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Generation of monoclonal antibodies against PBP2a to improve diagnosis and potential treatment of MRSA infections 生成针对PBP2a的单克隆抗体以提高MRSA感染的诊断和潜在治疗
Gastroenterology & Hepatology: Open Access Pub Date : 2023-02-09 DOI: 10.15406/ghoa.2023.14.00536
Manal M E Ahmed, A. Noureen, Ayesha Rafiq
{"title":"Generation of monoclonal antibodies against PBP2a to improve diagnosis and potential treatment of MRSA infections","authors":"Manal M E Ahmed, A. Noureen, Ayesha Rafiq","doi":"10.15406/ghoa.2023.14.00536","DOIUrl":"https://doi.org/10.15406/ghoa.2023.14.00536","url":null,"abstract":"Background: MRSA is a type of MDR bacterium. All around the world, it leads to significant nosocomial and community-acquired diseases. The discovery of fresh ideas is very important because there are so few effective treatments for MRSA infections. PBP2a is a great candidate for the development of MRSA-specific Mabs. Aim: The purpose of this study was to create murine Mabs against PBP2a in order to enhance MRSA laboratory detection and possibly treatment. Methods: Anti-PBP2a MAb was tested for biodistribution, therapeutic, and preventative effects in comparison to vancomycin. After receiving anti-PBP2a MAb therapy, biodistribution was assessed between 12 and 96 hours later. Results: During the observation timepoints, the majority of the generated MAb stayed in the serum and just a tiny fraction was found in the kidneys, lungs, and spleen. A prophylactic experiment in mice given the lethal dosage 50 (LD50) found that treated animals with anti-PBP2a MAb had a greater survival rate than the control group. In a therapeutic experiment, one dosage of anti-PBP2a MAb reduced bacterial load in the kidneys similarly to the group treated with five doses of vancomycin, and a combination therapy with anti-PBP2a MAb and vancomycin was more effective than either drug used alone. Conclusion: The findings of this study suggested that an anti-PBP2a MAb may be extremely useful in the creation of innovative diagnostic tools and promising treatments for preventative and therapeutic measures against MRSA infections.","PeriodicalId":163845,"journal":{"name":"Gastroenterology & Hepatology: Open Access","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116739735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting redox system in liver cancer 靶向肝癌氧化还原系统
Gastroenterology & Hepatology: Open Access Pub Date : 2023-01-30 DOI: 10.15406/ghoa.2023.14.00534
Zaved Ahmad, S. K. Mishra
{"title":"Targeting redox system in liver cancer","authors":"Zaved Ahmad, S. K. Mishra","doi":"10.15406/ghoa.2023.14.00534","DOIUrl":"https://doi.org/10.15406/ghoa.2023.14.00534","url":null,"abstract":"","PeriodicalId":163845,"journal":{"name":"Gastroenterology & Hepatology: Open Access","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121502304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Heat shock proteins as diagnostic markers for hepatocellular carcinoma: a novel approach 热休克蛋白作为肝细胞癌的诊断标志物:一种新的方法
Gastroenterology & Hepatology: Open Access Pub Date : 2023-01-30 DOI: 10.15406/ghoa.2023.14.00535
Haniya Waseem, Asharib Arshad, Mariam Tariq Awana, Hifza Masood
{"title":"Heat shock proteins as diagnostic markers for hepatocellular carcinoma: a novel approach","authors":"Haniya Waseem, Asharib Arshad, Mariam Tariq Awana, Hifza Masood","doi":"10.15406/ghoa.2023.14.00535","DOIUrl":"https://doi.org/10.15406/ghoa.2023.14.00535","url":null,"abstract":"Hepatocellular carcinoma (HCC) is a malignant tumor of the liver. Heat shock proteins play their part in response to cellular stress. They are overexpressed in many forms of cancers where they shield malignant cells from stressful environment thus contributing to poor prognosis and treatment resistance. HSP 27, a heat shock protein mostly associated with Hepatitis induced hepatocellular cancer, inhibits apoptosis and HSP 70 along with HSP 90 contributes to tumor metastasis. HSP 70 count is higher in tumor cells in comparison with normal cells and it is related to tumor size, stage and vessel invasion while HSP 20 count regresses as tumor progresses. Considering all these factors, differentiation of HCC from other liver pathologies becomes much easier at an early stage. Early diagnosis of HCC is important and timely and prompt treatment can decrease the mortality associated with HCC. On the grounds of many useful characteristics like early detection and accuracy in detailing of size, invasion and metastasis of tumor our Review suggests that along with it all HSPs also have therapeutic potential as targeting the specific markers can help patients diagnosed with HCC. HSPs are the innovation from diagnosis to management to cure of HCC. Extensive research exploring Heat Shock Proteins and Hepatocellular Carcinoma was done on search engines such as Science Direct, OVID, Google Scholar, PubMed, and MEDLINE. Articles published in languages other than English were also considered. Data that were solely published in conference or meeting proceedings, websites, or books were not included.","PeriodicalId":163845,"journal":{"name":"Gastroenterology & Hepatology: Open Access","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126187545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Insulin resistance, the unbrowning of brown adipose tissue and beige adipose tissue development in obese and obese-diabetic rats: Is there a link? 肥胖和肥胖糖尿病大鼠的胰岛素抵抗、棕色脂肪组织不褐变和米色脂肪组织发育:有联系吗?
Gastroenterology & Hepatology: Open Access Pub Date : 2023-01-11 DOI: 10.15406/ghoa.2023.14.00532
{"title":"Insulin resistance, the unbrowning of brown adipose tissue and beige adipose tissue development in obese and obese-diabetic rats: Is there a link?","authors":"","doi":"10.15406/ghoa.2023.14.00532","DOIUrl":"https://doi.org/10.15406/ghoa.2023.14.00532","url":null,"abstract":"","PeriodicalId":163845,"journal":{"name":"Gastroenterology & Hepatology: Open Access","volume":"94 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128575385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Innovative immune checkpoint inhibitors (ICIs) for cancer treatment: an overview 创新免疫检查点抑制剂(ICIs)用于癌症治疗:综述
Gastroenterology & Hepatology: Open Access Pub Date : 2023-01-06 DOI: 10.15406/ghoa.2023.14.00531
M. M. Ahmed
{"title":"Innovative immune checkpoint inhibitors (ICIs) for cancer treatment: an overview","authors":"M. M. Ahmed","doi":"10.15406/ghoa.2023.14.00531","DOIUrl":"https://doi.org/10.15406/ghoa.2023.14.00531","url":null,"abstract":"","PeriodicalId":163845,"journal":{"name":"Gastroenterology & Hepatology: Open Access","volume":"129 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115890770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sofosbuvir/Velpatasvir fixed dose combination in Indian patients with chronic hepatitis c virus (HCV) infection: an open-label, single-arm, multicenter phase IV study 索非布韦/维帕他韦固定剂量联合治疗印度慢性丙型肝炎病毒(HCV)感染患者:一项开放标签、单臂、多中心的IV期研究
Gastroenterology & Hepatology: Open Access Pub Date : 2022-12-22 DOI: 10.15406/ghoa.2022.13.00528
Parika Amardev Kalra, A. Konar, Hemant Gupta, Jignesh Babulal Patel, Macherla Ramanna Macherla Ramanna, Omesh Goya Omesh Goya, Shravan Kumar P, Praveen Sharma, R. Baijal, Rakesh P. Patel, Sandeep Shamrao Kulkarni Sandeep Shamrao Kulkarni, Sanjeev Hegde, Saumin Shah, Sanjay Hadigal, S. Vijayaraghavan
{"title":"Sofosbuvir/Velpatasvir fixed dose combination in Indian patients with chronic hepatitis c virus (HCV) infection: an open-label, single-arm, multicenter phase IV study","authors":"Parika Amardev Kalra, A. Konar, Hemant Gupta, Jignesh Babulal Patel, Macherla Ramanna Macherla Ramanna, Omesh Goya Omesh Goya, Shravan Kumar P, Praveen Sharma, R. Baijal, Rakesh P. Patel, Sandeep Shamrao Kulkarni Sandeep Shamrao Kulkarni, Sanjeev Hegde, Saumin Shah, Sanjay Hadigal, S. Vijayaraghavan","doi":"10.15406/ghoa.2022.13.00528","DOIUrl":"https://doi.org/10.15406/ghoa.2022.13.00528","url":null,"abstract":"Background: This Phase IV post-marketing study was conducted to demonstrate the safety and efficacy of sofosbuvir/velpatasvir fixed-dose combination (FDC) in adult Indian patients with HCV infection as per the recommendation of the Drugs Controller General (India). Methods: This single-arm, open-label, multicenter study was conducted across 22 sites in 409 patients in India. All the eligible patients received once-daily sofosbuvir/velpatasvir (400mg/100mg) FDC for 12weeks. Safety was assessed by monitoring the adverse events (AEs) and efficacy was measured by the proportion of patients achieving sustained virological response (HCV RNA <15 IU/mL or undetectable) at 12weeks after the end of the treatment (SVR12). Results: Between October 2018 to June 2020, 409 patients were enrolled. Twenty patients discontinued the study due to consent withdrawal or lost to follow-up. The SVR12 rate was 90.8%. Sensitivity analysis showed consistent results with SVR12 rates of more than 93%. The combination was well tolerated and none of the AEs reported were related to the study drug, requiring dose reduction, or discontinuation of the study treatment. Conclusions: Once daily sofosbuvir/velpatasvir FDC for 12 weeks was found to be safe, well tolerated, and effective in patients with HCV infection. Trial Registration: The trial is registered at clinical trial registry of India with registration number CTRI/2018/08/015359. (CTRI Trial Data)","PeriodicalId":163845,"journal":{"name":"Gastroenterology &amp; Hepatology: Open Access","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132500514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chronic hepatitis B infection: what to do when TDF is not enough to treat? 慢性乙型肝炎感染:当TDF不足以治疗时该怎么办?
Gastroenterology &amp; Hepatology: Open Access Pub Date : 2022-12-05 DOI: 10.15406/ghoa.2022.13.00529
Sara Casanova Sara Casanova, A. Miranda, E. Pádua, Kamal Mansinho Kamal Mansinho, R. Côrte-Real
{"title":"Chronic hepatitis B infection: what to do when TDF is not enough to treat?","authors":"Sara Casanova Sara Casanova, A. Miranda, E. Pádua, Kamal Mansinho Kamal Mansinho, R. Côrte-Real","doi":"10.15406/ghoa.2022.13.00529","DOIUrl":"https://doi.org/10.15406/ghoa.2022.13.00529","url":null,"abstract":"<jats:p>,1</jats:p>","PeriodicalId":163845,"journal":{"name":"Gastroenterology &amp; Hepatology: Open Access","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129681255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of fecal incontinence symptoms in adult women and impact on their quality of life 成年女性大便失禁症状的评价及其对生活质量的影响
Gastroenterology &amp; Hepatology: Open Access Pub Date : 2022-11-07 DOI: 10.15406/ghoa.2022.13.0052
Matheus Massahud Matheus Massahud
{"title":"Evaluation of fecal incontinence symptoms in adult women and impact on their quality of life","authors":"Matheus Massahud Matheus Massahud","doi":"10.15406/ghoa.2022.13.0052","DOIUrl":"https://doi.org/10.15406/ghoa.2022.13.0052","url":null,"abstract":"Fecal incontinence is an important complaint with great impact in patient’s quality of life. Its cause is multifactorial, its diagnosis greatly underestimated, and its prevalence increases with age. Fecal incontinence is defined as any involuntary loss of feces – liquid or solid – or gas in patients older than 4years of age. Fecal incontinence can be present in up to 15% of patients older than 70years. Only 10 to 30% of symptomatic patients seek medical attention. Up to 40% of symptomatic women have major fecal incontinence with even greater impact on quality of life. Health care professionals’ awareness and patient information are paramount for diagnosis and treatment of the issue.","PeriodicalId":163845,"journal":{"name":"Gastroenterology &amp; Hepatology: Open Access","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114245685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MRSA infections: priorities and future approaches for research MRSA感染:研究的重点和未来的方法
Gastroenterology &amp; Hepatology: Open Access Pub Date : 2022-11-04 DOI: 10.15406/ghoa.2022.13.00523
M. M. Ahmed
{"title":"MRSA infections: priorities and future approaches for research","authors":"M. M. Ahmed","doi":"10.15406/ghoa.2022.13.00523","DOIUrl":"https://doi.org/10.15406/ghoa.2022.13.00523","url":null,"abstract":"","PeriodicalId":163845,"journal":{"name":"Gastroenterology &amp; Hepatology: Open Access","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130249545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The outcome of acute pancreatitis patients with acute kidney injury- Single centre study from North India 急性胰腺炎合并急性肾损伤患者的预后——北印度单中心研究
Gastroenterology &amp; Hepatology: Open Access Pub Date : 2022-11-04 DOI: 10.15406/ghoa.2022.13.00522
P. Mathur
{"title":"The outcome of acute pancreatitis patients with acute kidney injury- Single centre study from North India","authors":"P. Mathur","doi":"10.15406/ghoa.2022.13.00522","DOIUrl":"https://doi.org/10.15406/ghoa.2022.13.00522","url":null,"abstract":"","PeriodicalId":163845,"journal":{"name":"Gastroenterology &amp; Hepatology: Open Access","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125425577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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