Journal of Movement Disorders最新文献

{"title":"Connectivity-based analysis of stimulation effects of globus pallidus interna deep brain stimulation in Parkinson's disease: A focus on freezing of gait.","authors":"Sungyang Jo, Moongwan Choi, Jihyun Lee, Sangjin Lee, Hwon Heo, Chong Hyun Suh, Woo Hyun Shim, Junhyung Kim, Sang Ryong Jeon, Hyunna Lee, Sun Ju Chung","doi":"10.14802/jmd.25005","DOIUrl":"https://doi.org/10.14802/jmd.25005","url":null,"abstract":"<p><strong>Objective: </strong>Freezing of gait (FOG) significantly affects the quality of life and increases the risk of falls in patients with Parkinson's disease (PD). Although deep brain stimulation (DBS) of the globus pallidus interna (GPi) is effective in managing motor complications, its efficacy in treating FOG remains inconsistent. This study aimed to determine whether preoperative structural brain connectivity can predict both the presence of FOG and its postoperative improvement following GPi DBS.</p><p><strong>Methods: </strong>We retrospectively analyzed 58 patients with PD who underwent GPi DBS. Preoperative diffusion tensor imaging was used to assess structural connectivity between the volume of activated tissue (VAT) and 82 cortical regions. Machine learning models were developed to predict baseline FOG and postoperative FOG improvement (defined as ≥1- or ≥2-point reduction), using demographic and connectivity features.</p><p><strong>Results: </strong>Machine learning models incorporating structural connectivity features between the VAT and cortical regions-including the prefrontal, cingulate, and premotor cortices-outperformed models based solely on demographic variables in predicting both the presence of preoperative FOG and postoperative improvement. For example, the support vector machine model to predict FOG improvement (≥1-point improvement) achieved an accuracy of 0.65 with demographic data alone, which increased to 0.77 with the addition of structural connectivity features. Similar performance enhancements were observed in sensitivity analyses using stricter FOG thresholds (≥2-point improvement).</p><p><strong>Conclusions: </strong>Preoperative structural connectivity between the GPi and key cortical regions involved in cognitive control and motor planning predicts FOG responsiveness to DBS. These results highlight the utility of connectomic biomarkers for personalizing DBS strategies and optimizing therapeutic outcomes in patients with advanced PD.</p>","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144753598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rotatory 'head on bed' alleviating maneuver in Pantothenate Kinase Associated Neurodegeneration.","authors":"Farsana Mustafa, Divyani Garg, Abhishek Mudda, Sreeja Samineni, Ayush Agarwal, Achal Kumar Srivastava","doi":"10.14802/jmd.25200","DOIUrl":"https://doi.org/10.14802/jmd.25200","url":null,"abstract":"","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144753600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retro-Walking and Cholinergic Network Correlates in Parkinson's Disease.","authors":"Alexis Griggs, Giulia Carli, Taylor Brown, Prabesh Kanel, Stiven Roytman, Chatkaew Pongmala, Miriam van Emde Boas, Nicolaas I Bohnen","doi":"10.14802/jmd.25109","DOIUrl":"https://doi.org/10.14802/jmd.25109","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the cholinergic underpinnings of forward and retro-walking in individuals with Parkinson's disease (PD) using [18F]FEOBV PET, a radiotracer that binds to the vesicular acetylcholine transporter (VAChT).</p><p><strong>Methods: </strong>We retrospectively included 44 patients with PD who underwent [18F]FEOBV PET imaging and forward- and retro-walking gait assessments. Voxel-wise correlation analyses were performed to examine associations between gait velocities and [18F]FEOBV binding, controlling for levodopa equivalent dose and disease duration. Linear regression and mediation analyses were then used to investigate the contribution of postural instability and gait disorder (PIGD) symptoms-measured using MDS-UPDRS items and the Mini-Balance Evaluation Systems Test (MiniBESTest)-as well as cognitive performance (attention, memory, executive, language, and visuospatial domains), to the observed associations.</p><p><strong>Results: </strong>Slower retro-walking velocity was associated with lower [18F]FEOBV uptake in a subcortical-frontal-temporal cluster, including bilateral middle frontal cortex, anterior cingulate, insula, basal forebrain, and striatal regions. No significant associations were found for forward walking time. Linear regression analyses showed that MiniBESTest total scores, the reactive postural control subscore, and attention domain scores were associated with both cholinergic uptake in the identified cluster and retro-walking velocities. Mediation analyses revealed that attention and reactive postural control mediated the relationship between [18F]FEOBV binding and retro-walking performance.</p><p><strong>Conclusions: </strong>Our findings indicate that retro-walking places greater demands on balance-particularly reactive postural control-and attentional resources than forward walking. Our results suggest that retro-walking might serve as part of an intervention strategy to improve balance and cognition in PD.</p>","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144753599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early-onset spastic ataxia in a patient with Prion (PRNP) p.Val180Ile variant.","authors":"Seungmin Lee, Dallah Yoo, Kyung-Sun Park, Tae-Beom Ahn","doi":"10.14802/jmd.25108","DOIUrl":"https://doi.org/10.14802/jmd.25108","url":null,"abstract":"","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tongue myorhythmia as a presenting manifestation of IgLON 5 disease.","authors":"Abeer Goel, Sahil Mehta, Shreshtha Gupta, Dhanush Mallesh, Sidharth Chand, Vivek Lal","doi":"10.14802/jmd.25161","DOIUrl":"https://doi.org/10.14802/jmd.25161","url":null,"abstract":"","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A mild ataxia-dominant phenotype of Phosphomannomutase 2-congenital disorders of glycosylation (PMM2-CDG) in a Tunisian Family: broadening the geographical scope.","authors":"Rania Zouari, Loua Hlioui, Mohamed Zakaria Saeid, Dina Ben Mohamed, Samia Ben Sassi, Rim Amouri","doi":"10.14802/jmd.25106","DOIUrl":"https://doi.org/10.14802/jmd.25106","url":null,"abstract":"","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subtyping of Parkinson's Disease by Longitudinal Trajectories of Levodopa Equivalent Daily Dose.","authors":"Young-Gun Lee, Kyoungwon Paik, Mincheol Park, Sung Woo Kang, So Hoon Yoon","doi":"10.14802/jmd.25099","DOIUrl":"https://doi.org/10.14802/jmd.25099","url":null,"abstract":"<p><strong>Objective: </strong>There is clinical heterogeneity on the optimal timing and dosage of symptomatic treatments in Parkinson's disease (PD). This study aimed to cluster PD patients based on longitudinal trajectories of LEDD and evaluate the clinical features and progression associated with these clusters.</p><p><strong>Methods: </strong>From the Parkinson's Progression Markers Initiative database, we enrolled 301 PD participants, who were followed up for at least three years after the initiation of anti-parkinsonian medications. Based on the longitudinal trajectories of LEDD increment, participants were classified into three clusters: slow-increment, initial-increment, and rapid-increment. Outcomes were initial and longitudinal changes in motor phenotype, on-time motor symptoms, and the efficacy of anti-parkinsonian medications.</p><p><strong>Results: </strong>The initial-increment cluster exhibited greatest symptomatic improvements by administration of higher doses of LEDD, although the motor improvement per unit of LEDD was comparable across clusters. Longitudinally, motor phenotypes changed rapidly in the initial-increment cluster. The initial-increment cluster showed continuous worsening of on-time motor symptoms, with limited LEDD efficacy. In contrast, the rapid-increment cluster exhibited stable on-time motor symptoms, while the efficacy of anti-parkinsonian medications declined over time. The risk of disability related to walking and balance milestone and motor complications were twice as high in the initial-increment and rapid-increment clusters compared to the slow-increment cluster.</p><p><strong>Conclusions: </strong>There is heterogeneity in the increment of anti-parkinsonian medications, driven by changes in motor phenotype, medication efficacy, and the occurrence of PD-relevant milestones. Subtyping patients based on LEDD trajectories may provide insight into clinical heterogeneity for future research on individualized treatment strategies in PD.</p>","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Treatment with Posterior Subthalamic Area-Deep Brain Stimulation in a patient with tremor and extensive brain lesion.","authors":"Taku Nonaka, Takashi Asahi, Shiro Horisawa, Kiyonobu Ikeda, Nobutaka Yamamoto, Takaomi Taira","doi":"10.14802/jmd.25096","DOIUrl":"https://doi.org/10.14802/jmd.25096","url":null,"abstract":"","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of Biofeedback therapy on Anxiety and Depression in Parkinson's disease: a Pilot Study.","authors":"Justus Chun-Yu Chen, Tzu-Yun Tseng, Jong-Ling Fuh, Yu-Hsiang Cheng, Dai-Wei Lin, Han-Lin Chiang","doi":"10.14802/jmd.25097","DOIUrl":"https://doi.org/10.14802/jmd.25097","url":null,"abstract":"<p><strong>Objective: </strong>This pilot study aimed to evaluate the feasibility and potential effects of biofeedback therapy (BT) on anxiety and depression in patients with Parkinson's disease (PD).</p><p><strong>Methods: </strong>A randomized waitlist-controlled trial was conducted involving 19 patients with PD and comorbid anxiety and/or depression. Anxiety and depression were assessed at baseline, post-treatment, and one-month follow-up.</p><p><strong>Results: </strong>All 19 patients completed the study. Compared with the control group, significant improvements were observed immediately after BT in the Hamilton Depression Rating Scale and the anxiety subscale of the Hospital Anxiety and Depression Scale (HADS), but not in the HADS depression subscale. In the pooled analysis, the anxiolytic effect persisted at one-month follow-up, with greater improvements observed in those with more severe baseline anxiety.</p><p><strong>Conclusion: </strong>These preliminary findings suggest that BT may help reduce anxiety symptoms in PD. Future studies with larger, more severely affected cohorts are needed to confirm these findings.</p>","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144626569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current Status of Pelvic Lateral Shift in Patients With Parkinson's Disease and Its Relationship With Lateral Trunk Flexion.","authors":"Kyohei Mikami, Makoto Shiraishi, Akika Yoshimoto, Tsutomu Kamo","doi":"10.14802/jmd.25017","DOIUrl":"10.14802/jmd.25017","url":null,"abstract":"<p><strong>Objective: </strong>A lack of standardized methods for evaluating postural abnormalities hinders treatment progress. The role of pelvic lateral shift (PLS) in patients with Parkinson's disease (PwP) exhibiting lateral trunk flexion (LTF) remains unclear. We hypothesized that PLS is related to LTF and investigated its characteristics and relationship with the LTF angle.</p><p><strong>Methods: </strong>PwP attending outpatient rehabilitation (March 2018-March 2023) were assessed via still images. The PLS direction, its relationship with the LTF angle, and the LTF angle on the PLS side were analyzed.</p><p><strong>Results: </strong>Among 158 patients, PLS was contralateral in 80 (50.6%), ipsilateral in 43 (27.2%), and absent in 35 (22.2%). In the contralateral PLS, but not in the ipsilateral PLS, the PLS angle was correlated with the LTF angle (r=0.48, p<0.001). The LTF angle was greater in the contralateral shift (8.5°±9.6°) than in the ipsilateral shift (2.8°±4.2°, p<0.001).</p><p><strong>Conclusion: </strong>Based on the positive relationship between the LTF angle and contralateral shift angle, evaluation criteria that include PLS are needed for PwP with LTF.</p>","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":"253-256"},"PeriodicalIF":2.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301854/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}