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Journal of Medical Toxicology最新文献

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A Case of Severe Lead Encephalopathy with Cardiac Arrest Managed During a Chelation Shortage. 一例严重铅中毒性脑病伴心脏骤停的病例。
IF 2.9 4区 医学
Journal of Medical Toxicology Pub Date : 2024-01-01 Epub Date: 2023-10-16 DOI: 10.1007/s13181-023-00970-2
Damilola Idowu, Zachary Gray, Matthew Stanton, William Rushton, David Gummin
{"title":"A Case of Severe Lead Encephalopathy with Cardiac Arrest Managed During a Chelation Shortage.","authors":"Damilola Idowu, Zachary Gray, Matthew Stanton, William Rushton, David Gummin","doi":"10.1007/s13181-023-00970-2","DOIUrl":"10.1007/s13181-023-00970-2","url":null,"abstract":"<p><strong>Introduction: </strong>For many years, the standard of care in the USA has been to treat acute lead encephalopathy with a combination parenteral dimercaprol (BAL) and CaNa<sub>2</sub>EDTA. We present a case of a pediatric patient with severe lead encephalopathy, complicated by cardiac arrest, who was treated with an alternative regimen when CaNa<sub>2</sub>EDTA was unavailable.</p><p><strong>Case report: </strong>A 24-month-old male was brought by ambulance to an emergency department (ED) with new onset seizures and sustained a cardiac arrest. An initial blood lead concentration returned at 263 mcg/dl. The hospital was unable to obtain CaNa<sub>2</sub>EDTA due to the nationwide shortage. For this reason, the patient was chelated with BAL IM for 12 days and dimercaptosuccinic acid (DMSA) for 28 days. He received a second 5-day course of BAL due to rebounding blood lead concentrations. Eight days after cardiac arrest, he was extubated; however, despite ongoing therapy, subsequent follow-up 2 months later demonstrated persistent cognitive deficits.</p><p><strong>Discussion: </strong>The combination of DMSA and BAL was effective in rapidly decreasing whole blood lead concentrations. Drug shortages continue to have implications for the management of poisoned patients. This case highlights how shortages of chelating agents complicate patient care.</p>","PeriodicalId":16429,"journal":{"name":"Journal of Medical Toxicology","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10774239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41236063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: American College of Medical Toxicology and the American Academy of Clinical Toxicology Position Statement: Nalmefene Should Not Replace Naloxone as the Primary Opioid Antidote at This Time. 更正：美国医学毒理学学会和美国临床毒理学学会立场声明：纳美芬目前不应取代纳洛酮作为阿片类药物的主要解毒剂。
IF 2.9 4区 医学
Journal of Medical Toxicology Pub Date : 2024-01-01 DOI: 10.1007/s13181-023-00987-7
Andrew I Stolbach, Maryann Mazer-Amirshahi, Lewis S Nelson, Jon B Cole
{"title":"Correction: American College of Medical Toxicology and the American Academy of Clinical Toxicology Position Statement: Nalmefene Should Not Replace Naloxone as the Primary Opioid Antidote at This Time.","authors":"Andrew I Stolbach, Maryann Mazer-Amirshahi, Lewis S Nelson, Jon B Cole","doi":"10.1007/s13181-023-00987-7","DOIUrl":"10.1007/s13181-023-00987-7","url":null,"abstract":"","PeriodicalId":16429,"journal":{"name":"Journal of Medical Toxicology","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10774307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139048912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
20 Years of JMT: Trying to Catch a Heffalump. 20 Years of JMT: Trying to Catch a Heffalump.
IF 2.9 4区 医学
Journal of Medical Toxicology Pub Date : 2024-01-01 Epub Date: 2023-12-22 DOI: 10.1007/s13181-023-00983-x
Kevin C Osterhoudt
{"title":"20 Years of JMT: Trying to Catch a Heffalump.","authors":"Kevin C Osterhoudt","doi":"10.1007/s13181-023-00983-x","DOIUrl":"10.1007/s13181-023-00983-x","url":null,"abstract":"","PeriodicalId":16429,"journal":{"name":"Journal of Medical Toxicology","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10774459/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138830095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comment on: "Methylene Blue-Induced Serotonin Toxicity: Case Files of the Medical Toxicology Fellowship at the New York City Poison Control Center". 评论:“亚甲基蓝诱导的血清素毒性:纽约市毒物控制中心医学毒理学奖学金的病例档案”。
IF 2.9 4区 医学
Journal of Medical Toxicology Pub Date : 2024-01-01 Epub Date: 2023-11-22 DOI: 10.1007/s13181-023-00978-8
Erin Ryan, Frank Paloucek
{"title":"Comment on: \"Methylene Blue-Induced Serotonin Toxicity: Case Files of the Medical Toxicology Fellowship at the New York City Poison Control Center\".","authors":"Erin Ryan, Frank Paloucek","doi":"10.1007/s13181-023-00978-8","DOIUrl":"10.1007/s13181-023-00978-8","url":null,"abstract":"","PeriodicalId":16429,"journal":{"name":"Journal of Medical Toxicology","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10774515/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138291192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
JMT's 20th Year of Publishing in 2024. 2024 年，JMT 出版 20 年。
IF 2.9 4区 医学
Journal of Medical Toxicology Pub Date : 2024-01-01 Epub Date: 2023-12-15 DOI: 10.1007/s13181-023-00984-w
Mark B Mycyk
{"title":"JMT's 20<sup>th</sup> Year of Publishing in 2024.","authors":"Mark B Mycyk","doi":"10.1007/s13181-023-00984-w","DOIUrl":"10.1007/s13181-023-00984-w","url":null,"abstract":"","PeriodicalId":16429,"journal":{"name":"Journal of Medical Toxicology","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10774513/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138801118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Women and Authorship in Medical Toxicology: Canaries in the Coal Mine. 医学毒理学中的女性与作者：煤矿中的金丝雀
IF 2.9 4区 医学
Journal of Medical Toxicology Pub Date : 2024-01-01 Epub Date: 2024-01-03 DOI: 10.1007/s13181-023-00985-9
Natalie R Neumann, Gillian A Beauchamp
{"title":"Women and Authorship in Medical Toxicology: Canaries in the Coal Mine.","authors":"Natalie R Neumann, Gillian A Beauchamp","doi":"10.1007/s13181-023-00985-9","DOIUrl":"10.1007/s13181-023-00985-9","url":null,"abstract":"","PeriodicalId":16429,"journal":{"name":"Journal of Medical Toxicology","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10774243/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139087255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Methylene Blue-Induced Serotonin Toxicity: Case Files of the Medical Toxicology Fellowship at the New York City Poison Control Center. 亚甲基蓝诱导血清素毒性：纽约市毒物控制中心医学毒理学研究金的案例档案。
IF 2.9 4区 医学
Journal of Medical Toxicology Pub Date : 2024-01-01 Epub Date: 2023-10-12 DOI: 10.1007/s13181-023-00972-0
Corey Hazekamp, Zach Schmitz, Anthony Scoccimarro
{"title":"Methylene Blue-Induced Serotonin Toxicity: Case Files of the Medical Toxicology Fellowship at the New York City Poison Control Center.","authors":"Corey Hazekamp, Zach Schmitz, Anthony Scoccimarro","doi":"10.1007/s13181-023-00972-0","DOIUrl":"10.1007/s13181-023-00972-0","url":null,"abstract":"","PeriodicalId":16429,"journal":{"name":"Journal of Medical Toxicology","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10774363/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41203469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Commercial Delta-8 THC Products: an Analysis of Content and Labeling. 商业Delta-8四氢大麻酚产品：含量和标签分析。
IF 2.9 4区 医学
Journal of Medical Toxicology Pub Date : 2024-01-01 Epub Date: 2023-11-02 DOI: 10.1007/s13181-023-00974-y
Eric E Kaczor, Kevin Greene, Kavita M Babu, Erin C Berthold, Abhisheak Sharma, Stephanie P Carreiro
{"title":"Commercial Delta-8 THC Products: an Analysis of Content and Labeling.","authors":"Eric E Kaczor, Kevin Greene, Kavita M Babu, Erin C Berthold, Abhisheak Sharma, Stephanie P Carreiro","doi":"10.1007/s13181-023-00974-y","DOIUrl":"10.1007/s13181-023-00974-y","url":null,"abstract":"<p><strong>Introduction: </strong>∆-8 tetrahydrocannabinol (THC) is a psychoactive cannabinoid and structural isomer of ∆-9 THC that is technically legal under United States Federal law. Commercial ∆-8-THC products being sold are currently unregulated. This study aims to (1) describe the advertising and labeling of Δ-8 THC retail products; (2) compare the advertised amount of Δ-8 THC for each product to that found during independent laboratory analysis; and (3) evaluate the presence and amount of other cannabinoids in those products.</p><p><strong>Methods: </strong>Twenty ∆-8 THC products were purchased from retail stores in Pittsburgh, PA, USA. Samples were analyzed to determine cannabinoid content using a validated UPLC-MS/MS method. Descriptive statistics were calculated for all variables. Spearman's rank order correlation was calculated for the labeled ∆-8 THC content compared to ∆-8 THC content found on our analysis. Differences in continuous variables were compared using ANOVA, Wilcoxon Rank Sum, or Kruskal-Wallis tests.</p><p><strong>Results: </strong>∆-8 THC was detected in 95% (N=19) of the sample products. A weakly positive correlation (Spearman's rho =0.40) was found between the advertised ∆-8 THC content and our analysis results. Factors associated with decreased difference in these variables included (1) solid matrix (chocolate, gummies) and (2) absence of a \"lab-tested\" label. Δ-9 THC was found in 35% (N=7) of the products, and CBD was found in one.</p><p><strong>Conclusion: </strong>A majority of the products analyzed contained ∆-8 THC in amounts that could cause intoxication. The range of ∆-8 THC content on independent analysis was wide and weakly correlated to the advertised content. ∆-8 THC, ∆-9 THC, and CBD were the only cannabinoids detected.</p>","PeriodicalId":16429,"journal":{"name":"Journal of Medical Toxicology","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10774316/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71424279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
American College of Medical Toxicology and the American Academy of Clinical Toxicology Position Statement: Nalmefene Should Not Replace Naloxone as the Primary Opioid Antidote at This Time. 美国医学毒理学学院和美国临床毒理学学会立场声明:纳美芬目前不应取代纳洛酮作为主要的阿片类解毒剂。
IF 2.9 4区 医学
Journal of Medical Toxicology Pub Date : 2024-01-01 Epub Date: 2023-11-30 DOI: 10.1007/s13181-023-00981-z
Andrew I Stolbach, Maryann Mazer-Amirshahi, Lewis S Nelson, Jon B Cole
{"title":"American College of Medical Toxicology and the American Academy of Clinical Toxicology Position Statement: Nalmefene Should Not Replace Naloxone as the Primary Opioid Antidote at This Time.","authors":"Andrew I Stolbach, Maryann Mazer-Amirshahi, Lewis S Nelson, Jon B Cole","doi":"10.1007/s13181-023-00981-z","DOIUrl":"10.1007/s13181-023-00981-z","url":null,"abstract":"","PeriodicalId":16429,"journal":{"name":"Journal of Medical Toxicology","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138460454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Poison Pen: A Primer to Writing Letters to the Editor. 毒笔:给编辑写信入门。
IF 2.9 4区 医学
Journal of Medical Toxicology Pub Date : 2024-01-01 Epub Date: 2023-11-27 DOI: 10.1007/s13181-023-00977-9
Paul F Ehlers, Lewis S Nelson
{"title":"The Poison Pen: A Primer to Writing Letters to the Editor.","authors":"Paul F Ehlers, Lewis S Nelson","doi":"10.1007/s13181-023-00977-9","DOIUrl":"10.1007/s13181-023-00977-9","url":null,"abstract":"","PeriodicalId":16429,"journal":{"name":"Journal of Medical Toxicology","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10774453/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138444908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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