Journal of Movement Disorders最新文献

Early-onset spastic ataxia in a patient with Prion (PRNP) p.Val180Ile variant. 朊病毒（PRNP） p.Val180Ile变异患者的早发性痉挛性共济失调

IF 2.5 4区医学

Journal of Movement Disorders Pub Date : 2025-07-21 DOI: 10.14802/jmd.25108

Seungmin Lee, Dallah Yoo, Kyung-Sun Park, Tae-Beom Ahn

引用次数: 0

Tongue myorhythmia as a presenting manifestation of IgLON 5 disease. 舌律动是iglon5疾病的一种表现。

IF 2.5 4区医学

Journal of Movement Disorders Pub Date : 2025-07-18 DOI: 10.14802/jmd.25161

Abeer Goel, Sahil Mehta, Shreshtha Gupta, Dhanush Mallesh, Sidharth Chand, Vivek Lal

引用次数: 0

A mild ataxia-dominant phenotype of Phosphomannomutase 2-congenital disorders of glycosylation (PMM2-CDG) in a Tunisian Family: broadening the geographical scope. 突尼斯家族中2型先天性糖基化障碍（PMM2-CDG）的轻度共济失调显性表型：扩大地理范围。

IF 2.5 4区医学

Journal of Movement Disorders Pub Date : 2025-07-18 DOI: 10.14802/jmd.25106

Rania Zouari, Loua Hlioui, Mohamed Zakaria Saeid, Dina Ben Mohamed, Samia Ben Sassi, Rim Amouri

引用次数: 0

Subtyping of Parkinson's Disease by Longitudinal Trajectories of Levodopa Equivalent Daily Dose. 左旋多巴当量日剂量纵向轨迹对帕金森病亚型的影响。

IF 2.5 4区医学

Journal of Movement Disorders Pub Date : 2025-07-18 DOI: 10.14802/jmd.25099

Young-Gun Lee, Kyoungwon Paik, Mincheol Park, Sung Woo Kang, So Hoon Yoon

{"title":"Subtyping of Parkinson's Disease by Longitudinal Trajectories of Levodopa Equivalent Daily Dose.","authors":"Young-Gun Lee, Kyoungwon Paik, Mincheol Park, Sung Woo Kang, So Hoon Yoon","doi":"10.14802/jmd.25099","DOIUrl":"https://doi.org/10.14802/jmd.25099","url":null,"abstract":"Objective: There is clinical heterogeneity on the optimal timing and dosage of symptomatic treatments in Parkinson's disease (PD). This study aimed to cluster PD patients based on longitudinal trajectories of LEDD and evaluate the clinical features and progression associated with these clusters.Methods: From the Parkinson's Progression Markers Initiative database, we enrolled 301 PD participants, who were followed up for at least three years after the initiation of anti-parkinsonian medications. Based on the longitudinal trajectories of LEDD increment, participants were classified into three clusters: slow-increment, initial-increment, and rapid-increment. Outcomes were initial and longitudinal changes in motor phenotype, on-time motor symptoms, and the efficacy of anti-parkinsonian medications.Results: The initial-increment cluster exhibited greatest symptomatic improvements by administration of higher doses of LEDD, although the motor improvement per unit of LEDD was comparable across clusters. Longitudinally, motor phenotypes changed rapidly in the initial-increment cluster. The initial-increment cluster showed continuous worsening of on-time motor symptoms, with limited LEDD efficacy. In contrast, the rapid-increment cluster exhibited stable on-time motor symptoms, while the efficacy of anti-parkinsonian medications declined over time. The risk of disability related to walking and balance milestone and motor complications were twice as high in the initial-increment and rapid-increment clusters compared to the slow-increment cluster.Conclusions: There is heterogeneity in the increment of anti-parkinsonian medications, driven by changes in motor phenotype, medication efficacy, and the occurrence of PD-relevant milestones. Subtyping patients based on LEDD trajectories may provide insight into clinical heterogeneity for future research on individualized treatment strategies in PD.","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Successful Treatment with Posterior Subthalamic Area-Deep Brain Stimulation in a patient with tremor and extensive brain lesion. 丘脑后底区-深部脑刺激成功治疗震颤伴大面积脑损伤患者1例。

IF 2.5 4区医学

Journal of Movement Disorders Pub Date : 2025-07-16 DOI: 10.14802/jmd.25096

Taku Nonaka, Takashi Asahi, Shiro Horisawa, Kiyonobu Ikeda, Nobutaka Yamamoto, Takaomi Taira

引用次数: 0

The effect of Biofeedback therapy on Anxiety and Depression in Parkinson's disease: a Pilot Study. 生物反馈疗法对帕金森病焦虑和抑郁的影响：一项初步研究。

IF 2.5 4区医学

Journal of Movement Disorders Pub Date : 2025-07-14 DOI: 10.14802/jmd.25097

Justus Chun-Yu Chen, Tzu-Yun Tseng, Jong-Ling Fuh, Yu-Hsiang Cheng, Dai-Wei Lin, Han-Lin Chiang

{"title":"The effect of Biofeedback therapy on Anxiety and Depression in Parkinson's disease: a Pilot Study.","authors":"Justus Chun-Yu Chen, Tzu-Yun Tseng, Jong-Ling Fuh, Yu-Hsiang Cheng, Dai-Wei Lin, Han-Lin Chiang","doi":"10.14802/jmd.25097","DOIUrl":"https://doi.org/10.14802/jmd.25097","url":null,"abstract":"Objective: This pilot study aimed to evaluate the feasibility and potential effects of biofeedback therapy (BT) on anxiety and depression in patients with Parkinson's disease (PD).Methods: A randomized waitlist-controlled trial was conducted involving 19 patients with PD and comorbid anxiety and/or depression. Anxiety and depression were assessed at baseline, post-treatment, and one-month follow-up.Results: All 19 patients completed the study. Compared with the control group, significant improvements were observed immediately after BT in the Hamilton Depression Rating Scale and the anxiety subscale of the Hospital Anxiety and Depression Scale (HADS), but not in the HADS depression subscale. In the pooled analysis, the anxiolytic effect persisted at one-month follow-up, with greater improvements observed in those with more severe baseline anxiety.Conclusion: These preliminary findings suggest that BT may help reduce anxiety symptoms in PD. Future studies with larger, more severely affected cohorts are needed to confirm these findings.","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144626569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phenotypic variability in ATP13A2 mutations-First Report of SPG78 from India. ATP13A2突变的表型变异——印度SPG78首次报道。

IF 2.5 4区医学

Journal of Movement Disorders Pub Date : 2025-06-29 DOI: 10.14802/jmd.25100

Lakshmi Priya L, Asish Vijayaraghavan, Syam Krishnan

引用次数: 0

Variability in Pull Test Performance Within a Tertiary Movement Disorders Center. 三级运动障碍中心拉力测试表现的变异性。

IF 2.5 4区医学

Journal of Movement Disorders Pub Date : 2025-06-20 DOI: 10.14802/jmd.25140

Carla Silva-Batista, Lee Neilson, Hanna Whang, Jacqueline Ellison, Delaram Safarpour, Lauren Talman, Fay B Horak, John Nutt, Marian L Dale

引用次数: 0

The Role of handedness and extrainstrumental burdens on the course of musicians' dystonia. 手性和乐器外负担在音乐家肌张力障碍过程中的作用。

IF 2.5 4区医学

Journal of Movement Disorders Pub Date : 2025-06-15 DOI: 10.14802/jmd.25064

J Doll-Lee, E Passarotto, Altenmüller E, Lee A

{"title":"The Role of handedness and extrainstrumental burdens on the course of musicians' dystonia.","authors":"J Doll-Lee, E Passarotto, Altenmüller E, Lee A","doi":"10.14802/jmd.25064","DOIUrl":"https://doi.org/10.14802/jmd.25064","url":null,"abstract":"Background: This study investigates the impact of extrainstrumental workload on musician's hand dystonia (MD) and its relation to playing ability by testing two hypotheses: 1) the dominant hand is more severely affected at dystonia-onset; 2) improvement during treatment depends on whether the dominant or non-dominant hand is affected.Methods: 151 patients with dominant-hand MD and 92 with non-dominant hand MD were assessed regarding their playing ability at dystonia-onset (T0) and after treatment (T1).Results: There was no significant difference in playing-ability at onset between groups. Significant improvement and a greater change in playing-ability was observed in the dominant-hand group. We found no difference in the proportional frequency of right-handed and left-handed individuals in the group of patients affected on the right or left side respectively.Conclusion: These findings suggest that handedness does not influence MD localization, but the prognosis is more favorable for those with dominant hand dystonia, potentially due to metaplasticity effects.","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Longitudinal Multimodal Functional Imaging: An Essential Tool for Visualizing Pathologic Progression in Parkinson's disease. 纵向多模态功能成像：帕金森病病理进展可视化的重要工具。

IF 2.5 4区医学

Journal of Movement Disorders Pub Date : 2025-06-08 DOI: 10.14802/jmd.24257

Antonio Martín-Bastida, María Cruz Rodríguez-Oroz

引用次数: 0