Journal of Movement Disorders最新文献

{"title":"Eyelid myoclonus in Subacute Sclerosing Panencephalitis - A newly recognised slow myoclonic pattern?","authors":"Arunmozhimaran Elavarasi, Animesh Das, Ajay Garg, Anil Dash, Manjari Tripathi, Deepti Vibha, Rajesh Kumar Singh, Jasmine Parihar","doi":"10.14802/jmd.26174","DOIUrl":"https://doi.org/10.14802/jmd.26174","url":null,"abstract":"","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Problematic Smartphone Use in Parkinson's Disease: Associations with Mood, Non-Motor Burden, and Impulsivity.","authors":"Müge Kuşoğlu, Mücahid Erdoğan, Banu Özen Barut","doi":"10.14802/jmd.26203","DOIUrl":"https://doi.org/10.14802/jmd.26203","url":null,"abstract":"<p><strong>Objective: </strong>To investigate problematic smartphone use and its associations with mood symptoms, impulsivity, and non-motor symptom burden in Parkinson's disease (PD).</p><p><strong>Methods: </strong>Forty-five patients with PD younger than 60 years and 43 matched healthy controls completed the Smartphone Addiction Scale, Beck Depression Inventory, and Beck Anxiety Inventory. Patients with PD additionally completed the Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale. Clinical characteristics and MDS-UPDRS scores were assessed.</p><p><strong>Results: </strong>SAS scores were lower in PD than in controls. In PD, smartphone use was associated with depressive symptoms, anxiety, non-motor symptom burden, and impulsivity, although none remained independently associated in multivariable analysis. Positive Anticipation showed the strongest association with impulsivity. In controls, depressive symptoms were associated only with the Overuse and Cyberspace-Oriented Relationships subscales.</p><p><strong>Conclusion: </strong>Problematic smartphone use in PD appears to involve multiple behavioral dimensions, with overall use related to mood symptoms and reward-related use more closely linked to impulsivity.</p>","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148840443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative Analysis of Automatically Segmented Perivascular Space in Subcortical White Matter of Parkinson's Disease: Its Clinical Relevance.","authors":"Chae Jung Park, Yoonho Nam, Hyun-Jae Jeong, Han Kyu Na, Kyunghwa Han, Hye Sun Lee, Jun Hwee Kim, Seung-Koo Lee, Phil Hyu Lee, Yun Joong Kim, Young H Sohn, Seok Jong Chung","doi":"10.14802/jmd.26157","DOIUrl":"https://doi.org/10.14802/jmd.26157","url":null,"abstract":"<p><strong>Objective: </strong>To examine the relationship between automatically quantified perivascular space (PVS) extent located in the subcortical white matter (WM), baseline motor deficits and cognitive function, as well as longitudinal motor and cognitive outcomes in patients with Parkinson's disease (PD).</p><p><strong>Methods: </strong>This retrospective cohort study included 270 consecutive patients with newly diagnosed PD. Subcortical WM PVS was automatically segmented using high-resolution T2-weighted images, and automated PVS (aPVS) volume and count were calculated. Multivariate linear regression analyses evaluated the association between subcortical WM aPVS and baseline Unified PD Rating Scale Part III, Mini-Mental State Examination, and Montreal Cognitive Assessment scores. Cox regression models assessed the prognostic value of baseline subcortical WM aPVS for the risk of developing freezing of gait (FOG) and dementia.</p><p><strong>Results: </strong>Greater subcortical WM aPVS volume, particularly in the frontal and parietal regions, correlated with milder parkinsonian motor deficits and better global cognitive function at baseline. Higher subcortical WM aPVS volume, especially in the frontal region, was linked to a lower risk of FOG (hazard ratio (HR), 0.5; 95% confidence interval (CI), 0.2-0.9; p=0.028). Additionally, greater subcortical WM aPVS volume, especially in the occipital region, was associated with a reduced risk of dementia conversion (HR, 0.4; 95% CI, 0.1-1.0; p=0.041) in Cox regression models. Higher subcortical WM aPVS count was linked to better baseline motor symptoms, cognitive function, and lower risk of FOG.</p><p><strong>Conclusions: </strong>These findings indicate that larger subcortical WM aPVS volume or higher aPVS count can be an indicator of favorable clinical outcomes in PD.</p>","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148840468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary Reference Values for Dual-Task Gait Performance and Data-Driven Gait Profiles Across the Lifespan in Healthy Korean Adults.","authors":"Bora Jin, Seungho Lee, Sang-Myung Cheon","doi":"10.14802/jmd.26105","DOIUrl":"https://doi.org/10.14802/jmd.26105","url":null,"abstract":"<p><strong>Objectives: </strong>Understanding normal gait characteristics is fundamental for characterizing disease-specific gait alterations. This study aimed to evaluate age-related differences in gait across various task conditions and identify data-driven gait profiles based on dual-task vulnerability in healthy Korean adults.</p><p><strong>Methods: </strong>A cross-sectional gait assessment was conducted using GAITRite® under four conditions: preferred speed, serial sevens subtraction, cell phone use, and backward walking. Gait parameters were categorized into five domains: pace, variability, rhythm, asymmetry, and postural control. Participants were stratified into younger (<60 years) and older adults (≥60 years). Latent profile analysis (LPA) was performed using the dual-task cost variables to identify data-driven gait profiles.</p><p><strong>Results: </strong>Ninety-eight healthy adults (aged 23-87 years) were analyzed. Age-related differences were most pronounced during cell phone use, which was supported by significant age × task interaction effects across the pace, variability, rhythm, and postural control domains (pfdr < 0.05). LPA identified three profiles: Pace-Preserved (Pa-P), Asymmetry-Dominant (Asym-D), and Postural control-Dominant (Pc-D). Younger adults were evenly distributed across the profiles, whereas older adults were predominantly classified into the Asym-D and Pc-D profiles. The Asym-D profile, characterized by the highest mean age, exhibited numerically lower cognitive scores, particularly in the visuospatial domain.</p><p><strong>Conclusions: </strong>Regardless of chronological age groups and data-driven profiles, dual-task gait interference was most pronounced in the cognitive-motor dual-task condition. Data-driven profiling also identified a subgroup characterized by gait asymmetry, older age, and lower cognitive scores, suggesting a potentially distinct cognitive-motor pattern that warrants longitudinal investigation. These preliminary reference values provide a valuable foundation for the identification of pathological gait patterns in clinical populations.</p>","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148794323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinct Patterns of Perivascular Diffusivity and Choroid Plexus Volume in De Novo Parkinson's Disease and Type 2 Diabetes.","authors":"Yun Jung Bae, Chaewon Shin, Hyunjae Jeong, Se Jin Cho, Sung Hyun Baik, So Yeong Jeong, Da Hyun Lee, Younbeom Jeong, Jong-Min Kim","doi":"10.14802/jmd.26131","DOIUrl":"https://doi.org/10.14802/jmd.26131","url":null,"abstract":"<p><strong>Background: </strong>Alterations in perivascular fluid dynamics have been implicated in Parkinson's disease (PD) and metabolic disorders such as type 2 diabetes mellitus (T2DM). However, the relative contributions of neurodegenerative and metabolic conditions to functional perivascular water diffusivity versus structural neurofluid markers remain to be elucidated.</p><p><strong>Objectives: </strong>To investigate the differences in perivascular water diffusivity and structural neurofluid markers using diffusion tensor image-analysis along the perivascular space (DTI-ALPS), perivascular space (PVS) burden, and choroid plexus volume (CPV) in PD and T2DM.</p><p><strong>Methods: </strong>Consecutive patients with de novo PD and disease controls were included. Subjects were classified into four groups according to PD and T2DM status and matched for age and sex. The ALPS-index was derived from DTI, whereas PVS burden and CPV were quantified on three-dimensional T1-weighted images and normalized to intracranial volume.</p><p><strong>Results: </strong>A total of 127 subjects were included. The ALPS-index differed significantly among the four groups (P < 0.001), with both PD groups demonstrating significantly lower values than control groups, irrespective of T2DM status. Within the PD cohort, longer disease duration and older age were independently associated with lower ALPS-index values. CPV also differed significantly across groups (P = 0.006) with higher values observed only in controls with T2DM, while PVS burden did not differ significantly.</p><p><strong>Conclusions: </strong>In early-stage PD, impaired perivascular diffusivity was associated primarily with neurodegeneration, and no significant additive effect of T2DM was detected. Conversely, the increase in normalized CPV associated with T2DM was observed only in controls and not in PD, suggesting that metabolic and neurodegenerative conditions may differentially influence neurofluid markers.</p>","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148794332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early improvement in depressive symptoms after pallidothalamic tract deep brain stimulation for drug-induced dystonia.","authors":"Esraa Shaban, Joseph Turner, Clemens Neudorfer, Kilsoo Kim, Yoshihiro Noda, Shiro Horisawa","doi":"10.14802/jmd.26125","DOIUrl":"https://doi.org/10.14802/jmd.26125","url":null,"abstract":"","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148794297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Marked Improvement after Globus Pallidus Deep Brain Stimulation in Dystonia-24 with a Novel ANO3 Variant: A Case Report and Literature Review.","authors":"Masataka Yamashiro, Tomoyo Hashimoto, Ryosuke Miyamoto, Yasushi Miyagi, Konoka Tachibana, Yuishin Izumi, Kazumasa Okada","doi":"10.14802/jmd.26139","DOIUrl":"https://doi.org/10.14802/jmd.26139","url":null,"abstract":"","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148578965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progressive ataxia with palatal tremor in a patient carrying the prion protein gene M232R variation: a case report.","authors":"Hak-Loh Lee, Yeeun Sun, Han Kyu Na, Seok Jong Chung, Phil Hyu Lee","doi":"10.14802/jmd.26153","DOIUrl":"https://doi.org/10.14802/jmd.26153","url":null,"abstract":"","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148578970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disease course, survival, and genetic heterogeneity in chorea-acanthocytosis: a case series of 34 patients.","authors":"Aida Ghasemi, Elahe Amini, Ahmad Chitsaz, Gholamali Shahidi, Seyed Amir Hassan Habibi, Atieh Jafarabadi Ashtiani, Arezoo Farzi, Vadieh Ghodsinezhad, Afagh Alavi, Mohammad Rohani","doi":"10.14802/jmd.25350","DOIUrl":"https://doi.org/10.14802/jmd.25350","url":null,"abstract":"<p><strong>Objective: </strong>To quantify key disease milestones, particularly loss of ambulation and survival, and to describe the VPS13A variant spectrum and clinical heterogeneity in patients with chorea-acanthocytosis (ChA).</p><p><strong>Methods: </strong>We conducted a cross-sectional study of 34 ChA patients from 24 unrelated families. Whole-exome sequencing identified VPS13A variants in all probands. Clinical and paraclinical data were collected through neurological evaluations and electronic medical records. Patients were classified as either surviving (ambulatory or non-ambulatory) or deceased.</p><p><strong>Results: </strong>Twenty-one VPS13A variants were identified, including 12 novel variants. Median current age and disease duration were 38.5 (IQR, 34-43) and 8 (IQR, 4-12.25) years, respectively. Loss of ambulation occurred in 26.5% of patients after a median of 10 years (range, 5-16) from onset. Kaplan-Meier analysis estimated a median time to loss of ambulation of 16.0 years (95% CI, 8.8-23.2), with estimated ambulation probabilities of 87% at 6 years and 38% at 16 years. Seven patients died after a median disease duration of 10 years (range, 3-17). The median survival time was not reached during follow-up; the estimated restricted mean survival time was 16.7 years (95% CI, 14.1-19.3). Compulsions co-occurred with obsessions in all cases and were associated with higher rates of suicidal ideation, while insomnia was more frequent in patients without compulsions. Suicide and sepsis were the leading causes of death.</p><p><strong>Conclusions: </strong>This study defines the natural history of ChA, providing prognostic data on ambulation and survival. The discovery of novel VPS13A variants highlights genetic heterogeneity and supports further investigation into disease mechanisms and therapeutic targets.</p>","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148447558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Painful Dystonia After GPi-DBS for Post-Stroke Hemiballism in an Older Patient.","authors":"Daecheol Moon, Dallah Yoo, Chang Kyu Park, Tae-Beom Ahn","doi":"10.14802/jmd.26103","DOIUrl":"https://doi.org/10.14802/jmd.26103","url":null,"abstract":"","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148447572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}