向美国毒物中心报告的 Delta-8 四氢大麻酚暴露：美国各州和地区之间的差异以及与公共政策的关联。

IF 2.5 4区医学 Q3 TOXICOLOGY

Journal of Medical Toxicology Pub Date : 2024-10-01 Epub Date: 2024-08-21 DOI:10.1007/s13181-024-01030-z

Gary A Smith, Alice Burgess, Jaahnavi Badeti, Natalie I Rine, Christopher E Gaw, Leah K Middelberg, Henry A Spiller, Hannah L Hays

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引用次数: 0

摘要

简介：本研究调查了向美国毒物中心（PCs）报告的涉及∆8-四氢大麻酚（∆8-THC）的暴露情况，包括各州和各地区之间的差异。该研究评估了在∆8-THC 规定的州和大麻（∆9-THC）使用合法的州，∆8-THC 暴露率是否较低：方法：分析了 2021-2022 年全国毒物数据系统的 ∆8-THC 暴露数据，包括各州和地区人口暴露率的比较：从 2021 年 1 月 1 日到 2022 年 12 月 31 日，美国 PCs 共收到 4925 起以 ∆8-THC 为主要物质的暴露报告，其中 69.8%发生在美国南部。每 10 万美国人口的接触率从 2021 年的 0.53 上升到 2022 年的 0.95，上升了 79.2%。2022 年，在大麻使用非法的各州，每 100,000 人口接触 ∆8-THC 的平均比率为 1.64（95% CI：1.08-2.20），而在大麻使用合法的各州，这一比率为 0.52（95% CI：0.29-0.76）（P = 0.0010）。2022 年，在未∆8-THC 受管制的州，每 100,000 人中接触∆8-THC 的平均比率为 1.36（95% CI：0.95-1.77），而在禁∆8-THC 的州，这一比率为 0.17（95% CI：0.06-0.27）（P = 0.0010）：从 2021 年到 2022 年，美国 PCs 报告的 ∆8-THC 暴露率增加了 79%，其中美国南部占三分之二以上。在禁止使用 ∆8-THC 的州和大麻使用合法的州，向 PC 报告的 ∆8-THC 暴露率明显较低。各州应对 ∆8-THC 采取一致的监管措施。

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Delta-8 Tetrahydrocannabinol Exposures Reported to US Poison Centers: Variations Among US States and Regions and Associations with Public Policy.

Introduction: This study investigated exposures involving ∆8-tetrahydrocannabinol (∆8-THC) reported to US poison centers (PCs), including variation among states and regions. It evaluated whether the ∆8-THC exposure rate was lower among states with ∆8-THC regulations and states where cannabis (∆9-THC) use was legal.

Methods: National Poison Data System data for ∆8-THC exposures in 2021-2022 were analyzed, including comparisons of state and regional population-based exposure rates.

Results: There were 4,925 exposures involving ∆8-THC as the primary substance reported to US PCs from January 1, 2021, to December 31, 2022, with 69.8% of these reported in the US South. The rate of exposure per 100,000 US population increased by 79.2% from 0.53 in 2021 to 0.95 in 2022. In 2022, the mean rate of ∆8-THC exposures in states where cannabis use was illegal was 1.64 per 100,000 population (95% CI: 1.08-2.20) compared with 0.52 (95% CI: 0.29-0.76) in states where cannabis use was legal (P = 0.0010). In 2022, the mean rate of ∆8-THC exposures in states where ∆8-THC was unregulated was 1.36 per 100,000 population (95% CI: 0.95-1.77) compared with 0.17 (95% CI: 0.06-0.27) in states where ∆8-THC was banned (P < 0.0001).

Conclusions: The rate of ∆8-THC exposures reported to US PCs increased by 79% from 2021 to 2022, with the US South accounting for more than two-thirds of exposures. The rate of ∆8-THC exposures reported to PCs was significantly lower among states where ∆8-THC was banned and among states where cannabis use was legal. Consistent regulation of ∆8-THC across all states should be adopted.

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来源期刊

Journal of Medical Toxicology TOXICOLOGY-

CiteScore

5.40

自引率

10.30%

发文量

期刊介绍： Journal of Medical Toxicology (JMT) is a peer-reviewed medical journal dedicated to advances in clinical toxicology, focusing on the diagnosis, management, and prevention of poisoning and other adverse health effects resulting from medications, chemicals, occupational and environmental substances, and biological hazards. As the official journal of the American College of Medical Toxicology (ACMT), JMT is managed by an editorial board of clinicians as well as scientists and thus publishes research that is relevant to medical toxicologists, emergency physicians, critical care specialists, pediatricians, pre-hospital providers, occupational physicians, substance abuse experts, veterinary toxicologists, and policy makers. JMT articles generate considerable interest in the lay media, with 2016 JMT articles cited by various social media sites, the Boston Globe, and the Washington Post among others. For questions or comments about the journal, please contact jmtinfo@acmt.net. For questions or comments about the journal, please contact jmtinfo@acmt.net.