Journal of Movement Disorders最新文献

The Clinical Significance of Thyroid Uptake in 123I- meta-iodobenzylguanidine Scintigraphy in Parkinson's disease. 帕金森病123I-间碘苄基胍显像甲状腺摄取的临床意义。

IF 2.8 4区医学

Journal of Movement Disorders Pub Date : 2026-05-05 DOI: 10.14802/jmd.26046

Sang-Won Yoo, Dong-Woo Ryu, Yoonsang Oh, Seunggyun Ha, Joong-Seok Kim

{"title":"The Clinical Significance of Thyroid Uptake in 123I- meta-iodobenzylguanidine Scintigraphy in Parkinson's disease.","authors":"Sang-Won Yoo, Dong-Woo Ryu, Yoonsang Oh, Seunggyun Ha, Joong-Seok Kim","doi":"10.14802/jmd.26046","DOIUrl":"https://doi.org/10.14802/jmd.26046","url":null,"abstract":"Background: The thyroid gland receives sympathetic innervation. 123I-meta-iodobenzylguanidine (123I-MIBG) is a noradrenaline analog taken up by adrenergic nerve terminals. Although thyroid uptake can be seen on 123I-MIBG scintigraphy, its quantitative value is poorly understood. This study examined the clinical relevance of thyroid 123I-MIBG uptake in Parkinson's disease (PD).Methods: A total of 233 de novo patients were enrolled in a longitudinal cohort and underwent 123I-MIBG scintigraphy. Early and late heart-to-mediastinum ratio (HMR) and early thyroid-to-mediastinum ratio (TMR) were calculated. Baseline TMR was estimated using a mixed model after verifying the empirical linear decline over time. Observed and model-implied uptake ratios were analyzed in relation to adrenergic blood pressure (BP) control, motor and non-motor burdens, and quality of life (QoL). Baseline thyroid uptake was further assessed for its influence on longitudinal disease progression.Results: Patients were assessed from early PD (mean age, 68.7 ± 8.7 years; median disease duration, 1.0 year). Mean follow-up was 57.3 ± 22.1 months. Lower baseline HMR correlated with greater orthostatic BP changes, autonomic symptom burden, and worsening motor, non-motor functions, and QoL. The TMR showed no significant correlations overall; however, it was associated with a higher occurrence of supine hypertension, orthostatic hypotension, and non-dipper or nocturnal hypertension. Thyroid uptake did not influence longitudinal changes in motor, non-motor, cognitive, and QoL measure, though higher uptake showed trends toward slower cognitive decline and better QoL.Conclusions: Thyroid 123I-MIBG uptake did not predict disease progression, but may indicate early blood pressure dysregulation, and could reflect non-motor vulnerability in PD.","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147839014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expanding the Phenotype: Myoclonus-Dystonia as a Novel Manifestation of 47 XXX Syndrome. 扩展表型：肌阵挛-肌张力障碍是47xxx综合征的新表现。

IF 2.8 4区医学

Journal of Movement Disorders Pub Date : 2026-05-05 DOI: 10.14802/jmd.26045

Lakshmi Priya Lalitha, Asish Vijayaraghavan, Kiren George Koshy, Sayooja Sachithanandan, Divya Kalikavil Puthenveedu, Syam Krishnan

引用次数: 0

Myotonic dystrophy type 1 with normal pressure hydrocephalus-like neuroimaging and a negative tap test: diagnostic pitfalls and management considerations. 1型肌强直性营养不良伴正常压力脑积水样神经影像学和阴性抽头试验：诊断陷阱和处理考虑。

IF 2.8 4区医学

Journal of Movement Disorders Pub Date : 2026-04-27 DOI: 10.14802/jmd.26029

Deep Faldu, Naresh Babu, Vikram V Holla, Shweta Prasad, Meera Purushottam, Nitish Kamble, Ravi Yadav, Pramod Kumar Pal

引用次数: 0

Reversible Dropped Head Syndrome Due to Olanzapine-Associated Cervical Dystonia in C9orf72-Associated bvFTD Within the FTD-ALS Spectrum. 在FTD-ALS谱系中，由奥氮平相关的c9orf72相关bvFTD引起的可逆性低垂头综合征

IF 2.8 4区医学

Journal of Movement Disorders Pub Date : 2026-04-27 DOI: 10.14802/jmd.26048

Rik Spons

引用次数: 0

Digital Technology for Sleep Symptoms in Parkinson's Disease: A Scoping Review. 帕金森病睡眠症状的数字技术：范围综述

IF 2.8 4区医学

Journal of Movement Disorders Pub Date : 2026-04-14 DOI: 10.14802/jmd.26098

Kye Won Park, Ki-Young Jung, Han-Joon Kim, Jung Hwan Shin

{"title":"Digital Technology for Sleep Symptoms in Parkinson's Disease: A Scoping Review.","authors":"Kye Won Park, Ki-Young Jung, Han-Joon Kim, Jung Hwan Shin","doi":"10.14802/jmd.26098","DOIUrl":"https://doi.org/10.14802/jmd.26098","url":null,"abstract":"Sleep disturbances are highly prevalent and clinically significant non-motor features of Parkinson's disease (PD). Although in-laboratory polysomnography remains the gold standard, its limited scalability and ecological validity constrain longitudinal and real-world assessment. Recent advances in digital health technologies have introduced a broad spectrum of portable, wearable, and contactless tools for sleep monitoring. In this scoping review, we systematically map the landscape of digital sleep technologies in PD using a tiered framework based on technical maturity and clinical validation (Tier 1-4), and further classify them by signal modality and sleep symptom domain. Through a systematic review of the literature, we identified 19 studies (Tier 2-4) applying digital biomarkers to assess sleep disturbances in PD, including REM sleep behavior disorder, nocturnal immobility, insomnia, circadian rhythm disturbances, excessive daytime sleepiness, and sleep-related respiratory and movement disorders. We additionally contextualize these findings against the rapid expansion of multimodal and AI-driven Tier 3-4 platforms in the general population. Despite this technological progress, a major translational gap persists in PD, characterized by limited disease-specific validation, small cohort sizes, and insufficient multimodal benchmarking. Multimodal systems leveraging machine learning offer a promising direction by enabling more precise characterization of complex and overlapping sleep phenotypes. Emerging contactless systems further expand the potential for continuous, low-burden monitoring, although their clinical validity remains to be established. Future development of digital sleep biomarkers in PD will require prospective validation against established standards and integration of multimodal data to enable scalable, longitudinal phenotyping and clinical trial applications.","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147674330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Successful immunosuppressive treatment of spinal segmental myoclonus in GlyR antibody-associated stiff-person spectrum disorder/PERM spectrum. GlyR抗体相关的僵硬-人谱系障碍/PERM谱系脊髓节段性肌阵挛的成功免疫抑制治疗

IF 2.8 4区医学

Journal of Movement Disorders Pub Date : 2026-04-10 DOI: 10.14802/jmd.25331

Yi Yang, Yuanhe Zhang, Pei Xiao, Ting Zeng, Xianwen Zhang, Yufeng Tang

引用次数: 0

Rehabilitation Gaps and Unmet Needs Across Disability Stages in Parkinson's Disease: A National Survey. 帕金森病残疾阶段的康复差距和未满足的需求：一项全国调查。

IF 2.8 4区医学

Journal of Movement Disorders Pub Date : 2026-04-10 DOI: 10.14802/jmd.26024

Yohei Okada, Yuki Kondo, Kyohei Mikami, Kazunori Sato, Makoto Sawada, Takayo Chuma

引用次数: 0

Rasmussen's Encephalitis Presenting as Parkinsonism Without Epilepsy. 拉斯穆森脑炎表现为无癫痫的帕金森病。