{"title":"Articles You Might Have Missed.","authors":"Christopher P Mitchell, Elizabeth G Shanahan","doi":"10.1007/s13181-023-00959-x","DOIUrl":"https://doi.org/10.1007/s13181-023-00959-x","url":null,"abstract":"","PeriodicalId":16429,"journal":{"name":"Journal of Medical Toxicology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2023-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9935113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Poison Centers and Pediatric Environmental Health Specialty Units: Productive Two-Way Partnerships.","authors":"Alan D Woolf, Carl R Baum, Michele Burns","doi":"10.1007/s13181-023-00942-6","DOIUrl":"10.1007/s13181-023-00942-6","url":null,"abstract":"","PeriodicalId":16429,"journal":{"name":"Journal of Medical Toxicology","volume":"19 3","pages":"241-243"},"PeriodicalIF":2.5,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10293540/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9705101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Christy Williams, Barbara Elena Sahagún, Mark K Su
{"title":"Biostatistics and Epidemiology Principles for the Toxicologist: The \"Testy\" Test Characteristics Part II: Positive Predictive Value and Negative Predictive Value.","authors":"Christy Williams, Barbara Elena Sahagún, Mark K Su","doi":"10.1007/s13181-023-00953-3","DOIUrl":"10.1007/s13181-023-00953-3","url":null,"abstract":"","PeriodicalId":16429,"journal":{"name":"Journal of Medical Toxicology","volume":"19 3","pages":"298-302"},"PeriodicalIF":2.5,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10293502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10065242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nicklaus Brandehoff, Alicia Dalton, Claire Daugherty, Richard C Dart, Andrew A Monte
{"title":"Total CroFab and Anavip Antivenom Vial Administration in US Rattlesnake Envenomations: 2019-2021.","authors":"Nicklaus Brandehoff, Alicia Dalton, Claire Daugherty, Richard C Dart, Andrew A Monte","doi":"10.1007/s13181-023-00941-7","DOIUrl":"https://doi.org/10.1007/s13181-023-00941-7","url":null,"abstract":"<p><strong>Introduction: </strong>In 2018, Anavip became available for the treatment of rattlesnake envenomations in the USA. No comparisons between the treatment characteristics of patients have been made since Anavip and CroFab have both been widely available. The objective of this study was to compare the number of antivenom vials administered of CroFab and Anavip during the treatment of rattlesnake envenomations in the USA.</p><p><strong>Methods: </strong>This was a secondary analysis of rattlesnake envenomations utilizing the North American Snakebite Registry (NASBR) from 2019 through 2021. Frequencies and proportions were used to summarize demographics and baseline clinical characteristics. The primary outcome was total antivenom vials administered during treatment. Secondary outcomes included the number antivenom administration events, total treatment time, and hospital length of stay.</p><p><strong>Results: </strong>Two hundred ninety-one rattlesnake envenomations were analyzed; most occurred in the Western USA (n = 279, 96 %). One hundred one patients (35%) received only CroFab, 110 (38%) received Anavip only, and 80 (27%) received both products. The median number of vials used was 10 for CroFab, 18 for Anavip, and 20 for both antivenoms. More than one antivenom administration was necessary in thirty-nine (39%) patients that received only CroFab and 76 (69%) patients that received Anavip only. The median total treatment time was 5.5 hours for CroFab, 6.5 for Anavip, and 15.5 hours when both antivenoms were administered. All antivenom groups had a median hospital length of stay of 2 days.</p><p><strong>Conclusions: </strong>Rattlesnake envenomated patients in the Western USA treated with CroFab had fewer antivenom vials and fewer antivenom administrations compared to patients treated with Anavip.</p>","PeriodicalId":16429,"journal":{"name":"Journal of Medical Toxicology","volume":"19 3","pages":"248-254"},"PeriodicalIF":2.9,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10293487/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9706767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luciana Mello de Oliveira, Tatiane da Silva Dal Pizzol
{"title":"Comment on \"Tacrolimus Drug-Drug Interaction with Nirmatrelvir/Ritonavir (Paxlovid™) Managed with Phenytoin\".","authors":"Luciana Mello de Oliveira, Tatiane da Silva Dal Pizzol","doi":"10.1007/s13181-023-00936-4","DOIUrl":"https://doi.org/10.1007/s13181-023-00936-4","url":null,"abstract":"","PeriodicalId":16429,"journal":{"name":"Journal of Medical Toxicology","volume":"19 3","pages":"307-308"},"PeriodicalIF":2.9,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10054184/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9696998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maryann Mazer-Amirshahi, Peggy Ye, Andrew Stolbach
{"title":"Keeping Safe and Effective Medications Accessible.","authors":"Maryann Mazer-Amirshahi, Peggy Ye, Andrew Stolbach","doi":"10.1007/s13181-023-00949-z","DOIUrl":"10.1007/s13181-023-00949-z","url":null,"abstract":"","PeriodicalId":16429,"journal":{"name":"Journal of Medical Toxicology","volume":"19 3","pages":"244-245"},"PeriodicalIF":2.5,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10293496/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10064675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pharmaceutical Purchasing: a Review of the Landscape and Implications for Antidotal Therapies.","authors":"Andrew Troger, Michele M Burns","doi":"10.1007/s13181-023-00943-5","DOIUrl":"10.1007/s13181-023-00943-5","url":null,"abstract":"<p><p>The management of the poisoned patient often requires the utilization of uncommonly used pharmaceutical interventions. These interventions can be associated with significant costs to both the patient and treating institution. Pharmaceutical supply shortages and issues with accessibility of antidotal therapies complicate the management of many toxic exposures. These challenges are an inherent property of the pharmaceutical purchasing infrastructure in the United States, which is a complicated network of public and private intra-institutional agreements. The cost and availability of any given therapy is dependent on the individual contracting agreements between the treating institution, payer, pharmacy benefit manager, manufacturer or wholesaler, and in some cases a specialty pharmacy. Small or remote hospitals may experience greater challenges related to insufficient patient volume to achieve predicable prescribing patterns of rare and expensive medications, necessitating consignment purchasing arrangements. Although pharmaceutical costs are the focus of recent legislative attention, these reforms are not expected to significantly alter the cost or availability of antidotal therapies.</p>","PeriodicalId":16429,"journal":{"name":"Journal of Medical Toxicology","volume":"19 3","pages":"262-267"},"PeriodicalIF":2.5,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10293135/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9707337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andrew I Stolbach, Paul I Dargan, Howard A Greller, Richard J Hamilton, Kelly Johnson-Arbor, Brian Patrick Murray, Daniel Ovakim, Laura Tormoehlen, Lewis S Nelson
{"title":"ACMT Position Statement: End the Use of the Term \"Excited Delirium\".","authors":"Andrew I Stolbach, Paul I Dargan, Howard A Greller, Richard J Hamilton, Kelly Johnson-Arbor, Brian Patrick Murray, Daniel Ovakim, Laura Tormoehlen, Lewis S Nelson","doi":"10.1007/s13181-023-00944-4","DOIUrl":"10.1007/s13181-023-00944-4","url":null,"abstract":"","PeriodicalId":16429,"journal":{"name":"Journal of Medical Toxicology","volume":"19 3","pages":"310-312"},"PeriodicalIF":2.5,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10293509/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10070033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Michael Keenan, Stephen Rice, Emma Frawley, Chelsie Jacques, Susan Wojcik, Jeanna Marraffa
{"title":"Rate of Adverse Outcomes During 6-Hour Observation for Asymptomatic Patients with Select Ingestions.","authors":"Michael Keenan, Stephen Rice, Emma Frawley, Chelsie Jacques, Susan Wojcik, Jeanna Marraffa","doi":"10.1007/s13181-023-00954-2","DOIUrl":"10.1007/s13181-023-00954-2","url":null,"abstract":"","PeriodicalId":16429,"journal":{"name":"Journal of Medical Toxicology","volume":"19 3","pages":"288-292"},"PeriodicalIF":2.5,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10293546/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9762354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Rivastigmine Use in the Treatment of Antimuscarinic Delirium.","authors":"Spencer C Greene","doi":"10.1007/s13181-023-00947-1","DOIUrl":"10.1007/s13181-023-00947-1","url":null,"abstract":"","PeriodicalId":16429,"journal":{"name":"Journal of Medical Toxicology","volume":"19 3","pages":"284-287"},"PeriodicalIF":2.5,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10293131/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10083271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}