Luciana Mello de Oliveira, Tatiane da Silva Dal Pizzol
{"title":"Comment on \"Tacrolimus Drug-Drug Interaction with Nirmatrelvir/Ritonavir (Paxlovid™) Managed with Phenytoin\".","authors":"Luciana Mello de Oliveira, Tatiane da Silva Dal Pizzol","doi":"10.1007/s13181-023-00936-4","DOIUrl":"https://doi.org/10.1007/s13181-023-00936-4","url":null,"abstract":"","PeriodicalId":16429,"journal":{"name":"Journal of Medical Toxicology","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10054184/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9696998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maryann Mazer-Amirshahi, Peggy Ye, Andrew Stolbach
{"title":"Keeping Safe and Effective Medications Accessible.","authors":"Maryann Mazer-Amirshahi, Peggy Ye, Andrew Stolbach","doi":"10.1007/s13181-023-00949-z","DOIUrl":"10.1007/s13181-023-00949-z","url":null,"abstract":"","PeriodicalId":16429,"journal":{"name":"Journal of Medical Toxicology","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10293496/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10064675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pharmaceutical Purchasing: a Review of the Landscape and Implications for Antidotal Therapies.","authors":"Andrew Troger, Michele M Burns","doi":"10.1007/s13181-023-00943-5","DOIUrl":"10.1007/s13181-023-00943-5","url":null,"abstract":"<p><p>The management of the poisoned patient often requires the utilization of uncommonly used pharmaceutical interventions. These interventions can be associated with significant costs to both the patient and treating institution. Pharmaceutical supply shortages and issues with accessibility of antidotal therapies complicate the management of many toxic exposures. These challenges are an inherent property of the pharmaceutical purchasing infrastructure in the United States, which is a complicated network of public and private intra-institutional agreements. The cost and availability of any given therapy is dependent on the individual contracting agreements between the treating institution, payer, pharmacy benefit manager, manufacturer or wholesaler, and in some cases a specialty pharmacy. Small or remote hospitals may experience greater challenges related to insufficient patient volume to achieve predicable prescribing patterns of rare and expensive medications, necessitating consignment purchasing arrangements. Although pharmaceutical costs are the focus of recent legislative attention, these reforms are not expected to significantly alter the cost or availability of antidotal therapies.</p>","PeriodicalId":16429,"journal":{"name":"Journal of Medical Toxicology","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10293135/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9707337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andrew I Stolbach, Paul I Dargan, Howard A Greller, Richard J Hamilton, Kelly Johnson-Arbor, Brian Patrick Murray, Daniel Ovakim, Laura Tormoehlen, Lewis S Nelson
{"title":"ACMT Position Statement: End the Use of the Term \"Excited Delirium\".","authors":"Andrew I Stolbach, Paul I Dargan, Howard A Greller, Richard J Hamilton, Kelly Johnson-Arbor, Brian Patrick Murray, Daniel Ovakim, Laura Tormoehlen, Lewis S Nelson","doi":"10.1007/s13181-023-00944-4","DOIUrl":"10.1007/s13181-023-00944-4","url":null,"abstract":"","PeriodicalId":16429,"journal":{"name":"Journal of Medical Toxicology","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10293509/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10070033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Michael Keenan, Stephen Rice, Emma Frawley, Chelsie Jacques, Susan Wojcik, Jeanna Marraffa
{"title":"Rate of Adverse Outcomes During 6-Hour Observation for Asymptomatic Patients with Select Ingestions.","authors":"Michael Keenan, Stephen Rice, Emma Frawley, Chelsie Jacques, Susan Wojcik, Jeanna Marraffa","doi":"10.1007/s13181-023-00954-2","DOIUrl":"10.1007/s13181-023-00954-2","url":null,"abstract":"","PeriodicalId":16429,"journal":{"name":"Journal of Medical Toxicology","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10293546/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9762354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Rivastigmine Use in the Treatment of Antimuscarinic Delirium.","authors":"Spencer C Greene","doi":"10.1007/s13181-023-00947-1","DOIUrl":"10.1007/s13181-023-00947-1","url":null,"abstract":"","PeriodicalId":16429,"journal":{"name":"Journal of Medical Toxicology","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10293131/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10083271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Morganne Sindelar, Daniel McCabe, Elisabeth Carroll
{"title":"Response to Comment on \"Tacrolimus Drug-Drug Interaction with Nirmatrelvir/Ritonavir (Paxlovid™) Managed with Phenytoin\".","authors":"Morganne Sindelar, Daniel McCabe, Elisabeth Carroll","doi":"10.1007/s13181-023-00940-8","DOIUrl":"https://doi.org/10.1007/s13181-023-00940-8","url":null,"abstract":"","PeriodicalId":16429,"journal":{"name":"Journal of Medical Toxicology","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10054203/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9694409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elisabeth Canitrot, Alexis F Turgeon, Lynne Moore, Ella Diendéré, Maude St-Onge
{"title":"Effect of Taste Additives on the Palatability of Activated Charcoal: a Systematic Review.","authors":"Elisabeth Canitrot, Alexis F Turgeon, Lynne Moore, Ella Diendéré, Maude St-Onge","doi":"10.1007/s13181-023-00934-6","DOIUrl":"10.1007/s13181-023-00934-6","url":null,"abstract":"<p><strong>Introduction: </strong>Activated charcoal is a decontaminating agent used for acute intoxication. It can be mixed with taste additives to overcome its poor palatability. Our purpose was to evaluate the taste additives used to improve activated charcoal's palatability.</p><p><strong>Methods: </strong>We conducted a systematic review of comparative studies on taste additives used to improve activated charcoal's palatability. We searched PubMed, Embase, Web of Science, Cochrane, and CINAHL. We included controlled trials and observational studies that evaluate the effect of at least one taste additive, compared with activated charcoal alone. Our primary outcome was palatability. Our secondary outcomes included treatment adherence, adsorption efficacy, and adverse events. The risk of bias was assessed using the Quality Assessment Tool for Quantitative Studies.</p><p><strong>Results: </strong>Among 38 eligible articles, seven observational studies and three crossover clinical trials met our inclusion criteria. The risk of bias was found to be high for seven studies and intermediate for three others. The preferred flavoring agents were cola and chocolate milk for children, and sweetening agents for adults. All taste additives studied seemed to improve activated charcoal's palatability, except for yogurt (n = 1). The addition of bentonite, sorbitol, carboxymethylcellulose, or yogurt showed no impact on the in-vivo adsorption capacity of activated charcoal, whereas the results were inconclusive for chocolate. No meta-analysis was performed due to insufficient data.</p><p><strong>Conclusion: </strong>Strategies to improve activated charcoal's palatability seem to enhance the taste. Descriptive data are in favor of a limited impact on activated charcoal's adsorption capacity when adding binding agents or sweeteners.</p><p><strong>Trial registration on prospero: </strong>This review is registered as PROSPERO CRD42019135092.</p>","PeriodicalId":16429,"journal":{"name":"Journal of Medical Toxicology","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10293545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9696876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Drug Shortages Negatively Impact Health Systems and Bedside Patient Care.","authors":"Joanne C Routsolias, Ashley N Webb","doi":"10.1007/s13181-023-00950-6","DOIUrl":"10.1007/s13181-023-00950-6","url":null,"abstract":"","PeriodicalId":16429,"journal":{"name":"Journal of Medical Toxicology","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10293503/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9707021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"ToxRunner: the Development of a Non-commercial Mobile Digital Question Bank for the Graduate Medical Education Sub-specialty of Medical Toxicology.","authors":"Adam Blumenberg","doi":"10.1007/s13181-023-00952-4","DOIUrl":"10.1007/s13181-023-00952-4","url":null,"abstract":"","PeriodicalId":16429,"journal":{"name":"Journal of Medical Toxicology","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10293127/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10083803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}