Tyler F Willing, Kira J Galeano, Sierra A Barber, Gillian A Beauchamp, Stephanie E Shara, Alison Sutter, Alexandra M Amaducci
{"title":"Use of Methylene Blue to Treat Hypotension in Poisoned Patients in the Toxicology Investigators Consortium (ToxIC) Core Registry: 2016-2023.","authors":"John D DelBianco, Tyler F Willing, Kira J Galeano, Sierra A Barber, Gillian A Beauchamp, Stephanie E Shara, Alison Sutter, Alexandra M Amaducci","doi":"10.1007/s13181-025-01103-7","DOIUrl":"10.1007/s13181-025-01103-7","url":null,"abstract":"","PeriodicalId":16429,"journal":{"name":"Journal of Medical Toxicology","volume":" ","pages":"44-48"},"PeriodicalIF":2.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145476846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ACMT Position Statement: Determining Brain Death in Adults and Children after Drug Overdose. ACMT立场声明：确定药物过量后成人和儿童的脑死亡。
IF 2.6 4区 医学
Journal of Medical Toxicology Pub Date : 2026-01-01 Epub Date: 2025-12-16 DOI: 10.1007/s13181-025-01115-3
Mark Neavyn, Andrew Stolbach, Laura Tormoehlen
{"title":"ACMT Position Statement: Determining Brain Death in Adults and Children after Drug Overdose.","authors":"Mark Neavyn, Andrew Stolbach, Laura Tormoehlen","doi":"10.1007/s13181-025-01115-3","DOIUrl":"10.1007/s13181-025-01115-3","url":null,"abstract":"","PeriodicalId":16429,"journal":{"name":"Journal of Medical Toxicology","volume":" ","pages":"103-105"},"PeriodicalIF":2.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145762958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Survival of Acute-on-Chronic 2,4-Dinitrophenol Overdose with Associated Pharmacokinetics. 急性对慢性2,4-二硝基苯酚过量与相关药代动力学的生存。
IF 2.6 4区 医学
Journal of Medical Toxicology Pub Date : 2026-01-01 Epub Date: 2025-11-17 DOI: 10.1007/s13181-025-01108-2
Annie Silvester, Zeff Koutsogiannis, Stacey Richards, David Thomson, Anselm Wong
{"title":"Survival of Acute-on-Chronic 2,4-Dinitrophenol Overdose with Associated Pharmacokinetics.","authors":"Annie Silvester, Zeff Koutsogiannis, Stacey Richards, David Thomson, Anselm Wong","doi":"10.1007/s13181-025-01108-2","DOIUrl":"10.1007/s13181-025-01108-2","url":null,"abstract":"<p><strong>Introduction: </strong>2,4-dinitrophenol (DNP) is an uncoupler of oxidative phosphorylation and is highly toxic in overdose.</p><p><strong>Case report: </strong>We present a case of an 18-year-old female who survived an acute-on-chronic DNP overdose resulting in hypermetabolic state and widespread ST depression with associated troponin I elevation. Serial DNP levels are plotted for this patient, demonstrating first order kinetics with a half-life of 18 h.</p><p><strong>Discussion: </strong>Survival in this case may be attributed to early management of hyperthermia and hypermetabolic state, as well as the acute-on-chronic nature of the overdose. Human pharmacokinetic data for DNP in overdose are rare, as are cases with ST-segment changes.</p>","PeriodicalId":16429,"journal":{"name":"Journal of Medical Toxicology","volume":" ","pages":"81-85"},"PeriodicalIF":2.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145541012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Case Files of the Medical Toxicology Fellowship at the Oregon Poison Center: Recurrent Methemoglobinemia Following Polypharmacy Overdose. 俄勒冈毒物中心医学毒理学奖学金的病例档案：多药过量后复发性高铁血红蛋白血症。
IF 2.6 4区 医学
Journal of Medical Toxicology Pub Date : 2026-01-01 Epub Date: 2025-11-11 DOI: 10.1007/s13181-025-01106-4
Samy Chettat, Keahi M Horowitz, Matthew S Correia
{"title":"Case Files of the Medical Toxicology Fellowship at the Oregon Poison Center: Recurrent Methemoglobinemia Following Polypharmacy Overdose.","authors":"Samy Chettat, Keahi M Horowitz, Matthew S Correia","doi":"10.1007/s13181-025-01106-4","DOIUrl":"10.1007/s13181-025-01106-4","url":null,"abstract":"","PeriodicalId":16429,"journal":{"name":"Journal of Medical Toxicology","volume":" ","pages":"86-93"},"PeriodicalIF":2.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145495884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evidence-Based Toxicology-Hypothesis Testing in Randomized Clinical Trials: Part II-Equivalence. 随机临床试验的循证毒理学假设检验：第二部分-等效性。
IF 2.6 4区 医学
Journal of Medical Toxicology Pub Date : 2026-01-01 Epub Date: 2026-01-09 DOI: 10.1007/s13181-025-01110-8
Joshua Trebach, Ali Graebner, Mark K Su
{"title":"Evidence-Based Toxicology-Hypothesis Testing in Randomized Clinical Trials: Part II-Equivalence.","authors":"Joshua Trebach, Ali Graebner, Mark K Su","doi":"10.1007/s13181-025-01110-8","DOIUrl":"10.1007/s13181-025-01110-8","url":null,"abstract":"","PeriodicalId":16429,"journal":{"name":"Journal of Medical Toxicology","volume":" ","pages":"67-69"},"PeriodicalIF":2.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145944549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Donovan Memorial Lecture: 'Fentanyl-Plus': A New Era of Fentanyl Polydrug Combinations in the North American Overdose Crisis. 多诺万纪念讲座：“芬太尼+”：北美过量危机中芬太尼多药组合的新时代。
IF 2 4区 医学
Journal of Medical Toxicology Pub Date : 2026-01-01 Epub Date: 2025-11-10 DOI: 10.1007/s13181-025-01104-6
Daniel Ciccarone
{"title":"The Donovan Memorial Lecture: 'Fentanyl-Plus': A New Era of Fentanyl Polydrug Combinations in the North American Overdose Crisis.","authors":"Daniel Ciccarone","doi":"10.1007/s13181-025-01104-6","DOIUrl":"10.1007/s13181-025-01104-6","url":null,"abstract":"<p><p>The 2025 ACMT Ward and Ryan Donovan Memorial Fund lecture was presented by Daniel Ciccarone, MD, MPH from Department of Family and Community Medicine at the University of California San Francisco (UCSF). This article is an edited version of his keynote address during ACMT's 2025 Annual Scientific Meeting. During the course of his talk, Dr. Ciccarone discussed polysubstance use in the \"Fentanyl-plus\" era. The epidemiology and economics of the four waves of opioid overdose deaths were examined, and promising harm reduction strategies to assist in reducing overdose mortality were highlighted.</p>","PeriodicalId":16429,"journal":{"name":"Journal of Medical Toxicology","volume":" ","pages":"49-62"},"PeriodicalIF":2.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12834897/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145489064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Features of Paralytic Shellfish Poisoning: a Case Series from the 2024 Oregon Outbreak. 麻痹性贝类中毒的临床特征：来自2024年俄勒冈州爆发的病例系列。
IF 2 4区 医学
Journal of Medical Toxicology Pub Date : 2026-01-01 Epub Date: 2025-11-28 DOI: 10.1007/s13181-025-01112-6
Keahi M Horowitz, Colleen P Cowdery, Robert G Hendrickson
{"title":"Clinical Features of Paralytic Shellfish Poisoning: a Case Series from the 2024 Oregon Outbreak.","authors":"Keahi M Horowitz, Colleen P Cowdery, Robert G Hendrickson","doi":"10.1007/s13181-025-01112-6","DOIUrl":"10.1007/s13181-025-01112-6","url":null,"abstract":"<p><p>INTRODUCTION: In Spring 2024, Oregon experienced an outbreak of paralytic shellfish poisoning following ingestion of locally harvested mussels containing elevated saxitoxin concentrations. Prior outbreak reports either do not specify clinical timelines or document variable clinical courses making it difficult to risk stratify patients or determine appropriate clinical monitoring times. We examined cases from this outbreak for symptom progression information that might help guide Poison Center recommendations on management. METHODS: This was a retrospective chart review of cases of paralytic shellfish poisoning reported to the Oregon Poison Center during the outbreak timeframe. Cases were reviewed for time of symptom onset, duration of symptoms, timeline of symptom progression, symptom severity, disposition from the emergency department, need for ventilator support, and number of shellfish ingested. RESULTS: Of eighteen cases reported to the Oregon Poison Center that met the case definition, one was excluded due to insufficient clinical data. Of the seventeen remaining cases, symptom onset occurred as late as 3.5 hours after exposure. Nine cases demonstrated progression of symptoms after initial healthcare contact. All progression to severe symptoms occurred within 6 hours of ingestion. No case demonstrated symptomatic progression beyond 13 hours. There were no deaths. Thirteen cases had a documented number of shellfish ingested, and most had“moderate” symptoms. CONCLUSION: This case series demonstrated symptom onset up to 3.5 hours after exposure and significant symptom progression within 6 hours with no symptomatic progression beyond 13 hours. These data may be useful when considering monitoring and risk-assessment of future cases. </p>","PeriodicalId":16429,"journal":{"name":"Journal of Medical Toxicology","volume":" ","pages":"39-43"},"PeriodicalIF":2.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12835469/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145634771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Introduction to the Donovan Memorial Lecture: 'Fentanyl Plus', A New Era of Fentanyl Polydrug Combinations in the North American Overdose Crisis. 多诺万纪念讲座简介：“芬太尼加”，北美过量危机中芬太尼多药联合的新时代。
IF 2.6 4区 医学
Journal of Medical Toxicology Pub Date : 2026-01-01 Epub Date: 2025-12-20 DOI: 10.1007/s13181-025-01105-5
Leslie Rae Dye
{"title":"Introduction to the Donovan Memorial Lecture: 'Fentanyl Plus', A New Era of Fentanyl Polydrug Combinations in the North American Overdose Crisis.","authors":"Leslie Rae Dye","doi":"10.1007/s13181-025-01105-5","DOIUrl":"10.1007/s13181-025-01105-5","url":null,"abstract":"","PeriodicalId":16429,"journal":{"name":"Journal of Medical Toxicology","volume":" ","pages":"1"},"PeriodicalIF":2.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145800550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evidence-Based Toxicology-Hypothesis Testing in Randomized Clinical Trials: Part I-Superiority. 随机临床试验的循证毒理学假设检验：第一部分：优势。
IF 2.6 4区 医学
Journal of Medical Toxicology Pub Date : 2026-01-01 Epub Date: 2026-01-13 DOI: 10.1007/s13181-025-01109-1
Joshua Trebach, Ali Graebner, Mark K Su
{"title":"Evidence-Based Toxicology-Hypothesis Testing in Randomized Clinical Trials: Part I-Superiority.","authors":"Joshua Trebach, Ali Graebner, Mark K Su","doi":"10.1007/s13181-025-01109-1","DOIUrl":"10.1007/s13181-025-01109-1","url":null,"abstract":"","PeriodicalId":16429,"journal":{"name":"Journal of Medical Toxicology","volume":" ","pages":"63-66"},"PeriodicalIF":2.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145966257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Toxicology Investigators Consortium 2024 Annual Report. 毒理学调查协会2024年年度报告。
IF 2 4区 医学
Journal of Medical Toxicology Pub Date : 2026-01-01 Epub Date: 2026-01-07 DOI: 10.1007/s13181-025-01099-0
Kim Aldy, Shao Li, Mari Costantini, Alyssa Falise, Rachel Culbreth, Paul M Wax, Jeffery Brent
{"title":"The Toxicology Investigators Consortium 2024 Annual Report.","authors":"Kim Aldy, Shao Li, Mari Costantini, Alyssa Falise, Rachel Culbreth, Paul M Wax, Jeffery Brent","doi":"10.1007/s13181-025-01099-0","DOIUrl":"10.1007/s13181-025-01099-0","url":null,"abstract":"<p><p>Established in 2010, the American College of Medical Toxicology (ACMT) Toxicology Investigators Consortium (ToxIC) Core Registry has systematically captured data from in-hospital and clinic-based medical toxicology physician consultations across the United States (US) and internationally. The ToxIC Core Registry contains deidentified patient data, including patient demographics, reason for medical toxicology evaluation, exposure agents, clinical signs and symptoms, treatments and antidotes administered, and mortality outcomes. This fifteenth annual report provides data from 8,868 patients entered into the Core Registry in 2024, bringing the total number of cases to 111,276 between 2010 and 2024. These cases were submitted by 41 participating sites encompassing 67 distinct hospitals over 23 US states and 3 international countries. In 2024, ethanol was the most commonly reported exposure agent class (17.8%), followed by opioids (15.8%), non-opioid analgesics (10.5%), and sympathomimetic agents (7.6%). A total of 107 fatalities were reported, corresponding to a case fatality rate of 1.2%. Additional descriptive analyses in this annual report were conducted to describe trends for opioid and psychoactive exposures between 2010 and 2024.</p>","PeriodicalId":16429,"journal":{"name":"Journal of Medical Toxicology","volume":" ","pages":"2-28"},"PeriodicalIF":2.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12834888/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145917784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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