Journal of Movement Disorders最新文献

{"title":"Caregiver Burden of Patients With Huntington's Disease in South Korea.","authors":"Chan Young Lee, Chaewon Shin, Yun Su Hwang, Eungseok Oh, Manho Kim, Hyun Sook Kim, Sun Ju Chung, Young Hee Sung, Won Tae Yoon, Jin Whan Cho, Jae-Hyeok Lee, Han-Joon Kim, Hee Jin Chang, Beomseok Jeon, Kyung Ah Woo, Seong-Beom Koh, Kyum-Yil Kwon, Jangsup Moon, Young Eun Kim, Jee-Young Lee","doi":"10.14802/jmd.23134","DOIUrl":"10.14802/jmd.23134","url":null,"abstract":"<p><strong>Objective: </strong>This is the first prospective cohort study of Huntington's disease (HD) in Korea. This study aimed to investigate the caregiver burden in relation to the characteristics of patients and caregivers.</p><p><strong>Methods: </strong>From August 2020 to February 2022, we enrolled patients with HD from 13 university hospitals in Korea. We used the 12-item Zarit Burden Interview (ZBI-12) to evaluate the caregiver burden. We evaluated the clinical associations of the ZBI-12 scores by linear regression analysis and investigated the differences between the low- and high-burden groups.</p><p><strong>Results: </strong>Sixty-five patients with HD and 45 caregivers were enrolled in this cohort study. The average age at onset of motor symptoms was 49.3 ± 12.3 years, with an average cytosine-adenine-guanine (CAG)n of 42.9 ± 4.0 (38-65). The median ZBI-12 score among our caregivers was 17.6 ± 14.2. A higher caregiver burden was associated with a more severe Shoulson-Fahn stage (p = 0.038) of the patients. A higher ZBI-12 score was also associated with lower independence scale (B = -0.154, p = 0.006) and functional capacity (B = -1.082, p = 0.002) scores of patients. The caregiving duration was longer in the high- than in the low-burden group. Caregivers' demographics, blood relation, and marital and social status did not affect the burden significantly.</p><p><strong>Conclusion: </strong>HD patients' neurological status exerts an enormous impact on the caregiver burden regardless of the demographic or social status of the caregiver. This study emphasizes the need to establish an optimal support system for families dealing with HD in Korea. A future longitudinal analysis could help us understand how disease progression aggravates the caregiver burden throughout the entire disease course.</p>","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":"30-37"},"PeriodicalIF":3.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10846961/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10193403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Survey of Perspectives on Telemedicine for Patients With Parkinson's Disease.","authors":"Jae Young Joo, Ji Young Yun, Young Eun Kim, Yu Jin Jung, Ryul Kim, Hui-Jun Yang, Woong-Woo Lee, Aryun Kim, Han-Joon Kim","doi":"10.14802/jmd.23130","DOIUrl":"10.14802/jmd.23130","url":null,"abstract":"<p><strong>Objective: </strong>Parkinson's disease (PD) patients often find it difficult to visit hospitals because of motor symptoms, distance to the hospital, or the absence of caregivers. Telemedicine is one way to solve this problem.</p><p><strong>Methods: </strong>We surveyed 554 PD patients from eight university hospitals in Korea. The questionnaire consisted of the clinical characteristics of the participants, possible teleconferencing.</p><p><strong>Methods: </strong>, and preferences for telemedicine.</p><p><strong>Results: </strong>A total of 385 patients (70%) expressed interest in receiving telemedicine. Among them, 174 preferred telemedicine whereas 211 preferred in-person visits. The longer the duration of disease, and the longer the time required to visit the hospital, the more patients were interested in receiving telemedicine.</p><p><strong>Conclusion: </strong>This is the first study on PD patients' preferences regarding telemedicine in Korea. Although the majority of patients with PD have a positive view of telemedicine, their interest in receiving telemedicine depends on their different circumstances.</p>","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":"89-93"},"PeriodicalIF":3.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10846964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10039226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Absence of Alpha-Synuclein Aggregation in Patients With Parkinson's Disease Complicated by Sigmoid Volvulus.","authors":"Dallah Yoo, Jae Young Joo, Sung-Hye Park, Sun Jin Park, Tae-Beom Ahn","doi":"10.14802/jmd.23173","DOIUrl":"10.14802/jmd.23173","url":null,"abstract":"","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":"118-119"},"PeriodicalIF":3.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10846979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71424299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cough as a presenting symptom in Wilson’s Disease","authors":"C. Phua, Shalini Bhaskar, Kelly Bertram","doi":"10.14802/jmd.23221","DOIUrl":"https://doi.org/10.14802/jmd.23221","url":null,"abstract":"","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":"51 34","pages":""},"PeriodicalIF":3.9,"publicationDate":"2023-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138588169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GBA1 Variants and Parkinson's Disease: Paving the Way for Targeted Therapy.","authors":"Young Eun Huh,&nbsp;Tatiana Usnich,&nbsp;Clemens R Scherzer,&nbsp;Christine Klein,&nbsp;Sun Ju Chung","doi":"10.14802/jmd.23023","DOIUrl":"10.14802/jmd.23023","url":null,"abstract":"<p><p>Glucosylceramidase beta 1 (GBA1) variants have attracted enormous attention as the most promising and important genetic candidates for precision medicine in Parkinson's disease (PD). A substantial correlation between GBA1 genotypes and PD phenotypes could inform the prediction of disease progression and promote the development of a preventive intervention for individuals at a higher risk of a worse disease prognosis. Moreover, the GBA1-regulated pathway provides new perspectives on the pathogenesis of PD, such as dysregulated sphingolipid metabolism, impaired protein quality control, and disrupted endoplasmic reticulum-Golgi trafficking. These perspectives have led to the development of novel disease-modifying therapies for PD targeting the GBA1-regulated pathway by repositioning treatment strategies for Gaucher's disease. This review summarizes the current hypotheses on a mechanistic link between GBA1 variants and PD and possible therapeutic options for modulating GBA1-regulated pathways in PD patients.</p>","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":"261-278"},"PeriodicalIF":3.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/38/c5/jmd-23023.PMC10548077.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9769536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cervical proprioception in Parkinson's disease and its correlation with manual dexterity function.","authors":"Özlem Menevşe,&nbsp;Büşra Kepenek-Varol,&nbsp;Murat Gültekin,&nbsp;Sevil Bilgin","doi":"10.14802/jmd.23039","DOIUrl":"10.14802/jmd.23039","url":null,"abstract":"<p><strong>Objective: </strong>Cervical proprioception plays a crucial role in posture and movement control. This study aimed to determine the relationships of cervical proprioception, cervical muscle strength and endurance with manual dexterity and hand strength in individuals with idiopathic Parkinson's disease (PD).</p><p><strong>Methods: </strong>Twenty individuals with PD (mean age: 63.9 years) and 20 healthy individuals as a control group (mean age: 61.9 years) were recruited. Cervical joint position error (JPE), static endurance of neck muscles, activation of deep cervical flexor muscles (Craniocervical Flexion Test, CCFT), manual dexterity (Purdue Pegboard Test, PPT), cognitive and motor tasks of the PPT, finger tapping test (FTT), pinch strength, and grip strength were assessed.</p><p><strong>Results: </strong>Cervical JPE was significantly higher in individuals with PD than in controls (p < 0.05). The strength and endurance of the cervical muscles were significantly decreased in individuals with PD (p < 0.05). Cervical JPE measurements were negatively correlated with PPT, cognitive and motor tasks of the PPT in individuals with PD (all p < 0.05). The endurance of cervical flexor muscles was negatively correlated with PPT and cognitive PPT scores in the PD group (p < 0.05). In addition, a significant positive correlation was found between cervical flexor endurance and hand strength in the PD group (p < 0.05).</p><p><strong>Conclusion: </strong>Cervical proprioception and the strength and endurance of cervical muscles decrease in individuals with PD compared to healthy individuals. Impairment of cervical proprioception appears to be associated with poorer upper extremity performance. Detailed evaluation of the cervical region in PD may help determine the factors affecting upper extremity function.</p>","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":"295-306"},"PeriodicalIF":3.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/07/32/jmd-23039.PMC10548074.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9742973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gravitational syncope induced by rising elevators in a Parkinson's disease patient.","authors":"Seon woo Son, Dallah Yoo, Tae-Beom Ahn","doi":"10.14802/jmd.23076","DOIUrl":"10.14802/jmd.23076","url":null,"abstract":"","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":"331-332"},"PeriodicalIF":2.5,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/92/22/jmd-23076.PMC10548082.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9586816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nine Hereditary Movement Disorders First Described in Asia: Their History and Evolution.","authors":"Priya Jagota,&nbsp;Yoshikazu Ugawa,&nbsp;Zakiyah Aldaajani,&nbsp;Norlinah Mohamed Ibrahim,&nbsp;Hiroyuki Ishiura,&nbsp;Yoshiko Nomura,&nbsp;Shoji Tsuji,&nbsp;Cid Diesta,&nbsp;Nobutaka Hattori,&nbsp;Osamu Onodera,&nbsp;Saeed Bohlega,&nbsp;Amir S N AlDin,&nbsp;Shen-Yang Lim,&nbsp;Jee-Young Lee,&nbsp;Beomseok Jeon,&nbsp;Pramod Kumar Pal,&nbsp;Huifang Shang,&nbsp;Shinsuke Fujioka,&nbsp;Prashanth Lingappa Kukkle,&nbsp;Onanong Phokaewvarangkul,&nbsp;Chin-Hsien Lin,&nbsp;Cholpon Shambetova,&nbsp;Roongroj Bhidayasiri","doi":"10.14802/jmd.23065","DOIUrl":"10.14802/jmd.23065","url":null,"abstract":"<p><p>Clinical case studies and reporting are important to the discovery of new disorders and the advancement of medical sciences. Both clinicians and basic scientists play equally important roles leading to treatment discoveries for both cures and symptoms. In the field of movement disorders, exceptional observation of patients from clinicians is imperative, not just for phenomenology but also for the variable occurrences of these disorders, along with other signs and symptoms, throughout the day and the disease course. The Movement Disorders in Asia Task Force (TF) was formed to help enhance and promote collaboration and research on movement disorders within the region. As a start, the TF has reviewed the original studies of the movement disorders that were preliminarily described in the region. These include nine disorders that were first described in Asia: Segawa disease, PARK-Parkin, X-linked dystonia-parkinsonism, dentatorubral-pallidoluysian atrophy, Woodhouse-Sakati syndrome, benign adult familial myoclonic epilepsy, Kufor-Rakeb disease, tremulous dystonia associated with mutation of the calmodulin-binding transcription activator 2 gene, and paroxysmal kinesigenic dyskinesia. We hope that the information provided will honor the original researchers and help us learn and understand how earlier neurologists and basic scientists together discovered new disorders and made advances in the field, which impact us all to this day.</p>","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":"231-247"},"PeriodicalIF":3.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a3/d4/jmd-23065.PMC10548072.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9994082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Historical and More Common Nongenetic Movement Disorders From Asia.","authors":"Norlinah Mohamed Ibrahim,&nbsp;Priya Jagota,&nbsp;Pramod Kumar Pal,&nbsp;Roongroj Bhidayasiri,&nbsp;Shen-Yang Lim,&nbsp;Yoshikazu Ugawa,&nbsp;Zakiyah Aldaajani,&nbsp;Beomseok Jeon,&nbsp;Shinsuke Fujioka,&nbsp;Jee-Young Lee,&nbsp;Prashanth Lingappa Kukkle,&nbsp;Huifang Shang,&nbsp;Onanong Phokaewvarangkul,&nbsp;Cid Diesta,&nbsp;Cholpon Shambetova,&nbsp;Chin-Hsien Lin","doi":"10.14802/jmd.22224","DOIUrl":"10.14802/jmd.22224","url":null,"abstract":"<p><p>Nongenetic movement disorders are common throughout the world. The movement disorders encountered may vary depending on the prevalence of certain disorders across various geographical regions. In this paper, we review historical and more common nongenetic movement disorders in Asia. The underlying causes of these movement disorders are diverse and include, among others, nutritional deficiencies, toxic and metabolic causes, and cultural Latah syndrome, contributed by geographical, economic, and cultural differences across Asia. The industrial revolution in Japan and Korea has led to diseases related to environmental toxin poisoning, such as Minamata disease and β-fluoroethyl acetate-associated cerebellar degeneration, respectively, while religious dietary restriction in the Indian subcontinent has led to infantile tremor syndrome related to vitamin B12 deficiency. In this review, we identify the salient features and key contributing factors in the development of these disorders.</p>","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":"248-260"},"PeriodicalIF":3.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/fb/aa/jmd-22224.PMC10548075.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9586814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Evidence to the Dish: A Viewpoint of Implementing a Thai-Style Mediterranean Diet for Parkinson's Disease.","authors":"Onanong Phokaewvarangkul,&nbsp;Nitinan Kantachadvanich,&nbsp;Vijittra Buranasrikul,&nbsp;Appasone Phoumindr,&nbsp;Saisamorn Phumphid,&nbsp;Priya Jagota,&nbsp;Roongroj Bhidayasiri","doi":"10.14802/jmd.23021","DOIUrl":"10.14802/jmd.23021","url":null,"abstract":"1Chulalongkorn Centre of Excellence for Parkinson’s Disease and Related Disorders, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand 2The Academy of Science, The Royal Society of Thailand, Bangkok, Thailand VIEWPOINT https://doi.org/10.14802/jmd.23021 / J Mov Disord 2023;16(3):279-284 pISSN 2005-940X / eISSN 2093-4939","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":"279-284"},"PeriodicalIF":3.9,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3c/66/jmd-23021.PMC10548080.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9657549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}